IL2 Receptor beta Protein (Fc Tag)

Catalog No. ABIN7320916

Product Details

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This IL2 Receptor beta protein is labelled with Fc Tag.

Purpose: Recombinant Mouse IL-2 Receptor Subunit Beta/IL-2RB/CD122 (C-Fc)

Sequence: Ala27-Glu240

Characteristics: Recombinant Mouse Interleukin-2 Receptor subunit beta is produced by our Mammalian expression system and the target gene encoding Ala27-Glu240 is expressed with a Fc tag at the C-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.5.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Alternative Name: IL-2 Receptor Subunit Beta/IL-2RB/CD122 (IL2RB Products)

Synonyms: IL2RB Protein, il-2rb Protein, CD122 Protein, IL15RB Protein, P70-75 Protein, IL2RBC Protein, IL-15Rbeta Protein, IL15Rbeta Protein, Il-2/15Rbeta Protein, Il-2Rbeta Protein, p70 Protein, interleukin 2 receptor subunit beta Protein, interleukin-2 receptor subunit beta Protein, interleukin 2 receptor, beta Protein, interleukin 2 receptor, beta chain Protein, IL2RB Protein, LOC510185 Protein, il2rb Protein, Il2rb Protein

Background:

Background: IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for receptor-mediated signaling via physically or functionally coupling to other signaling molecules, such as the Jak-STAT and Src-family protein tyrosine kinase although it lacks apparent catalytic motifs.

Synonym: Interleukin-2 receptor subunit beta, IL2RB, IL-2 receptor subunit beta, IL-2R subunit beta, High affinity IL-2 receptor subunit beta, CD122

Molecular Weight: 52.2 kDa

UniProt: P16297

Pathways: JAK-STAT Signaling, Growth Factor Binding