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Human IL7 Protein expressed in Escherichia coli (E. coli) - ABIN1305105
Goodwin, Lupton, Schmierer, Hjerrild, Jerzy, Clevenger, Gillis, Cosman, Namen: Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 3 Pubmed References
Mouse (Murine) IL7 Protein expressed in Escherichia coli (E. coli) - ABIN1888631
Chari, Winandy: Ikaros regulates Notch target gene expression in developing thymocytes. in Journal of immunology (Baltimore, Md. : 1950) 2008
Human IL7 Protein expressed in Escherichia coli (E. coli) - ABIN1888605
Staron, Yang, Liu, Li, Shen, Zúñiga-Pflücker, Aguila, Goldschneider, Li: gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. in Blood 2010
increased IL-7 protein production in situ (lung tissue) from non-human primates who received rBCG vaccination, which was associated with increased survival.
IL-7 inhibits the osteogenic differentiation of Periodontal ligament stem cells probably via inactivation of mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) signaling pathway.
this study shows that IL-7 restores T Lymphocyte immunometabolic failure in septic shock patients through mTOR (show FRAP1 Proteins) activation
In CRC (show CALR Proteins), IL-7 was higher in patients with lymph node and distant metastases and with tumors located in right colon. In adenomas, IL-7 elevation was associated exclusively with villous growth pattern, while in IBD, circulating IL-7 reflected clinical activity of Crohn's disease and ulcerative colitis.
Tuberculosis patients had lower soluble IL-7R and higher IL-7 plasma concentrations as compared to healthy contacts.
CD56 (show NCAM1 Proteins)(bright) NK IL-7Ralpha (show IL7R Proteins) expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections
IL-7 has a role inducing epitope masking of gammac protein in IL-7 receptor signaling complex
Therefore, generalized CD8 (show CD8A Proteins)+ T-cell impairment in HCV infection is characterized, in part, by impaired IL-7-mediated signalling and survival, independent of CD127 (show IL7R Proteins) expression. This impairment is more pronounced in the liver and may be associated with an increased potential for apoptosis. This generalized CD8 (show CD8A Proteins)+ T-cell impairment represents an important immune dysfunction in chronic HCV infection that may alter patient health.
These results reveal a novel role of IL-7 and IL-15 (show IL15 Proteins) in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells.
The results show that SNPs in IL7 caused a significant association in this OA Chinese Han population.
IL-7 is capable of enhancing functional T cell activity without causing significant functional inbalance between various T cell subsets.
study reveals a unique, previously undescribed role of IL-7-IL-7R in T(H)17 cell survival and expansion and has implications in the treatment of autoimmune disease
this study shows that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells
lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7; the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (show LTB Proteins) (LT)betaR signaling
DNM2 (show DNM2 Proteins) mutations cooperate with Lmo2 (show LMO2 Proteins) T-cell oncogenes by enhancing IL-7 signalling.
IL-7 responsiveness in RTE is designed to maximize survival at the expense of reduced proliferation, consistent with RTE serving as a subpopulation of T cells rich in diversity but not in frequency.
Expression of IL-7 is beneficial for induction of potent and long-lasting humoral immune responses.
findings support a redundant role for adaptive Th17 cell- and innate gammadeltaT17 cell-derived IL17 (show IL17A Proteins) in bacteria-induced colon carcinogenesis, stressing the importance of therapeutically targeting the cytokine itself rather than its cellular sources
functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells.
continuous IL7 signaling was not required for tumor regression, although LIP of naive CD8 (show CD8A Proteins)+ T cells is usually regulated by IL7
IL7 represses the follicular helper T cell gene program.
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.