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Human Leptin Receptor Protein expressed in Human Cells - ABIN2002563
Tartaglia, Dembski, Weng, Deng, Culpepper, Devos, Richards, Campfield, Clark, Deeds, Muir, Sanker, Moriarty, Moore, Smutko, Mays, Wool, Monroe, Tepper: Identification and expression cloning of a leptin receptor, OB-R. in Cell 1996
Show all 3 references for ABIN2002563
Human Leptin Receptor Protein expressed in Human - ABIN593497
Sato, Schehr, Ikegami: Leptin does not influence surfactant synthesis in fetal sheep and mice lungs. in American journal of physiology. Lung cellular and molecular physiology 2011
leptin (show LEP Proteins)-LepRb plays an important role in the pathogenesis and depression in gastric cancer
In 2 unrelated girls with severe obesity, three novel LEPR mutations were detected. Longitudinal growth data show normal childhood growth, and in the older girl, a normal adult height despite hypogonadotropic hypogonadism and the lack of an obvious pubertal growth spurt (show BPIFA1 Proteins).
genetic variability in the LEPR gene is associated with idiopathic recurrent spontaneous abortion; more frequent LEPR genotype in patients - rs7516341 (nominal P=0.034, odds ratio [OR] 0.61, 95% confidence interval [CI] 0.38-0.97) and rs1137101 (nominal P=0.048, OR 1.66, 95% CI 1.00-2.80)
our findings suggest that leptin (show LEP Proteins) promoted the proliferation, migration and invasion of gallbladder cancer (GBC) cells by increasing OB-Rb expression through the SOCS3 (show SOCS3 Proteins)/JAK2 (show JAK2 Proteins)/p-STAT3 (show STAT3 Proteins) signal pathway. Targeting the leptin (show LEP Proteins)/OB-Rb axis could be an attractive therapeutic strategy for treatment of GBC.
genetic association studies in population of children (ages 5-10 years) in Poland: Data suggest that SNPs in LEPR are associated with predisposition to weight loss while engaging in lifestyle modifications for treatment of pediatric obesity in the population studied; carriers of wild-type K665N and at least one minor Q223R allele indicate greatest likelihood of losing weight.
The placental weight ratio exerted a positive effect on the placental mRNA expression of insulin- like growth factor-I (show IGF1 Proteins) and the long isoform of the leptin receptor in malaria-infected pregnant women without fever or chill symptoms.
Data showed that TNF-a and IL-6 polymorphisms were associated with overall and site-specific osteoporosis in both sexes, and that these associations were dependent on rs1805096 and rs1892534 genotypes of LEPR.
Genetic alterations in the leptin, LEPR and MC$R genes are associated with severe obesity.
Effects of leptin (show LEP Proteins) and leptin receptor SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension.
this study shows the role of LEPR polymorphisms in the risk of multiple sclerosis and its severity in Iran
Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus.
JAK-STAT and hormone biosynthesis pathways were involved in the follicular development and ovulation disorders caused by LepR deficiency in ovaries
Global loss of the leptin receptor results in reduced viral clearance and worse outcomes following influenza A infection.
Human and murine pancreatic cancer cell lines were found to express the short as well as the long form of the leptin receptor and functionally responded to leptin (show LEP Proteins) induced activation through an increased phosphorylation of AKT473.
leptin (show LEP Proteins) of dermal white adipose tissue might regulate hair growth and, therefore, hair cycle progression via leptin receptor on the hair follicle epithelium
absence of leptin receptor on thymic epithelial cells or T cells does not lead to the loss of thymic function, demonstrating the thymoprotective effect of leptin (show LEP Proteins) is mediated by obesity suppression rather than signalling to the thymus.
High LEPR expression is associated with onset of obesity.
The newly recognized effect of the leptin receptor Q223R mutation on diminished neutrophil chemotaxis and the impact of this mutation on multiple infectious diseases suggest a broader impact of this mutation on susceptibility to disease.
data suggest that both adipose and placenta-derived leptin (show LEP Proteins) system are involved in the regulation of energy metabolism during fetal growth.
LepR(+) cells are the major source of bone and adipocytes in adult bone marrow
LEPR showed a lower variability than LEP (show LEP Proteins) in the different analysed populations, especially in the Iberian breed that showed no variability
Superactive human leptin (show LEP Proteins) antagonist reverses leptin (show LEP Proteins)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (show LEP Proteins) receptors.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (show LEP Proteins)
Leptin (show LEP Proteins) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (show LEP Proteins) mRNA expression as well as E and P on leptin (show LEP Proteins) secretion by those cells obtained in early pregnancy.
These data suggest that leptin (show LEP Proteins) might have a direct effect on porcine follicles and plays an important role in the follicular development.
Locally produced leptin (show LEP Proteins) plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.
results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake
Here, the association between DGAT1 (show DGAT1 Proteins) K232A, SCD1 (show SCD Proteins) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (show DGAT1 Proteins), SCD1 (show SCD Proteins), and LEPR polymorphisms were GC/GC (show GC Proteins), C, and C, respectively.
I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
The use of leptin (show LEP Proteins), leptin receptor, and DGAT1 (show DGAT1 Proteins) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
The leptin (show LEP Proteins) and receptor gene markers would be useful for marker-assisted selection.
The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.
The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.
the possible involvement of locally produced leptin (show LEP Proteins)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.
findings indicate that acetate and butyrate enhance leptin (show LEP Proteins) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries
A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).
These results indicate that horse major salivary glands, like those of humans, are likely targets of leptin (show LEP Proteins) actions, suggesting a functional role of leptin (show LEP Proteins) on these glands.
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
, leptin receptor gene-related protein
, Leptin receptor (fatty)
, cytokine receptor
, leptin receptor long insert isoform
, OB-R gene-related protein