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Human Leptin Receptor Protein expressed in Human - ABIN593497
Sato, Schehr, Ikegami: Leptin does not influence surfactant synthesis in fetal sheep and mice lungs. in American journal of physiology. Lung cellular and molecular physiology 2011
systematic review and meta-analysis indicated that the LEPR gene variants (rs6700896, 109G allele, and 109GG genotype) were significantly associated with increased risk of cardiovascular disease (CVD); however, the present study is limited in its small number of included studies, considerable heterogeneity and observational study design
Leptin receptor Gln223Arg polymorphism does not appear to be related to male fertility.
In tissue samples, hypoxia-inducible factor 1-alpha (show HIF1A Proteins) messenger RNA and protein expression of leptin (show LEP Proteins) and leptin receptor were high in oral squamous cell carcinoma cases. Serum leptin (show LEP Proteins) levels were increased in first clinical stages of the disease.
LEPR polymorphisms are associated with type 2 diabetes risk. [Meta-Analysis]
over-expression of LEPR, rather than that of LEP has a fundamental role in breast carcinogenesis in particular, and probably for LEP-LEPR associated tumors in general
Data suggest that hypothalamic leptin/leptin (show LEP Proteins) receptor signaling plays a critical role in neurodevelopment, sympathetic activation, and prevention/development of hypertension. [REVIEW]
leptin (show LEP Proteins)-LepRb plays an important role in the pathogenesis and depression in gastric cancer
In 2 unrelated girls with severe obesity, three novel LEPR mutations were detected. Longitudinal growth data show normal childhood growth, and in the older girl, a normal adult height despite hypogonadotropic hypogonadism and the lack of an obvious pubertal growth spurt (show BPIFA1 Proteins).
genetic variability in the LEPR gene is associated with idiopathic recurrent spontaneous abortion; more frequent LEPR genotype in patients - rs7516341 (nominal P=0.034, odds ratio [OR] 0.61, 95% confidence interval [CI] 0.38-0.97) and rs1137101 (nominal P=0.048, OR 1.66, 95% CI 1.00-2.80)
our findings suggest that leptin (show LEP Proteins) promoted the proliferation, migration and invasion of gallbladder cancer (GBC) cells by increasing OB-Rb expression through the SOCS3 (show SOCS3 Proteins)/JAK2 (show JAK2 Proteins)/p-STAT3 (show STAT3 Proteins) signal pathway. Targeting the leptin (show LEP Proteins)/OB-Rb axis could be an attractive therapeutic strategy for treatment of GBC.
Neurotensin (show NTS Proteins)-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.
Suggest that intact endothelial leptin (show LEP Proteins) signaling limits neointima formation and that obesity represents a state of endothelial leptin (show LEP Proteins) resistance.
Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA (show PDGFRA Proteins) signalling could be an effective way to treat bone marrow fibrosis.
Leptin (show LEP Proteins) expression is regulated by DNA methylation (show HELLS Proteins) in adipocytes.
Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1 (show PRDM1 Proteins)).
LepRb preoptic area neurons are stimulatory glutamatergic neurons, contrary to prevalent models
Leptin (show LEP Proteins) receptors on agouti-related peptide neurons modulate the onset of puberty and adult fertility.
Leptin/LepR signaling regulates adipogenesis and osteogenesis by mesenchymal stromal cells in the bone marrow in response to diet and adiposity.
These data show that leptin (show LEP Proteins) directly impairs vascular relaxation via a vascular skeletal muscle-LepR-mediated mechanism, suggesting a potential pathogenic role for leptin (show LEP Proteins) to increase cardiovascular risk during obesity.
These mice showed an increase in FSH (show BRD2 Proteins) levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin (show LEP Proteins)-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
LEPR showed a lower variability than LEP (show LEP Proteins) in the different analysed populations, especially in the Iberian breed that showed no variability
Superactive human leptin (show LEP Proteins) antagonist reverses leptin (show LEP Proteins)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (show LEP Proteins) receptors.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (show LEP Proteins)
Leptin (show LEP Proteins) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (show LEP Proteins) mRNA expression as well as E and P on leptin (show LEP Proteins) secretion by those cells obtained in early pregnancy.
These data suggest that leptin (show LEP Proteins) might have a direct effect on porcine follicles and plays an important role in the follicular development.
Locally produced leptin (show LEP Proteins) plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.
Here, the association between DGAT1 (show DGAT1 Proteins) K232A, SCD1 (show SCD Proteins) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (show DGAT1 Proteins), SCD1 (show SCD Proteins), and LEPR polymorphisms were GC/GC (show GC Proteins), C, and C, respectively.
I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
The use of leptin (show LEP Proteins), leptin receptor, and DGAT1 (show DGAT1 Proteins) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
The leptin (show LEP Proteins) and receptor gene markers would be useful for marker-assisted selection.
The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.
The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.
the possible involvement of locally produced leptin (show LEP Proteins)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.
findings indicate that acetate and butyrate enhance leptin (show LEP Proteins) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries
A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).
These results indicate that horse major salivary glands, like those of humans, are likely targets of leptin (show LEP Proteins) actions, suggesting a functional role of leptin (show LEP Proteins) on these glands.
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
, leptin receptor gene-related protein
, Leptin receptor (fatty)
, cytokine receptor
, leptin receptor long insert isoform
, OB-R gene-related protein