Leptin Receptor Protein (LEPR) (C-Term, Extracellular Domain)
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- Target See all Leptin Receptor (LEPR) Proteins
- Leptin Receptor (LEPR)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- C-Term, Extracellular Domain
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Origin
- Human
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Source
- HEK-293T Cells
- Specificity
- Optimized DNA sequence encoding extracellular domain of human leptin receptor including a C-terminal Human IgG1 Fc tag was expressed in HEK293 cells.
- Characteristics
- Recombinant human leptin receptor is a homodimer protein consisting of two 1070 amino acid residue subunit chains, due to glycosylation migrates as an approximately 160kDa protein on SDS-PAGE.
- Purity
- > 98 %, as determined by SDS-PAGE and HPLC
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
- Top Product
- Discover our top product LEPR Protein
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Leptin Receptor (LEPR) (AA 22-839) protein (His tag)
LEPR Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Leptin Receptor (LEPR) protein (Fc Tag)LEPR Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) protein (Fc Tag)LEPR Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) (AA 31-130) protein (GST tag)LEPR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Leptin Receptor (LEPR) protein (mFc Tag)LEPR Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Leptin Receptor (LEPR) protein (His tag)LEPR Origin: Mouse Host: Human Cells Recombinant >90 % as determined by reducing SDS-PAGE.
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- Comment
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Biologically active: Measured by its ability to bind immobilized recombinant human Leptin (1 µg/mL) at a linear concentration range of 0.01-4 µg/mL.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS solution, pH7.2
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- The lyophilized antibody is stable for at least 1 year from date of receipt at -20 °C. Upon reconstitution, this antibody can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months without detectable loss of activity.
- Expiry Date
- 12 months
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- Target
- Leptin Receptor (LEPR)
- Alternative Name
- LEPR (LEPR Products)
- Synonyms
- CD295 Protein, LEP-R Protein, LEPRD Protein, OB-R Protein, OBR Protein, obr Protein, cd295 Protein, ob-rb Protein, Fa Protein, LEPROT Protein, Leprb Protein, Modb1 Protein, OB-RGRP Protein, Obr Protein, db Protein, diabetes Protein, obese-like Protein, obl Protein, ObRb Protein, Ob-R Protein, Ob-RM Protein, lepr Protein, leptin receptor Protein, leptin receptor S homeolog Protein, LEPR Protein, lepr Protein, Lepr Protein, lepr.S Protein
- Background
- FGF-10 is involved in the initial budding as well as the continuous outgrowth of vertebrate limbs, FGF10 mRNA is expressed preferentially in neurons but not in glial cells and may have a distinct role in the brain. Human FGF-10 is mitogenic for fetal rat keratinizing epidermal cells but not for NIH 3T3 cells. Recombinant FGF-10 induces the proliferation of human urothelial cells in vitro and induces the proliferation of transitional epithelium. FGF-10 is secreted by cultured mouse pre-adipocytes, prevention of FGF-10 signaling inhibits subsequent differentiation. The ability of embryonic fibroblasts derived from FGF-10 knock-out mice to differentiate into adipocytes is also impaired.
- UniProt
- P48357
- Pathways
- JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour
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