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Browse our anti-PTPN11 (PTPN11) Antibodies

Full name:
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 Antibodies (PTPN11)
On www.antibodies-online.com are 362 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Antibodies from 31 different suppliers available. Additionally we are shipping PTPN11 Kits (24) and PTPN11 Proteins (12) and many more products for this protein. A total of 413 PTPN11 products are currently listed.
Synonyms:
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all antibodies Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

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Most Popular Reactivities for anti-PTPN11 (PTPN11) Antibodies

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anti-Human PTPN11 Antibodies:

anti-Mouse (Murine) PTPN11 Antibodies:

anti-Rat (Rattus) PTPN11 Antibodies:

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Top referenced anti-PTPN11 Antibodies

  1. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN360824 : Sturla, Amorino, Alexander, Mikkelsen, Valerie, Schmidt-Ullrichr: Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for ABIN360824

  2. Human Polyclonal PTPN11 Primary Antibody for DB, WB - ABIN1881807 : Carver, Piazza, Schuler: Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN1881807

  3. Human Polyclonal PTPN11 Primary Antibody for IF, WB - ABIN392907 : Chan, Leedy, Munugalavadla, Voorhorst, Li, Yu, Kapur: Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. in Blood 2005 (PubMed)
    Show all 3 references for ABIN392907

  4. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN500708 : Ostman, Hellberg, Böhmer: Protein-tyrosine phosphatases and cancer. in Nature reviews. Cancer 2006 (PubMed)
    Show all 3 references for ABIN500708

  5. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN500710 : Bard-Chapeau, Yuan, Droin, Long, Zhang, Nguyen, Feng: Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. in Molecular and cellular biology 2006 (PubMed)
    Show all 3 references for ABIN500710

  6. Human Monoclonal PTPN11 Primary Antibody for ICC, FACS - ABIN1098117 : Li, Modi, McDonald, Rossi, Yee, Bhatia: A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells. in Blood 2011 (PubMed)
    Show all 2 references for ABIN1098117

  7. Human Polyclonal PTPN11 Primary Antibody for WB - ABIN318781 : Salmond, Alexander: SHP2 forecast for the immune system: fog gradually clearing. in Trends in immunology 2006 (PubMed)
    Show all 2 references for ABIN318781

  8. Human Polyclonal PTPN11 Primary Antibody for IHC, ELISA - ABIN184604 : Saxton, Ciruna, Holmyard, Kulkarni, Harpal, Rossant, Pawson: The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. in Nature genetics 2000 (PubMed)

  9. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN453321 : Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ... in Cell 2007 (PubMed)

More Antibodies against PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. mutation in PTPN11 is associated with co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome.

  2. The existence of a tight association between SHP2 and EGFR (show EGFR Antibodies) expression in tumors and cell lines further suggested the importance of SHP2 in EGFR (show EGFR Antibodies) expression.

  3. patients with low Shp2 expression exhibited superior prognosis to sorafenib

  4. Combined X-ray crystallography, small-angle X-ray scattering, and biochemistry to elucidate structural and mechanistic features of three cancer-associated SHP2 variants with single point mutations within the N-SH2:PTP interdomain autoinhibitory interface.

  5. In vitro assays suggested that LEOPARD syndrome-associated SHP-2 mutations might enhance melanin synthesis in melanocytes, and that the activation of Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signalling may contribute to this process.

  6. SHP2 may promote invadopodia formation through inhibition of Rho signaling in cancer cells.

  7. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3 (show F2RL2 Antibodies)/PAR6 (show PARD6A Antibodies)/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition

  8. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

  9. SHP2 preferentially binds to and dephosphorylates Ras to increase its association with Raf and (show HRAS Antibodies)activate downstream proliferative Ras/ERK/MAPK signaling.

  10. Data show that SNP interactions among H. pylori-related genes PGC (show PGC Antibodies), PTPN11, and IL1B (show IL1B Antibodies), are associated with susceptibility to gastric carcinogenesis.

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 Antibodies), beta-catenin (show CTNNB1 Antibodies), and p190RhoGAP (show GRLF1 Antibodies) and the activity of RhoA (show RHOA Antibodies).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  2. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

  3. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

  4. SHP2 activity is elevated in astrocytes isolated from glioblastoma multiforme (GBM)-prone H-Ras (show HRAS Antibodies)(12V) knock-in mice.

  5. find that Shp2 is distributed to the kinetochore, centrosome, spindle midzone, and midbody

  6. Mouse podocytes lacking Shp2 do not develop foot process spreading when subjected to podocyte injury in vivo using protamine sulfate or nephrotoxic serum.

  7. Shp2 and Pten (show PTEN Antibodies) have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.

  8. Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

  9. SHP2 silencing in P815 mouse mastocytoma cell line harboring KITD814Y mutation results in impaired signaling to ERK (show EPHB2 Antibodies), Btk (show BTK Antibodies), Lyn (show LYN Antibodies) and STAT5 (show STAT5A Antibodies) pathways, and reduced rates of cell growth and colony formation.

  10. Shp2 regulates IEC homeostasis through activation of Ras and thereby protects against the development of colitis.

PTPN11 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11) antibody
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) antibody
  • 2700084A17Rik antibody
  • AW536184 antibody
  • BPTP3 antibody
  • CFC antibody
  • NS1 antibody
  • PTP-1D antibody
  • PTP1D antibody
  • PTP2C antibody
  • SAP-2 antibody
  • SH-PTP2 antibody
  • SH-PTP3 antibody
  • SHP-2 antibody
  • Shp2 antibody
  • SYP antibody

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

GENE ID SPECIES
5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
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