Browse our anti-PTPN11 (PTPN11) Antibodies

Full name:
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 Antibodies (PTPN11)
On are 378 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Antibodies from 30 different suppliers available. Additionally we are shipping PTPN11 Kits (26) and PTPN11 Proteins (10) and many more products for this protein. A total of 428 PTPN11 products are currently listed.
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all antibodies Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

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Top referenced anti-PTPN11 Antibodies

  1. Chicken Monoclonal PTPN11 Primary Antibody for IF, IP - ABIN968068 : Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for 968068

  2. Human Polyclonal PTPN11 Primary Antibody for DB, WB - ABIN1881807 : Carver, Piazza, Schuler: Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for 1881807

  3. Human Polyclonal PTPN11 Primary Antibody for IF, WB - ABIN392907 : Chan, Leedy, Munugalavadla, Voorhorst, Li, Yu, Kapur: Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. in Blood 2005 (PubMed)
    Show all 3 references for 392907

  4. Human Monoclonal PTPN11 Primary Antibody for ICC, FACS - ABIN1098117 : Li, Modi, McDonald, Rossi, Yee, Bhatia: A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells. in Blood 2011 (PubMed)
    Show all 2 references for 1098117

  5. Human Polyclonal PTPN11 Primary Antibody for WB - ABIN2476469 : Fujioka, Matozaki, Noguchi, Iwamatsu, Yamao, Takahashi, Tsuda, Takada, Kasuga: A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. in Molecular and cellular biology 1997 (PubMed)
    Show all 2 references for 2476469

  6. Human Polyclonal PTPN11 Primary Antibody for WB - ABIN318781 : Salmond, Alexander: SHP2 forecast for the immune system: fog gradually clearing. in Trends in immunology 2006 (PubMed)
    Show all 2 references for 318781

  7. Human Polyclonal PTPN11 Primary Antibody for IHC, ELISA - ABIN184604 : Saxton, Ciruna, Holmyard, Kulkarni, Harpal, Rossant, Pawson: The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. in Nature genetics 2000 (PubMed)

  8. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN453321 : Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ... in Cell 2007 (PubMed)

More Antibodies against PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. High PTPN11 expression is associated with Pancreatic cancer.

  2. SHP-2 acts together with PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) to regulate a ZEB1 (show ZEB1 Antibodies)-miR (show MLXIP Antibodies)-200 feedback loop in PDGFRalpha-driven gliomas.

  3. Results provide evidence that repression of SHP-1 (show PTPN6 Antibodies), SHP-2 and SOCS-1 (show SOCS1 Antibodies) gene expression in patient plasma cells supports the constitutive activation of the JAK (show JAK3 Antibodies)/STAT3 (show STAT3 Antibodies) pathway and probably leads to higher degrees of bone marrow invasion.

  4. The data presented in the current study reveal that intestinal serotonin transporter (SERT (show SLC6A4 Antibodies)) is a target of the tyrosine phosphatase SHP2 and show a novel mechanism by which a common diarrheagenic pathogen, EPEC, activates cellular SHP2 to inhibit SERT (show SLC6A4 Antibodies) function.

  5. The effects of SHP2 overexpression and inhibition on fibroblast response to profibrotic stimuli were analyzed in in primary human fibroblasts. SHP2 was down-regulated and lung fibroblasts obtained from patients with IPF, revealing SHP2 was absent within fibroblastic foci sufficient to induce fibroblast-to-myofibroblast differentiation in primary human lung fibroblasts, resulting in reduced cell survival.

  6. PTPN11 variant was identified in a case with a lethal presentation of Noonan syndrome.

  7. our results provide strong evidence that CD244 (show CD244 Antibodies) co-operates with c-Kit (show KIT Antibodies) to regulate leukemogenesis through SHP-2/p27 (show PAK2 Antibodies) signaling.

  8. SHP2, SOCS3 (show SOCS3 Antibodies) and PIAS3 (show PIAS3 Antibodies) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 Antibodies) downregulation is more reversely correlated with STAT3 (show STAT3 Antibodies) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Antibodies) downregulation and decreased incidence of STAT3 (show STAT3 Antibodies) nuclear translocation, PIAS3 (show PIAS3 Antibodies) is upregulated, the SHP2 level remains unchanged and SOCS3 (show SOCS3 Antibodies) is downregulated.

  9. SHP2-ERK2 (show MAPK1 Antibodies) signaling acts upstream of C/EBPalpha (show CEBPA Antibodies) as a regulator of cell surface I antigen synthesis.

  10. could promote hepatocellular carcinoma cell dedifferentiation and liver cancer stem cell expansion by amplifying beta-catenin (show CTNNB1 Antibodies) signaling

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 Antibodies), beta-catenin (show CTNNB1 Antibodies), and p190RhoGAP (show GRLF1 Antibodies) and the activity of RhoA (show RHOA Antibodies).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. data suggested that deletion of Shp2 impaired IL-25 (show IL25 Antibodies) production in bronchial epithelial cells in vitro, but might yet have minor influence on OVA-induced allergic reaction in vivo

  2. The effects of SHP2 overexpression and inhibition on fibroblast response to profibrotic stimuli were analyzed in in the bleomycin model of lung fibrosis by SHP2-lentiviral administration in transgenic mice carrying a constitutively active SHP2 mutation. Mice carrying the Noonan syndrome-associated SHP2 mutation were resistant bleomycin induced pulmonary fibrosis.

  3. Data show aberrant neuronal activity-induced signaling and regulation of gene expression in protein tyrosine phosphatase (show ACP1 Antibodies), non-receptor type 11 (Ptpn11D61Y) mutation and suggest that these deficits contribute to the pathophysiology of cognitive impairments in Noonan syndrome (NS).

  4. This study indicates that Shp2 is required to orchestrate macrophage function and regulate host innate immunity against pulmonary bacterial infection.

  5. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 (show AKT2 Antibodies) strongly influences osteoblast differentiation from bone marrow stromal cells.

  6. SHP-2 is functionally important for the maintenance of appropriate barrier function and host-microbiota homeostasis in the large intestine.

  7. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 (show CCL3 Antibodies) as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias.

  8. SHP2 is a potential positive regulator of eosinophil differentiation, and inhibition of SHP2 specifically in myeloid cells eventually alleviates eosinophilic airway inflammation.

  9. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  10. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

PTPN11 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11) antibody
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) antibody
  • 2700084A17Rik antibody
  • AW536184 antibody
  • BPTP3 antibody
  • CFC antibody
  • NS1 antibody
  • PTP-1D antibody
  • PTP1D antibody
  • PTP2C antibody
  • SAP-2 antibody
  • SH-PTP2 antibody
  • SH-PTP3 antibody
  • SHP-2 antibody
  • Shp2 antibody
  • SYP antibody

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
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