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Browse our anti-PTPN11 (PTPN11) Antibodies

Full name:
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 Antibodies (PTPN11)
On www.antibodies-online.com are 353 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Antibodies from 30 different suppliers available. Additionally we are shipping PTPN11 Kits (24) and PTPN11 Proteins (10) and many more products for this protein. A total of 401 PTPN11 products are currently listed.
Synonyms:
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all antibodies Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

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All available anti-PTPN11 Antibodies

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Top referenced anti-PTPN11 Antibodies

  1. Chicken Monoclonal PTPN11 Primary Antibody for IF, IP - ABIN968068 : Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN968068

  2. Human Polyclonal PTPN11 Primary Antibody for DB, WB - ABIN1881807 : Carver, Piazza, Schuler: Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN1881807

  3. Human Polyclonal PTPN11 Primary Antibody for IF, WB - ABIN392907 : Chan, Leedy, Munugalavadla, Voorhorst, Li, Yu, Kapur: Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. in Blood 2005 (PubMed)
    Show all 3 references for ABIN392907

  4. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN500710 : Ostman, Hellberg, Böhmer: Protein-tyrosine phosphatases and cancer. in Nature reviews. Cancer 2006 (PubMed)
    Show all 3 references for ABIN500710

  5. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN500708 : Bard-Chapeau, Yuan, Droin, Long, Zhang, Nguyen, Feng: Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. in Molecular and cellular biology 2006 (PubMed)
    Show all 3 references for ABIN500708

  6. Human Polyclonal PTPN11 Primary Antibody for WB - ABIN318781 : Salmond, Alexander: SHP2 forecast for the immune system: fog gradually clearing. in Trends in immunology 2006 (PubMed)
    Show all 2 references for ABIN318781

  7. Human Monoclonal PTPN11 Primary Antibody for ICC, FACS - ABIN1098117 : Li, Modi, McDonald, Rossi, Yee, Bhatia: A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells. in Blood 2011 (PubMed)
    Show all 2 references for ABIN1098117

  8. Human Polyclonal PTPN11 Primary Antibody for IHC, ELISA - ABIN184604 : Saxton, Ciruna, Holmyard, Kulkarni, Harpal, Rossant, Pawson: The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. in Nature genetics 2000 (PubMed)

  9. Human Polyclonal PTPN11 Primary Antibody for EIA, WB - ABIN453321 : Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ... in Cell 2007 (PubMed)

More Antibodies against PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2, SOCS3 (show SOCS3 Antibodies) and PIAS3 (show PIAS3 Antibodies) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 Antibodies) downregulation is more reversely correlated with STAT3 (show STAT3 Antibodies) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Antibodies) downregulation and decreased incidence of STAT3 (show STAT3 Antibodies) nuclear translocation, PIAS3 (show PIAS3 Antibodies) is upregulated, the SHP2 level remains unchanged and SOCS3 (show SOCS3 Antibodies) is downregulated.

  2. SHP2-ERK2 (show MAPK1 Antibodies) signaling acts upstream of C/EBPalpha (show CEBPA Antibodies) as a regulator of cell surface I antigen synthesis.

  3. could promote hepatocellular carcinoma cell dedifferentiation and liver cancer stem cell expansion by amplifying beta-catenin (show CTNNB1 Antibodies) signaling

  4. The results revealed that although the expression levels of SOCS1 (show SOCS1 Antibodies), SOCS3 (show SOCS3 Antibodies) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 (show PIAS3 Antibodies) downregulation is more negatively correlated with STAT3 (show STAT3 Antibodies) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

  5. In a retroviral transduction/transplantation mouse model, mice transplanted with MLL (show MLL Antibodies)/AF10 (show MLLT10 Antibodies)(OM-LZ) cells harboring PTPN11(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11(G503A) -induced monocytic leukemia (show KAT6B Antibodies) in a shorter latency. Adding PTPN11(G503A) to MLL (show MLL Antibodies)/AF10 (show MLLT10 Antibodies) affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression.

  6. Shp2 (Src (show SRC Antibodies)-homology 2 domain-containing phosphatase 2) functions as a negative regulator for STAT3 (show STAT3 Antibodies) transcription factor (Stat3 (show STAT3 Antibodies)) activation in esophageal squamous cell cancer (ESCC).

  7. the phosphatase activity of Shp2 and its tyrosine phosphorylation, are necessary for the IL-6 (show IL6 Antibodies)-induced downregulation of E-cadherin (show CDH1 Antibodies) and the phosphorylation of Erk1/2 (show MAPK1/3 Antibodies). Our findings uncover an important function that links Shp2 to IL-6 (show IL6 Antibodies)-promoted breast cancer progression.

  8. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 (show CCL3 Antibodies) as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias.

  9. higher expression of SHP2 might be involved in the progression of pancreatic ductal adenocarcinoma, suggesting that SHP2 may be a potential prognostic marker and target for therapy

  10. Data indicate that the most prominent proteins associating with Gab2 (show GAB2 Antibodies) are PTPN11, PIK3R1 and ARID3B (show ARID3B Antibodies).

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 Antibodies), beta-catenin (show CTNNB1 Antibodies), and p190RhoGAP (show GRLF1 Antibodies) and the activity of RhoA (show RHOA Antibodies).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. Data show aberrant neuronal activity-induced signaling and regulation of gene expression in protein tyrosine phosphatase (show ACP1 Antibodies), non-receptor type 11 (Ptpn11D61Y) mutation and suggest that these deficits contribute to the pathophysiology of cognitive impairments in Noonan syndrome (NS).

  2. This study indicates that Shp2 is required to orchestrate macrophage function and regulate host innate immunity against pulmonary bacterial infection.

  3. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 (show AKT2 Antibodies) strongly influences osteoblast differentiation from bone marrow stromal cells.

  4. SHP-2 is functionally important for the maintenance of appropriate barrier function and host-microbiota homeostasis in the large intestine.

  5. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 (show CCL3 Antibodies) as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias.

  6. SHP2 is a potential positive regulator of eosinophil differentiation, and inhibition of SHP2 specifically in myeloid cells eventually alleviates eosinophilic airway inflammation.

  7. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  8. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

  9. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

  10. SHP2 activity is elevated in astrocytes isolated from glioblastoma multiforme (GBM)-prone H-Ras (show HRAS Antibodies)(12V) knock-in mice.

PTPN11 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11) antibody
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) antibody
  • 2700084A17Rik antibody
  • AW536184 antibody
  • BPTP3 antibody
  • CFC antibody
  • NS1 antibody
  • PTP-1D antibody
  • PTP1D antibody
  • PTP2C antibody
  • SAP-2 antibody
  • SH-PTP2 antibody
  • SH-PTP3 antibody
  • SHP-2 antibody
  • Shp2 antibody
  • SYP antibody

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

GENE ID SPECIES
5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
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