PTPN11 antibody (AA 263-329)

Catalog No. ABIN1098117

This anti-PTPN11 antibody is a Mouse Monoclonal antibody detecting PTPN11 in IHC, ELISA, ICC and FACS. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for PTPN11 antibody (AA 263-329) (ABIN1098117)

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTPN11 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 6D9

Product Details anti-PTPN11 Antibody

Binding Specificity: AA 263-329

Purpose: PTPN11 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PTPN11 antibody (ABIN1098117)

Li, Modi, McDonald, Rossi, Yee, Bhatia: "A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells." in: Blood, Vol. 118, Issue 6, pp. 1504-15, (2011) (PubMed).

Bard-Chapeau, Li, Ding, Zhang, Zhu, Princen, Fang, Han, Bailly-Maitre, Poli, Varki, Wang, Feng: "Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis." in: Cancer cell, Vol. 19, Issue 5, pp. 629-39, (2011) (PubMed).

Target Details for PTPN11

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Alternative Name: PTPN11

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 68.4 kDa

Gene ID: 5781

UniProt: Q06124

Pathways: JAK-STAT Signaling, RTK Signaling, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effect