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Human SOCS3 ELISA Kit for Sandwich ELISA - ABIN414790
Zeitvogel, Dalpke, Eiz-Vesper, Kracht, Dittrich-Breiholz, Werfel, Wittmann: Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages. in The Journal of biological chemistry 2012
Show all 3 references for ABIN414790
Mouse (Murine) SOCS3 ELISA Kit for Sandwich ELISA - ABIN425023
Speth, Bourdonnay, Penke, Mancuso, Moore, Weinberg, Peters-Golden: Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2016
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (show STAT3 ELISA Kits)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 ELISA Kits) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 ELISA Kits)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 ELISA Kits) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 ELISA Kits) and SOCS3 proteins.
None of the clinicopathological parameters were associated with the expressions of FIH-1 and SOCS3 at mRNA level.
Micronome revealed miR (show MLXIP ELISA Kits)-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma.
IGFBP2 (show IGFBP2 ELISA Kits) and SOCS3 were up-regulated in Kashin-Beck disease chondrocytes and decreased with increasing selenium concentrations. IGFBP2 (show IGFBP2 ELISA Kits) expressed highest in the middle zone of KBD cartilage, SOCS3 expressed higher in the middle and deep zone. IGFBP2 (show IGFBP2 ELISA Kits) and SOCS3 may be the biomarkers for KBD diagnosis and evaluating the effect of selenium supplement.
Results show that IFN-alpha (show IFNA ELISA Kits) antagonizes STAT3 (show STAT3 ELISA Kits) and SOCS3 signaling triggered by hepatitis C virus (HCV )and that STAT3 (show STAT3 ELISA Kits) regulation correlates inversely with SOCS3 induction by IFN-alpha (show IFNA ELISA Kits), which may be important in better understanding the complex interplay between IFN-alpha (show IFNA ELISA Kits) and signal molecules during HCV infection.
data show that HBV-induced mitochondrial ROS (show ROS1 ELISA Kits) production represses SOCS3 expression through Snail (show SNAI1 ELISA Kits)-mediated epigenetic silencing, leading to the sustained activation of IL-6 (show IL6 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) pathway and ultimately contributing to hepatocarcinogenesis.
These data thus suggest that overexpression of SOCS1 (show SOCS1 ELISA Kits) and SOCS3 induced by denguevirus infection leads to impairment of antiviral response through the inhibition of STAT (show STAT1 ELISA Kits) functionality.
demonstrate an epigenetic mechanism of SOCS3 up-regulation in steroid resistant children with the nephrotic syndrome. The assessment of methylation/unmethylation of SOCS3 promoter might be an early marker for steroid responsiveness in NS patients
Treatment of isolinderalactone increased the protein level of SCOS3, decreased phosphorylation of the STAT3 (show STAT3 ELISA Kits) and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein (show XIAP ELISA Kits)
miR (show MLXIP ELISA Kits)-203 and miR (show MLXIP ELISA Kits)-221 regulate SOCS1 (show SOCS1 ELISA Kits) and SOCS3 in essential thrombocythemia
Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer. (Review)
SOCS3 is an important negative regulator of insulin (show INS ELISA Kits) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 ELISA Kits) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Results identify unrecognized functions of Yes-associated protein (YAP (show YAP1 ELISA Kits)) in preventing reactive astrogliosis and reveal a pathway of YAP (show YAP1 ELISA Kits)- suppressor of cytokine signaling 3 (SOCS (show CISH ELISA Kits)) for the negatively control of neuroinflammation.
SOCS3 serves as an immune modulator interfering with T cells and B cells, and SOCS3 may act as a predictive marker for immune modulation of mesenchymal stromal cells.
Signal transducer and activator of transcription 3 (show STAT3 ELISA Kits) and suppressor of cytokine signaling 3 play important, yet unexpected, roles in NG2 (show Vcan ELISA Kits) cell proliferation and differentiation after spinal cord injury.
The results of this study showed that the role of SOCS3 in mediating pregnancy-induced metabolic adaptations.
Concentration of SOCS-3 protein and coimmunoprecipitation of SOCS-3 protein with both the IR-beta subunit (show POLG ELISA Kits) as well as IRS-1 (show IRS1 ELISA Kits) was found to be decreased by 4-HIL
CCR5 (show CCR5 ELISA Kits) blockade suppresses B16 melanoma growth by inhibiting of IL-6 (show IL6 ELISA Kits)-Stat3 (show STAT3 ELISA Kits) signaling pathway via upregulation of SOCS3.
AHR (show AHR ELISA Kits) plays protective roles against high-fat diet-induced hepatic steatosis and the subsequent lipotoxicity via direct transcriptional regulation of Socs3 gene expression.
The liver regenerative effects of HCM appear to be mediated by persistent and uninhibited expression of STAT3 (show STAT3 ELISA Kits) in the liver, which results from decreased expression of SOCS3
SOCS3 gene expression attenuates contact hypersensitivity by suppressing MMP12 (show MMP12 ELISA Kits) production.
These results suggest that neuronal and glial cell SOCS3 limits pathological retinal angiogenesis by suppressing VEGF signaling.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3