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Human SOCS3 ELISA Kit for Sandwich ELISA - ABIN414790
Zeitvogel, Dalpke, Eiz-Vesper, Kracht, Dittrich-Breiholz, Werfel, Wittmann: Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages. in The Journal of biological chemistry 2012
Show all 3 references for ABIN414790
Mouse (Murine) SOCS3 ELISA Kit for Sandwich ELISA - ABIN425023
Speth, Bourdonnay, Penke, Mancuso, Moore, Weinberg, Peters-Golden: Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2016
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (show STAT3 ELISA Kits)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 ELISA Kits) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 ELISA Kits)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 ELISA Kits) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 ELISA Kits) and SOCS3 proteins.
Treatment of isolinderalactone increased the protein level of SCOS3, decreased phosphorylation of the STAT3 (show STAT3 ELISA Kits) and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein (show XIAP ELISA Kits)
miR (show MLXIP ELISA Kits)-203 and miR (show MLXIP ELISA Kits)-221 regulate SOCS1 (show SOCS1 ELISA Kits) and SOCS3 in essential thrombocythemia
Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer. (Review)
induction of SOCS3 may be a novel mechanism by which FXR (show NR1H4 ELISA Kits) exerts its anti-hepatocellular carcinoma effects
H. pylori infection induced hepatic insulin (show INS ELISA Kits) resistance by the c-Jun (show JUN ELISA Kits)/miR (show MLXIP ELISA Kits)-203/SOCS3 signaling pathway and provide possible implications with regard to resolving insulin (show INS ELISA Kits) resistance.
A significant relevance involved in SOCS3 gene polymorphisms and infantile asthma development based on a Chinese Han population.
In hepatocellular carcinoma tumor tissues, SOCS3 showed an increased methylation frequency and intensity compared with that in the adjacent non-tumor tissues.
Data suggest that PCSK9 (show PCSK9 ELISA Kits) is involved in regulation of lipid metabolism in hepatocytes by proinflammatory cytokine TNFalpha (show TNF ELISA Kits); induction of lipogenesis and insulin (show INS ELISA Kits) resistance in liver (as seen in obesity) involves up-regulation of both PCSK9 (show PCSK9 ELISA Kits) and SOCS3.
Epigenetic inhibition of SOCS3 is regulated by miR1264 which specifically targets DNMT1 (show DNMT1 ELISA Kits) transcript.
Decreased SOCS3 expression is associated with cholangiocarcinoma.
SOCS3 is an important negative regulator of insulin (show INS ELISA Kits) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 ELISA Kits) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
CCR5 (show CCR5 ELISA Kits) blockade suppresses B16 melanoma growth by inhibiting of IL-6 (show IL6 ELISA Kits)-Stat3 (show STAT3 ELISA Kits) signaling pathway via upregulation of SOCS3.
AHR (show AHR ELISA Kits) plays protective roles against high-fat diet-induced hepatic steatosis and the subsequent lipotoxicity via direct transcriptional regulation of Socs3 gene expression.
The liver regenerative effects of HCM appear to be mediated by persistent and uninhibited expression of STAT3 (show STAT3 ELISA Kits) in the liver, which results from decreased expression of SOCS3
SOCS3 gene expression attenuates contact hypersensitivity by suppressing MMP12 (show MMP12 ELISA Kits) production.
These results suggest that neuronal and glial cell SOCS3 limits pathological retinal angiogenesis by suppressing VEGF signaling.
Socs3 deletion in cortical neurons promotes sprouting of corticospinal axons after unilateral pyramidotomy, restoring skilled locomotion.
SOCS3-deficient and sufficient B-lineage cell migration towards CXCL12 (show CXCL12 ELISA Kits) in vitro was undistinguishable, and B-lineage cell amoeboid motility within BM parenchyma was also unaffected by SOCS3-deficiency
RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation
findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI.
The critical function of SOCS3 is as a negative regulator of MDSC development and function via inhibition of STAT3 (show STAT3 ELISA Kits) activation.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3