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SOCS3 Products

(Suppressor of Cytokine Signaling 3 (SOCS3))

Categories

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008].

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Featured SOCS3 Categories

SOCS3 Antibodies

High quality antibodies with extensive validation data.

SOCS3 ELISA Kits

Reliable ELISA kits for a wide range of species.

SOCS3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SOCS3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC, WB
Validations
  • (1)
  • (7)
Cat. No. ABIN3021100
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, IHC (p), ELISA
Validations
  • (1)
  • (3)
Cat. No. ABIN522456
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (4)
  • (2)
Cat. No. ABIN670416
Quantity 100 μL
Datasheet Datasheet

Recommended SOCS3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
  • (1)
Cat. No. ABIN6959767
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6959768
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970483
Quantity 96 tests
Datasheet Datasheet

Recommended SOCS3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1320930
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131674
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095584
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SOCS3 products

Draijer, Speth, Penke, Zaslona, Bazzill, Lugogo, Huang, Moon, Peters-Golden: "Resident alveolar macrophage-derived vesicular SOCS3 dampens allergic airway inflammation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 3, pp. 4718-4731, (2021) (PubMed).

Speth, Penke, Bazzill, Park, de Rubio, Schneider, Ouchi, Moon, Keshamouni, Zemans, Lama, Arenberg, Peters-Golden: "Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics." in: JCI insight, Vol. 4, Issue 20, (2020) (PubMed).

Abo El-Nasr, Saleh, Mahmoud, Nofal, Abdelsalam, Safar, El-Abhar: "Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways." in: European journal of pharmacology, Vol. 874, pp. 173010, (2020) (PubMed).

Li, Wu, Li, Chen, Xu, Xu, Su: "SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection." in: Molecular immunology, Vol. 125, pp. 51-62, (2020) (PubMed).

Attia, Tawfiq, Ali, Elmazar: "The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway." in: Scientific reports, Vol. 7, Issue 1, pp. 12502, (2019) (PubMed).

Kim, Plaza, Thomas, Draijer, Radford, Peters-Golden, Mukherjee, Nair: "Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs." in: Journal of immunological methods, Vol. 454, pp. 76-79, (2018) (PubMed).

Yang, Tian, Zhang, Xu, Yang, Yu, Li, Li, Li, Li: "Role of the JAK2/STAT3 signaling pathway in the pathogenesis of type 2 diabetes mellitus with macrovascular complications." in: Oncotarget, Vol. 8, Issue 57, pp. 96958-96969, (2017) (PubMed).

Zou, Liao, Fu, Zhao, Chen, Zhang: "MicroRNA-30c-5p ameliorates hypoxia-reoxygenation-induced tubular epithelial cell injury via HIF1α stabilization by targeting SOCS3." in: Oncotarget, Vol. 8, Issue 54, pp. 92801-92814, (2017) (PubMed).

Speth, Bourdonnay, Penke, Mancuso, Moore, Weinberg, Peters-Golden: "Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 12, pp. 5112-20, (2016) (PubMed).

Wan, Che, Kang, Wu: "SOCS3 blocks HIF-1? expression to inhibit proliferation and angiogenesis of human small cell lung cancer by downregulating activation of Akt, but not STAT3." in: Molecular medicine reports, Vol. 12, Issue 1, pp. 83-92, (2015) (PubMed).

Synonyms and alternative names related to SOCS3

suppressor of cytokine signaling 3a (socs3a), suppressor of cytokine signaling 3 S homeolog (socs3.S), suppressor of cytokine signaling 3 (socs3), suppressor of cytokine signaling 3 L homeolog (socs3.L), suppressor of cytokine signaling 3 (SOCS3), suppressor of cytokine signaling 3a (socs3), suppressor of cytokine signaling 3 (Socs3), atod4, ATOD4, cis3, CIS3, Cis3, cish3, Cish3, EF-10, Ef10, fj09e12, MGC64393, MGC75749, MGC81248, socs-3, SOCS-3, Socs-3, socs3, SOCS3, ssi-3, SSI-3, Ssi-3, ssi3, SSI3, Ssi3, wu:fj09e12, xsocs3, zgc:56537

Protein level used designations for SOCS3

  • suppressor of cytokine signaling 3
  • suppressor of cytokine signaling 3a
  • STAT-induced STAT inhibitor 3
  • cytokine-inducible SH2 protein 3
  • cytokine signaling suppressor
  • SOCS-3
  • CIS-3
  • E2a-Pbx1 target gene in fibroblasts 10
  • cytokine inducible SH2-containing protein 3
  • suppressors of cytokine signaling 3
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