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Four new members of the SOCS (show CISH ELISA Kits) family of molecules in rainbow trout (Oncorhynchus mykiss), CISH (show CISH ELISA Kits) and SOCS6, 7 and 9, are described for the first time in this species
Together, our data provide important evidence for miR (show MLXIP ELISA Kits)-19 mediated SOCS6 in OS growth and revealed miR (show MLXIP ELISA Kits)-19/SOCS6/JAK2 (show JAK2 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) pathway as a potential therapeutic strategy for OS patients.
Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples.
our results describe for the first time the role of miR (show MLXIP ELISA Kits)-494-3p during normal hematopoietic stem/progenitor cells differentiation and suggest that its increased expression, and the subsequent downregulation of its target SOCS6, might contribute to the megakaryocyte hyperplasia commonly observed in primary myelofibrosis patients.
miR (show MLXIP ELISA Kits)-142-3p regulates NPC (show NPC1 ELISA Kits) development by down-regulating SOCS6 expression and suggest that modulation of miR (show MLXIP ELISA Kits)-142-3p expression could be a therapeutic strategy for NPC (show NPC1 ELISA Kits)
Stage-independent downregulation of SOCS2 (show SOCS2 ELISA Kits) and SOCS6 correlate with disease-free survival in colorectal cancer.
Studied both the function of upregulated miR (show MLXIP ELISA Kits)-424-5p in pancreatic cancer and how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR (show MLXIP ELISA Kits)-424-5p.
miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer
SOCS2 (show SOCS2 ELISA Kits) and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis
Results show that SOCS6 forms complex with DRP1 (show CRMP1 ELISA Kits) and the mitochondrial phosphatase PGAM5 (show PGAM5 ELISA Kits), attenuates DRP1 (show CRMP1 ELISA Kits) phosphorylation, and promotes DRP1 (show CRMP1 ELISA Kits) mitochondrial translocation.
SOCS6 negatively regulates Flt3 (show FLT3 ELISA Kits) activation, the downstream Erk (show EPHB2 ELISA Kits) signaling pathway, and cell proliferation.
Our results show that endogenous Cul5 (show CUL5 ELISA Kits) suppresses epithelial cell transformation by several pathways, including inhibition of Src (show SRC ELISA Kits)-Cas (show CTNND1 ELISA Kits)-induced ruffling through SOCS6
SOCS-6 binds to insulin receptor substrate 4 (show IRS4 ELISA Kits), and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
SOCS4 expression, in contrast, does not appear to be EPO (show EPO ELISA Kits) inducible.SOCS4 is ineffective at counteracting EPO (show EPO ELISA Kits)-mediated events.
SOCS6 has a role as a negative regulator of receptor tyrosine kinases
SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase
TH1 (show HAND1 ELISA Kits)-specific chromatin structure is created by early recruitment of Swi (show SMARCA1 ELISA Kits)-SNF (show SNRPA ELISA Kits) complexes and nucleosome remodeling dependent on Stat4 (show STAT4 ELISA Kits).
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
suppressor of cytokine signaling 6
, suppressor of cytokine signaling
, hypothetical protein LOC100124796
, STAT induced STAT inhibitor-4
, cytokine-inducible SH2 protein 4
, suppressor of cytokine signaling 4
, SH2 domain containing SOCS box protein SOCS6
, cytokine inducible SH2-containing protein 4
, cytokine inducible SH2-containing protein CIS4