Browse our TYK2 Proteins (TYK2)

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Tyrosine Kinase 2 Proteins (TYK2)
On are 7 Tyrosine Kinase 2 (TYK2) Proteins from 5 different suppliers available. Additionally we are shipping TYK2 Antibodies (179) and TYK2 Kits (19) and many more products for this protein. A total of 212 TYK2 products are currently listed.
list all proteins Gene Name GeneID UniProt
TYK2 7297 P29597
TYK2 54721  
Rat TYK2 TYK2 100361294  

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TYK2 Proteins (TYK2) by Origin

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Human Tyrosine Kinase 2 (TYK2) interaction partners

  1. TYK2 is associated with systemic sclerosis susceptibility and reinforce the relevance of the IL-12 (show IL12A Proteins) pathway in SSc (show CYP11A1 Proteins) pathophysiology.

  2. Clinical genomic analysis of the current series of NF1 (show NF1 Proteins)-MPNST cases found that TYK2 is a new gene mutated in MPNST.

  3. Results demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with systemic lupus erythematous (SLE) in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians. [meta-analysis]

  4. demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population.

  5. The TYK2 promoter variant is associated with an overall risk for diabetes.

  6. Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus

  7. the role of TYK2 in the pathogenesis of rheumatoid arthritis

  8. present findings suggest that TYK2 regulates apoptotic and proinflammatory pathways in pancreatic beta-cells via modulation of IFNalpha signaling, subsequent increase in MHC class I protein, and modulation of chemokines such as CXCL10 (show CXCL10 Proteins).

  9. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

  10. Data indicate a chimeric fusion involving nucleophosmin NPM1 (show NPM1 Proteins) (5q35) and TYK2 kinase (19p13) that encodes an NPM1 (show NPM1 Proteins)-TYK2 protein in cutaneous CD30 (show TNFRSF8 Proteins) antigen-positve lymphoproliferative disorders.

Mouse (Murine) Tyrosine Kinase 2 (TYK2) interaction partners

  1. Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN (show PRSS27 Proteins)) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN (show PRSS27 Proteins).

  2. mutated form which lacks tyrosine kinase (show TYRO3 Proteins) activity restores differentiation of brown preadipocytes

  3. Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus.

  4. Tyk2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL-22 (show IL22 Proteins) signaling to STAT3 (show STAT3 Proteins)

  5. A reduced survival fitness of the Th17 in the absence of Tyk-2 mediated by the up-regulation of SOCS3 (show SOCS3 Proteins).

  6. Data indicate the important role of Tyk2 in skin inflammation and the therapeutic potential of Tyk2 inhibition in psoriasis.

  7. The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer.

  8. In cellular assays, SAR (show SRL Proteins)-20347 dose dependently (1 nM-10 muM) inhibited JAK1 (show JAK1 Proteins)- and/or TYK2-dependent signaling from the IL-12 (show IL12A Proteins)/IL-23 (show IL23A Proteins), IL-22 (show IL22 Proteins), and IFN-alpha (show IFNA Proteins) receptors.

  9. this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27 (show IL27 Proteins).

  10. Tyk2-mediated IL-12 (show IL12A Proteins) signaling is differentially required for the development of different Th1 (show HAND1 Proteins) cell subsets but similarly induces their bystander IFN-gamma (show IFNG Proteins) production

TYK2 Protein Profile

Protein Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Alternative names and synonyms associated with TYK2

  • tyrosine kinase 2 (TYK2)
  • tyrosine kinase 2 (Tyk2)
  • tyrosine kinase 2-like (LOC100344622)
  • JTK1 protein

Protein level used designations for Tyrosine Kinase 2 Proteins (TYK2)

non-receptor tyrosine-protein kinase TYK2 , tyrosine kinase TYK2 , non-receptor tyrosine kinase Tyk2

7297 Homo sapiens
54721 Mus musculus
100361294 Rattus norvegicus
430113 Gallus gallus
476714 Canis lupus familiaris
397363 Sus scrofa
512484 Bos taurus
100715734 Cavia porcellus
100344622 Oryctolagus cuniculus
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