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TYK2 genetic variants are differentially associated with common autoimmune diseases
High TYK2 expression is associated with B-cell lymphoma.
These data indicate that germline activating TYK2 mutations predispose to the development of ALL.
TYK2 rs280519 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
TYK2 is associated with systemic sclerosis susceptibility and reinforce the relevance of the IL-12 (show IL12A Proteins) pathway in SSc (show CYP11A1 Proteins) pathophysiology.
Clinical genomic analysis of the current series of NF1 (show NF1 Proteins)-MPNST cases found that TYK2 is a new gene mutated in MPNST.
Results demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with systemic lupus erythematous (SLE) in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians. [meta-analysis]
demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population.
The TYK2 promoter variant is associated with an overall risk for diabetes.
Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus
Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN (show PRSS27 Proteins)) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN (show PRSS27 Proteins).
mutated form which lacks tyrosine kinase (show TYRO3 Proteins) activity restores differentiation of brown preadipocytes
Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus.
Tyk2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL-22 (show IL22 Proteins) signaling to STAT3 (show STAT3 Proteins)
A reduced survival fitness of the Th17 in the absence of Tyk-2 mediated by the up-regulation of SOCS3 (show SOCS3 Proteins).
Data indicate the important role of Tyk2 in skin inflammation and the therapeutic potential of Tyk2 inhibition in psoriasis.
The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer.
In cellular assays, SAR (show SRL Proteins)-20347 dose dependently (1 nM-10 muM) inhibited JAK1 (show JAK1 Proteins)- and/or TYK2-dependent signaling from the IL-12 (show IL12A Proteins)/IL-23 (show IL23A Proteins), IL-22 (show IL22 Proteins), and IFN-alpha (show IFNA Proteins) receptors.
this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27 (show IL27 Proteins).
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
non-receptor tyrosine-protein kinase TYK2
, tyrosine kinase TYK2
, non-receptor tyrosine kinase Tyk2