Browse our anti-CDT1 (CDT1) Antibodies

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anti-Chromatin Licensing and DNA Replication Factor 1 Antibodies (CDT1)
On are 53 Chromatin Licensing and DNA Replication Factor 1 (CDT1) Antibodies from 14 different suppliers available. Additionally we are shipping CDT1 Kits (7) and CDT1 Proteins (3) and many more products for this protein. A total of 68 CDT1 products are currently listed.
2610318F11Rik, AW545653, C76791, CDT1, dup, fc37h07, im:7158083, ris2, wu:fc37h07, wu:fi38h09, xcdt1
list all antibodies Gene Name GeneID UniProt
CDT1 81620 Q9H211
CDT1 67177 Q8R4E9
CDT1 292071  

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anti-Human CDT1 Antibodies:

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anti-Rat (Rattus) CDT1 Antibodies:

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Top referenced anti-CDT1 Antibodies

  1. Human Polyclonal CDT1 Primary Antibody for ICC, IF - ABIN251007 : Pos, Wiener, Pocza, Racz, Toth, Darvas, Molnar, Hegyesi, Falus: Histamine suppresses fibulin-5 and insulin-like growth factor-II receptor expression in melanoma. in Cancer research 2008 (PubMed)
    Show all 4 references for 251007

  2. Cow (Bovine) Polyclonal CDT1 Primary Antibody for IHC, WB - ABIN2782592 : Hu, Xiong: An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. in The Journal of biological chemistry 2006 (PubMed)

  3. Human Monoclonal CDT1 Primary Antibody for WB - ABIN2668790 : Arentson, Faloon, Seo, Moon, Studts, Fremont, Choi: Oncogenic potential of the DNA replication licensing protein CDT1. in Oncogene 2002 (PubMed)

  4. Human Polyclonal CDT1 Primary Antibody for ELISA, WB - ABIN184819 : Whittaker, Royzman, Orr-Weaver et al.: Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase ... in Genes & development 2000 (PubMed)

More Antibodies against CDT1 Interaction Partners

Zebrafish Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. DTL (show DTL PLURAL_@3036@) promotes genomic stability through two distinct mechanisms. First, it is an essential component of the CUL4-DDB1 (show DDB1 PLURAL_@3036@) complex that controls CDT1 levels, thereby preventing rereplication. Second, it is required for the early G2/M checkpoint.

Human Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. mismatch repair (MMR (show MRC1 Antibodies)) proteins are also involved in the degradation of Cdt1 after ultraviolet irradiation in the G1 phase

  2. Cdt1-binding protein GRWD1 promotes chromatin fluidity by influencing nucleosome structures, e.g., by transient eviction of H2A-H2B, and thereby promotes efficient MCM loading at replication origins.

  3. ATM (show ATM Antibodies) silencing induced partial reduction in levels of Skp2, a component of SCF (show KITLG Antibodies)(Skp2) ubiquitin ligase that controls Cdt1 degradation.

  4. FBXO31 (show FBXO5 Antibodies) interacts with Cdt1 and regulates the degradation of Cdt1 in G2 phase.

  5. Protein levels of Geminin (show GMNN Antibodies) and Cdt1 are tightly regulated through the cell cycle, and the Cdt1-Geminin (show GMNN Antibodies) complex likely acts as a molecular switch that can enable or disable the firing of each origin of replication.

  6. These results demonstrate an important role for Cdt1 in human papillomavirus E7-induced rereplication and shed light on mechanisms by which human papillomavirus induces genomic instability.

  7. ATR (show ANTXR1 Antibodies), activated after DNA damage, phosphorylates Cdt2 (show DTL Antibodies) and promotes the rapid degradation of Cdt1 after UV irradiation in the G1 phase of the cell cycle.

  8. A lethal phenotype was seen in four individuals with compound heterozygous CDT1 mutations

  9. results support the conclusion that Cdt1 binding to Hec1 (show NDC80 Antibodies) is essential for an extended Ndc80 (show NDC80 Antibodies) configuration and stable kinetochore-microtubule attachment

  10. Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC (show CACNA1C Antibodies) indices. Our results provide insights into the molecular basis underlying variation in RBC (show CACNA1C Antibodies) traits.

Mouse (Murine) Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. conserved arginine residues play critical roles in interaction with Geminin (show GMNN Antibodies) and Mcm that are crucial for proper conformation of the complexes and its licensing activity.

  2. Study shows that ablation of Geminin (show GMNN Antibodies) induces massive rereplication as a result of unrestrained Cdt1 activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 activity is intact.

  3. This study reveals a conserved new regulatory Cdt1 domain crucial for proper DNA licensing activity.

  4. Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase (show DNA2 Antibodies) Mcm proteins.

  5. Determined the structures of mCdt1CS (mCdt1C_small; residues 452 to 557) and mCdt1CL (mCdt1C_large; residues 420 to 557) using X-ray crystallography and NMR. This study reveals that Cdt1 is formed with a tandem repeat of the winged helix domain.

  6. Cdt1 function is negatively regulated by the Cdk (show CDK4 Antibodies) phosphorylation independent of geminin (show GMNN Antibodies) binding

  7. crystal structure of the mouse geminin (show GMNN Antibodies)-Cdt1 complex using tGeminin (residues 79-157, truncated geminin (show GMNN Antibodies)) and tCdt1 (residues 172-368, truncated Cdt1)

  8. In situ hybridization and immunohistochemistry localize Cdt1 as well as geminin (show GMNN Antibodies) to the proliferative compartment of the developing mouse gut (show GUSB Antibodies) epithelium

  9. Cdt1 expression characterizes progenitor cells in G1 phase

  10. These results suggested that, at least in vitro, oleic acid-containing cell membranes of the lipid bilayer inhibit Cdt1-geminin (show GMNN Antibodies) complex formation by binding to Cdt1 and thereby liberating Cdt1 from inhibition by geminin (show GMNN Antibodies).

Xenopus laevis Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. The results showed that the Cdt1 region spanning amino acids (a. a.) 255-620 is required for efficient inhibition of DNA replication, and that, within this region, a. a. 255-289 have a critical role in inhibition.

  2. conserved arginine residues play critical roles in interaction with Geminin (show GMNN Antibodies) and Mcm that are crucial for proper conformation of the complexes and its licensing activity.

  3. These findings suggested that excess Cdt1 suppressed the progression of replication forks.

  4. Dynamic interactions of high Cdt1 and geminin (show GMNN Antibodies) levels regulate S phase in early Xenopus embryos.

  5. p97 (show vcp Antibodies) is an essential regulator of DNA damage-dependent CDT1 destruction

  6. CDC-48/p97 (show vcp Antibodies) coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication

  7. Loading of geminin (show GMNN Antibodies) onto chromatin requires Cdt1, suggesting that geminin (show GMNN Antibodies) is targeted at replication origins.

  8. results allow us to build a comprehensive model of how re-replication of DNA is prevented in Xenopus, with Cdt1 regulation being the key feature

  9. Removal of Cdt1 from chromatin and its nuclear exclusion in G2 is critical in regulating licensing and limiting DNA replication in S phase to only one round.

  10. Cdt1 and DDB1 (show DDB1 PLURAL_@3036@) interact in extracts, and DDB1 (show DDB1 PLURAL_@3036@) chromatin loading is dependent on the binding of Cdt1 to PCNA (show PCNA PLURAL_@3036@), which indicates that PCNA (show PCNA PLURAL_@3036@) docking activates the pre-formed Cdt1-Cul4(DDB1 (show DDB1 PLURAL_@3036@)) ligase complex.

CDT1 Antigen Profile

Antigen Summary

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein.

Alternative names and synonyms associated with CDT1

  • chromatin licensing and DNA replication factor 1 (CDT1) antibody
  • chromatin licensing and DNA replication factor 1 (cdt1) antibody
  • chromatin licensing and DNA replication factor 1 (Cdt1) antibody
  • 2610318F11Rik antibody
  • AW545653 antibody
  • C76791 antibody
  • CDT1 antibody
  • dup antibody
  • fc37h07 antibody
  • im:7158083 antibody
  • ris2 antibody
  • wu:fc37h07 antibody
  • wu:fi38h09 antibody
  • xcdt1 antibody

Protein level used designations for CDT1

chromatin licensing and DNA replication factor 1 , DNA replication factor Cdt1-like , DNA replication factor Cdt1 , Double parked, Drosophila, homolog of , DUP , double parked homolog , retroviral insertion site 2 protein , retroviral integration site 1 , retroviral integration site 2 , DNA replication factor

426254 Gallus gallus
479616 Canis lupus familiaris
566787 Danio rerio
100051139 Equus caballus
100379812 Xenopus (Silurana) tropicalis
100388665 Callithrix jacchus
100525749 Sus scrofa
100583916 Nomascus leucogenys
81620 Homo sapiens
67177 Mus musculus
292071 Rattus norvegicus
398024 Xenopus laevis
519016 Bos taurus
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