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CDT2/RAMP Antibodies

(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
CDT2/RAMP antibody  (C-Term) CDT2/RAMP antibody  (C-Term) CDT2/RAMP antibody (C-Term) (ABIN2451940)

DTL Reactivity: Human, Mouse WB, FACS, IP, IF Host: Rabbit Polyclonal unconjugated

CDT2/RAMP antibody  (Middle Region) CDT2/RAMP antibody  (Middle Region) CDT2/RAMP antibody (Middle Region) (ABIN951451)

DTL Reactivity: Human, Mouse WB, FACS, EIA Host: Rabbit Polyclonal unconjugated

CDT2/RAMP antibody  (AA 393-550) CDT2/RAMP antibody  (AA 393-550) CDT2/RAMP antibody (AA 393-550) (ABIN7149691)

DTL Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated

CDT2/RAMP Antibodies by Reactivity

Find CDT2/RAMP Antibodies for a variety of species such as anti-Human CDT2/RAMP, anti-Mouse CDT2/RAMP, anti-Rat CDT2/RAMP. The species listed below are among those available. Click on a link to go to the corresponding products.

CDT2/RAMP Antibodies by Application

Find CDT2/RAMP Antibodies validated for a specific application such as WB, ELISA, FACS, IP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

CDT2/RAMP Antibodies by Host

Find CDT2/RAMP Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

CDT2/RAMP Antibodies by Binding Specificity

Find CDT2/RAMP Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

CDT2/RAMP Antibodies by Clonality

Find available monoclonal or polyclonal CDT2/RAMP Antibodies. Click on a link to go to the corresponding products.

CDT2/RAMP Antibodies by Clone

Find CDT2/RAMP Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

CDT2/RAMP Antibodies by Conjugate

Find CDT2/RAMP Antibodies with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular CDT2/RAMP Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, FACS, IP, IF
Validations
  • (6)
Cat. No. ABIN2451940
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, FACS, EIA
Validations
  • (1)
  • (2)
Cat. No. ABIN951451
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7149691
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, FACS
Validations
  • (2)
Cat. No. ABIN654926
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN949333
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6139847
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6738232
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN2782560
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7149693
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7149694
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7149692
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA
Validations
Cat. No. ABIN6390479
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
Cat. No. ABIN873173
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IP
Validations
Cat. No. ABIN7113419
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IP, IHC (fp)
Validations
Cat. No. ABIN7454381
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CDT2/RAMP Antibodies

Yamashita, Ide, Furukawa, Suzuki, Hirano, Ohno: "Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex." in: Molecular biology of the cell, Vol. 26, Issue 13, pp. 2426-38, (2015) (PubMed).

Kobayashi, Komatsu, Ichikawa, Kawaguchi, Hirajima, Miyamae, Okajima, Ohashi, Kosuga, Konishi, Shiozaki, Fujiwara, Okamoto, Tsuda, Otsuji: "Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma." in: Oncotarget, Vol. 6, Issue 34, pp. 36615-24, (2015) (PubMed).

Tateossian, Morse, Simon, Dean, Brown: "Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung." in: Disease models & mechanisms, Vol. 8, Issue 12, pp. 1531-42, (2015) (PubMed).

Rossi, Duan, Jeong, Horn, Saraf, Florens, Washburn, Antebi, Pagano: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).

Jørgensen, Eskildsen, Fugger, Hansen, Larsen, Kousholt, Syljuåsen, Trelle, Jensen, Helin, Sørensen: "SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation." in: The Journal of cell biology, Vol. 192, Issue 1, pp. 43-54, (2011) (PubMed).

Karaayvaz, Pal, Song, Zhang, Georgakopoulos, Mehmood, Burke, Shroyer, Ju: "Prognostic significance of miR-215 in colon cancer." in: Clinical colorectal cancer, Vol. 10, Issue 4, pp. 340-7, (2011) (PubMed).

Abbas, Sivaprasad, Terai, Amador, Pagano, Dutta: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).

Aliases for CDT2/RAMP Antibodies

denticleless E3 ubiquitin protein ligase homolog (DTL) Antibodies
denticleless E3 ubiquitin protein ligase (Dtl) Antibodies
denticleless E3 ubiquitin protein ligase homolog (Dtl) Antibodies
denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) Antibodies
denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) Antibodies
2810047L02Rik Antibodies
5730564G15Rik Antibodies
cb151 Antibodies
CDT2 Antibodies
cdt2 Antibodies
cdt2-a Antibodies
chunp6871 Antibodies
DCAF2 Antibodies
dcaf2 Antibodies
L2DTL Antibodies
l2dtl Antibodies
RAMP Antibodies
Ramp Antibodies
ramp Antibodies
RGD1310439 Antibodies
wu:fb54b02 Antibodies
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