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Browse our anti-EIF4EBP1 (EIF4EBP1) Antibodies

Full name:
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 Antibodies (EIF4EBP1)
On www.antibodies-online.com are 461 Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Antibodies from 28 different suppliers available. Additionally we are shipping EIF4EBP1 Proteins (25) and EIF4EBP1 Kits (16) and many more products for this protein. A total of 523 EIF4EBP1 products are currently listed.
Synonyms:
4e-bp, 4e-bp1, 4ebp, 4EBP1, 43-BP, 153432_at, AA959816, anon-WO0172774.158, BcDNA.HL08053, BcDNA:HL08053, BP-1, CG8846, CT8705, d4e-bp, d4E-BP1, d4eBP, Dm 4E-BP, Dmel\\CG8846, dthor, eIF4E-BP, EIF4EBP1, fc04h09, l(2)06270, l(2)k07736, l(2)k13517, PHAS-I, Phas1, pp20, thor, Thor/EIF4EBP, wu:fc04h09, zgc:64137
list all antibodies Gene Name GeneID UniProt
EIF4EBP1 1978 Q13541
EIF4EBP1 13685 Q60876
EIF4EBP1 116636 Q62622

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Top referenced anti-EIF4EBP1 Antibodies

  1. Human Monoclonal EIF4EBP1 Primary Antibody for WB - ABIN659184 : She, Halilovic, Ye, Zhen, Shirasawa, Sasazuki, Solit, Rosen: 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. in Cancer cell 2010 (PubMed)
    Show all 2 references for ABIN659184

  2. Human Polyclonal EIF4EBP1 Primary Antibody for EIA - ABIN358355 : Fonseca, Smith, Lee, MacKintosh, Proud: PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN358355

  3. Human Polyclonal EIF4EBP1 Primary Antibody for EIA, WB - ABIN950187 : Aoyagi, Gaspar, Shenk: Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for ABIN950187

  4. Human Polyclonal EIF4EBP1 Primary Antibody for EIA, IHC (p) - ABIN357350 : Armengol, Rojo, Castellví, Iglesias, Cuatrecasas, Pons, Baselga, Ramón y Cajal: 4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. in Cancer research 2007 (PubMed)
    Show all 2 references for ABIN357350

  5. Human Polyclonal EIF4EBP1 Primary Antibody for IHC, ELISA - ABIN1533149 : Pause, Belsham, Gingras, Donzé, Lin, Lawrence, Sonenberg: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. in Nature 1994 (PubMed)

More Antibodies against EIF4EBP1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) interaction partners

  1. longevity assurance mutants of chico, the Drosophila insulin receptor (show INSR Antibodies) substrate homolog, require Drosophila d4eBP to slow aging.

  2. These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.

  3. eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E (show EIF4E Antibodies) to repress translation.

  4. PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression

  5. These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging.

  6. Induction of 4EBP likely leads to growth inhibition by Dfoxo (show FOXO Antibodies), whereas activation of InR (show INSR Antibodies) provides a novel transcriptionally induced feedback control mechanism.

  7. S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathways.

  8. Drosophila 4E-BP activity becomes critical for survival under dietary restriction and oxidative stress, and is linked to life span.

  9. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense.

  10. Results show that it is via 4E-BP, regulators of the translation factor eIF4E, FOXO and TOR also converge to regulate protein synthesis.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) interaction partners

  1. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (show PTCHD3 Antibodies) cells through activation of the MTOR (show FRAP1 Antibodies)-RPS6K-RPS6 (show RPS6 Antibodies)-EIF4EBP1 signal transduction pathway.

Human Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) interaction partners

  1. Twist1 (show TWIST1 Antibodies) is correlated with p-4E-BP1 in predicting the prognostic outcome of NSCLC.

  2. Increased 4EBP1 abundance was a common feature in prostate cancer patients who had been treated with the PI3K (show PIK3CA Antibodies) pathway inhibitor BKM120; thus, 4EBP1 may be associated with drug resistance in human tumors

  3. results suggest that respiratory syncytial virus is a virus that still contains unknown mechanisms involved in the translation of their mRNAs through the alteration or modification of some translation factors, such as 4EBP1, possibly to favor its replicative

  4. eIF4E binding protein 1 expression has a role in clinical survival outcomes in colorectal cancer

  5. It was concluded that over-activation of the mTORC1/4E-BP1/p21 (show CDKN1A Antibodies) pathway is a frequent and clinically relevant alteration in head and neck squamous cell carcinomas.

  6. The aim of the present work was to probe the conformation of the intrinsically disordered protein 4E-BP1 in the native and partly folded states by limited proteolysis and to reveal regions with a high propensity to form an ordered structure.

  7. Taken together, these results highlight the potential dependence of eIF4G (show EIF4G1 Antibodies) overexpression and 4E-BP1 phosphorylation in CLL survival.

  8. Molecular structure of EIF4E (show EIF4E Antibodies) bound to 4E-BP1 provides insight into the consequences of phosphorylation.Phosphorylation of 4E-BP1 impairs the competition with eIF4G (show EIF4G1 Antibodies) for eIF4E (show EIF4E Antibodies) binding.

  9. Results suggest that blocking both the mTOR (show FRAP1 Antibodies) kinase downstream targets 4E-BP1 protein and p70 S6 kinase (show PRKACB Antibodies) 1, but not p70 S6 kinase (show PRKACB Antibodies) 1 alone, prevents the migration of retinal pigment epithelium (RPE (show RPE Antibodies)) cells.

  10. phosphorylation site affected the prognostic significance of 4EBP1 in non-small cell lung cancer.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) interaction partners

  1. Thus, translational control by 4E-BP1 downstream of mTOR (show FRAP1 Antibodies) effects the expression of neuroligin 1 (show NLGN1 Antibodies) and excitatory synaptic transmission in the spinal cord, and thereby contributes to enhanced mechanical nociception.

  2. The findings support a model whereby elevated 4E-BP1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of 4E-BP1 within its PEST motif.

  3. The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.

  4. Oxidative stress-induced (show SQSTM1 Antibodies) premature senescence occurred due to impaired autophagy function through 4EBP1 phosphorylation.

  5. Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production.

  6. Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 Antibodies)-mediated S6K1 (show RPS6KB1 Antibodies) and 4E-BP1/eIF4E (show EIF4E Antibodies) pathways, resulting in caspase (show CASP3 Antibodies)-dependent and -independent apoptosis in neuronal cells.

  7. These findings indicate that regulation of 4E-BP1 in skeletal muscle may serve as an important conduit through which mTORC1 controls metabolism.

  8. Disruption of genes encoding Eif4ebp1 and Eif4ebp2 (show EIF4EBP2 Antibodies) does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.

  9. 4E-BP1/2-null cells express less ATGL (show PNPLA2 Antibodies) and accumulate more fat than control cells, while knock down of Egr1 (show EGR1 Antibodies) in 4E-BP1/2-null cells increases ATGL (show PNPLA2 Antibodies) expression and decreases fat storage.

  10. mTORC1 also regulates HIF-1alpha (show HIF1A Antibodies) synthesis on a translational level via co-operative regulation of both initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase-1 (S6K1 (show RPS6KB1 Antibodies))

EIF4EBP1 Antigen Profile

Antigen Summary

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Alternative names and synonyms associated with EIF4EBP1

  • CG8846 gene product from transcript CG8846-RA (Thor) antibody
  • eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) antibody
  • eukaryotic translation initiation factor 4E binding protein 1 (eif4ebp1) antibody
  • eukaryotic translation initiation factor 4E binding protein 1 (LOC100230789) antibody
  • eukaryotic translation initiation factor 4E binding protein 1 (Eif4ebp1) antibody
  • 4e-bp antibody
  • 4e-bp1 antibody
  • 4ebp antibody
  • 4EBP1 antibody
  • 43-BP antibody
  • 153432_at antibody
  • AA959816 antibody
  • anon-WO0172774.158 antibody
  • BcDNA.HL08053 antibody
  • BcDNA:HL08053 antibody
  • BP-1 antibody
  • CG8846 antibody
  • CT8705 antibody
  • d4e-bp antibody
  • d4E-BP1 antibody
  • d4eBP antibody
  • Dm 4E-BP antibody
  • Dmel\\CG8846 antibody
  • dthor antibody
  • eIF4E-BP antibody
  • EIF4EBP1 antibody
  • fc04h09 antibody
  • l(2)06270 antibody
  • l(2)k07736 antibody
  • l(2)k13517 antibody
  • PHAS-I antibody
  • Phas1 antibody
  • pp20 antibody
  • thor antibody
  • Thor/EIF4EBP antibody
  • wu:fc04h09 antibody
  • zgc:64137 antibody

Protein level used designations for EIF4EBP1

CG8846-PA , Eif4e-binding protein , Thor-PA , eIF-4E-binding protein , eif4e-binding protein 4EBP , eukaryotic initiation factor 4E binding protein , eukaryotic initiation factor 4E-binding protein , eukaryotic translation initiation factor 4E binding protein , eukaryotic translation initiation factor 4E-binding protein , insulin-stimulated eIF-4E binding protein , lethal (2) 06270 , thor , eukaryotic translation initiation factor 4E binding protein 1 , translation initiation factor 4E binding protein 1 , eukaryotic translation initiation factor 4E-binding protein 1 , eIF4E-binding protein 1 , phosphorylated heat- and acid-stable protein regulated by insulin 1 , 4E-BP1

GENE ID SPECIES
33569 Drosophila melanogaster
397633 Sus scrofa
464114 Pan troglodytes
703628 Macaca mulatta
799566 Danio rerio
100230789 Taeniopygia guttata
1978 Homo sapiens
13685 Mus musculus
116636 Rattus norvegicus
426773 Gallus gallus
475590 Canis lupus familiaris
100627508 Sus scrofa
509613 Bos taurus
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