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Browse our HSPB1 Proteins (HSPB1)

Full name:
Heat Shock 27kDa Protein 1 Proteins (HSPB1)
On www.antibodies-online.com are 31 Heat Shock 27kDa Protein 1 (HSPB1) Proteins from 11 different suppliers available. Additionally we are shipping HSPB1 Antibodies (862) and HSPB1 Kits (59) and many more products for this protein. A total of 979 HSPB1 products are currently listed.
Synonyms:
27kDa, 2810021G24Rik, cb153, cb660, CMT2F, HMN2B, HS.76067, Hs.78846, hsp1, Hsp25, Hsp27, HSP28, HSPB1, id:ibd2821, LOH11CR1K, MKBP, sb:cb660, SRP27, zgc:103437
list all proteins Gene Name GeneID UniProt
HSPB1 3315 P04792
HSPB1 24471 P42930
HSPB1 15507 P14602

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HSPB1 Proteins (HSPB1) by Origin

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Top referenced HSPB1 Proteins

  1. Human HSPB1 Protein expressed in Escherichia coli (E. coli) - ABIN2002650 : Bruey, Paul, Fromentin, Hilpert, Arrigo, Solary, Garrido: Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. in Oncogene 2000 (PubMed)
    Show all 6 references for ABIN2002650

  2. Human HSPB1 Protein expressed in Wheat germ - ABIN1307214 : Iizuka, Okamoto, Matsushita, Kimura, Nagai, Arito, Kurokawa, Masuko, Suematsu, Hirohata, Kato: Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement. in Lupus 2010 (PubMed)
    Show all 2 references for ABIN1307214

  3. Human HSPB1 Protein expressed in Escherichia coli (E. coli) - ABIN1686697 : Van Montfort, Slingsby, Vierling: Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones. in Advances in protein chemistry 2002 (PubMed)
    Show all 2 references for ABIN1686697

More Proteins for HSPB1 Interaction Partners

Zebrafish Heat Shock 27kDa Protein 1 (HSPB1) interaction partners

  1. Loss of HspB1 specifically reduces myofibril size in embryonic craniofacial muscles.

  2. Results show the sequence, expression, regulation, and function of a zebrafish protein (zfHsp27) and define zebrafish as a new model for the study of Hsp27 function.

  3. initial upregulation of hsp27 expression occurs during early gastrulation

  4. hspb1 is expressed during development

  5. Hsp27 is dispensable for zebrafish morphogenesis but could play a role in long-term maintenance of heart and muscle tissues.

  6. The data support a mechanism of Hsp27 function where interactions with the titin (show TTN Proteins) filament system protect myofibrils from stress-induced degradation.

Xenopus laevis Heat Shock 27kDa Protein 1 (HSPB1) interaction partners

  1. Xenopus HSP27, like HSP30, is a developmentally-regulated heat-inducible molecular chaperone (show HSP90AA1 Proteins).

Human Heat Shock 27kDa Protein 1 (HSPB1) interaction partners

  1. High HSP27 expression is associated with chemoresistance in neoplasms.

  2. In this instance, the ATP5B (show ATP5B Proteins)/CALR (show CALR Proteins)/HSP90B1 (show HSP90B1 Proteins)/HSPB1/HSPD1 (show HSPD1 Proteins)-signaling network was revealed as the predominant target which was associated with the majority of the observed protein-protein interactions. As a result, the identified targets may be useful in explaining the anticancer mechanisms of ursolic acid and as potential targets for colorectal cancer therapy.

  3. Soluble glycoprotein 130 (show IL6ST Proteins) and hsp27 are novel candidate biomarkers for diagnosing Chronic Heart Failure with preserved ejection fraction and thus warrant further investigation; neither dpp4 (show DPP4 Proteins) nor CTSS (show CTSS Proteins) showed promise as biomarkers of Chronic Heart Failure.

  4. Addition of the Hsp27 inhibitor KRIBB3 (5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)-isoxazol) to Jurkat cells resulted in glutathione redox imbalance (increased GSSG and increased glutathione reductase (show GSR Proteins) activity), a decrease in Hsp70 (show HSP70 Proteins) concentrations, and also increased cell apoptosis

  5. HSP27 expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 modulates lung fibroblast differentiation through the Smad3 (show SMAD3 Proteins) and ERK (show EPHB2 Proteins) pathways.

  6. TRAP-induced activation of Akt (show AKT1 Proteins) in addition to p38 MAP kinase (show MAPK14 Proteins) positively regulates the release of phosphorylated-HSP27 from human platelets, which is closely related to the platelet hyper-aggregation in type 2 diabetes mellitus patients.

  7. phosphorylated Hsp27 stimulates autophagy and lipid droplet clearance and interacts with STAT3 (show STAT3 Proteins).

  8. The expression levels of HSP27 and HSP90 (show HSP90 Proteins) are elevated in acute pulmonary embolism reflecting endothelial dysfunction.

  9. High expression of HSP27 is associated with molecular apocrine breast cancer.

  10. HSP27 was found to be regulator of translation initiation and STAT3 (show STAT3 Proteins) level. Therefore, it suggests that HSP27 is a key protein during placental development and trophoblast cell differentiation.

Cow (Bovine) Heat Shock 27kDa Protein 1 (HSPB1) interaction partners

  1. These findings suggest that HSPB1 mediates androgen signaling by binding directly to androgen receptor (show AR Proteins) and then enhancing androgen-mediated myogenesis in myogenic cells.

  2. HSPB1 could have an important role during testosterone-related myogenesis.

  3. CaMKII (show CAMK2G Proteins) is required for redox-sensitive activation of p38 MAPK (show MAPK14 Proteins)/heat shock protein 27 pathway and ERK1/2

Pig (Porcine) Heat Shock 27kDa Protein 1 (HSPB1) interaction partners

  1. It indicated that Hsp27 was required for porcine circovirus type 2 replication in PK-15 cells culture.

  2. HSP27 expression is gut (show GUSB Proteins) region- and cell type-specific in response to dietary components, microbes, and microbial metabolites to which the mucosa surface is exposed.

  3. These results indicate that Hsp27 expression in the porcine gut (show GUSB Proteins) could be associated with specific dietary fiber components but not the overall microbiota diversity.

  4. Data suggest that targeting HSP27 might offer a useful strategy in cancer treatment.

  5. Data show that the expression of HSP27 and CLIC1 (show CLIC1 Proteins) was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively.

  6. Data suggest that HSP27 enhanced the metastatic property of NPC (show NPC1 Proteins) cells probably via the NF-kappaB (show NFKB1 Proteins)-mediated activation of MMPs.

  7. Hsp27 expression and its direct chaperoning interaction increase Akt (show AKT1 Proteins) stability and p21 (show CDKN1A Proteins) phosphorylation and nuclear-to-cytoplasm translocation, both essential effects for the survival of ultraviolet-induced DNA-damaged cells.

  8. HSP27 could be a good candidate involved in migration and/or function of neutrophils within the porcine endmetrium.

  9. HSP27 and HSP70 (show HSP70 Proteins) may be used as differential markers to distinguish conventional and low grade central osteosarcoma.

  10. HSP-27 and HSP-70 (show HSP70 Proteins) contribute to modulation of K(+) channel (show KCNC4 Proteins)-induced pial artery dilation

Mouse (Murine) Heat Shock 27kDa Protein 1 (HSPB1) interaction partners

  1. e confirmed the modulatory effect of Hspb1 on Purkinje cell degeneration (show AGTPBP1 Proteins) in vivo, as knockdown by Hspb1 shRNA significantly enhanced neuron loss. These results suggest that strategies to promote HSPB1 activity may slow the rate of cerebellar degeneration in NPC (show NPC1 Proteins) disease and highlight the use of bioinformatics tools to uncover pathways leading to neuronal protection in neurodegenerative disorders

  2. Dp71Delta78-79 dystrophin (show DMD Proteins) mutant stimulates neurite outgrowth in cultured neuronal cells via upregulation and phosphorylation of HspB1.

  3. HSP27 expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 modulates lung fibroblast differentiation through the Smad3 (show SMAD3 Proteins) and ERK (show EPHB2 Proteins) pathways.

  4. phosphorylated Hsp27 stimulates autophagy and lipid droplet clearance and interacts with STAT3 (show STAT3 Proteins).

  5. The phosphorylation of S82 of the heat shock protein 27 kDa (HSP27), was especially abundant and consistently upregulated in tissues with delays in freezing as short as 2 minutes.

  6. HSPB1 depletion in a mouse model of lung tumorigenesis induced the endothelial-to-mesenchymal transition

  7. HspB2 (show HSPB2 Proteins) has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis

  8. Overexpression of HSP27-S135F protein causes peripheral neuropathy. The mouse model can be applied to future development of therapeutic strategies forhereditary motor neuropathy (dHMN) and Charcot-Marie-Tooth disease type 2 F.

  9. cardiac HMGB1 (show HMGB1 Proteins) increases HSPB1 expression and attenuates cardiomyocyte apoptosis associated with doxorubicin-induced cardiomyopathy.

  10. Hsp27 binding to the 3'UTR of Bim (show BCL2L11 Proteins) mRNA prevents neuronal death during oxidative stress-induced (show SQSTM1 Proteins) injury.

HSPB1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function.

Alternative names and synonyms associated with HSPB1

  • heat shock protein, alpha-crystallin-related, 1 (hspb1)
  • heat shock 27kDa protein 1 (hspb1)
  • heat shock 27kDa protein 1 (HSPB1)
  • heat shock 27kDa protein 1 (HSP27)
  • heat shock 27kDa protein 2 (HSPB2)
  • heat shock protein 1 (Hspb1)
  • heat shock protein 2 (Hspb2)
  • heat shock protein 25 (HSP25)
  • 27kDa protein
  • 2810021G24Rik protein
  • cb153 protein
  • cb660 protein
  • CMT2F protein
  • HMN2B protein
  • HS.76067 protein
  • Hs.78846 protein
  • hsp1 protein
  • Hsp25 protein
  • Hsp27 protein
  • HSP28 protein
  • HSPB1 protein
  • id:ibd2821 protein
  • LOH11CR1K protein
  • MKBP protein
  • sb:cb660 protein
  • SRP27 protein
  • zgc:103437 protein

Protein level used designations for HSPB1

25 kDa heat shock protein , heat shock 27kDa protein 1 , heat shock protein 27 , heat shock protein beta-1 , 28 kDa heat shock protein , HSP 27 , estrogen-regulated 24 kDa protein , heat shock 27 kDa protein , heat shock 27kD protein 1 , stress-responsive protein 27 , heat-shock protein , 25 kDa IAP , HSP 25 , actin polymerization inhibitor , heat shock 25 kDa protein , inhibitor of actin polymerization , DMPK-binding protein , heat shock protein beta-2 , heat-shock protein beta-2 , heat shock 27 kDa protein 1 , growth-related 25 kDa protein , heat shock protein, 25 kDa , p25 , truncated hsp25 , heat shock 27kD protein 2

GENE ID SPECIES
368243 Danio rerio
447107 Xenopus laevis
463488 Pan troglodytes
715615 Macaca mulatta
780278 Xenopus (Silurana) tropicalis
3315 Homo sapiens
403979 Canis lupus familiaris
396227 Gallus gallus
516099 Bos taurus
493184 Sus scrofa
3316 Homo sapiens
24471 Rattus norvegicus
15507 Mus musculus
69253 Mus musculus
428310 Gallus gallus
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