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Sirtuin 1 Proteins (SIRT1)
On www.antibodies-online.com are 18 Sirtuin 1 (SIRT1) Proteins from 11 different suppliers available. Additionally we are shipping SIRT1 Antibodies (329) and SIRT1 Kits (44) and many more products for this protein. A total of 398 SIRT1 products are currently listed.
Synonyms:
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all proteins Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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SIRT1 Proteins (SIRT1) by Origin

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Top referenced SIRT1 Proteins

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
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More Proteins for SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.

  2. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. Sirt1 interacts with NF-kappa B (show NFKB1 Proteins) and PPAR alpha (show PPARA Proteins) to mediate the effects of the high-fat diet on the heart.

  2. SIRT1 regulated hepatocellular proliferation, circadian rhythms, and lipid metabolism during liver regeneration.

  3. Obesity-linked phosphorylation of SIRT1 inhibits its function and promotes pathological symptoms of nonalcoholic fatty liver disease. Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not lean, mice, and this phosphorylation was catalyzed by casein kinase 2.

  4. SIRT1 promotes early-onset AHL (show CDH23 Proteins) through suppressing FOXO3a (show FOXO3 Proteins)-mediated oxidative stress resistance in the cochlea of C57BL/6 mice.

  5. In analyses of intestinal tissues, colitis induction, and gut (show GUSB Proteins) microbiota in mice with intestinal epithelial disruption of SIRT1, we found this protein to prevent intestinal inflammation by regulating the gut (show GUSB Proteins) microbiota.

  6. this study shows that SIRT1-dependent differentiation of Th9 cells confers protection against tumors and contributes to allergic airway inflammation

  7. SIRT1 interacts with and promotes the transactivation potential of RUNX2 (show RUNX2 Proteins).

  8. Sirt1 might be directly involved in spermiogenesis in germ cells but not in steroidogenic cells. Germ cell-specific Sirt1 knockout mice were almost completely infertile; the early mitotic and meiotic progression of germ cells in spermatogenesis were not obviously affected after Sirt1 depletion, but subsequent spermiogenesis was disrupted by a defect in acrosome biogenesis.

  9. Sirt1 significantly reduced the levels of raptor (show RPTOR Proteins) and inactivated mammalian target of rapamycin (mTOR (show FRAP1 Proteins))C1 signal by interacting with Akt2 (show AKT2 Proteins).

  10. These findings indicate that SIRT1 is a key regulator of macrophage self-renewal that integrates cell cycle and longevity pathways.

Human Sirtuin 1 (SIRT1) interaction partners

  1. In cigarette smoke extract stimulated bronchial epithelial cells, carbocysteine increased cell proliferation, and SIRT1 and FoxO3 (show FOXO3 Proteins) nuclear expression, and reduced beta galactosidase (show GLB1 Proteins) and survivin (show BIRC5 Proteins) expression.

  2. O-GlcNAcylation is a central component linking metabolism to invasion and metastasis via an SIRT1/ERK (show EPHB2 Proteins)/FOXM1 (show FOXM1 Proteins) axis.

  3. Phosphorylated S164-SIRT1 and Casein Kinase 2 levels were also highly elevated in liver samples of nonalcoholic fatty liver disease patients and correlated with disease severity.

  4. Our data suggest that the p53 (show TP53 Proteins)-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-adrenergic receptor (show ADRB2 Proteins) signaling

  5. Up-regulation of transcription factor DeltaNp63 led to the decline of miR (show MLXIP Proteins)-181a expression, resulting in an overexpression of the antiaging protein Sirt1, in CD4 (show CD4 Proteins)(+) T cells from HCV-infected individuals. Either reconstituting miR (show MLXIP Proteins)-181a or silencing DeltaNp63 or Sirt1 expression in CD4 (show CD4 Proteins)(+) T cells led to accelerated T cell senescence.

  6. data reveals that the pathway 'HULC/USP22 (show USP22 Proteins)/Sirt1/ protective autophagy' attenuates the sensitivity of hepatocellular carcinoma cells to chemotherapeutic agents, suggesting that this pathway may be a novel target for developing sensitizing strategy to hepatocellular carcinoma chemotherapy

  7. SIRT1 plays a key role in the inflammatory response in aseptic loosening through NF-kappaB (show NFKB1 Proteins) deacetylation .

  8. The tumor-associated NADH oxidase (tNOX (show ENOX2 Proteins))-mediated modulation of the NAD+ concentration and SIRT1 are involved in oxaliplatin-induced apoptosis.

  9. Up-regulated SIRT1 expression may serve as a potential biomarker for predicting the progression of cervical squamous intraepithelial lesions to invasive squamous cell carcinoma.

  10. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F (show HNRNPF Proteins), SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.

  5. CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 protein
  • SIR2 protein
  • Sir2a protein
  • Sir2alpha protein
  • sir2l1 protein
  • sirtuin protein
  • sirtuin 1 protein

Protein level used designations for Sirtuin 1 Proteins (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

GENE ID SPECIES
100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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