You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our SIRT1 Proteins (SIRT1)

Full name:
Sirtuin 1 Proteins (SIRT1)
On www.antibodies-online.com are 18 Sirtuin 1 (SIRT1) Proteins from 11 different suppliers available. Additionally we are shipping SIRT1 Antibodies (307) and SIRT1 Kits (44) and many more products for this protein. A total of 376 SIRT1 products are currently listed.
Synonyms:
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all proteins Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

Show all synonyms

SIRT1 Proteins (SIRT1) by Origin

Select your origin of interest

Top referenced SIRT1 Proteins

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for ABIN2004752

More Proteins for SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 Proteins) levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 Proteins) reduction and telomeric DNA damage.

  2. this study shows that the expression of SIRT1 is decreased in sepsis; SIRT1 functions as a negative regulator of pro-inflammatory cytokines

  3. Hepatic G6Pase-alpha (show G6PC Proteins) deficiency leads to reduced expression of SIRT1. Downregulation of SIRT1 signaling impairs autophagy.

  4. AMPK (show PRKAA1 Proteins) phosphorylation of cortactin (show CTTN Proteins) followed by SIRT1 deacetylation modulates the interaction of cortactin (show CTTN Proteins) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Proteins)/SIRT1 coregulated cortactin (show CTTN Proteins)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Proteins) subcellular translocation/activation and is atheroprotective

  5. Activation of alpha7nAChR alleviates Ang II (show AGT Proteins)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 pathway.

  6. data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1 (show SP1 Proteins)/SIRT1 signaling pathway.

  7. Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc (show SHC1 Proteins) to upregulate endothelial miR (show MLXIP Proteins)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1.

  8. Data demonstrate that CLOCK and BMAL1 (show ARNTL Proteins) regulate muscle insulin (show INS Proteins) sensitivity via SIRT1, and activation of SIRT1 might be a potential valuable strategy to attenuate muscle insulin (show INS Proteins) resistance related to circadian misalignment.

  9. NAMPT (show NAMPT Proteins) inhibited endothelial progenitor cell senescence through an SIRT1 AS lncRNA/miR (show MLXIP Proteins)-22/SIRT1 pathway

  10. this study shows that fisetin exerts anti-inflammatory effects and attenuates the progression of osteoarthritis through activating SIRT1

Human Sirtuin 1 (SIRT1) interaction partners

  1. in chronic hyperoxia, SIRT1 promotes hyperoxia-induced lung epithelial cell damage and death by altering pro- and antiapoptotic balance, not by dampening optimal NRF2 (show GABPA Proteins)-dependent antioxidant enxyme expression.

  2. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 Proteins) levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 Proteins) reduction and telomeric DNA damage.

  3. our results showed that the expression and activity of SIRT1 are decreased in PASMCs exposed to H/R.

  4. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (show FOXO3 Proteins)/EGR1 (show EGR1 Proteins)/SIRT1 signaling, and AKT (show AKT1 Proteins) and p300 (show EP300 Proteins) negatively regulate this process via Bim (show BCL2L11 Proteins) upregulation.

  5. AMPK (show PRKAA1 Proteins) phosphorylation of cortactin (show CTTN Proteins) followed by SIRT1 deacetylation modulates the interaction of cortactin (show CTTN Proteins) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Proteins)/SIRT1 coregulated cortactin (show CTTN Proteins)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Proteins) subcellular translocation/activation and is atheroprotective

  6. Activation of alpha7nAChR alleviates Ang II (show AGT Proteins)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 pathway.

  7. Structural features important for SIRT1 activation.

  8. SIRT1 predominantly localizes to the nucleus in cancer cells.

  9. A potential mechanism for the role of Sirt1 in lung fibrosis was through regulating the expression of p300 (show EP300 Proteins). Thus, we characterized Sirt1 as an important regulator of lung fibrosis and provides a proof of principle for activation or overexpression of Sirt1 as a potential novel therapeutic strategy for IPF.

  10. the interplay between SIRT1 and HBx in the activation of hepatitis b virus transcription, is reported.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.

  5. CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 protein
  • SIR2 protein
  • Sir2a protein
  • Sir2alpha protein
  • sir2l1 protein
  • sirtuin protein
  • sirtuin 1 protein

Protein level used designations for Sirtuin 1 Proteins (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

GENE ID SPECIES
100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
Selected quality suppliers for SIRT1 Proteins (SIRT1)
Did you look for something else?