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Browse our SIRT1 Proteins (SIRT1)

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Sirtuin 1 Proteins (SIRT1)
On are 22 Sirtuin 1 (SIRT1) Proteins from 11 different suppliers available. Additionally we are shipping SIRT1 Antibodies (309) and SIRT1 Kits (41) and many more products for this protein. A total of 379 SIRT1 products are currently listed.
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all proteins Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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SIRT1 Proteins (SIRT1) by Origin

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Top referenced SIRT1 Proteins

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for ABIN2004752

More Proteins for SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. Data demonstrate that CLOCK and BMAL1 (show ARNTL Proteins) regulate muscle insulin (show INS Proteins) sensitivity via SIRT1, and activation of SIRT1 might be a potential valuable strategy to attenuate muscle insulin (show INS Proteins) resistance related to circadian misalignment.

  2. NAMPT (show NAMPT Proteins) inhibited endothelial progenitor cell senescence through an SIRT1 AS lncRNA/miR (show MLXIP Proteins)-22/SIRT1 pathway

  3. this study shows that fisetin exerts anti-inflammatory effects and attenuates the progression of osteoarthritis through activating SIRT1

  4. Renal tissues of vitamin D receptor mutant (VDR-M) mice showed down regulation of SIRT1 but enhanced expression of p53.

  5. Sirt1 knockdown abolished the protective effects of Lin28a (show LIN28A Proteins) against cardiac remodeling and dysfunction after MI, and Lin28a (show LIN28A Proteins) failed to increase the numbers of GFP-LC3 (show MAP1LC3A Proteins)-positive punctae and decrease aggresome and p62 (show GTF2H1 Proteins) accumulation in Sirt1-knockdown neonatal cardiomyocytes subjected to hypoxia-induced injury.

  6. endothelial SIRT1 counteracts Peritubular capillary rarefaction by repression of Notch1 (show NOTCH1 Proteins) signaling and antagonizes fibrosis via suppression of endothelial DLL4 (show DLL4 Proteins) expression.

  7. IGF-1 (show IGF1 Proteins) promotes DNA repair in irradiated parotid glands through the maintenance and activation of SirT-1

  8. Taken together, we provide crucial evidence that miR (show MLXIP Proteins)-132 plays a key role in regulating osteogenic differentiation through Sirt1 in a PPARbeta (show PPARD Proteins)/delta-dependent manner, indicating that miR (show MLXIP Proteins)-132 and Sirt1-PPARbeta (show PPARD Proteins)/delta may act as potential therapeutic targets for T2DM-induced osteoporosis.

  9. Together, these results reveal a novel mechanism for Sirt1 in osteogenic differentiation through downregulation of PPARgamma (show PPARG Proteins) activity. These findings suggest that the Sirt1-PPARgamma (show PPARG Proteins) pathway may represent a potential target for enhancement of osteogenesis and treatment of osteoporosis.

  10. Based on these findings, this study showed that CTRP9 might induce mitochondrial biogenesis and protect high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1alpha signaling pathway.

Human Sirtuin 1 (SIRT1) interaction partners

  1. overexpression of SIRT1 could reverse the effect of miR (show MLXIP Proteins)-601 on pancreatic cancer cells; miR (show MLXIP Proteins)-601 suppresses pancreatic cancer cell proliferation and migration

  2. Low SIRT1 expression is associated with obesity.

  3. Data show that enhanced podocyte vitamin D receptor (VDR) expression is associated with increased SIRT1 expression.

  4. Bmal1 (show ARNTL Proteins) is a key clock gene to involve in cartilage homeostasis mediated through sirt1.

  5. Acetylation of lysine 109 modulates PXR (show NR1I2 Proteins) DNA binding and transcriptional activity; PXR (show NR1I2 Proteins) acetylation status and transcriptional activity are modulated by E1A binding protein (p300 (show EP300 Proteins)) and SIRT1.

  6. these studies highlight the potential of SIRT1 activation as a therapeutic strategy in progressive, fibrotic kidney disease.

  7. This article reviews the current literature from research showing interdependent association between cav1 (show CAV1 Proteins)-PRMT1 (show PRMT1 Proteins)-SIRT1 to the outcomes of experimental and clinical research aiming to preserve endothelial function with gene- or pharmaco-therapy. [review]

  8. Reversal of S-nitrosation resulted in full restoration of Sirt1 activity only in the presence of Zn(2+), consistent with S-nitrosation of the Zn(2+)-tetrathiolate as the primary source of Sirt1 inhibition upon S-nitrosoglutathione treatment.

  9. The aim of this study was to evaluate the effect of miR (show MLXIP Proteins)-138-5p on apoptosis in human nucleus pulposus cells induced by TNF-alpha (show TNF Proteins) and to explore the mechanism of this process.

  10. cells with low SIRT1 levels can maintain their resistance and survival by increasing SIRT3 (show SIRT3 Proteins) expression.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.

  5. CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 protein
  • SIR2 protein
  • Sir2a protein
  • Sir2alpha protein
  • sir2l1 protein
  • sirtuin protein
  • sirtuin 1 protein

Protein level used designations for Sirtuin 1 Proteins (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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