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Browse our SIRT1 Proteins (SIRT1)

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Sirtuin 1 Proteins (SIRT1)
On are 22 Sirtuin 1 (SIRT1) Proteins from 11 different suppliers available. Additionally we are shipping SIRT1 Antibodies (303) and SIRT1 Kits (35) and many more products for this protein. A total of 367 SIRT1 products are currently listed.
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all proteins Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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SIRT1 Proteins (SIRT1) by Origin

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Top referenced SIRT1 Proteins

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for ABIN2004752

More Proteins for SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. this study showed that SIRT1 downregulates PAFR (show PTAFR Proteins) expression on platelets via proteasomal and lysosomal pathways, and that this downregulation inhibits platelet aggregation in vitro and pulmonary thrombus formation in vivo.

  2. we confirm that resveratrol prevents high-fat diet induced oxidative stress, cell senescence, and renal damage by elevating the level of SIRT1

  3. these findings indicate that RSV supplement decreases the inflammatory level and improves hepatic steatosis through activating AMPKalpha (show GRK4 Proteins)-SIRT1 pathway.

  4. Inhibiting Sirtuin-1 can be a useful asset in controlling T-cell-mediated rejection in murine model of kidney transplantation.

  5. SIRT1 overexpression and caloric restriction both improve glucose metabolism and insulin (show INS Proteins) sensitivity, however, the etiologies of these benefits are largely different.

  6. Study shows that mTORC1 signaling in intestinal stem cells (ISCs (show NFS1 Proteins)) is instead upregulated during calorie restriction; SIRT1 deacetylates S6K1 (show RPS6KB1 Proteins), thereby enhancing its phosphorylation by mTORC1, which leads to an increase in protein synthesis and an increase in ISC number.

  7. SIRT1 promoted the stability of NRF2 (show NFE2L2 Proteins) by regulating the deacetylation and activation of the NRF2 (show NFE2L2 Proteins)/ARE antioxidant pathway.

  8. In summary, SIRT1 reduced histopathologic injury, apoptosis, oxidative stress, and the inflammatory response during hepatic ischemia reperfusion injury, and the protective mechanisms of SIRT1 are involved in the activation of the JNK (show MAPK8 Proteins), p38MAPK (show MAPK14 Proteins), and ERK (show EPHB2 Proteins) kinases before ischemia

  9. A novel regulatory mechanism was found in which Sirt1 antisense long non-coding RNA preferably interacted with Sirt1 mRNA forming RNA duplex to promote Sirt1 ranslation by competing with miR (show MLXIP Proteins)-34a, inhibiting muscle formation.

  10. Treatment of the cells with ursolic acid (UA) showed that UA up-regulated SIRT1 ( approximately 35 folds) and overexpressed PGC-1alpha ( approximately 175 folds) gene significantly.

Human Sirtuin 1 (SIRT1) interaction partners

  1. These results reveal different characteristics in the biological actions between WAT and BAT (show BAAT Proteins) in obese humans. Increased levels of IL6 (show IL6 Proteins), UCP1 (show UCP1 Proteins) and SIRT1 in the BAT (show BAAT Proteins) were associated with metabolic parameters improvements.

  2. nuclear expression in a majority of the lymphoblasts from bone marrow clot (show TXNDC17 Proteins) preparations of each of the study cases for both silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+ histone deacetylase (show HDAC1 Proteins) and enhancer of Zeste homolog 2 (EZH2 (show EZH2 Proteins)), a histone methyltransferase.

  3. SIRT1 could regulate osteogenesis of dental pulp stem cells through Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal.

  4. miR (show MLXIP Proteins)-34a has a crucial role in the pathogenesis of osteoarthritis through direct regulation of the SIRT1/p53 (show TP53 Proteins) signaling pathway.

  5. this study showed that SIRT1 downregulates PAFR (show PTAFR Proteins) expression on platelets via proteasomal and lysosomal pathways, and that this downregulation inhibits platelet aggregation in vitro and pulmonary thrombus formation in vivo.

  6. Sirtuin 1 rs1467568 and rs7895833 in occur more frequently in South African Indians than South African blacks.

  7. UA exerted antiatherosclerosis effects in quails and protected HUVECs from ox-LDL induced cytotoxicity, and the mechanism is associated with increased SIRT1 expression, decreased Atg5 acetylation on lysine residue, and increased autophagy.

  8. These data suggest that SIRT1 is involved in hydroquinone -induced malignant transformation associated with suppressing p53 signaling and activation of KRAS.

  9. High SIRT1 expression (alone or in combination with BECN1 (show BECN1 Proteins))predicted shorter overall survival and relapse-free survival in gastric cancer.

  10. miR (show MLXIP Proteins)-22 inhibited cell proliferation, migration, and invasion via targeting the 3'-UTR of SIRT1 in the progression of glioblastoma and miR (show MLXIP Proteins)-22-SIRT1 pathway can be recommended as a potential target for treatment of glioblastoma.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.

  5. CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 protein
  • SIR2 protein
  • Sir2a protein
  • Sir2alpha protein
  • sir2l1 protein
  • sirtuin protein
  • sirtuin 1 protein

Protein level used designations for Sirtuin 1 Proteins (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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