You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our SIRT1 Proteins (SIRT1)

Full name:
Sirtuin 1 Proteins (SIRT1)
On are 22 Sirtuin 1 (SIRT1) Proteins from 11 different suppliers available. Additionally we are shipping SIRT1 Antibodies (233) and SIRT1 Kits (30) and many more products for this protein. A total of 292 SIRT1 products are currently listed.
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all proteins Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

Show all synonyms

SIRT1 Proteins (SIRT1) by Origin

Select your origin of interest

Top referenced SIRT1 Proteins

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for ABIN2004752

More Proteins for SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. overexpression of miR (show MLXIP Proteins)-27b could benefit mitochondrial function, the effects of overexpressed miR (show MLXIP Proteins)-27b were Sirt1-dependent.

  2. The acetylation-dependent interaction between HMGB1 (show HMGB1 Proteins) and SIRT1 is critical for LPS (show TLR4 Proteins)-induced lethality.

  3. Demonstrate that cardiac Sirt1 plays an essential role in caloritc restriction-induced cardioprotection against myocardial I/R injury by suppressing cardiac C3 expression.

  4. SIRT1 and the axis AII (show ARG2 Proteins)/AT1 (show SLC33A1 Proteins)/NADPH-oxidase (show NOX1 Proteins) regulate each other

  5. Long-lasting exposure to ox-LDL decreases the expression of Sirt1 and Runx2 (show RUNX2 Proteins) in bone mesenchymal stem cells which may explain the decreased bone formation in aged apoE (show APOE Proteins)(-/-) mice.

  6. SIRT1 signaling is required for rapid cardioprotective metabolic adaptation in acute ischemic preconditioning.

  7. A mouse model of developmentally primed nonalcoholic steatohepatitis is c characterized by an altered cellular redox status, sirtuin abundance and clock gene expression.

  8. SIRT1 activity is down-regulated in the brains of two complementary HD mouse models, which correlated with altered SIRT1 phosphorylation levels.

  9. Sirt1 mediates both Hsp70 (show HSP70 Proteins)-dependent and Hsp70 (show HSP70 Proteins)-independent protein quality control.

  10. Fenofibrate could prevent type 1 diabetes-induced pathological and functional abnormalities of the heart by increasing FGF21 (show FGF21 Proteins) and up-regulating Sirt1-mediated autophagy.

Human Sirtuin 1 (SIRT1) interaction partners

  1. Our findings indicate that phosphorylation-dependent restriction of SIRT1 activity by HIPK2 (show HIPK2 Proteins) shapes the p53 (show TP53 Proteins) response

  2. SIRT1 overexpression in iPSC-endothelial cells maintains EC phenotype, improves EC function, and extends cell lifespan.

  3. inhibitory effect of RSV on the HIF-1alpha (show HIF1A Proteins)/VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) signaling axis is mediated, at least in part, through SIRT1

  4. Studies indicate that when NAD+ levels drop, SIRT1 protein activity is reduced, leading to mitochondrial dysfunction.

  5. SIRT1-mediated mitochondrial and Akt (show AKT1 Proteins) pathways have roles in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes

  6. Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure.

  7. SIRT1 exerted anti-inflammatory effects in degenerative nucleus pulposus cells through TLR2/SIRT1/NF-kappaB (show NFKB1 Proteins) pathway.

  8. SIRT1 expression correlated positively with Fra-1 (show FOSL1 Proteins) expression, metastasis and overall survival in patients with colorectal cancer

  9. Studies indicate that Many of the metabolic disorders have been associated with a reduction of sirtuins SIRT1 and SIRT3 (show SIRT3 Proteins) at critical developmental windows throughout development.

  10. TGFbeta (show TGFB1 Proteins) interferes with SIRT1 expression and lncRNA HIF1alphaAS1 was significantly downregulated following overexpression of SIRT1.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.

  5. CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 protein
  • SIR2 protein
  • Sir2a protein
  • Sir2alpha protein
  • sir2l1 protein
  • sirtuin protein
  • sirtuin 1 protein

Protein level used designations for Sirtuin 1 Proteins (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
Selected quality suppliers for SIRT1 Proteins (SIRT1)
Did you look for something else?