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Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
Regulation of Oct4 (show POU5F1 Proteins) by SirT1 may link stem cell development to environmental conditions, and it may provide strategies to manipulate epiblast cell state.
a tissue-restricted isoform of SIRT1 (SIRT1-DeltaE2) that lacks exon 2 (E2), is reported.
Thus we concluded that the AMPKalpha (show GRK4 Proteins)-SIRT1 molecular pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target for the development of potential treatments for improving metabolic and reproductive function in PCOS.
SIRT1 knock-out embryos display reduced Mat2a (show MAT2A Proteins) expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
The present study demonstrates that the aging heart is characterized by contractile dysfunction associated with increased oxidative stress and endoplasmic reticulum stress and Sirtuin 1 might have the ability to protect the aging hearts from the inhibition of endoplasmic reticulum-mediated apoptosis.
SIRT1 has the ability to effectively regulate the wear particle-induced inflammatory responses, apoptosis, osteolysis in particle-stimulated osteoblasts and particle-induced osteolysis animal models.
Taken together, our data indicated that increased expression of miR (show MLXIP Proteins)-181b potentially contributes to altered lipid metabolism in NAFLD. Downregulation of miR (show MLXIP Proteins)-34a may be a therapeutic strategy against NAFLD by regulating its target SIRT1.
data demonstrate that resveratrol requires neuronal SIRT1 to elicit ischemic tolerance and identify a novel role for SIRT1 in the regulation of glycolytic function in brain.
The Sirt7 (show SIRT7 Proteins) mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (show DNMT1 Proteins) and another member of the sirtuin family, Sirt1.
findings reveal an unexpected mechanism for SIRT3 (show SIRT3 Proteins) regulation via SIRT1-mediated deacetylation. Improving mitochondrial SIRT3 (show SIRT3 Proteins) functions by inhibiting SIRT3 (show SIRT3 Proteins) acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.
Data confirm that SIRT1 plays role in regulation of pre-rRNA synthesis/transcription and processing of RNA (specifically pre-rRNA and 28S rRNA); lysine acetylation stoichiometry is involved in gene expression regulation.
Long non-coding RNA HNF1A (show HNF1A Proteins)-AS1 (show PTGDR Proteins) mediated the metastatic progression of colon cancer in part through miR (show MLXIP Proteins)-34a/SIRT1/p53 (show TP53 Proteins) signaling axis.
Association between SIRT1 variation and pediatric obesity in Korean children with a gender difference.
The results suggested that inhibition of glycolysis using sub-lethal doses of 2-DG down-regulated the expression of VEGF (show VEGFA Proteins) and also significantly reduced its biological activity. Further mechanistic studies revealed that the down regulation of VEGF (show VEGFA Proteins) gene expression by 2-DG was due to an increase in SIRT-1 activity
The present results suggest that resveratrol and EPA, but not DHA, markedly activated the SIRT1 gene expression in THP1 cells, and that high glucose medium could inhibit the basic gene expression, but not powerful resveratrol-induced gene expression, in those cells.
Accordingly, our results demonstrated that NAMPT (show NAMPT Proteins) is a prognostic marker in melanoma, and the identificationofNAMPT-E2F2 (show E2F2 Proteins)-SIRT1 pathway establishes another link between NAMPT (show NAMPT Proteins) and apoptosis events in melanoma, with therapeutic implications for this deadly cancer.
These data suggest that SIRT1 activates HBG expression through facilitating LCR looping to the HBG promoter, inhibiting the expression of transcriptional suppressors of HBG, and indirectly increasing histone acetylation in the HBG promoter.
Levels of miR106a are modulated during cellular migration, causing a change in the levels of SIRT-1 mRNA by affecting its stability and the levels of SIRT-1 in turn can regulate the levels of MMP9 (show MMP9 Proteins).
Study demonstrated a functional role of the SIRT1/miR (show MLXIP Proteins)-15b-5p/ACOX1 (show ACOX1 Proteins) axis in CRC (show CALR Proteins) metastasis.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.
CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1