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Browse our SIRT1 Proteins (SIRT1)

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Sirtuin 1 Proteins (SIRT1)
On are 22 Sirtuin 1 (SIRT1) Proteins from 11 different suppliers available. Additionally we are shipping SIRT1 Antibodies (274) and SIRT1 Kits (30) and many more products for this protein. A total of 333 SIRT1 products are currently listed.
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all proteins Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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SIRT1 Proteins (SIRT1) by Origin

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Top referenced SIRT1 Proteins

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for ABIN2004752

More Proteins for SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. indicated that melatonin facilitated AD-MSCs-based therapy in MI, possibly through promoting survival of AD-MSCs via SIRT1 signaling.

  2. results shed novel insight into CML LSCs and support a crucial role of SIRT1 in CML LSCs.

  3. HDAC4 (show HDAC5 Proteins) increases endogenous SIRT1 expression by enhancing its sumoylation modification levels

  4. In the cochlea, the expression of SIRT1, 3, and 5 (both mRNA and protein) was decreased in the old mice

  5. SIRT1 overexpression substantially increased autophagy in wild-type cells, but not in MFN2 (show MFN2 Proteins)-deficient cells.

  6. overexpression of miR (show MLXIP Proteins)-27b could benefit mitochondrial function, the effects of overexpressed miR (show MLXIP Proteins)-27b were Sirt1-dependent.

  7. The acetylation-dependent interaction between HMGB1 (show HMGB1 Proteins) and SIRT1 is critical for LPS (show TLR4 Proteins)-induced lethality.

  8. Demonstrate that cardiac Sirt1 plays an essential role in caloritc restriction-induced cardioprotection against myocardial I/R injury by suppressing cardiac C3 expression.

  9. SIRT1 and the axis AII (show ARG2 Proteins)/AT1 (show SLC33A1 Proteins)/NADPH-oxidase (show NOX1 Proteins) regulate each other

  10. Long-lasting exposure to ox-LDL decreases the expression of Sirt1 and Runx2 (show RUNX2 Proteins) in bone mesenchymal stem cells which may explain the decreased bone formation in aged apoE (show APOE Proteins)(-/-) mice.

Human Sirtuin 1 (SIRT1) interaction partners

  1. In Hodgkin lymphoma infiltrating lymphocytes, there was a difference of Sirt1 to FoxP3 (show FOXP3 Proteins) ratios between remission and recurrence groups, being significantly higher in the recurrence group

  2. Data suggest that activation of SIRT1 may improve insulin (show INS Proteins) sensitivity of liver, skeletal muscle, and adipose tissues and protect function and cell mass of pancreatic beta-cells. [REVIEW]

  3. HDAC4 (show HDAC4 Proteins) increases endogenous SIRT1 expression by enhancing its sumoylation modification levels

  4. myeloid cell-specific deletion of SIRT1 appeared to suppress CIA (show ASF1A Proteins) by modulating DC maturation.

  5. Findings showed that miR (show MLXIP Proteins)-22 functioned as tumor suppressor in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) and blocked RCC (show XRCC1 Proteins) growth and metastasis by directly targeting SIRT1.

  6. Our findings indicate that phosphorylation-dependent restriction of SIRT1 activity by HIPK2 (show HIPK2 Proteins) shapes the p53 (show TP53 Proteins) response

  7. SIRT1 overexpression in iPSC-endothelial cells maintains EC phenotype, improves EC function, and extends cell lifespan.

  8. inhibitory effect of RSV on the HIF-1alpha (show HIF1A Proteins)/VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) signaling axis is mediated, at least in part, through SIRT1

  9. Studies indicate that when NAD+ levels drop, SIRT1 protein activity is reduced, leading to mitochondrial dysfunction.

  10. SIRT1-mediated mitochondrial and Akt (show AKT1 Proteins) pathways have roles in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL (show PNPLA2 Proteins) in adipocytes.

  5. CDK5 (show CDK5 Proteins)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Proteins).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Proteins) gene in adipocytes, and PPAR gamma (show PPARG Proteins) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Proteins) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Proteins) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 protein
  • SIR2 protein
  • Sir2a protein
  • Sir2alpha protein
  • sir2l1 protein
  • sirtuin protein
  • sirtuin 1 protein

Protein level used designations for Sirtuin 1 Proteins (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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