Browse our RHOA Proteins (RHOA)

Full name:
Ras Homolog Gene Family, Member A Proteins (RHOA)
On are 7 Ras Homolog Gene Family, Member A (RHOA) Proteins from 2 different suppliers available. Additionally we are shipping RHOA Antibodies (9) and RHOA Kits (6) and many more products for this protein. A total of 22 RHOA products are currently listed.
ARH12, Arha, Arha1, Arha2, RHO1, RHO12, Rhoa, RHOH12, wu:fa66g04, wu:fb26g07, xrhoa, zgc:66058, zgc:85805
list all proteins Gene Name GeneID UniProt
RHOA 297173  
RHOA 387 P61586
Mouse RHOA RHOA 11848 Q9QUI0

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RHOA Proteins (RHOA) by Origin

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More Proteins for RHOA Interaction Partners

Xenopus laevis Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure

  2. Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.

  3. CASZ1/Egfl7 (show EGFL7 Proteins)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.

  4. RhoA can be considered a component of the intracellular pattern formation system.

  5. Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA activity.

  6. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.

Human Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation.

  2. Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13 (show GNA13 Proteins)) and rhoA GTP-binding protein (RhoA) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL).

  3. RhoA/ROCK and Raf-1 (show RAF1 Proteins)/CK2 (show CSNK2A1 Proteins) pathway are responsible for TNF-alpha (show TNF Proteins)-mediated endothelial cytotoxicity via regulation of the vimentin (show VIM Proteins) cytoskeleton.

  4. Rac (show AKT1 Proteins) is required to stimulate the remodeling of mast cells, triggering actin-mediated flattening of the cell periphery to create an active degranulation zone, whereas RhoA controls the streaming of highly motile granules into the active zone.

  5. the use of N1-Guanyl (show GUCA2A Proteins)-1,7-diaminoheptane, a DHPS (show DHPS Proteins) inhibitor, resulted in a significant decrease in tumor formation in vivo. In patients with esophageal squamous cell carcinoma (ESCC), overexpression of DHPS (show DHPS Proteins) in ESCC tumors was significantly associated with worse recurrence-free survival, and correlated with distant metastasis.

  6. Besides controlling cyclin (show PCNA Proteins)/CDK (show CDK4 Proteins) kinase activity, p27 (show PAK2 Proteins) also regulates cytoskeletal dynamics, cell motility and cell invasion. Following processing by caspases, p27 (show PAK2 Proteins) fails to bind to RhoA and to inhibit its activation, and thereby abolishes the ability of p27 (show PAK2 Proteins) to stimulate cell migration and invasion

  7. Higher proportions of early-onset Diffuse Gastric Cancers (DGCs) contained somatic mutations in CDH1 (show CDH1 Proteins) or TGFBR1 (show TGFBR1 Proteins) compared with late-onset DGCs. A smaller proportion of early-onset DGCs contained somatic mutations in RHOA. CDH1 (show CDH1 Proteins) alterations, but not RHOA mutations, were associated with shorter survival times. Female predominance in early-onset DGC (show GGCX Proteins) may be related to relatively high rates of somatic CDH1 (show CDH1 Proteins) and TGFBR1 (show TGFBR1 Proteins) mutations.

  8. Data suggest that SmgGDS (show RAP1GDS1 Proteins)-558 splice variant exhibits a fold containing tandem copies of armadillo (show PKP1 Proteins)-repeat motifs not present in other guanine nucleotide exchange factors (GEFs); SmgGDS (show RAP1GDS1 Proteins) harbors distinct positively and negatively charged regions, both of which play critical roles in binding to RhoA and in GEF (show SLC2A4RG Proteins) activity. (SmgGDS (show RAP1GDS1 Proteins) = smg (show SNRPG Proteins) p21 (show CDKN1A Proteins) stimulatory GDP exchange protein; RhoA = ras homolog gene family, member A (show CXCL14 Proteins))

  9. RhoA had a positive effect on ESC proliferation, and PKN1 (show PKN1 Proteins) activity was up-regulated by the active RhoA mutant (G14V) and suppressed by RhoA T19N. The effect of RhoA on ESC proliferation is mediated by activation of the PKN1 (show PKN1 Proteins)-cyclin D1 (show CCND1 Proteins) pathway in vitro.

  10. RhoA works in concert with Fmn1 to control assembly of the specialized apical actin network in multiciliated epithelial cells.

Pig (Porcine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.

  2. Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE (show ADAM17 Proteins), and RhoA through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).

  3. Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (show LIMK1 Proteins) phosphorylation.

  4. Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (show TGFB1 Proteins) in the process of endothelial tube formation in collagen I gels.

  5. The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (show ROCK1 Proteins) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.

  6. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Mouse (Murine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. The in vivo function of RhoA in corpus luteum (CL) luteal cell cytoskeleton integrity, cholesterol transport, StAR expression, and progesterone synthesis, and a positive feedback on StAR expression in CL by progesterone signaling.

  2. Reveal novel intracellular signaling mechanisms involving RhoA/STAT3 (show STAT3 Proteins) underlying the contribution of reactive astrocyte dynamics to glial scar formation.

  3. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation.

  4. We show that RhoA mRNA levels were significantly higher compared with the RhoB mRNA levels in ESCs (show NR2E3 Proteins) as well in various cancer cell lines and this difference could be accounted for by differences in the activities of the corresponding promoters.

  5. Results strongly support the hypothesis that spinal RhoA/ROCK signaling plays a central role in the neuropathic pain. In addition, simvastatin might exert its antihyperalgesic and antiallodynic effects through the attenuation of sensitization of spinal nociceptive transmission that is modulated by mechanisms dependent on the RhoA/ROCK signaling.

  6. Findings suggest that atorvastatin attenuates diabetes-associated renal injury by reducing reactive oxygen species (ROS) generation, RhoA activity and normalizing Akt/GSK3beta signaling pathways.

  7. findings describe a novel RhoA regulatory mechanism.

  8. ANXA1 (show ANXA1 Proteins) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA-ROCK signaling pathway

  9. study delineates a mechanism in which NCAM (show NCAM1 Proteins) promotes ephrin-A5 (show EFNA5 Proteins)-dependent clustering of EphA3 (show EPHA3 Proteins) through interaction of the NCAM (show NCAM1 Proteins) Ig2 domain and the EphA3 (show EPHA3 Proteins) CRD (show CRX Proteins), stimulating EphA3 (show EPHA3 Proteins) autophosphorylation and RhoA signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo.

  10. M0 and M2 macrophages have a radically different phenotype and polarity from M1 macrophages, and that this is mirrored in dissonant response to RhoA pathway interference.

Cow (Bovine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. RhoA and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK (show PTK2 Proteins) activation in response to shear stress.

  2. the Lbc/alpha-catulin (show CTNNAL1 Proteins) axis participates in 5-HT (show DDC Proteins)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.

  3. The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.

  4. Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion

  5. Thrombospondin has a role in inducing RhoA inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly

  6. KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (show CA2 Proteins)+)](i), as well as the voltage-dependent Ca(2 (show CA2 Proteins)+) currents

  7. the Rho-ROCK signal pathway contributes to VEGF-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF stimulation.

  8. Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.

  9. Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.

  10. Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (show PTK2 Proteins) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.

Zebrafish Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.

RHOA Protein Profile

Protein Summary

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Alternative names and synonyms associated with RHOA

  • RSA-14-44 protein (RSA-14-44)
  • ras homolog family member A (RHOA)
  • ras homolog family member A (rhoa-b)
  • ras homolog family member A (rhoa)
  • ras homolog family member A (Rhoa)
  • ras homolog family member A (rhoa-a)
  • ras homolog gene family, member A (Rhoa)
  • ras homolog gene family, member A (RHOA)
  • ras homolog gene family, member Aa (rhoaa)
  • ARH12 protein
  • Arha protein
  • Arha1 protein
  • Arha2 protein
  • RHO1 protein
  • RHO12 protein
  • Rhoa protein
  • RHOH12 protein
  • wu:fa66g04 protein
  • wu:fb26g07 protein
  • xrhoa protein
  • zgc:66058 protein
  • zgc:85805 protein

Protein level used designations for RHOA

ras homolog gene family, member A , transforming protein RhoA , aplysia ras-related homolog A2 , Aplysia ras-related homolog 12 , h12 , oncogene RHO H12 , rho cDNA clone 12 , small GTP binding protein RhoA , plysia ras-related homolog A2 , rho1 GTP-binding protein , Rho A , Ras family member A , Rho family GTPase , aplysia ras-related homolog A , aplysia ras-related homolog A1 , ras homolog A1 , ras homolog A2 , ras homolog gene family, member A1 , ras homolog gene family, member A2 , gb , p21 , RhoA GTPase

297173 Rattus norvegicus
100302078 Ovis aries
380133 Xenopus laevis
448080 Xenopus (Silurana) tropicalis
387 Homo sapiens
117273 Rattus norvegicus
403954 Canis lupus familiaris
379416 Xenopus laevis
396849 Sus scrofa
11848 Mus musculus
338049 Bos taurus
395442 Gallus gallus
406411 Danio rerio
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