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Browse our RHOA Proteins (RHOA)

Full name:
Ras Homolog Gene Family, Member A Proteins (RHOA)
On are 18 Ras Homolog Gene Family, Member A (RHOA) Proteins from 10 different suppliers available. Additionally we are shipping RHOA Antibodies (134) and RHOA Kits (11) and many more products for this protein. A total of 172 RHOA products are currently listed.
ARH12, Arha, Arha1, Arha2, RHO1, RHO12, Rhoa, RHOH12, wu:fa66g04, wu:fb26g07, xrhoa, zgc:66058, zgc:85805
list all proteins Gene Name GeneID UniProt
RHOA 297173  
RHOA 387 P61586
RHOA 11848 Q9QUI0

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RHOA Proteins (RHOA) by Origin

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Top referenced RHOA Proteins

  1. Human RHOA Protein expressed in Escherichia coli (E. coli) - ABIN667309 : Madaule, Axel: A novel ras-related gene family. in Cell 1985 (PubMed)
    Show all 2 references for ABIN667309

More Proteins for RHOA Interaction Partners

Xenopus laevis Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure

  2. Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.

  3. CASZ1/Egfl7 (show EGFL7 Proteins)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.

  4. RhoA can be considered a component of the intracellular pattern formation system.

  5. Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA activity.

  6. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.

Human Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Listeria monocytogenes infection could promote host cell apoptosis and down-regulate RhoA expression.

  2. RhoA-ROCK-Rnd3 feedback loop determined the local reassembly sites of the actin cortex during membrane blebbing.

  3. FGF-2 (show FGF2 Proteins), VEGF-A (show VEGFA Proteins), and HIV-Tat (show TAT Proteins), may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A and Src (show SRC Proteins) activity

  4. Young MetS (show ETV3 Proteins) subjects, between 20 and 40 years old, already have RhoA/ROCK activation, increased oxidative stress markers and endothelial dysfunction.

  5. ODAM (show ODAM Proteins) induced RhoA activity. ODAM (show ODAM Proteins)-mediated RhoA signalling resulted in actin filament rearrangement, increased cell adhesion and inhibited the migration/invasion of MCF7 cells. These results suggest that ODAM (show ODAM Proteins) expression maintains their adhesion, resulting in the prevention of their metastasis via the regulation of RhoA signalling in breast cancer cells.

  6. Deoxypodophyllotoxin suppresses gastric tumor vasculature by promoting cytoskeleton remodeling through LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) dependent Rho A activation.

  7. Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility.

  8. The complex formation mediated by the Clostridium botulinum C3 exoenzyme ARTT-loop is through the intrinsic plasticity of C3 exoenzyme and RhoA.

  9. our results suggest a role for oncogenic RHOA mutation in the development of gastrointestinal cancers.

  10. These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis of IBDs.

Pig (Porcine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.

  2. Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE (show ADAM17 Proteins), and RhoA through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).

  3. Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (show LIMK1 Proteins) phosphorylation.

  4. Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (show TGFB1 Proteins) in the process of endothelial tube formation in collagen I gels.

  5. The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (show ROCK1 Proteins) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.

  6. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Mouse (Murine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix.

  2. TcdB proteins target Rac (show AKT1 Proteins), Cdc42 (show CDC42 Proteins), Rap (show LRPAP1 Proteins), and R-Ras and glucosylates RhoA.

  3. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF (show CTGF Proteins).

  4. Inhibition of the RhoA/Rock2 (show ROCK2 Proteins) kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins) in the mouse spinal cord.

  5. indicates that the up-regulation of ROCK1 (show ROCK1 Proteins) activity in RhoA-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 (show CASP3 Proteins) and are sensitive to Caspase-3 (show CASP3 Proteins) inhibition

  6. These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis of IBDs.

  7. Spindle organization and actin assembly are regulated through a RhoA-FMNL1 (show FMNL1 Proteins)-GM130 (show GOLGA2 Proteins) pathway in oocyte meiosis.

  8. Soluble beta-amyloid disrupts actin and microtubule dynamics via activation of RhoA and inhibition of histone deacetylase 6 (show HDAC6 Proteins) in cultured hippocampal neurons.

  9. A very rapid reduction in p27 (show CDKN1B Proteins)-phospho-Ser10 levels at the onset of atherogenesis, which contributes to early plaque build-up through RhoA/ROCK-induced integrin expression, is reported.

  10. Findings indicate GTPase (show RACGAP1 Proteins) RhoA as a central regulator of dendritic cells (DCs) homeostasis.

Cow (Bovine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. RhoA and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK (show PTK2 Proteins) activation in response to shear stress.

  2. the Lbc/alpha-catulin (show CTNNAL1 Proteins) axis participates in 5-HT (show DDC Proteins)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.

  3. The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.

  4. Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion

  5. Thrombospondin has a role in inducing RhoA inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly

  6. KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (show CA2 Proteins)+)](i), as well as the voltage-dependent Ca(2 (show CA2 Proteins)+) currents

  7. the Rho-ROCK signal pathway contributes to VEGF-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF stimulation.

  8. Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.

  9. Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.

  10. Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (show PTK2 Proteins) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.

Zebrafish Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.

RHOA Protein Profile

Protein Summary

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Alternative names and synonyms associated with RHOA

  • RSA-14-44 protein (RSA-14-44)
  • ras homolog family member A (RHOA)
  • ras homolog family member A (rhoa-b)
  • ras homolog family member A (rhoa)
  • ras homolog family member A (Rhoa)
  • ras homolog family member A (rhoa-a)
  • ras homolog gene family, member A (Rhoa)
  • ras homolog gene family, member A (RHOA)
  • ras homolog gene family, member Aa (rhoaa)
  • ARH12 protein
  • Arha protein
  • Arha1 protein
  • Arha2 protein
  • RHO1 protein
  • RHO12 protein
  • Rhoa protein
  • RHOH12 protein
  • wu:fa66g04 protein
  • wu:fb26g07 protein
  • xrhoa protein
  • zgc:66058 protein
  • zgc:85805 protein

Protein level used designations for RHOA

ras homolog gene family, member A , transforming protein RhoA , aplysia ras-related homolog A2 , Aplysia ras-related homolog 12 , h12 , oncogene RHO H12 , rho cDNA clone 12 , small GTP binding protein RhoA , plysia ras-related homolog A2 , rho1 GTP-binding protein , Rho A , Ras family member A , Rho family GTPase , aplysia ras-related homolog A , aplysia ras-related homolog A1 , ras homolog A1 , ras homolog A2 , ras homolog gene family, member A1 , ras homolog gene family, member A2 , gb , p21 , RhoA GTPase

297173 Rattus norvegicus
100302078 Ovis aries
380133 Xenopus laevis
448080 Xenopus (Silurana) tropicalis
387 Homo sapiens
117273 Rattus norvegicus
403954 Canis lupus familiaris
379416 Xenopus laevis
396849 Sus scrofa
11848 Mus musculus
338049 Bos taurus
395442 Gallus gallus
406411 Danio rerio
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