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Browse our RHOA Proteins (RHOA)

Full name:
Ras Homolog Gene Family, Member A Proteins (RHOA)
On are 7 Ras Homolog Gene Family, Member A (RHOA) Proteins from 2 different suppliers available. Additionally we are shipping RHOA Antibodies (9) and RHOA Kits (6) and many more products for this protein. A total of 22 RHOA products are currently listed.
ARH12, Arha, Arha1, Arha2, RHO1, RHO12, Rhoa, RHOH12, wu:fa66g04, wu:fb26g07, xrhoa, zgc:66058, zgc:85805
list all proteins Gene Name GeneID UniProt
RHOA 297173  
RHOA 387 P61586
Mouse RHOA RHOA 11848 Q9QUI0

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RHOA Proteins (RHOA) by Origin

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More Proteins for RHOA Interaction Partners

Xenopus laevis Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure

  2. Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.

  3. CASZ1/Egfl7 (show EGFL7 Proteins)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.

  4. RhoA can be considered a component of the intracellular pattern formation system.

  5. Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA activity.

  6. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.

Human Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. The authors observed that microvascular endothelial cells infected with the Andes virus hantavirus or expressing the Andes virus nucleocapsid (N) protein showed increased size and permeability by activating the Rheb (show RHEB Proteins) and RhoA GTPases.

  2. ACTB (show ACTB Proteins), CDKN1B (show CDKN1B Proteins), GAPDH (show GAPDH Proteins), GRB2 (show GRB2 Proteins), RHOA and SDCBP (show SDCBP Proteins) are potent reference genes in neuroendocrine tumors of the lung.

  3. The loss of junctional NMIIA, upon Coronin 1B (show CORO1B Proteins) knockdown, perturbed RhoA signaling.

  4. this study shows that ulinastatin (show AMBP Proteins) inhibites the hyperpermeability of vascular endothelial cells induced by TNF-alpha (show TNF Proteins), and that this inhibitory effect may be related to the RhoA/ROCK2 (show ROCK2 Proteins) signaling pathway

  5. Knocking down WIP (show WIPF1 Proteins) expression in A549 cells significantly reduced RhoA levels and WIP (show WIPF1 Proteins) was found to interact with RhoA suggesting that WIP (show WIPF1 Proteins) might be executing its function by regulating RhoA.

  6. Silencing Drp1 (show CRMP1 Proteins) inhibits glioma cells proliferation and invasion by RHOA/ ROCK1 (show ROCK1 Proteins) pathway.

  7. We successfully identified a novel pathway via which SIN (show EFS Proteins) exerted antioxidative and renal protective functions, and provided a molecular basis for potential SIN (show EFS Proteins) applications in treating DN vascular disorders.

  8. Kank1 plays a crucial role in regulating the activity of RhoA through retrieving excess Daam1 (show DAAM1 Proteins) and balancing the activities of RhoA and its effectors.

  9. FlnA (show FLNA Proteins) more strongly binds RhoA, although both filamins overlap with RhoA expression in the cell cytoplasm. FlnA (show FLNA Proteins) promotes RhoA activation whereas FlnB (show FLNB Proteins) indirectly inhibits this pathway. Moreover, FlnA (show FLNA Proteins) loss leads to diminished expression of b1-integrin, whereas FlnB (show FLNB Proteins) loss promotes integrin expression

  10. endocytosis vesicle enrichment of GRP75 (show HSPA9 Proteins) by mitochondria trafficking upregulates clathrin-independent endocytosis through an actin cytoskeleton reorganization mechanism mediated by the concurrent activation of Cdc42 (show CDC42 Proteins) and RhoA.

Pig (Porcine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.

  2. Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE (show ADAM17 Proteins), and RhoA through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).

  3. Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (show LIMK1 Proteins) phosphorylation.

  4. Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (show TGFB1 Proteins) in the process of endothelial tube formation in collagen I gels.

  5. The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (show ROCK1 Proteins) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.

  6. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Mouse (Murine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. findings describe a novel RhoA regulatory mechanism.

  2. ANXA1 (show ANXA1 Proteins) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA-ROCK signaling pathway

  3. study delineates a mechanism in which NCAM (show NCAM1 Proteins) promotes ephrin-A5 (show EFNA5 Proteins)-dependent clustering of EphA3 (show EPHA3 Proteins) through interaction of the NCAM (show NCAM1 Proteins) Ig2 domain and the EphA3 (show EPHA3 Proteins) CRD (show CRX Proteins), stimulating EphA3 (show EPHA3 Proteins) autophosphorylation and RhoA signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo.

  4. M0 and M2 macrophages have a radically different phenotype and polarity from M1 macrophages, and that this is mirrored in dissonant response to RhoA pathway interference.

  5. the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (show WNT3A Proteins), which induces GSK-3beta phosphorylation and beta-catenin (show CTNNB1 Proteins) accumulation through RhoA and ROCK activation.

  6. these findings reveal that Arhgef1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics.

  7. presentation of a form of biochemical computation in dendrites involving the controlled complementation of three molecules--Rac1, RhoA and Cdc42 (show CDC42 Proteins)--that simultaneously ensures signal specificity and primes the system for BDNF (show BDNF Proteins)-dependent homo- and heterosynaptic plasticity

  8. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA/MRTF-A luciferase reporter.

  9. In conclusion, these results indicate the sub-chronic ethanol treatment decreased the expression of RhoA in mouse corpus cavernosum

  10. RhoA-PLD1 signaling is involved in acidic extracellular pH-induced matrix metalloproteinase-9 (show MMP9 Proteins) in mouse metastatic B16-BL6 melanoma cells

Cow (Bovine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. RhoA and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK (show PTK2 Proteins) activation in response to shear stress.

  2. the Lbc/alpha-catulin (show CTNNAL1 Proteins) axis participates in 5-HT (show DDC Proteins)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.

  3. The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.

  4. Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion

  5. Thrombospondin has a role in inducing RhoA inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly

  6. KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (show CA2 Proteins)+)](i), as well as the voltage-dependent Ca(2 (show CA2 Proteins)+) currents

  7. the Rho-ROCK signal pathway contributes to VEGF-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF stimulation.

  8. Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.

  9. Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.

  10. Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (show PTK2 Proteins) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.

Zebrafish Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.

RHOA Protein Profile

Protein Summary

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Alternative names and synonyms associated with RHOA

  • RSA-14-44 protein (RSA-14-44)
  • ras homolog family member A (RHOA)
  • ras homolog family member A (rhoa-b)
  • ras homolog family member A (rhoa)
  • ras homolog family member A (Rhoa)
  • ras homolog family member A (rhoa-a)
  • ras homolog gene family, member A (Rhoa)
  • ras homolog gene family, member A (RHOA)
  • ras homolog gene family, member Aa (rhoaa)
  • ARH12 protein
  • Arha protein
  • Arha1 protein
  • Arha2 protein
  • RHO1 protein
  • RHO12 protein
  • Rhoa protein
  • RHOH12 protein
  • wu:fa66g04 protein
  • wu:fb26g07 protein
  • xrhoa protein
  • zgc:66058 protein
  • zgc:85805 protein

Protein level used designations for RHOA

ras homolog gene family, member A , transforming protein RhoA , aplysia ras-related homolog A2 , Aplysia ras-related homolog 12 , h12 , oncogene RHO H12 , rho cDNA clone 12 , small GTP binding protein RhoA , plysia ras-related homolog A2 , rho1 GTP-binding protein , Rho A , Ras family member A , Rho family GTPase , aplysia ras-related homolog A , aplysia ras-related homolog A1 , ras homolog A1 , ras homolog A2 , ras homolog gene family, member A1 , ras homolog gene family, member A2 , gb , p21 , RhoA GTPase

297173 Rattus norvegicus
100302078 Ovis aries
380133 Xenopus laevis
448080 Xenopus (Silurana) tropicalis
387 Homo sapiens
117273 Rattus norvegicus
403954 Canis lupus familiaris
379416 Xenopus laevis
396849 Sus scrofa
11848 Mus musculus
338049 Bos taurus
395442 Gallus gallus
406411 Danio rerio
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