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Browse our RHOA Proteins (RHOA)

Full name:
Ras Homolog Gene Family, Member A Proteins (RHOA)
On are 8 Ras Homolog Gene Family, Member A (RHOA) Proteins from 3 different suppliers available. Additionally we are shipping RHOA Antibodies (9) and RHOA Kits (5) and many more products for this protein. A total of 22 RHOA products are currently listed.
ARH12, Arha, Arha1, Arha2, RHO1, RHO12, Rhoa, RHOH12, wu:fa66g04, wu:fb26g07, xrhoa, zgc:66058, zgc:85805
list all proteins Gene Name GeneID UniProt
RHOA 297173  
RHOA 387 P61586
Mouse RHOA RHOA 11848 Q9QUI0

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RHOA Proteins (RHOA) by Origin

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More Proteins for RHOA Interaction Partners

Xenopus laevis Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure

  2. Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.

  3. CASZ1/Egfl7 (show EGFL7 Proteins)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.

  4. RhoA can be considered a component of the intracellular pattern formation system.

  5. Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA activity.

  6. Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.

Human Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Collectively, these findings demonstrate that stimulation of G12 (show TCF3 Proteins) proteins is capable of promoting invasion through RhoA/ROCK-JNK (show MAPK8 Proteins) activation.

  2. Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein (show RASA1 Proteins) ARAP3 (show ARAP3 Proteins).

  3. It describes acetylation as a novel mechanism of Rhoa guanine nucleotide exchange factors regulation in cell motility that can be targeted in cancer and metastasis.

  4. Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1 (show NEUROG1 Proteins), RhoA, and ROCK2 (show ROCK2 Proteins).

  5. A MAPK (show MAPK1 Proteins)-Driven Feedback Loop Suppresses Rac (show AKT1 Proteins) Activity to Promote RhoA-Driven Cancer Cell Invasion. Our model predicted an unanticipated feedback loop, whereby Raf (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signalling maintains suppression of Rac1 by inhibiting the Rac (show AKT1 Proteins)-activating Sos1 (show SOS1 Proteins)-Eps8 (show EPS8 Proteins)-Abi1 (show ABI1 Proteins) complex, allowing RhoA activity to predominate in invasive protrusions.

  6. High RHOA expression is associated with gastric cancer.

  7. RhoA is a potential target of miR (show MLXIP Proteins)-146a.

  8. Abnormal RhoA expression in vulvar carcinoma is involved in tumor proliferation and invasion and may be a treatment target.

  9. TPM2 (show TPM2 Proteins) appears to be commonly silenced by aberrant DNA methylation (show HELLS Proteins) in colon cancer. TPM2 (show TPM2 Proteins) loss is associated with RhoA activation and tumor proliferation.

  10. we found that CXCR4 (show CXCR4 Proteins)-CXCL12 (show CXCL12 Proteins)/AKT (show AKT1 Proteins) axis regulates RhoA, Rac-1, and Cdc42 (show CDC42 Proteins) to modulate cell invasion and tumor metastasis. Together, these results demonstrate a role for CXCR4 (show CXCR4 Proteins) in ESCC metastasis and progression and suggest potential targets for therapeutic intervention.

Pig (Porcine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.

  2. Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE (show ADAM17 Proteins), and RhoA through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).

  3. Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (show LIMK1 Proteins) phosphorylation.

  4. Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (show TGFB1 Proteins) in the process of endothelial tube formation in collagen I gels.

  5. The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (show ROCK1 Proteins) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.

  6. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Mouse (Murine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. these findings reveal that Arhgef1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics.

  2. presentation of a form of biochemical computation in dendrites involving the controlled complementation of three molecules--Rac1, RhoA and Cdc42 (show CDC42 Proteins)--that simultaneously ensures signal specificity and primes the system for BDNF (show BDNF Proteins)-dependent homo- and heterosynaptic plasticity

  3. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA/MRTF-A luciferase reporter.

  4. In conclusion, these results indicate the sub-chronic ethanol treatment decreased the expression of RhoA in mouse corpus cavernosum

  5. RhoA-PLD1 signaling is involved in acidic extracellular pH-induced matrix metalloproteinase-9 (show MMP9 Proteins) in mouse metastatic B16-BL6 melanoma cells

  6. Caspase-11 (show CASP4 Proteins) targets cofilin (show CFL1 Proteins) via the RhoA GTPase, whereas caspase-1 (show CASP1 Proteins) engages the Slingshot phosphatase

  7. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix.

  8. TcdB proteins target Rac (show AKT1 Proteins), Cdc42 (show CDC42 Proteins), Rap (show LRPAP1 Proteins), and R-Ras and glucosylates RhoA.

  9. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF (show CTGF Proteins).

  10. Inhibition of the RhoA/Rock2 (show ROCK2 Proteins) kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins) in the mouse spinal cord.

Cow (Bovine) Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. RhoA and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK (show PTK2 Proteins) activation in response to shear stress.

  2. the Lbc/alpha-catulin (show CTNNAL1 Proteins) axis participates in 5-HT (show DDC Proteins)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.

  3. The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.

  4. Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion

  5. Thrombospondin has a role in inducing RhoA inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly

  6. KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (show CA2 Proteins)+)](i), as well as the voltage-dependent Ca(2 (show CA2 Proteins)+) currents

  7. the Rho-ROCK signal pathway contributes to VEGF-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF stimulation.

  8. Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.

  9. Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.

  10. Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (show PTK2 Proteins) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.

Zebrafish Ras Homolog Gene Family, Member A (RHOA) interaction partners

  1. Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.

RHOA Protein Profile

Protein Summary

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Alternative names and synonyms associated with RHOA

  • RSA-14-44 protein (RSA-14-44)
  • ras homolog family member A (RHOA)
  • ras homolog family member A (rhoa-b)
  • ras homolog family member A (rhoa)
  • ras homolog family member A (Rhoa)
  • ras homolog family member A (rhoa-a)
  • ras homolog gene family, member A (Rhoa)
  • ras homolog gene family, member A (RHOA)
  • ras homolog gene family, member Aa (rhoaa)
  • ARH12 protein
  • Arha protein
  • Arha1 protein
  • Arha2 protein
  • RHO1 protein
  • RHO12 protein
  • Rhoa protein
  • RHOH12 protein
  • wu:fa66g04 protein
  • wu:fb26g07 protein
  • xrhoa protein
  • zgc:66058 protein
  • zgc:85805 protein

Protein level used designations for RHOA

ras homolog gene family, member A , transforming protein RhoA , aplysia ras-related homolog A2 , Aplysia ras-related homolog 12 , h12 , oncogene RHO H12 , rho cDNA clone 12 , small GTP binding protein RhoA , plysia ras-related homolog A2 , rho1 GTP-binding protein , Rho A , Ras family member A , Rho family GTPase , aplysia ras-related homolog A , aplysia ras-related homolog A1 , ras homolog A1 , ras homolog A2 , ras homolog gene family, member A1 , ras homolog gene family, member A2 , gb , p21 , RhoA GTPase

297173 Rattus norvegicus
100302078 Ovis aries
380133 Xenopus laevis
448080 Xenopus (Silurana) tropicalis
387 Homo sapiens
117273 Rattus norvegicus
403954 Canis lupus familiaris
379416 Xenopus laevis
396849 Sus scrofa
11848 Mus musculus
338049 Bos taurus
395442 Gallus gallus
406411 Danio rerio
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