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anti-Human UCP2 Antibodies:
anti-Mouse (Murine) UCP2 Antibodies:
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Human Polyclonal UCP2 Primary Antibody for IF (p), IHC (p) - ABIN675428
Chuang, Lin, Huang, Chang, Liou, Chen, Chang, Chan et al.: Peroxisome proliferator-activated receptors ?/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status ... in Journal of neuroinflammation 2012
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except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.
Cellular feedback regulation may occur between UCP2/UCP3 (show UCP3 Antibodies) and ACE (show ACE Antibodies). Cellular UCP (show UCP1 Antibodies) regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism.
Study reports that insulin (show INS Antibodies) resistance-related gene polymorphisms effects colorectal cancer (CRC (show CALR Antibodies)) risk. The results showed that the gene polymorphism of ADIPOQ (show ADIPOQ Antibodies) rs2241766 was associated with CRC (show CALR Antibodies) risk. Furthermore, the interactions of ADIPOQ (show ADIPOQ Antibodies) rs2241766, UCP2 rs659366, FABP2 (show FABP2 Antibodies) rs1799883 and red meat consumption may contribute to the risk of CRC (show CALR Antibodies).
the major components of metabolic syndrome in patients with non-alcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)) and nutritional intakes according to different genotype of uncoupling protein-2 (UCP2) -866G/A gene polymorphism in these patients, are reported.
Data suggest that UCP2 is an important regulator of mitochondrial redox status and lipid signaling, and that hydrogen peroxide might mediate UCP2's tumor promoting activity in skin.
our data revealed that COL1A1 (show COL1A1 Antibodies), UCP2, and PRPF40A (show PRPF40A Antibodies) are novel players implicated in the complex network of hypoxia response in non-small cell lung cancer
effects of UCP2 polymorphisms on the brain
genetic association studies on population in Brazil: Data suggest that a missense mutation (rs660339, Ala55Val) and an SNP (rs659366, -866G>A) in UCP2 are associated with weight loss in patients with morbid obesity following Roux-en-Y gastric bypass; individuals who carry T (CT+TT) and A (GA+AA) mutated alleles for Ala55Val and -866G>A, respectively, exhibit higher weight loss and fat-free (show VPS51 Antibodies) mass loss.
Dominant UCP2 mutations are a more important cause of congenital hyperinsulinism than has been recognized and that affected individuals are markedly hypersensitive to glucose-induced hypoglycemia.
UCP2 has an apoptotic effect in beta cells via regulation of the intrinsic pathway of apoptosis in brain dead organ donors.
genetic association studies in population in Brazil: Data suggest that two SNPs in UCP2 (rs660339, Ala55Val; rs659366, -866G>A) are associated with ability of patients to comply with dietary restrictions follow bariatric surgery for morbid obesity; thus, UCP2 may be involved in appetite regulation and/or satiety response.
UCP-2 prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E (show APOE Antibodies)-knockout mice via antioxidant and antiapoptotic activities.
This study demonstrating a FABP4 (show FABP4 Antibodies)-UCP2 axis with the potential to modulate the microglial inflammatory response.
The miR (show MLXIP Antibodies)-133a-UCP2 pathway participates in inflammatory bowel disease (IBD) by altering downstream inflammation, oxidative stress and markers of energy metabolism, which provides novel clues and potential therapeutic targets for IBD.
PPARgamma (show PPARG Antibodies) inhibited PDGF (show PDGFA Antibodies)-BB-induced ROS (show ROS1 Antibodies) in VSMCs by upregulating UCP2 expression.
these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression.
Ucp2 affects glutathione metabolism by regulating hepatic efflux of glutathione. Nrf2 (show NFE2L2 Antibodies) deficiency may not aggravate oxidative stress in Ucp2-deficient mice.
Induction of autophagy by SCFAs required PPARgamma (show PPARG Antibodies) stimulation of Uncoupling Protein 2 (UCP2) expression that was associated with reduced intracellular ATP levels and activation of PRKAA1/AMPK (show PRKAA1 Antibodies) (protein kinase (show CDK7 Antibodies), AMP (show TMPRSS5 Antibodies)-activated, alpha 1 catalytic subunit). In addition, elimination of gut (show GUSB Antibodies) flora by chronic antibiotic treatment diminished basal hepatic autophagy in mice suggesting that gut (show GUSB Antibodies) microbiota can regulate hepatic auto...
UCP2 induces protective effects on ROS (show ROS1 Antibodies) and ATP levels during aging. Additionally, the results suggest an imbalance in hematopoiesis because of the lack of UCP2.
Intriguingly, on the molecular level this acceleration in aging predominantly is accompanied by increased levels of circulating IGF-1 (show IGF1 Antibodies) in Ucp2(-/-) mice, hinting at a crosstalk between UCP2 and the classical Insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) signaling aging pathway.
PPARbeta (show PPARD Antibodies)/PPARgamma (show PPARG Antibodies) activation restored the LPS (show TLR4 Antibodies)-induced endothelial dysfunction by upregulation of UCP2, with the subsequent alleviation of ER stress and NADPH oxidase (show NOX1 Antibodies) activity, thus reducing intracellular reactive oxygen species production and increasing nitric oxide bioavailability.
Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.
Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3 (show UCP3 Antibodies), showing that UCPs have conservation and genetic reliability.
The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 (show UCP3 Antibodies) expression in selected muscles.
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (show UCP1 Antibodies) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Antibodies)) in Angus steers selected to have high or low RFI (show RNF34 Antibodies) is presented.
These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
mitochondrial uncoupling protein 2
, uncoupling protein 2 (mitochondrial, proton carrier)
, Mitochondrial uncoupling protein 2
, uncoupling protein 2
, UCP 2
, solute carrier family 25 member 8
, uncoupling protein 2, mitochondrial
, uncoupling protein homolog
, Uncoupling protein 2, mitochondrial