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Browse our PKC iota Proteins (PRKCI)

Full name:
Protein Kinase C, iota Proteins (PRKCI)
On www.antibodies-online.com are 11 Protein Kinase C, iota (PRKCI) Proteins from 8 different suppliers available. Additionally we are shipping PKC iota Antibodies (57) and PKC iota Kits (21) and many more products for this protein. A total of 96 PKC iota products are currently listed.
Synonyms:
2310021H13Rik, AI427505, aPKClambda, aPKC[l], DXS1179E, hal, has, mKIAA4165, nPKC-iota, PKC, PKCI, Pkcl, PKClambda, Prkci, Prkcl
list all proteins Gene Name GeneID UniProt
PRKCI 690660 P62959
PRKCI 5584 P41743
PRKCI 18759 Q62074

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PKC iota Proteins (PRKCI) by Origin

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Human Protein Kinase C, iota (PRKCI) interaction partners

  1. the results revealed that PRKCI rs546950 variant decreased the risk of prostate cancer in an Iranian population

  2. effects. Further studies indicated that PRKCI knockdown-mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT (show AKT1 Proteins)-mammalian target of rapamycin (show FRAP1 Proteins) (PIK3CA (show PIK3CA Proteins)/AKT (show AKT1 Proteins)-MTOR (show FRAP1 Proteins)) signaling.

  3. the knockdown of aPKC increases and extends TGFbeta (show TGFB1 Proteins)-induced p38 MAPK (show MAPK14 Proteins) activation, which sensitizes NSCLC cells to undergo apoptosis.

  4. PKCiota binds to Rab14 (show RAB14 Proteins) and that PKCiota requires Rab14 (show RAB14 Proteins) for its correct distribution in cells. As with Rab14 (show RAB14 Proteins), PKCiota protects claudin-2 (show CLDN2 Proteins) from lysosomal degradation and, in consequence, modulates epithelial barrier.

  5. The results indicate that induction and activation of PKClambda promote TNBC growth, invasion and metastasis.

  6. Targeting aPKC disables oncogenic signaling by both the EGFR (show EGFR Proteins) and the proinflammatory cytokine TNFalpha (show TNF Proteins) in glioblastoma.

  7. PRKCI expression is linked with factors pointing to worse prognosis, higher HER2 (show ERBB2 Proteins) levels and a lower survival rate in breast cancer.

  8. These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells.

  9. PKCiota positively regulated beta-catenin (show CTNNB1 Proteins) through negatively regulated autophagy and depletion of PKCiota promoted apoptosis via autophagic degradation of beta-catenin (show CTNNB1 Proteins) in esophageal cancer cells.

  10. Report up-regulation of MT1-MMP (show MMP14 Proteins) and atypical protein kinase C (show PRKCZ Proteins) in hormone receptor (show NR4A1 Proteins)-negative breast tumors in association with a higher risk of metastasis. Silencing of aPKC impaired delivery of MT1-MMP (show MMP14 Proteins) from storage compartments and inhibited invasion.

Mouse (Murine) Protein Kinase C, iota (PRKCI) interaction partners

  1. Prkci regulates expansion of various stem cells via Notch (show NOTCH1 Proteins)-dependent pathway.

  2. PKClambda/iota could be a crucial regulator of mitochondrial function and energy metabolism in stem cells and other cellular contexts

  3. Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.

  4. adenoviral-mediated supplementation of hepatic PKC-lambda induced a diabetic state in heterozygous PKC-lambda knockout mice.

  5. Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C (show PRKCZ Proteins)-lambda and atypical protein kinase C-zeta (show PRKCZ Proteins).

  6. Loss of aPKClambda in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.

  7. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

  8. Phosphatidylinositol-3,4,5-triphosphate but not phosphatidylinositol-4,5-biphosphate plays an important role in GLUT4 (show SLC2A4 Proteins) upregulation and glucose metabolism mediated by AKT (show AKT1 Proteins)/PKCzeta (show PRKCZ Proteins)/lambda phosphorylation.

  9. FGF21 (show FGF21 Proteins) inhibits hepatic glucose production by the PI3K-dependent activation of protein kinase c iota.

  10. aPKClambda is critical for PDGF-induced actin cytoskeletal reorganization and cell migration.

Zebrafish Protein Kinase C, iota (PRKCI) interaction partners

  1. Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.

  2. a loss of zBves affects the proteins involved in the pathway of the PAR (show AFG3L2 Proteins) junctional complex, especially aPKC, and both aPKC and Bves (show BVES Proteins) are indispensable to claudin expression.

  3. Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis.

  4. PrkCi function and planar divisions are necessary for asymmetric, self-renewing division of spinal cord precursors.

Cow (Bovine) Protein Kinase C, iota (PRKCI) interaction partners

  1. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

PKC iota (PRKCI) Protein Profile

Protein Summary

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Alternative names and synonyms associated with PKC iota (PRKCI)

  • protein kinase C, iota (PRKCI)
  • histidine triad nucleotide binding protein 1 (Hint1)
  • protein kinase C, iota (Prkci)
  • protein kinase C, iota (LOC100348584)
  • protein kinase C, iota (prkci)
  • 2310021H13Rik protein
  • AI427505 protein
  • aPKClambda protein
  • aPKC[l] protein
  • DXS1179E protein
  • hal protein
  • has protein
  • mKIAA4165 protein
  • nPKC-iota protein
  • PKC protein
  • PKCI protein
  • Pkcl protein
  • PKClambda protein
  • Prkci protein
  • Prkcl protein

Protein level used designations for Protein Kinase C, iota Proteins (PRKCI)

protein kinase C, iota , protein kinase C iota , nPKC-iota , protein kinase C iota type , 17 kDa inhibitor of protein kinase C , PKCI-1 , adenosine 5'-monophosphoramidase , histidine triad nucleotide-binding protein 1 , protein kinase C inhibitor 1 , protein kinase C-interacting protein 1 , PRKC-lambda/iota , aPKC-lambda/iota , atypical protein kinase C-lambda/iota , protein kinase C, lambda , heart and soul protein

GENE ID SPECIES
450143 Pan troglodytes
574352 Macaca mulatta
100063737 Equus caballus
100166344 Acyrthosiphon pisum
100173964 Pongo abelii
690660 Rattus norvegicus
5584 Homo sapiens
18759 Mus musculus
100348584 Oryctolagus cuniculus
100731983 Cavia porcellus
100174945 Sus scrofa
117507 Danio rerio
478686 Canis lupus familiaris
528478 Bos taurus
424991 Gallus gallus
101118322 Ovis aries
84006 Rattus norvegicus
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