Browse our PKC iota Proteins (PRKCI)

Full name:
Protein Kinase C, iota Proteins (PRKCI)
On www.antibodies-online.com are 14 Protein Kinase C, iota (PRKCI) Proteins from 9 different suppliers available. Additionally we are shipping PKC iota Antibodies (54) and PKC iota Kits (12) and many more products for this protein. A total of 85 PKC iota products are currently listed.
Synonyms:
2310021H13Rik, AI427505, aPKClambda, aPKC[l], DXS1179E, hal, has, mKIAA4165, nPKC-iota, PKC, PKCI, Pkcl, PKClambda, Prkci, Prkcl
list all proteins Gene Name GeneID UniProt
PRKCI 690660 P62959
PRKCI 5584 P41743
PRKCI 18759 Q62074

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PKC iota Proteins (PRKCI) by Origin

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More Proteins for PKC iota Interaction Partners

Human Protein Kinase C, iota (PRKCI) interaction partners

  1. Polarity signaling via CDC42 (show CDC42 Proteins)/atypical protein kinase C (show PRKCZ Proteins) can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself.

  2. a PI3K (show PIK3CA Proteins)/PKCiota/cyclin E (show CCNE1 Proteins) signaling pathway as a therapeutic target during ovarian tumorigenesis

  3. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  4. the polarity function of PRKCI during cavitation

  5. 14-3-3zeta (show YWHAZ Proteins)-mediated invasion of cancer cells was found to upregulate Snail (show SNAI1 Proteins) through the activation of atypical protein kinase C (show PRKCZ Proteins) (aPKC).

  6. Upregulated expression of PRKCI and interaction with CDK7 (show CDK7 Proteins) is associated with esophageal squamous cell carcinoma.

  7. the results revealed that PRKCI rs546950 variant decreased the risk of prostate cancer in an Iranian population

  8. effects. Further studies indicated that PRKCI knockdown-mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT (show AKT1 Proteins)-mammalian target of rapamycin (show FRAP1 Proteins) (PIK3CA (show PIK3CA Proteins)/AKT (show AKT1 Proteins)-MTOR (show FRAP1 Proteins)) signaling.

  9. the knockdown of aPKC increases and extends TGFbeta (show TGFB1 Proteins)-induced p38 MAPK (show MAPK14 Proteins) activation, which sensitizes NSCLC cells to undergo apoptosis.

  10. PKCiota binds to Rab14 (show RAB14 Proteins) and that PKCiota requires Rab14 (show RAB14 Proteins) for its correct distribution in cells. As with Rab14 (show RAB14 Proteins), PKCiota protects claudin-2 (show CLDN2 Proteins) from lysosomal degradation and, in consequence, modulates epithelial barrier.

Mouse (Murine) Protein Kinase C, iota (PRKCI) interaction partners

  1. Selective deletion of the aPKC isoform Pkc-lambda in proopiomelanocortin (POMC (show POMC Proteins)) neurons disrupts leptin (show LEP Proteins) action, reduces melanocortin content in the paraventricular nucleus, and markedly increases susceptibility to obesity, glucose intolerance, and insulin (show INS Proteins) resistance specifically in HFD-fed male mice.

  2. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  3. Prkci and its downstream partners direct polarized cell division of luminal myocardial cells to drive trabeculation in the nascent heart.

  4. Prkci regulates expansion of various stem cells via Notch (show NOTCH1 Proteins)-dependent pathway.

  5. PKClambda/iota could be a crucial regulator of mitochondrial function and energy metabolism in stem cells and other cellular contexts

  6. Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.

  7. adenoviral-mediated supplementation of hepatic PKC-lambda induced a diabetic state in heterozygous PKC-lambda knockout mice.

  8. Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C (show PRKCZ Proteins)-lambda and atypical protein kinase C-zeta (show PRKCZ Proteins).

  9. Loss of aPKClambda in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.

  10. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

Zebrafish Protein Kinase C, iota (PRKCI) interaction partners

  1. Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.

  2. a loss of zBves affects the proteins involved in the pathway of the PAR (show AFG3L2 Proteins) junctional complex, especially aPKC, and both aPKC and Bves (show BVES Proteins) are indispensable to claudin expression.

  3. Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis.

  4. PrkCi function and planar divisions are necessary for asymmetric, self-renewing division of spinal cord precursors.

Cow (Bovine) Protein Kinase C, iota (PRKCI) interaction partners

  1. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

PKC iota (PRKCI) Protein Profile

Protein Summary

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Alternative names and synonyms associated with PKC iota (PRKCI)

  • protein kinase C, iota (PRKCI)
  • histidine triad nucleotide binding protein 1 (Hint1)
  • protein kinase C, iota (Prkci)
  • protein kinase C, iota (LOC100348584)
  • protein kinase C, iota (prkci)
  • 2310021H13Rik protein
  • AI427505 protein
  • aPKClambda protein
  • aPKC[l] protein
  • DXS1179E protein
  • hal protein
  • has protein
  • mKIAA4165 protein
  • nPKC-iota protein
  • PKC protein
  • PKCI protein
  • Pkcl protein
  • PKClambda protein
  • Prkci protein
  • Prkcl protein

Protein level used designations for Protein Kinase C, iota Proteins (PRKCI)

protein kinase C, iota , protein kinase C iota , nPKC-iota , protein kinase C iota type , 17 kDa inhibitor of protein kinase C , PKCI-1 , adenosine 5'-monophosphoramidase , histidine triad nucleotide-binding protein 1 , protein kinase C inhibitor 1 , protein kinase C-interacting protein 1 , PRKC-lambda/iota , aPKC-lambda/iota , atypical protein kinase C-lambda/iota , protein kinase C, lambda , heart and soul protein

GENE ID SPECIES
450143 Pan troglodytes
574352 Macaca mulatta
100063737 Equus caballus
100166344 Acyrthosiphon pisum
100173964 Pongo abelii
690660 Rattus norvegicus
5584 Homo sapiens
18759 Mus musculus
100348584 Oryctolagus cuniculus
100731983 Cavia porcellus
100174945 Sus scrofa
117507 Danio rerio
478686 Canis lupus familiaris
528478 Bos taurus
424991 Gallus gallus
101118322 Ovis aries
84006 Rattus norvegicus
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