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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346
Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996
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Human IL1A Protein expressed in Human Cells - ABIN2002135
Hogquist, Nett, Unanue, Chaplin: Interleukin 1 is processed and released during apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 5 references for ABIN2002135
Human IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667487
Yatabe, Mochizuki, Takizawa, Chijiiwa, Okada, Kimura, Fujita, Matsumoto, Toyama, Okada: Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes. in Annals of the rheumatic diseases 2009
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Human IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667482
Boraschi, Tagliabue: The interleukin-1 receptor family. in Vitamins and hormones 2006
Show all 3 references for ABIN2667482
Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667484
Son, Roby: Interleukin-1alpha-induced chemokines in mouse granulosa cells: impact on keratinocyte chemoattractant chemokine, a CXC subfamily. in Molecular endocrinology (Baltimore, Md.) 2006
Show all 3 references for ABIN2667484
Human IL1A Protein expressed in HEK-293 Cells - ABIN2181296
Bankers-Fulbright, Kalli, McKean: Interleukin-1 signal transduction. in Life sciences 1996
Show all 2 references for ABIN2181296
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF (show CSF3 Proteins) during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
Studies indicate that SHP1 (show PTPN6 Proteins) and SYK (show SYK Proteins) crosstalk as a critical regulator of MyD88 (show MYD88 Proteins) post-translational modifications and IL-1-driven inflammation.
We investigated the role of IL-1 signaling during MAV (show KLHL2 Proteins)-1-induced encephalitis. Unexpectedly, the lack of IL-1 signaling increased the mortality and inflammation in mice infected with MAV (show KLHL2 Proteins)-1.
As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP (show DDIT3 Proteins) intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.
findings point to a prominent role of IL-1 signaling in the immune response to Trichophyton rubrum
These data demonstrate that DC and macrophages display distinct patterns of cytokine regulation, particularly with respect to IL-1, as a consequence of cell-type specific differences in the physicochemical properties of the P2X(7 (show P2RX7 Proteins))R
Data suggest the role of stromal cell IL-1alpha and IL-1beta (show IL1B Proteins) in Kawasaki disease vasculitis model.
IL-1alpha-positive cells were identified in the epithelium in dextran sulfate sodium (DSS (show PMP22 Proteins))-induced colitis. IL-1alpha was detected in the stool of colitic mice before IL-1beta (show IL1B Proteins).
Addition of anti-IL-1 Antibodies restored B lymphopoiesis in bone marrow cultures containing myeloid-derived suppressor cells, showing that myeloid-derived suppressor cell inhibition of B lymphopoiesis is mediated by IL-1.
Studies indicate that interleukin (IL)-1beta (show IL1B Proteins), IL-1alpha, IL-33 (show IL33 Proteins) and high-mobility group box 1 (HMGB1 (show HMGB1 Proteins)) enter the extracellular space through mechanisms collectively known as unconventional secretion.
This study demonstrates that the rs3783553 polymorphism may be involved in susceptibility to endometrial cancer. The II genotype seems to be a protective factor for endometrial cancer in Chinese Han women.
Circulating Il1a levels were not altered in nonalcoholic fatty liver disease.
this study shows that IL-1a gene variants are not associated with susceptibility to juvenile idiopathic arthritis in Iranian population
IL1 and IL6 (show IL6 Proteins) are important components of the tumor microenvironment, displaying multiple functions. These cytokines take part at all stages of oncogenesis: from initiation to tumor, invasion, and metastasis of already established malignant and mutant epithelial cells. [Review]
Genetic polymorphisms in the IL1A, IL1B (show IL1B Proteins), IL2 (show IL2 Proteins) and IL6 (show IL6 Proteins) genes are not genetic modulators of depression in a cohort of Polish subjects.
functional polymorphism rs3783553 in IL-1A could contribute to gastric cancer susceptibility, possibly or at least partially through affecting the transcriptional activity of IL-1A.
The prevalence of the CT genotype of IL1A rs17561 polymorphism was increased in preeclamptic women compared with controls.
IL-1A rs17561 and IL-1B (show IL1B Proteins) rs1143634 polymorphisms are associated with periodontitis.
A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta (show IL1B Proteins) are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta (show IL1B Proteins) may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta (show IL1B Proteins) are produced by the stromal cells, that IL-1beta (show IL1B Proteins) is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen (show PLG Proteins) activator in bovine endometrial cells.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1-alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha
, interleukin 1 alpha
, precursor interleukin 1 alpha