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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346
Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996
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Human IL1A Protein expressed in Human Cells - ABIN2002135
Hogquist, Nett, Unanue, Chaplin: Interleukin 1 is processed and released during apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Human IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667487
Yatabe, Mochizuki, Takizawa, Chijiiwa, Okada, Kimura, Fujita, Matsumoto, Toyama, Okada: Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes. in Annals of the rheumatic diseases 2009
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Human IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667482
Boraschi, Tagliabue: The interleukin-1 receptor family. in Vitamins and hormones 2006
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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667484
Son, Roby: Interleukin-1alpha-induced chemokines in mouse granulosa cells: impact on keratinocyte chemoattractant chemokine, a CXC subfamily. in Molecular endocrinology (Baltimore, Md.) 2006
Show all 3 references for 2667484
Human IL1A Protein expressed in HEK-293 Cells - ABIN2181296
Bankers-Fulbright, Kalli, McKean: Interleukin-1 signal transduction. in Life sciences 1996
Show all 2 references for 2181296
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
Our findings indicate that IL-1 plays an important role in skin lesions of systemic lupus erythematosus (SLE), suggesting that IL-1 is a therapeutic target in skin lesions of SLE.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE (show AGER Proteins)-p38 MAPK (show MAPK14 Proteins) and calpain-1 (show CAPN1 Proteins) pathway in keratinocyte and this mechanism may play an important role during psoriasis.
IL-1 and IL-36 have roles as inflammatory mediators in pustular psoriasis in a mouse model
These data demonstrate that IL-1 functions as a mitogenic mediator of encephalitogenic Th17 cells rather than qualitative inducer of their generation
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF (show CSF3 Proteins) during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
Studies indicate that SHP1 (show PTPN6 Proteins) and SYK (show SYK Proteins) crosstalk as a critical regulator of MyD88 (show MYD88 Proteins) post-translational modifications and IL-1-driven inflammation.
We investigated the role of IL-1 signaling during MAV (show KLHL2 Proteins)-1-induced encephalitis. Unexpectedly, the lack of IL-1 signaling increased the mortality and inflammation in mice infected with MAV (show KLHL2 Proteins)-1.
As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP (show DDIT3 Proteins) intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.
the results indicate prominent antagonistic effects of IL-1alpha on TGF-beta (show TGFB1 Proteins) regulated interferon (show IFNA Proteins) signaling, as well as on a wide variety of other genes and pathways in fibroblasts.
IL1A polymorphism rs1800587 is associated with chronic pain in patients with sickle cell disease.
Data indicate that interleukin 1alpha (IL-1alpha) propiece can activate NF-kappa B (NFkappaB (show NFKB1 Proteins)) and Sp1 transcription factor (SP1 (show SP1 Proteins)).
cytokines of the IL-1 family play an important role in homeostatic as well as "emergency" hematopoiesis and are involved in the pathogenesis of several myeloid and lymphoid hematological malignancies.
These results suggest that IL-1alpha enhances the translocation of TRPA1 (show TRPA1 Proteins) to the plasma membrane via the activation of Erk (show EPHB2 Proteins) in A549.
Single Nucleotide Variants of Candidate Genes in Aggrecan (show ACAN Proteins) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
Polymorphisms of Il1a were not significantly associated with bipolar I disorder in Iranian patients.
we show that IL-1 induces robust p38a (show MAPK14 Proteins) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (show MAPK14 Proteins) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 (show DUSP1 Proteins) through a negative feedback to pp38, its basal activity is controlled by both TAB1 (show TAB1 Proteins) and MKP1 (show DUSP1 Proteins) through a positive feedback loop.
Studies indicate that interleukin (IL)-1beta (show IL1B Proteins), IL-1alpha, IL-33 (show IL33 Proteins) and high-mobility group box 1 (HMGB1 (show HMGB1 Proteins)) enter the extracellular space through mechanisms collectively known as unconventional secretion.
This study demonstrates that the rs3783553 polymorphism may be involved in susceptibility to endometrial cancer. The II genotype seems to be a protective factor for endometrial cancer in Chinese Han women.
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta (show IL1B Proteins) are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta (show IL1B Proteins) may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta (show IL1B Proteins) are produced by the stromal cells, that IL-1beta (show IL1B Proteins) is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen (show PLG Proteins) activator in bovine endometrial cells.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1-alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha
, interleukin 1 alpha
, precursor interleukin 1 alpha