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anti-Human Insulin Receptor Antibodies:
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Human Polyclonal Insulin Receptor Primary Antibody for IF, WB - ABIN968448
Kasus-Jacobi, Béréziat, Perdereau, Girard, Burnol: Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. in Oncogene 2000
Show all 5 Pubmed References
Rat (Rattus) Polyclonal Insulin Receptor Primary Antibody for IF, WB - ABIN968449
Lu, Guidotti: Identification of the cysteine residues involved in the class I disulfide bonds of the human insulin receptor: properties of insulin receptor monomers. in Molecular biology of the cell 1997
Show all 5 Pubmed References
Mouse (Murine) Monoclonal Insulin Receptor Primary Antibody for IF, IP - ABIN967752
Ebina, Ellis, Jarnagin, Edery, Graf, Clauser, Ou, Masiarz, Kan, Goldfine: The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. in Cell 1985
Show all 5 Pubmed References
Mouse (Murine) Monoclonal Insulin Receptor Primary Antibody for IF, IP - ABIN967753
Frattali, Treadway, Pessin: Insulin/IGF-1 hybrid receptors: implications for the dominant-negative phenotype in syndromes of insulin resistance. in Journal of cellular biochemistry 1992
Show all 5 Pubmed References
Human Monoclonal Insulin Receptor Primary Antibody for FACS - ABIN2689096
Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 3 Pubmed References
Human Polyclonal Insulin Receptor Primary Antibody for IHC (p) - ABIN2479300
Jamner, Shapiro, Goldstein, Hug: Ambulatory blood pressure and heart rate in paramedics: effects of cynical hostility and defensiveness. in Psychosomatic medicine 1991
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Human Polyclonal Insulin Receptor Primary Antibody for CyTOF, FACS - ABIN4900627
Purushothaman, Babitz, Sanderson: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. in The Journal of biological chemistry 2012
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Human Polyclonal Insulin Receptor Primary Antibody for IF (p), IHC (p) - ABIN671841
Bai, Chen, Liu, Tian, Zhou, Liu, Fang, Chen: Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice. in Journal of ethnopharmacology 2009
Show all 2 Pubmed References
Human Polyclonal Insulin Receptor Primary Antibody for WB - ABIN4226906
Cappuzzo, Toschi, Tallini, Ceresoli, Domenichini, Bartolini, Finocchiaro, Magrini, Metro, Cancellieri, Trisolini, Crino, Bunn, Santoro, Franklin, Varella-Garcia, Hirsch: Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. in Annals of oncology : official journal of the European Society for Medical Oncology 2006
Human Polyclonal Insulin Receptor Primary Antibody for FACS - ABIN4897181
Saiya-Cork, Collins, Parkin, Ouillette, Kuizon, Kujawski, Erba, Campagnaro, Shedden, Kaminski, Malek: A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (show CTSA Antibodies) biosynthesis, prevents inappropriate activation of insulin (show INS Antibodies) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.
Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis
data indicate that post-receptor signalling abnormalities might contribute to Myotonic dystrophy insulin (show INS Antibodies) resistance regardless the alteration of INSR splicing.
We identified vascular INSR expression as a potential biomarker for progression in bladder cancer. The data suggest that IGF-2/INSR mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target.
The INSR rs2059806 SNP is associated with pre-eclampsia phenotypes in two independent cohorts suggesting that genetic susceptibility may be implicated in the link between pre-eclampsia and subsequent vascular and metabolic diseases.
IGF2 and insulin receptor A are important for uterine leiomyoma stem cell proliferation and may represent paracrine signaling between leiomyoma cell types.
Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells
Results show that IR expression level in renal cell carcinoma (show MOK Antibodies) tissue was significantly lower in patients with tumor stage pT2-4 and/or distant metastases.
Findings suggest that the induction of microRNA miR (show MLXIP Antibodies)-1271 by saturated fatty acid palmitate promotes the development of insulin (show INS Antibodies) resistance by targeting insulin receptor (INSR) and insulin receptor substrate 1 (show IRS1 Antibodies) protein (IRS-1 (show IRS1 Antibodies)) in hepatocytes.
Study reveals an important function of CHIP-mediated proteolysis in insulin (show INS Antibodies) and IGF1 (show IGF1 Antibodies) signaling; upon proteotoxic stress conditions and during aging, CHIP is recruited toward disposal of misfolded proteins, reducing its capacity to degrade the INSR; identify a degradation pathway that controls the level of active DAF-2/INSR in C. elegans, Drosophila and human cells.
EGF (show EGF Antibodies) and insulin receptor tyrosine kinase exemplify how receptor location is coupled to signal transduction. (Review)
a straightforward protocol for production of recombinant IGF-II and prepared six IGF-II analogs with IGF-I-like mutations. All modified molecules exhibit significantly reduced affinity toward IR-A, particularly the analogs with a Pro-Gln insertion in the C-domain. Moreover, one of the analogs has enhanced binding affinity for IGF-1R due to a synergistic effect of the Pro-Gln insertion and S29N point mutation.
the overlap of IR and IGF1R (show IGF1R Antibodies) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 Antibodies)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (show PRKCE Antibodies) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (show INS Antibodies) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (show AGRP Antibodies) neurons (AgRP (show AGRP Antibodies) IR KO) exhibited impaired hepatic insulin (show INS Antibodies) action because the ability of insulin (show INS Antibodies) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (show INS Antibodies) to suppress lipolysis was unaltered. To the contrary, in POMC (show POMC Antibodies) IR KO mice, insulin (show INS Antibodies) lowered hGP but failed to suppress adipose tissue lipolysis.
Intracellular retention of the insulin receptor is caused by elevated amounts of alpha-taxilin (show TXLNA Antibodies), a free syntaxin binding protein, in HBV expressing hepatocytes preventing proper targeting of the insulin receptor to the cell surface.
Results found that glioblastoma tumors resistant to PDGFR (show PDGFRB Antibodies) inhibition required the expression and activation of the insulin receptor (IR)/insulin (show INS Antibodies) growth-like factor receptor (IGF1R (show IGF1R Antibodies)) for tumor cell proliferation and survival.
The IR in the intestinal epithelium plays important roles in intestinal gene expression, glucose uptake, and GIP (show GIP Antibodies) production, which may contribute to pathophysiological changes in individuals with diabetes, metabolic syndrome, and other insulin (show INS Antibodies)-resistant states.
In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Antibodies)/PDPK1 (show PDPK1 Antibodies)/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1 (show PDPK1 Antibodies). This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati
Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a (show PPP2R2A Antibodies)). Inheritance of either allele results in insulin (show INS Antibodies) resistance but not overt diabetes. Double heterozygosity leads to insulin (show INS Antibodies) resistance and diabetes type 2 without increase in body weight.
ZIP14 (show SLC39A14 Antibodies)-mediated zinc transport contributes to regulation of endosomal insulin receptor activity and glucose homeostasis in hepatocytes.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (show IGF1 Antibodies), IGF-2, IGFBP-2 (show IGFBP2 Antibodies), IGFBP-3 (show IGFBP3 Antibodies), IGF-1R (show IGF1R Antibodies), IGF-2R, GHR (show GHR Antibodies), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (show BRD2 Antibodies), but not E2, stimulated the expression of IR and GHR (show GHR Antibodies) genes during follicular development.
Data conclude that insulin (show INS Antibodies) and IGF-I (show IGF1 Antibodies) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor-like
, insulin receptor, beta-subunit
, insulin receptor tyrosine kinase
, tyrosine kinase