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Browse our anti-Insulin Receptor (INSR) Antibodies

Full name:
anti-Insulin Receptor Antibodies (INSR)
On www.antibodies-online.com are 342 Insulin Receptor (INSR) Antibodies from 30 different suppliers available. Additionally we are shipping Insulin Receptor Kits (37) and Insulin Receptor Proteins (36) and many more products for this protein. A total of 441 Insulin Receptor products are currently listed.
Synonyms:
18402, 4932439J01Rik, cd220, CG18402, CTK-1, D630014A15Rik, DIHR, DILR, dinr, dInsR, dir, Dir-a, Dir-b, DIRbeta, dIRH, Dmel\\CG18402, er10, hhf5, inr, Inr-alpha, Inr-beta, INS, INSR, insulin/insulin-like growth factor receptor, ir, ir-A, IR-B, l(3)05545, l(3)93Dj, l(3)er10, lnR, NV14476
list all antibodies Gene Name GeneID UniProt
INSR 3643 P06213
INSR 16337 P15208
INSR 24954  

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All available anti-Insulin Receptor Antibodies

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Top referenced anti-Insulin Receptor Antibodies

  1. Mouse (Murine) Monoclonal Insulin Receptor Primary Antibody for IF, IP - ABIN967752 : Ebina, Ellis, Jarnagin, Edery, Graf, Clauser, Ou, Masiarz, Kan, Goldfine: The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. in Cell 1985 (PubMed)
    Show all 5 references for ABIN967752

  2. Human Polyclonal Insulin Receptor Primary Antibody for EIA, IHC (p) - ABIN359886 : George, Johansen, Soos, Mortensen, Gammeltoft, Saudek, Siddle, Hansen, ORahilly: Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject. in Endocrinology 2003 (PubMed)
    Show all 5 references for ABIN359886

  3. Human Polyclonal Insulin Receptor Primary Antibody for EIA - ABIN358482 : Nakamaru, Matsumoto, Taguchi, Suefuji, Murata, Igata, Kawashima, Kondo, Motoshima, Tsuruzoe, Miyamura, Toyonaga, Araki: AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells. in Biochemical and biophysical research communications 2005 (PubMed)
    Show all 5 references for ABIN358482

  4. Human Polyclonal Insulin Receptor Primary Antibody for WB - ABIN1881461 : Pandini, Frasca, Mineo, Sciacca, Vigneri, Belfiore: Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN1881461

  5. Human Polyclonal Insulin Receptor Primary Antibody for FACS - ABIN4897181 : Saiya-Cork, Collins, Parkin, Ouillette, Kuizon, Kujawski, Erba, Campagnaro, Shedden, Kaminski, Malek: A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011 (PubMed)

  6. Dog (Canine) Polyclonal Insulin Receptor Primary Antibody for IHC, WB - ABIN2792204 : Netzer, Freudenberg, Heinze, Heinze-Kuhn, Goebel, McCarthy, Roses, Göbel, Todt, Kubisch: Replication study of the insulin receptor gene in migraine with aura. in Genomics 2008 (PubMed)

  7. Human Polyclonal Insulin Receptor Primary Antibody for FACS - ABIN4897184 : Mancini, Gariboldi, Taiana, Bonzi, Craparotta, Pagin, Monti: Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. in British journal of cancer 2014 (PubMed)

  8. Dog (Canine) Polyclonal Insulin Receptor Primary Antibody for IHC (p), WB - ABIN1106088 : Taira, Taira, Hashimoto, Shimada, Suzuki, Kanatsuka, Nakamura, Ebina, Tatibana, Makino: Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor. in Science (New York, N.Y.) 1989 (PubMed)

More Antibodies against Insulin Receptor Interaction Partners

Fruit Fly (Drosophila melanogaster) Insulin Receptor (INSR) interaction partners

  1. Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.

  2. Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress

  3. results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep

  4. This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.

  5. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.

  6. InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.

  7. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.

  8. Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis

  9. Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain

  10. The phospholipase C (show PLC Antibodies)-gamma (PLC (show PLC Antibodies)-gamma) encoded by small wing (sl) acts as such a link between growth and patterning/differentiation by modulating some MAPK (show MAPK1 Antibodies) outputs once activated by the insulin (show INS Antibodies) pathway.

Human Insulin Receptor (INSR) interaction partners

  1. Results show that IR expression level in renal cell carcinoma (show MOK Antibodies) tissue was significantly lower in patients with tumor stage pT2-4 and/or distant metastases.

  2. Findings suggest that the induction of microRNA miR (show MLXIP Antibodies)-1271 by saturated fatty acid palmitate promotes the development of insulin (show INS Antibodies) resistance by targeting insulin receptor (INSR) and insulin receptor substrate 1 (show IRS1 Antibodies) protein (IRS-1 (show IRS1 Antibodies)) in hepatocytes.

  3. Study reveals an important function of CHIP-mediated proteolysis in insulin (show INS Antibodies) and IGF1 (show IGF1 Antibodies) signaling; upon proteotoxic stress conditions and during aging, CHIP is recruited toward disposal of misfolded proteins, reducing its capacity to degrade the INSR; identify a degradation pathway that controls the level of active DAF-2/INSR in C. elegans, Drosophila and human cells.

  4. EGF (show EGF Antibodies) and insulin receptor tyrosine kinase exemplify how receptor location is coupled to signal transduction. (Review)

  5. a straightforward protocol for production of recombinant IGF-II and prepared six IGF-II analogs with IGF-I-like mutations. All modified molecules exhibit significantly reduced affinity toward IR-A, particularly the analogs with a Pro-Gln insertion in the C-domain. Moreover, one of the analogs has enhanced binding affinity for IGF-1R due to a synergistic effect of the Pro-Gln insertion and S29N point mutation.

  6. Conus geographus G1 (Con (show DISP1 Antibodies)-Ins (show INS Antibodies) G1), is the smallest known insulin (show INS Antibodies) found in nature and lacks the C-terminal segment of the B chain that, in human insulin (show INS Antibodies), mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. This study found that Con (show DISP1 Antibodies)-Ins (show INS Antibodies) G1 is monomeric, strongly binds the human insulin receptor and activates receptor signaling.

  7. Mutations of the INSR gene is associated with acanthosis nigricans and hyperandrogenism.

  8. Identification of a Novel Homozygous INSR Variant in a Patient with Rabson-Mendenhall Syndrome from the United Arab Emirates.

  9. Findings suggest that insulin receptor substrate -1 (show IRS1 Antibodies) Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (show IRS2 Antibodies) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

  10. Two miR (show MLXIP Antibodies)-binding SNPs SLC30A8 (show SLC30A8 Antibodies) rs2466293 and INSR rs1366600 increased Gestational diabetes mellitus susceptibility. Functional studies were required to confirm the underlying mechanism.

Mouse (Murine) Insulin Receptor (INSR) interaction partners

  1. The IR in the intestinal epithelium plays important roles in intestinal gene expression, glucose uptake, and GIP (show GIP Antibodies) production, which may contribute to pathophysiological changes in individuals with diabetes, metabolic syndrome, and other insulin (show INS Antibodies)-resistant states.

  2. In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Antibodies)/PDPK1 (show PDPK1 Antibodies)/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1 (show PDPK1 Antibodies). This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati

  3. Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a (show PPP2R2A Antibodies)). Inheritance of either allele results in insulin (show INS Antibodies) resistance but not overt diabetes. Double heterozygosity leads to insulin (show INS Antibodies) resistance and diabetes type 2 without increase in body weight.

  4. ZIP14 (show SLC39A14 Antibodies)-mediated zinc transport contributes to regulation of endosomal insulin receptor activity and glucose homeostasis in hepatocytes.

  5. Suggest that overexpression of IGF-IR or IRA isoform, as homodimers or as part of IRA/IGF-IR hybrid receptors, confers a stronger migratory capability to vascular smooth muscle cells and might occur in early stages of atherosclerotic process.

  6. Acute knockdown of Insr or both Irs1 (show IRS1 Antibodies) and Irs2 (show IRS2 Antibodies) in adipocytes increased Adipoq (show ADIPOQ Antibodies) mRNA expression but reduced adiponectin (show ADIPOQ Antibodies) secretion.

  7. unsuppressed lipolysis in adipocytes elicited by HFD feeding is linked with enhanced gluconeogenesis from glycerol and with alterations in BA physiology in Insr(P1195L/+)/HFD liver.

  8. NF-kappaB (show NFKB1 Antibodies)-miR (show MLXIP Antibodies)-195/497-Igf1r (show IGF1R Antibodies)/Insr-Ccnd2 (show CCND2 Antibodies)/Ccne1 (show CCNE1 Antibodies) plays important roles in myogenesis.

  9. Therefore, overexpression of insulin receptor improves obese and diabetic phenotypes in db/db (show LEPR Antibodies) mice, with consequences on growth.

  10. only Ptprj (show PTPRJ Antibodies) was co-expressed with the IR in major insulin (show INS Antibodies) target tissues : the skeletal muscle, liver and adipose tissue. the activation of IR and Akt (show AKT1 Antibodies) by insulin (show INS Antibodies) was enhanced, and glucose and insulin (show INS Antibodies) tolerance was improved in Ptprj (show PTPRJ Antibodies)-deficient mice

Cow (Bovine) Insulin Receptor (INSR) interaction partners

  1. studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (show IGF1 Antibodies), IGF-2, IGFBP-2 (show IGFBP2 Antibodies), IGFBP-3 (show IGFBP3 Antibodies), IGF-1R (show IGF1R Antibodies), IGF-2R, GHR (show GHR Antibodies), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum

  2. insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments

  3. FSH (show BRD2 Antibodies), but not E2, stimulated the expression of IR and GHR (show GHR Antibodies) genes during follicular development.

  4. Data conclude that insulin (show INS Antibodies) and IGF-I (show IGF1 Antibodies) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.

Insulin Receptor (INSR) Antigen Profile

Antigen Summary

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Insulin Receptor (INSR)

  • Insulin-like receptor (InR) antibody
  • insulin receptor (INSR) antibody
  • insulin receptor (Insr) antibody
  • insulin receptor (insr) antibody
  • insulin receptor precursor (DAF-2) antibody
  • 18402 antibody
  • 4932439J01Rik antibody
  • cd220 antibody
  • CG18402 antibody
  • CTK-1 antibody
  • D630014A15Rik antibody
  • DIHR antibody
  • DILR antibody
  • dinr antibody
  • dInsR antibody
  • dir antibody
  • Dir-a antibody
  • Dir-b antibody
  • DIRbeta antibody
  • dIRH antibody
  • Dmel\\CG18402 antibody
  • er10 antibody
  • hhf5 antibody
  • inr antibody
  • Inr-alpha antibody
  • Inr-beta antibody
  • INS antibody
  • INSR antibody
  • insulin/insulin-like growth factor receptor antibody
  • ir antibody
  • ir-A antibody
  • IR-B antibody
  • l(3)05545 antibody
  • l(3)93Dj antibody
  • l(3)er10 antibody
  • lnR antibody
  • NV14476 antibody

Protein level used designations for anti-Insulin Receptor (INSR) Antibodies

CG18402-PA , CG18402-PB , CG18402-PC , CG18402-PD , InR-PA , InR-PB , InR-PC , InR-PD , drosophila insulin receptor , insulin , insulin receptor , insulin receptor homolog , insulin receptor homologue , insulin-like receptor , insulin-receptor , lethal(3)93Dj , insulin receptor-like , IR , XTK-1b , insulin receptor, beta-subunit , xe-InsR , insulin receptor tyrosine kinase , tyrosine kinase

GENE ID SPECIES
42549 Drosophila melanogaster
455649 Pan troglodytes
455650 Pan troglodytes
100027215 Monodelphis domestica
100066248 Equus caballus
100122567 Nasonia vitripennis
100126753 Papio anubis
100127108 Felis catus
100403400 Callithrix jacchus
100451802 Pongo abelii
100473956 Ailuropoda melanoleuca
3643 Homo sapiens
16337 Mus musculus
396755 Sus scrofa
408017 Bos taurus
443431 Ovis aries
100141504 Oryctolagus cuniculus
24954 Rattus norvegicus
398006 Xenopus laevis
484990 Canis lupus familiaris
420133 Gallus gallus
100718484 Cavia porcellus
706009 Macaca mulatta
100008911 Oryctolagus cuniculus
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