Insulin Receptor antibody (C-Term)

Catalog No. ABIN6254165

The Goat Polyclonal anti-Insulin Receptor antibody is suitable to detect Insulin Receptor in samples from Human, Mouse, Rat, Monkey, Dog, Horse, Cow, Guinea Pig, Rabbit, Pig, Sheep, Hamster, Chicken, Avian, Cat, Donkey and Goat. It has been validated for WB, IHC (p) and IHC (fro).

Quick Overview for Insulin Receptor antibody (C-Term) (ABIN6254165)

Target: Insulin Receptor (INSR)

Reactivity: Human, Mouse, Rat, Monkey, Dog, Horse, Cow, Guinea Pig, Rabbit, Pig, Sheep, Hamster, Chicken, Avian, Cat, Donkey, Goat

Host: Goat

Clonality: Polyclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Insulin Receptor Antibody

Binding Specificity: C-Term

Purpose: anti-INSR

Sequence: KAPESEELEM EFEDMENVPL DRSSHCQREE AGGRDGGSSL GFKRSYEEHI PYTHMNGGKK NGRILTLPRS NPS

Specificity: Using liver, HeLa and Skov3 cell lysates detects a 180 kDa band by Western blot.

Characteristics: Insulin receptor

Purification: Epitope affinity purified

Immunogen: Purified recombinant peptide within residues 1310 aa to the C-terminus of human INSR produced in E. coli.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:5,000

Restrictions: For Research Use only

Handling

Buffer: PBS, 20 % glycerol and 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: The antibody solution should be gently mixed before use.

Storage: 4 °C,-20 °C

Storage Comment: For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: INSR

Background:

Goat polyclonal antibody to insulin receptor. INSR is a receptor tyrosine kinase. Preprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. The insulin signalling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein is activated by the binding of insulin or other ligands to this receptor.

CD220, HHF5, insulin receptor antibody.

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity