Browse our TNFSF11 Proteins (TNFSF11)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins (TNFSF11)
On are 60 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Proteins from 14 different suppliers available. Additionally we are shipping TNFSF11 Antibodies (259) and TNFSF11 Kits (105) and many more products for this protein. A total of 441 TNFSF11 products are currently listed.
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
list all proteins Gene Name GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

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TNFSF11 Proteins (TNFSF11) by Origin

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Top referenced TNFSF11 Proteins

  1. Human TNFSF11 Protein expressed in HEK-293 - ABIN2666867 : Dehm, Bonham: SRC gene expression in human cancer: the role of transcriptional activation. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004 (PubMed)
    Show all 8 references for 2666867

  2. Mouse (Murine) TNFSF11 Protein expressed in Insect Cells - ABIN2666593 : Ha, Choi, Lee, Kwon, Song, Kim: CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 7 references for 2666593

  3. Cynomolgus TNFSF11 Protein expressed in Human Cells - ABIN2010125 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Show all 3 references for 2010125

  4. Human TNFSF11 Protein expressed in Human Cells - ABIN2004520 : Nagai, Kyakumoto, Sato: Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 3 references for 2004520

  5. Human TNFSF11 Protein expressed in Escherichia coli (E. coli) - ABIN667474 : Ito, Wakabayashi, Ubukata, Hayashi, Okada, Hata: Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for 667474

  6. Mouse (Murine) TNFSF11 Protein expressed in HEK-293 Cells - ABIN1344301 : Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Proteins for TNFSF11 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Correlations between sRANKL and IL-18 (show IL18 Proteins) in BALF.

  2. RANK/RANKL signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin (show TNFRSF11B Proteins) to prevent bone metastasis.

  3. This study suggested that RANKL could be a marker to differentiate between pagetoid squamous cell carcinoma in situ and extramammary Paget disease .

  4. TNF-alpha-converting enzyme (show ADAM17 Proteins) -mediated cleavage of soluble RANKL from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  5. RANKL is required for progesterone-mediated cell proliferation in BRCA1mut/+ breast tissue.

  6. MAOA (show MAOA Proteins) provides tumor cell growth advantages in the bone microenvironment by stimulating interleukin-6 (IL6 (show IL6 Proteins)) release from osteoblasts, and triggers skeletal colonization by activating osteoclastogenesis through osteoblast production of RANKL and IL6 (show IL6 Proteins).

  7. In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer

  8. The results showed that AG490 inhibited (p)-JAK2 (show JAK2 Proteins) and RANKL expression.

  9. Review: OPG (show TNFRSF11B Proteins), RANKL and TRAIL are involved in vascular calcification.

  10. Our results suggest that the polymorphism of the RANKL, RANK, and OPG (show TNFRSF11B Proteins) genes does not make a significant genetic contribution to heel ultrasound measurements in a population of young Caucasian adults. Further studies replicating the results in independent populations are needed to support these initial findings.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. sRANKL increased macrophage glucose uptake at normal glucose concentrations, which was impaired by hyperglycemia pretreatment through the inhibition of Glut1 (show SLC2A1 Proteins) membrane translocation and the insulin receptor (show INSR Proteins) and IRS-1 (show IRS1 Proteins) gene transcription.

  2. Our findings show that anti-RANKL antibody administration during pregnancy results in not only an undesirable increase in bone mass, but also has harmful effects on newborn survival.

  3. RANKL represses the transcription of the E3 ubiquitin ligase (show MUL1 Proteins) RNF146 (show RNF146 Proteins) through an NF-kappaB (show NFKB1 Proteins)-related inhibitory element in the RNF146 (show RNF146 Proteins) promoter.

  4. This study showed that RANKL favors osteoclastogenesis via attenuation of Nrf2 (show NFE2L2 Proteins)-mediated antioxidant enzyme expression by competing with Bach1 (show BACH1 Proteins) nuclear accumulation.

  5. Membrane-bound RANKL induces M cell differentiation and CCL20 (show CCL20 Proteins) expression in the follicle associated epithelium of gut (show GUSB Proteins)-associated lymphoid tissues.

  6. The data show that S. aureus enhances bone resorption and periosteal osteoclast formation by increasing osteoblast RANKL production through TLR2.

  7. Data (including data from studies using knockout mice) suggest that RANKL enhances TNF (show TNF Proteins)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 (show TRAF6 Proteins) by degrading Traf3 (show TRAF3 Proteins), a known inhibitor of osteoclastogenesis. (RANKL = osteoclast differentiation factor; TNF (show TNF Proteins) = tumor necrosis factor (show TNF Proteins); Traf (show TRAF1 Proteins) = TNF (show TNF Proteins) receptor-associated factor)

  8. Results suggest that MAPK (show MAPK1 Proteins) signaling pathway is necessary for receptor activator of nuclear factor kappa-B ligand (RANKL) expression in bone marrow stromal cell.

  9. endocortical resorption is driven by reduced osteoprotegerin (show TNFRSF11B Proteins) rather than elevated RANKL expression

  10. The results showed that AG490 inhibited (p)-JAK2 (show JAK2 Proteins) and RANKL expression.

TNFSF11 Protein Profile

Protein Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11)
  • basic transcription factor 3 pseudogene 11 (BTF3P11)
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • BTF3L1 protein
  • CD254 protein
  • hRANKL2 protein
  • HUMBTFB protein
  • Ly109l protein
  • OCIF protein
  • ODF protein
  • Opg protein
  • OPGL protein
  • OPTB2 protein
  • RANKL protein
  • sOdf protein
  • TNFRSF11B protein
  • TNFSF11 protein
  • Trance protein

Protein level used designations for TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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