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Browse our TNFSF11 Proteins (TNFSF11)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins (TNFSF11)
On are 54 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Proteins from 13 different suppliers available. Additionally we are shipping TNFSF11 Antibodies (263) and TNFSF11 Kits (102) and many more products for this protein. A total of 432 TNFSF11 products are currently listed.
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
list all proteins Gene Name GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

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TNFSF11 Proteins (TNFSF11) by Origin

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Top referenced TNFSF11 Proteins

  1. Human TNFSF11 Protein expressed in HEK-293 - ABIN2666867 : Dehm, Bonham: SRC gene expression in human cancer: the role of transcriptional activation. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004 (PubMed)
    Show all 8 references for ABIN2666867

  2. Mouse (Murine) TNFSF11 Protein expressed in Insect Cells - ABIN2666593 : Ha, Choi, Lee, Kwon, Song, Kim: CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 7 references for ABIN2666593

  3. Cynomolgus TNFSF11 Protein expressed in Human Cells - ABIN2010125 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Show all 3 references for ABIN2010125

  4. Human TNFSF11 Protein expressed in Human Cells - ABIN2004520 : Nagai, Kyakumoto, Sato: Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 3 references for ABIN2004520

  5. Human TNFSF11 Protein expressed in Escherichia coli (E. coli) - ABIN667474 : Ito, Wakabayashi, Ubukata, Hayashi, Okada, Hata: Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667474

  6. Mouse (Murine) TNFSF11 Protein expressed in Human - ABIN1344301 : Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Proteins for TNFSF11 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. the overexpression of RANKL and high membranous RANKL localization in osteoblasts are related to defective CF transmembrane conductance regulator, and may worsen bone resorption, leading to bone loss in patients with cystic fibrosis (show S100A8 Proteins).

  2. The expression for RANKL and OPG (show TNFRSF11B Proteins) and the RANKL/OPG ratio were not significantly different between symptomatic and asymptomatic periapical lesions.

  3. HBOT increased serum OPG (show TNFRSF11B Proteins) levels but receptor activator of nuclear factor kappa-B ligand (RANKL) levels did not change.

  4. Preterm neonates exposed to Antenatal Glucocorticosteroid have higher serum levels of OPG (show TNFRSF11B Proteins), while premature neonates not exposed to Antenatal Glucocorticosteroid have serum OPG (show TNFRSF11B Proteins) and RANKL levels similar to those measured in healthy term neonates.

  5. Twenty-one single-nucleotide polymorphisms (SNPs) of TNFSF11, TNFRSF11A, and TNFRSF11B were genotyped. This study suggests that TNFRSF11B but not TNFSF11 and TNFRSF11A genetic polymorphisms are associated with Type 2 Diabetes Mellitus in Southern Han Chinese women.

  6. the OPG/RANKL/RANK system might be directly influenced by genetic variants of NOTCH1 (show NOTCH1 Proteins) in aortic valve calcification.

  7. results suggest that serum OPG (show TNFRSF11B Proteins) and RANKL levels are inversely associated with bone loss in men with advanced stage COPD (show ARCN1 Proteins).

  8. These data show that the osteoprotegerin (show TNFRSF11B Proteins) and receptor-activator of nuclear factor-kappaB ligand system is associated with bone markers and bone mineral density at the lumbar spine after obesity surgery.

  9. the functional expression of RANKL in CD4 (show CD4 Proteins)+/CD8 (show CD8A Proteins)+ T cells and Th17 cells, and the potential role of these cells in chronic obstructive pulmonary disease-associated bone loss was investigated.

  10. Postmenopausal women with Rheumatoid Arthritis, carrying either the RANKL-290T allele or possessing the RANK 575CC genotype were more likely to develop osteoporosis.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. miR (show MLXIP Proteins)-338-3p may play a significant role in glucocorticoid-induced osteoclast differentiation and function by targeting RANKL in osteoclasts.

  2. the protein and RNA levels of RANKLinduced cFos and nuclear factor of activated T-cell (show NFATC3 Proteins) cytoplasmic 1 were suppressed by centipedegrass extract (CGE). These results indicated that CGE may serve as a useful drug in the prevention of bone loss.

  3. Lipopolysaccharides significantly up-regulated RANKL expression and activated the ERK1/2 pathway to induce IL-6 (show IL6 Proteins) mRNA expression and protein synthesis in MLO-Y4 cells.

  4. Mechanistically, RL negatively regulates Stat5 (show STAT5A Proteins) phosphorylation and Elf5 (show ELF5 Proteins) expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin (show PRL Proteins)/p-Stat5 (show STAT5A Proteins) pathway.

  5. this study shows that OPG constitutes an early biomarker with in experimental model od severe malaria

  6. Osteoprotegerin (show TNFRSF11B Proteins) plays a role in preserving myocardial structure and function with ageing through a reduction in apoptosis and preservation of the matrix structure

  7. These results indicate that activation of Panx1 (show PANX1 Proteins) and P2X7 (show P2RX7 Proteins) R are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.

  8. These results suggest that GP2(+)Tnfaip2 (show TNFAIP2 Proteins)(+) cells in NALT are equivalent to intestinal M cells, and that RANKL-RANK signaling induces their differentiation.

  9. These results highlight the role of distal enhancers in the regulation of RANKL expression by PTH (show PTH Proteins) and perhaps 1,25(OH)2D3 and suggest that the RL-D2 and RL-D5 enhancers contribute in either an additive or synergistic manner to regulate bone remodeling.

  10. NMP4 (show ZNF384 Proteins) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 (show MMP3 Proteins) mRNA.

TNFSF11 Protein Profile

Protein Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11)
  • basic transcription factor 3 pseudogene 11 (BTF3P11)
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • BTF3L1 protein
  • CD254 protein
  • hRANKL2 protein
  • HUMBTFB protein
  • Ly109l protein
  • OCIF protein
  • ODF protein
  • Opg protein
  • OPGL protein
  • OPTB2 protein
  • RANKL protein
  • sOdf protein
  • TNFRSF11B protein
  • TNFSF11 protein
  • Trance protein

Protein level used designations for TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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