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Browse our TNFSF11 Proteins (TNFSF11)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins (TNFSF11)
On are 54 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Proteins from 13 different suppliers available. Additionally we are shipping TNFSF11 Antibodies (249) and TNFSF11 Kits (91) and many more products for this protein. A total of 407 TNFSF11 products are currently listed.
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
list all proteins Gene Name GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

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TNFSF11 Proteins (TNFSF11) by Origin

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Top referenced TNFSF11 Proteins

  1. Human TNFSF11 Protein expressed in HEK-293 - ABIN2666867 : Dehm, Bonham: SRC gene expression in human cancer: the role of transcriptional activation. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004 (PubMed)
    Show all 8 references for ABIN2666867

  2. Mouse (Murine) TNFSF11 Protein expressed in Insect Cells - ABIN2666593 : Ha, Choi, Lee, Kwon, Song, Kim: CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 7 references for ABIN2666593

  3. Cynomolgus TNFSF11 Protein expressed in Human Cells - ABIN2010125 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Show all 3 references for ABIN2010125

  4. Human TNFSF11 Protein expressed in Human Cells - ABIN2004520 : Nagai, Kyakumoto, Sato: Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 3 references for ABIN2004520

  5. Human TNFSF11 Protein expressed in Escherichia coli (E. coli) - ABIN667474 : Ito, Wakabayashi, Ubukata, Hayashi, Okada, Hata: Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667474

  6. Mouse (Murine) TNFSF11 Protein expressed in Human - ABIN1344301 : Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Proteins for TNFSF11 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Study identified a novel RANKL function in the promotion of cell adhesion to type I collagen through the RANKL-NF-kappa B (show NFKB1 Proteins)-integrin alpha 2 (show ITGA2 Proteins) pathway and found integrin alpha2 and RANKL up-regulated in non small cell lung carcinoma.

  2. OPG (show TNFRSF11B Proteins) and RANKL polymorphisms were associated with the occurrence of alcohol-induced ONFH.

  3. Results demonstrated that the type of inflammatory infiltrate present in periradicular cysts appears to influence the expression of RANK, RANKL, and osteoprotegerin (show TNFRSF11B Proteins)

  4. Results showed that the expressions of RANKL and IL-17A (show IL17A Proteins) were higher in the treatment group than the nontreatment group (P < .05) and higher in males than in females (P < .05). Their increments were well correlated with each other (r = 0.788, P = < .01) but were not time dependent

  5. PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway stimulates the expressions of RANKL, PTHrP, and BMP-2 (show BMP2 Proteins) partly through NF-kappaB (show NFKB1 Proteins), suggesting its importance for bone metastasis of prostate carcinoma

  6. This study demonstrates that clodronate decreases the compression-induced RANKL/OPG ratio expressed by human osteoblasts.

  7. High RANKL expression is associated with endometrial metastasis.

  8. OPG (show TNFRSF11B Proteins) and RANKL may play an integral role in breast cancer cells homing to the bone environment

  9. In conclusion, rheumatoid arthritis synovial fibroblasts were activated by CXCL16 (show CXCL16 Proteins) to produce RANKL via pathways involving JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) and p38/MAPK (show MAPK14 Proteins)

  10. Alendronate stimulated OPG (show TNFRSF11B Proteins) mRNA and protein expression, but not RANKL expression, in fibroblasts from patients with aseptic loosening following total hip arthroplasty.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Lipopolysaccharides significantly up-regulated RANKL expression and activated the ERK1/2 pathway to induce IL-6 (show IL6 Proteins) mRNA expression and protein synthesis in MLO-Y4 cells.

  2. Mechanistically, RL negatively regulates Stat5 (show STAT5A Proteins) phosphorylation and Elf5 (show ELF5 Proteins) expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin (show PRL Proteins)/p-Stat5 (show STAT5A Proteins) pathway.

  3. this study shows that OPG constitutes an early biomarker with in experimental model od severe malaria

  4. Osteoprotegerin (show TNFRSF11B Proteins) plays a role in preserving myocardial structure and function with ageing through a reduction in apoptosis and preservation of the matrix structure

  5. These results indicate that activation of Panx1 (show PANX1 Proteins) and P2X7 (show P2RX7 Proteins) R are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.

  6. These results suggest that GP2(+)Tnfaip2 (show TNFAIP2 Proteins)(+) cells in NALT are equivalent to intestinal M cells, and that RANKL-RANK signaling induces their differentiation.

  7. These results highlight the role of distal enhancers in the regulation of RANKL expression by PTH (show PTH Proteins) and perhaps 1,25(OH)2D3 and suggest that the RL-D2 and RL-D5 enhancers contribute in either an additive or synergistic manner to regulate bone remodeling.

  8. NMP4 (show ZNF384 Proteins) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 (show MMP3 Proteins) mRNA.

  9. the results of the present study strongly suggest that mimosine, a normoxic inducer of HIF, inhibits the PGF2ainduced osteoprotegerin (show TNFRSF11B Proteins) synthesis without affecting the IL-6 (show IL6 Proteins) synthesis in osteoblasts

  10. Adiponectin (show ADIPOQ Proteins) exerts novel effects to limit the production and action of mono-MPs, underscoring yet another pleiotropic effect of this adipokine.

TNFSF11 Protein Profile

Protein Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11)
  • basic transcription factor 3 pseudogene 11 (BTF3P11)
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • BTF3L1 protein
  • CD254 protein
  • hRANKL2 protein
  • HUMBTFB protein
  • Ly109l protein
  • OCIF protein
  • ODF protein
  • Opg protein
  • OPGL protein
  • OPTB2 protein
  • RANKL protein
  • sOdf protein
  • TNFRSF11B protein
  • TNFSF11 protein
  • Trance protein

Protein level used designations for TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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