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Browse our TNFSF11 Proteins (TNFSF11)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins (TNFSF11)
On www.antibodies-online.com are 54 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Proteins from 13 different suppliers available. Additionally we are shipping TNFSF11 Antibodies (254) and TNFSF11 Kits (104) and many more products for this protein. A total of 429 TNFSF11 products are currently listed.
Synonyms:
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
list all proteins Gene Name GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

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TNFSF11 Proteins (TNFSF11) by Origin

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Top referenced TNFSF11 Proteins

  1. Human TNFSF11 Protein expressed in HEK-293 - ABIN2666867 : Dehm, Bonham: SRC gene expression in human cancer: the role of transcriptional activation. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004 (PubMed)
    Show all 8 references for ABIN2666867

  2. Mouse (Murine) TNFSF11 Protein expressed in Insect Cells - ABIN2666593 : Ha, Choi, Lee, Kwon, Song, Kim: CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 7 references for ABIN2666593

  3. Cynomolgus TNFSF11 Protein expressed in Human Cells - ABIN2010125 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Show all 3 references for ABIN2010125

  4. Human TNFSF11 Protein expressed in Human Cells - ABIN2004520 : Nagai, Kyakumoto, Sato: Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 3 references for ABIN2004520

  5. Human TNFSF11 Protein expressed in Escherichia coli (E. coli) - ABIN667474 : Ito, Wakabayashi, Ubukata, Hayashi, Okada, Hata: Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667474

  6. Mouse (Murine) TNFSF11 Protein expressed in Human - ABIN1344301 : Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Proteins for TNFSF11 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. MAOA (show MAOA Proteins) provides tumor cell growth advantages in the bone microenvironment by stimulating interleukin-6 (IL6 (show IL6 Proteins)) release from osteoblasts, and triggers skeletal colonization by activating osteoclastogenesis through osteoblast production of RANKL and IL6 (show IL6 Proteins).

  2. In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer

  3. The results showed that AG490 inhibited (p)-JAK2 (show JAK2 Proteins) and RANKL expression.

  4. Review: OPG (show TNFRSF11B Proteins), RANKL and TRAIL are involved in vascular calcification.

  5. Our results suggest that the polymorphism of the RANKL, RANK, and OPG (show TNFRSF11B Proteins) genes does not make a significant genetic contribution to heel ultrasound measurements in a population of young Caucasian adults. Further studies replicating the results in independent populations are needed to support these initial findings.

  6. OPG (show TNFRSF11B Proteins) rs2073618, RANK rs75404003, and RANKL rs9594782 single nucleotide poymorphisms may predispose LVH in thalassemia patients.

  7. the overexpression of RANKL and high membranous RANKL localization in osteoblasts are related to defective CF transmembrane conductance regulator, and may worsen bone resorption, leading to bone loss in patients with cystic fibrosis (show S100A8 Proteins).

  8. The expression for RANKL and OPG (show TNFRSF11B Proteins) and the RANKL/OPG ratio were not significantly different between symptomatic and asymptomatic periapical lesions.

  9. HBOT increased serum OPG (show TNFRSF11B Proteins) levels but receptor activator of nuclear factor kappa-B ligand (RANKL) levels did not change.

  10. Preterm neonates exposed to Antenatal Glucocorticosteroid have higher serum levels of OPG (show TNFRSF11B Proteins), while premature neonates not exposed to Antenatal Glucocorticosteroid have serum OPG (show TNFRSF11B Proteins) and RANKL levels similar to those measured in healthy term neonates.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Results suggest that MAPK (show MAPK1 Proteins) signaling pathway is necessary for receptor activator of nuclear factor kappa-B ligand (RANKL) expression in bone marrow stromal cell.

  2. endocortical resorption is driven by reduced osteoprotegerin (show TNFRSF11B Proteins) rather than elevated RANKL expression

  3. The results showed that AG490 inhibited (p)-JAK2 (show JAK2 Proteins) and RANKL expression.

  4. Play a supportive role in the RANKL-dependent differentiation.

  5. increased expression of RANKL in heterogeneous bone marrow cells provoked bone destruction during Group A Streptococcus infection.

  6. beta-lapachone inhibits RANKL-induced osteoclastogenesis and could be considered a potent inhibitor of RANKL-mediated bone diseases

  7. differentiation by suppressing the Ca(2 (show CA2 Proteins)+)-calcineurin (show PPP3CA Proteins)-NFATc1 (show NFATC1 Proteins) signaling pathway. Although many questions remain unresolved, to our knowledge, this is the first report demonstrating that PEMF is beneficial against RANKL-dependent osteoclastic differentiation in RAW264.7 cells in vitro via inhibiting the Ca(2 (show CA2 Proteins)+)-calcineurin (show PPP3CA Proteins)-NFATc1 (show NFATC1 Proteins) signaling pathway.

  8. these results demonstrate that RANKL expressed by osteocytes is required for the bone loss as well as the increase in B cell number caused by estrogen deficiency.

  9. In conclusion, the present study demonstrated that EA can suppress osteoclastogenesis in vitro. Moreover, we clarified that these inhibitory effects of EA occur through suppression of NF-kappaB (show NFKB1 Proteins) and ERK (show EPHB2 Proteins) activation. Therefore, EA may be a potential agent in the treatment of osteoclast-related diseases such as osteoporosis.

  10. MDH1 (show MDH1 Proteins) expression was induced by receptor activator of nuclear factor kappa-B ligand (RANKL) treatment.

TNFSF11 Protein Profile

Protein Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11)
  • basic transcription factor 3 pseudogene 11 (BTF3P11)
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • BTF3L1 protein
  • CD254 protein
  • hRANKL2 protein
  • HUMBTFB protein
  • Ly109l protein
  • OCIF protein
  • ODF protein
  • Opg protein
  • OPGL protein
  • OPTB2 protein
  • RANKL protein
  • sOdf protein
  • TNFRSF11B protein
  • TNFSF11 protein
  • Trance protein

Protein level used designations for TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

GENE ID SPECIES
467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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