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Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins

(Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].
RANKL Protein (AA 63-244) (His-DYKDDDDK Tag) RANKL Protein (AA 63-244) (His-DYKDDDDK Tag) RANKL Protein (AA 63-244) (His-DYKDDDDK Tag) (ABIN7275517)

TNFSF11 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE

RANKL Protein (AA 63-244) RANKL Protein (AA 63-244) RANKL Protein (AA 63-244) (ABIN7275516)

TNFSF11 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC

RANKL Protein (AA 70-316) (His tag) RANKL Protein (AA 70-316) (His tag) RANKL Protein (AA 70-316) (His tag) (ABIN7275518)

TNFSF11 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins by Grade

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Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins by Origin

Find Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins for a variety of species such as anti-Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11, anti-Mouse Tumor Necrosis Factor (Ligand) Superfamily, Member 11, anti-Rat Tumor Necrosis Factor (Ligand) Superfamily, Member 11. The species listed below are among those available. Click on a link to go to the corresponding products.

Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins by Source

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Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins by Protein Type

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Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins by Application

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Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins by Biological Activity

Find Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275517
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275516
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275518
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana benthamiana)
Validations
  • (2)
Cat. No. ABIN1019704
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source
Validations
  • (4)
  • (1)
Cat. No. ABIN1112027
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293T Cells
Validations
  • (2)
Cat. No. ABIN1323211
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7013608
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN6253590
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN5674645
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN6386415
Quantity 200 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN6973285
Quantity 200 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN1344301
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125526
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125527
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5571252
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins

Nguyen, Nohe: "Factors that Affect the Osteoclastogenesis of RAW264.7 Cells." in: Journal of biochemistry and analytical studies, Vol. 2, Issue 1, (2017) (PubMed).

Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken: "Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 7, pp. 2989-94, (2010) (PubMed).

DAmelio, Isaia, Isaia: "The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease." in: Journal of endocrinological investigation, Vol. 32, Issue 4 Suppl, pp. 6-9, (2009) (PubMed).

Takahashi, Udagawa, Suda: "A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function." in: Biochemical and biophysical research communications, Vol. 256, Issue 3, pp. 449-55, (1999) (PubMed).

Suda, Takahashi, Udagawa, Jimi, Gillespie, Martin: "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families." in: Endocrine reviews, Vol. 20, Issue 3, pp. 345-57, (1999) (PubMed).

Yasuda, Shima, Nakagawa, Yamaguchi, Kinosaki, Mochizuki, Tomoyasu, Yano, Goto, Murakami, Tsuda, Morinaga, Higashio, Udagawa, Takahashi, Suda: "Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 7, pp. 3597-602, (1998) (PubMed).

Wong, Rho, Arron, Robinson, Orlinick, Chao, Kalachikov, Cayani, Bartlett, Frankel, Lee, Choi: "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25190-4, (1997) (PubMed).

Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function." in: Nature, Vol. 390, Issue 6656, pp. 175-9, (1997) (PubMed).

Aliases for Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins

TNF superfamily member 11 (TNFSF11) Proteins
tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) Proteins
TNF superfamily member 11 (Tnfsf11) Proteins
TNF receptor superfamily member 11b (TNFRSF11B) Proteins
TNF superfamily member 11 L homeolog (tnfsf11.L) Proteins
CD254 Proteins
cd254 Proteins
hRANKL2 Proteins
Ly109l Proteins
ODF Proteins
odf Proteins
OPG Proteins
OPGL Proteins
opgl Proteins
OPTB2 Proteins
optb2 Proteins
RANKL Proteins
rankl Proteins
sOdf Proteins
sodf Proteins
TNFSF11 Proteins
tnfsf11 Proteins
TRANCE Proteins
Trance Proteins
trance Proteins
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