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Browse our TNFSF11 Proteins (TNFSF11)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteins (TNFSF11)
On www.antibodies-online.com are 53 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Proteins from 13 different suppliers available. Additionally we are shipping TNFSF11 Antibodies (248) and TNFSF11 Kits (108) and many more products for this protein. A total of 422 TNFSF11 products are currently listed.
Synonyms:
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
list all proteins Gene Name GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

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TNFSF11 Proteins (TNFSF11) by Origin

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Top referenced TNFSF11 Proteins

  1. Human TNFSF11 Protein expressed in HEK-293 - ABIN2666867 : Dehm, Bonham: SRC gene expression in human cancer: the role of transcriptional activation. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004 (PubMed)
    Show all 8 references for ABIN2666867

  2. Mouse (Murine) TNFSF11 Protein expressed in Insect Cells - ABIN2666593 : Ha, Choi, Lee, Kwon, Song, Kim: CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 7 references for ABIN2666593

  3. Human TNFSF11 Protein expressed in Human Cells - ABIN2004520 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Show all 3 references for ABIN2004520

  4. Cynomolgus TNFSF11 Protein expressed in Human Cells - ABIN2010125 : Nagai, Kyakumoto, Sato: Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 3 references for ABIN2010125

  5. Human TNFSF11 Protein expressed in Escherichia coli (E. coli) - ABIN667474 : Ito, Wakabayashi, Ubukata, Hayashi, Okada, Hata: Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667474

  6. Mouse (Murine) TNFSF11 Protein expressed in Human - ABIN1344301 : Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Proteins for TNFSF11 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. Alendronate stimulated OPG (show TNFRSF11B Proteins) mRNA and protein expression, but not RANKL expression, in fibroblasts from patients with aseptic loosening following total hip arthroplasty.

  2. Atorvastatin treatment reduced circulating osteoprogenitor cells and RANKL expression in T cells, and increased OPG (show TNFRSF11B Proteins) serum levels in postmenopausal osteoporisis.

  3. Hypoxia can affect the expression of RANKL and OPG (show TNFRSF11B Proteins) in human periodontal ligament cells

  4. Osteoprotegerin (OPG (show TNFRSF11B Proteins)), The Endogenous Inhibitor of Receptor Activator of NF-kappaB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers

  5. expression of OPG (show TNFRSF11B Proteins), RANK and RANKL genes exert a crucial role in the progression of avascular necrosis

  6. IL-29 (show IL29 Proteins) directly induces RANKL expression in rheumatoid arthritis-fibroblasts like synoviocytes via MAPK (show MAPK1 Proteins) signaling pathway.

  7. Src (show SRC Proteins) expression showed a significantly positive linear relationship with RANK, suggesting a potential mechanism of the RANKL-RANK axis in regulating breast cancer cell differentiation and antiapoptosis.

  8. a dual action of HDFCs in osteoclastogenesis; moreover, parathyroid hormone-related protein, CSF-1 (show CSF1 Proteins) and BMP-2 (show BMP2 Proteins) might influence osteoclastogenesis by regulating the expression of RANKL and OPG (show TNFRSF11B Proteins) in HDFCs

  9. the independent and positive (beta = 0.449, p = 0.004, and R(2) = 0.185) association between the OxS marker and RANKL/OPG ratio which was found in osteopenic but not in the other 2 sample groups.

  10. Despite comparable osteoprotegerin (show TNFRSF11B Proteins) concentrations, lumbar disc herniation cases express lower RANKL than controls. Disc herniation was strongly associated with RANKL and the presence of the F allele of the VDR (show CYP27B1 Proteins) gene.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) interaction partners

  1. NF-kappaB (show NFKB1 Proteins) regulates RANKL-induced osteoclast differentiation and mitochondrial biogenesis via independent mechanisms

  2. In the presence of the LentisiTNFalphaOPG vector, the mRNA expression levels of the inflammatory factors and RANKL were downregulated, as were the protein levels of TNFalpha (show TNF Proteins)

  3. RANKL has a role in proliferation-coupled osteoclast differentiation

  4. Whole-body Rankl deletion completely abrogates tumorigenesis.

  5. a dual action of HDFCs in osteoclastogenesis; moreover, parathyroid hormone-related protein, CSF-1 (show CSF1 Proteins) and BMP-2 (show BMP2 Proteins) might influence osteoclastogenesis by regulating the expression of RANKL and OPG in HDFCs

  6. In palmatine-treated mice, RANKL and OPG expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition.

  7. OPG inhibits osteoclast differentiation via the MAPK (show MAPK1 Proteins) signaling pathway.

  8. Stromal reticular cells activate lymphatic endothelial cells via RANKL and support the action of hematopoietic cell-derived lymphotoxin (show LTB Proteins).

  9. SAA (show SAA1 Proteins) inhibits osteoclast formation from mouse macrophages. SAA (show SAA1 Proteins) blocks RANKL-induced osteoclastogenesis.

  10. Adseverin (show SCIN Proteins) knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell (show NFATC3 Proteins) c1 (NFATc1 (show NFATC1 Proteins)), which is a key transcription factor in osteoclastogenesis.

TNFSF11 Protein Profile

Protein Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11)
  • basic transcription factor 3 pseudogene 11 (BTF3P11)
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • BTF3L1 protein
  • CD254 protein
  • hRANKL2 protein
  • HUMBTFB protein
  • Ly109l protein
  • OCIF protein
  • ODF protein
  • Opg protein
  • OPGL protein
  • OPTB2 protein
  • RANKL protein
  • sOdf protein
  • TNFRSF11B protein
  • TNFSF11 protein
  • Trance protein

Protein level used designations for TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

GENE ID SPECIES
467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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