RANKL Protein (AA 157-316, Soluble) (Fc Tag)
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- Target See all RANKL (TNFSF11) Proteins
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- Soluble, AA 157-316
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This RANKL protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to mouse RANK.
- Cross-Reactivity
- Mouse (Murine)
- Characteristics
- Mouse RANKL (aa 157-316) is fused at the N-terminus to the Fc portion of human IgG1.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFSF11 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Induces osteoclastogenesis of bone marrow-derived macrophages.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 7, pp. 2989-94, (2010) (PubMed).
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Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 7, pp. 2989-94, (2010) (PubMed).
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- Target
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
- Alternative Name
- Fc :RANKL (TNFSF11 Products)
- Synonyms
- CD254 Protein, ODF Protein, OPGL Protein, OPTB2 Protein, RANKL Protein, TRANCE Protein, hRANKL2 Protein, sOdf Protein, TNFSF11 Protein, Ly109l Protein, OPG Protein, Trance Protein, cd254 Protein, odf Protein, opgl Protein, optb2 Protein, rankl Protein, sodf Protein, tnfsf11 Protein, trance Protein, TNF superfamily member 11 Protein, tumor necrosis factor (ligand) superfamily, member 11 Protein, TNF receptor superfamily member 11b Protein, TNF superfamily member 11 L homeolog Protein, TNFSF11 Protein, Tnfsf11 Protein, TNFRSF11B Protein, tnfsf11.L Protein
- Background
- RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.
- Molecular Weight
- ~55kDa (SDS-PAGE)
- UniProt
- O35235
- Pathways
- NF-kappaB Signaling
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