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anti-Human Tumor Necrosis Factor Antibodies:
anti-Mouse (Murine) Tumor Necrosis Factor Antibodies:
anti-Rat (Rattus) Tumor Necrosis Factor Antibodies:
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Mouse (Murine) Polyclonal Tumor Necrosis Factor Primary Antibody for ELISA, IHC (p) - ABIN3042817
Zhang, Liu, Goldstein, Li, Ge, He, Fei, Wang, Ruiz: Role of the JAK/STAT signaling pathway in the pathogenesis of acute myocardial infarction in rats and its effect on NF-?B expression. in Molecular medicine reports 2013
Show all 30 Pubmed References
Mouse (Murine) Polyclonal Tumor Necrosis Factor Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900489
Ramkhelawon, Hennessy, Ménager, Ray, Sheedy, Hutchison, Wanschel, Oldebeken, Geoffrion, Spiro, Miller, McPherson, Rayner, Moore: Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. in Nature medicine 2014
Show all 45 Pubmed References
Mouse (Murine) Polyclonal Tumor Necrosis Factor Primary Antibody for WB - ABIN3043313
Liu, Shan, Dong, Liu, Ma, Liu: Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. in World journal of gastroenterology 2013
Show all 38 Pubmed References
Rat (Rattus) Polyclonal Tumor Necrosis Factor Primary Antibody for WB - ABIN3042522
Qin, Ma, Yang, Hu, Zhou, Fu, Tian, Liu, Xu, Shen: A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes. in Natural products and bioprospecting 2015
Show all 38 Pubmed References
Human Monoclonal Tumor Necrosis Factor Primary Antibody for - ABIN1383955
Hervé, Racadot, Wijdenes, Flesch, Tiberghien, Bordigoni, Holler, Powles, Bourdeau, Wilmer: Monoclonal anti TNF alpha antibody in the treatment of acute GvHD refractory both to corticosteroids and anti IL-2 R antibody. in Bone marrow transplantation 1991
Show all 15 Pubmed References
Human Polyclonal Tumor Necrosis Factor Primary Antibody for ICC, IF - ABIN446837
Kwon, Jung, Hwang, Choi: Evaluation of Bronchiolar and Alveolar Cell Injuries Induced by Short- and Long-term Exposure to Sidestream Smoke. in Korean journal of pathology 2012
Show all 11 Pubmed References
Human Polyclonal Tumor Necrosis Factor Primary Antibody for IF (p), IHC (p) - ABIN677318
Morishita, Oku, Horie, Tonari, Kida, Okubo, Sugiyama, Takai, Hara, Ikeda: Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-?B activation. in PLoS ONE 2014
Show all 10 Pubmed References
Human Polyclonal Tumor Necrosis Factor Primary Antibody for IHC (p), IHC - ABIN153474
Roth, Städler, Lemann, Hösli, Simon, Simon: Distinct eosinophil cytokine expression patterns in skin diseases - the possible existence of functionally different eosinophil subpopulations. in Allergy 2011
Show all 9 Pubmed References
Human Monoclonal Tumor Necrosis Factor Primary Antibody for FACS - ABIN4898910
Glässner, Eisenhardt, Krämer, Körner, Coenen, Sauerbruch, Spengler, Nattermann: NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. in Laboratory investigation; a journal of technical methods and pathology 2012
Show all 7 Pubmed References
Human Monoclonal Tumor Necrosis Factor Primary Antibody for Func, ELISA - ABIN1690734
Cesaro-Tadic, Dernick, Juncker, Buurman, Kropshofer, Michel, Fattinger, Delamarche: High-sensitivity miniaturized immunoassays for tumor necrosis factor alpha using microfluidic systems. in Lab on a chip 2004
Show all 6 Pubmed References
Our findings demonstrate that TNF-alpha plays a pivotal role in HF-mediated neuroinflammation and associated alterations of cortical dendritic spine density and has the potential to reveal novel treatment strategies for HF-associated memory deficits.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Antibodies)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.
The expression of miR (show MYLIP Antibodies)-125b-1 regulated by NF-kappaB (show NFKB1 Antibodies) has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-kappaB (show NFKB1 Antibodies) in TNFalpha-stimulated HeLa and HepG2 cells
In the Han Chinese population, the allele 'A' of TNF-alpha -308 may increase the risk for osteoarthritis (OA), whereas TNF-alpha -238 polymorphisms do not play a role in OA patients.
Letter: serum TNF-alpha was not elevated in chronic spontaneous urticaria.
Metastatic cells can escape the proapoptotic effects of TNF-alpha through increased autocrine IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) signaling
The predicted 3D structures of IL-1beta (show IL1B Antibodies), TNF-alpha, and IL-8 (show IL8 Antibodies) from Oncorhynchus mykiss, Dicentrarchus labrax, and Chionodraco hamatus are reported and the differences between them and their mammalian counterparts investigated.
The mitochondrial dysfunction may be caused by increased brain levels of TNFalpha without physiological stress but will be exacerbated after middle cerebral artery occlusion.
TNF-alpha is released rapidly in trout macrophages after stimulation with lipopolysaccharide and zymosan, and its secretion is dependent on TACE (show ADAM17 Antibodies)-like activity that is regulated by ERK (show MAPK1 Antibodies), JNK (show MAPK8 Antibodies) and p38MAPK (show MAPK14 Antibodies) signaling pathways.
Recombinant, as well as native trout TNF-alpha, directly stimulates glucose uptake in trout muscle cells and provide evidence, for the first time in nonmammalian vertebrates, for a potential regulatory role of TNF-alpha in skeletal muscle metabolism.
Subjects carrying the GG genotype for the SNP rs1800629 at the TNFA gene show a greater activation of the proinflammatory status than A-allele carriers, which is related to ROS (show ROS1 Antibodies) formation. These ROS (show ROS1 Antibodies) could induce DNA damage especially in the telomeric sequence, by decreasing the telomere length and inducing cellular aging.
Study assessed the influence of TNF-alpha and IL-10 (show IL10 Antibodies) single nucleotide polymorphisms on the progression of HCV-induced chronic hepatitis to cirrhosis in HIV-coinfected patients; -238 TNF-alpha (rs361525) and IL-10 (show IL10 Antibodies) (rs1800872) assessed; in this cohort of Caucasian patients, TNF-alpha -238 polymorphism was involved in the risk of liver cirrhosis.
Our results suggest that TNF-alpha, IFN-gamma (show IFNG Antibodies) and TGF-beta (show TGFB1 Antibodies) function cooperatively to regulate the expressions of IL-6 (show IL6 Antibodies) and MMP-9 (show MMP9 Antibodies), and may play important roles in pathological behaviour of AMs (show MAT1A Antibodies), such as bone resorption.
this study shows that TNFalpha significantly augments IFNgamma production from IL-2 (show IL2 Antibodies)-/IL-12 (show IL12A Antibodies)-treated NK cells in vitro, an effect mimicked by a TNFR2 (show TNFRSF1B Antibodies) agonistic antibodies
the GA genotype of the TNF-alpha -308G>A polymorphism is a significant genetic risk factor for the pathogenesis of keratoconus (KC); this SNP was observed to be associated with deregulated expression of downstream molecules, t further reinforcing the role of the inflammatory pathway components in the development of KC
associations between the genetic variants and the LPS (show IRF6 Antibodies)-induced IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies), IL-10 (show IL10 Antibodies), IL-1ra (show IL1RN Antibodies) and TNF-alpha cytokine levels were not significant in the meta-analysis. This present study does not support a strong genetic effect of LPS (show IRF6 Antibodies)-stimulated cytokine production; however, the potential for type II errors should be considered
Carriers of -308 GG promoter variant of TNF-alpha gene have a better metabolic response than -308 GA obese with a high protein hypocaloric diet
the carriage of the TNFA-308 A/A and GA genotype may act as a marker of enhanced susceptibility to contact polysensitization
CUX-1 (show CUX1 Antibodies) overexpression enhanced TNF- production on sCD26 (show CDC26 Antibodies)/LPS (show IRF6 Antibodies) stimulation, while CUX-1 (show CUX1 Antibodies) depletion had no effect. Neither CUX-1 (show CUX1 Antibodies) overexpression nor CUX-1 (show CUX1 Antibodies) depletion had an effect on IL-6 (show IL6 Antibodies) stimulation. These results are discussed in the context of a model that describes the mechanisms by which stimulation of monocytic cells by sCD26 (show CDC26 Antibodies) and LPS (show IRF6 Antibodies) leads to elevation of TNF- and IL-6 (show IL6 Antibodies) expression.
first proteomic study to identify inflammation factors such as TNF-alpha involved in thoracic ossification of the ligamentum flavum (TOLF), which may contribute to a better understanding of the cause of TOLF
Increased basal transmission and plasticity of glutamate (show GRIN1 Antibodies) synapses that was related to increased levels of tumor necrosis factor alpha (TNFalpha).
Results showed that lncRNA SeT and miR (show MLXIP Antibodies)-155 mediate Tnfalpha gene dosage control by regulating the homologous pairing of the two gene alleles and ultimately regulating its biallelic pattern.
Internalized CpG oligodeoxynucleotide (ODN)-conjugated PPMs (PPM-CpG) greatly enhance the induction of selected cytokines (TNF-alpha and IL-6 (show IL6 Antibodies)) in RAW 264.7 cells compared to that by the soluble CpG ODN and ionic complexes.
Wnt10b (show WNT10B Antibodies) expression was assessed by flow cytometry under estrogen- and TNFalpha-deficient conditions
Tumor necrosis factor (TNF), a cell-extrinsic potent negative regulator of hematopoietic stem cells (HSCs), was overexpressed in bone marrow niche cells from FLT3 (show FLT3 Antibodies) internal tandem duplications (FLT3 (show FLT3 Antibodies) ITDs) mice.
conclude that TNF-alpha produced by B2 cells is a key mechanism by which B2 cells promote atherogenesis through augmenting macrophage TNF-alpha production to induce cell death and inflammation that promote plaque vulnerability
robust caspase (show CASP3 Antibodies) activation in NEMO (show IKBKG Antibodies)-deficient cells is concomitant with RIPK3 (show RIPK3 Antibodies) recruitment to the apoptosis-mediating complex.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 (show CD28 Antibodies) and the inflammatory cytokine TNF
MK2 (show KCNA2 Antibodies)-mediated phosphorylation of RIPK1 (show RIPK1 Antibodies) serves as a checkpoint within the TNF signaling pathway that integrates cell survival and cytokine production.
TLR4 (show TLR4 Antibodies) activates CASPASE-8 (show CASP8 Antibodies) to cleave and remove the deubiquitinase cylindromatosis (CYLD (show CYLD Antibodies)) in a TRIF (show RNF138 Antibodies)- and RIPK1 (show RIPK1 Antibodies)-dependent manner to disable necroptosis in macrophages.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (show PDCD4 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/ TNF-alpha pathway in cardiomyocytes.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (show OTX2 Antibodies) and essential retinal pigment epithelium genes.
TNF-alpha induced MMP-13 (show MMP13 Antibodies) expression by condylar cells might be involved in the degradation of the juvenile condyle.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (show MAMLD1 Antibodies) resistance.
Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (show IL1B Antibodies), IL-8 (show IL8 Antibodies) and TNF-alpha in porcine alveolar macrophages.
the role of miR (show MYLIP Antibodies)-181a in adipocyte differentiation by regulation of TNF-alpha
The NOS (show NOS Antibodies) inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.
High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.
Data suggest that luteolytic factors (such as TNFa, interferon gamma (show IFNG Antibodies), and PGF2a) control expression of MMP1 (show MMP1 Antibodies), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (show TNFRSF1B Antibodies) mRNA transcription in the embryo.
There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (show PTGES Antibodies)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (show FAS Antibodies) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
TNF-alpha up-regulates NaV1.7 (show SCN9A Antibodies) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (show NOS2 Antibodies) pathways in the regulation of this pathological condition.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
The results obtained showed that IL-6 (show IL6 Antibodies) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.
Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG (show IFNG Antibodies) and FASL (show FASL Antibodies) regulate nitric oxide activity, via eNOS (show NOS3 Antibodies) expression modulation.
These data show the presence of cytokines TNF and IFNG (show IFNG Antibodies), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Antibodies), IL-10 (show IL10 Antibodies) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.
Inflammatory factors such as TNF-alpha can stimulate MMP-2 (show MMP2 Antibodies)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.
The JNK (show MAPK8 Antibodies) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (show IL8 Antibodies) expression may be regulated by other signaling pathways.
The TNFalpha-evoked Cl- current.
IL-1beta (show IL1B Antibodies) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (show IL1B Antibodies) and TNF-alpha.
Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.
In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (show VEGFA Antibodies) and TNFalpha.
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (show TGFB1 Antibodies)) and TNF-alpha in lung of rabbits.
TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (show PLAT Antibodies) on the vascular compartment
These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (show CD4 Antibodies)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Primary role for IL-1beta (show IL1B Antibodies) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.
The results reveal a crucial role for TNFalpha/TNFR2 (show TNFRSF1B Antibodies) axis in the protection of the skin against DUOX1 (show DUOX1 Antibodies)-mediated oxidative stress.
TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.
The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.
TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
tumor necrosis factor (TNF superfamily, member 2)
, tumor necrosis factor alpha
, tumor necrosis factor
, tumour necrosis factor alpha
, putative tumour necrosis factor alpha
, LPS-induced TNF-alpha factor homolog
, TNF-alpha factor
, lipid-induced TNF-alpha factor
, lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
, small integral membrane protein of lysosome/late endosome
, tissue necrosis factor-alpha
, APC1 protein
, TNF, macrophage-derived
, TNF, monocyte-derived
, tumor necrosis factor ligand superfamily member 2
, tumor necrosis factor-alpha
, tumor-necrosis factor
, tumour necrosis factor
, ATP-binding cassette, sub-family F (GCN20), member 1
, TNF alpha
, tumor necrosis factor, alpha