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Browse our DLL3 Proteins (DLL3)

Full name:
delta Like Protein 3 Proteins (DLL3)
On are 11 delta Like Protein 3 (DLL3) Proteins from 3 different suppliers available. Additionally we are shipping DLL3 Antibodies (81) and DLL3 Kits (7) and many more products for this protein. A total of 103 DLL3 products are currently listed.
pu, pudgy, SCDO1
list all proteins Gene Name GeneID UniProt
DLL3 10683 Q9NYJ7
DLL3 13389 O88516
DLL3 114125 O88671

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DLL3 Proteins (DLL3) by Origin

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More Proteins for DLL3 Interaction Partners

Human delta Like Protein 3 (DLL3) interaction partners

  1. DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells.

  2. We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice.

  3. mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis

  4. no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis.

  5. The intracellular region of Notch (show NOTCH1 Proteins) ligands Dll1 (show DLL1 Proteins) and Dll3 regulates their trafficking and signaling activity

Mouse (Murine) delta Like Protein 3 (DLL3) interaction partners

  1. O-fucosylation of DLL3 is required for its function during somitogenesis.

  2. Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng (show LFNG Proteins) models of idiopathic scoliosis.

  3. Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch (show NOTCH1 Proteins).

  4. Dll3 targets Notch1 (show NOTCH1 Proteins) for lysosomal degradation preventing Notch1 (show NOTCH1 Proteins) from undergoing post-translational processing.

  5. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm.

  6. DLL3 knockout mice have segmentation and neural defects

  7. Notch (show NOTCH1 Proteins) ligands, including Delta-like1 and 3 and Jagged1 (show JAG1 Proteins) and Jagged2 (show JAG2 Proteins), show distinct expression patterns in the developing and adult brain overlapping that of Notch1 (show NOTCH1 Proteins)

  8. Data describe the genetic interactions between Dll1 (show DLL1 Proteins), Dll3, Mesp2 (show Mesp2 Proteins) and Psen1 (show PSEN1 Proteins), and the roles of Dll1 (show DLL1 Proteins)- and Dll3-Notch (show NOTCH1 Proteins) pathways, with or without Psen1 (show PSEN1 Proteins), in rostrocaudal patterning.

  9. spondylocostal dysostosis (SCD (show SCD Proteins)) is caused by mutation in Delta-like (show DLK1 Proteins) 3 (DLL3), Mesoderm posterior 2 (MESP2 (show Mesp2 Proteins)), and Lunatic fringe (LFNG (show LFNG Proteins)); three genes that are components of the Notch (show NOTCH1 Proteins) signaling pathway.

  10. Data demonstrate distinct in vivo functions for DLL1 (show DLL1 Proteins) and DLL3, and suggest that DLL3 does not antagonize DLL1 (show DLL1 Proteins) in the presomitic mesoderm.

DLL3 Protein Profile

Protein Summary

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with DLL3

  • delta-like 3 (Drosophila) (DLL3)
  • delta-like 3 (Drosophila) (Dll3)
  • pu protein
  • pudgy protein
  • SCDO1 protein

Protein level used designations for delta Like Protein 3 Proteins (DLL3)

delta-like protein 3 , delta3 , drosophila Delta homolog 3 , M-Delta-3

10683 Homo sapiens
484508 Canis lupus familiaris
505993 Bos taurus
13389 Mus musculus
114125 Rattus norvegicus
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