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Mouse (Murine) NOTCH2 Protein expressed in CHO Cells - ABIN1344244
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
Findings indicate that niclosamide inhibits the progression of colon cancer by downregulating Notch1 (show NOTCH1 Proteins), Notch2 and Notch3 (show NOTCH3 Proteins) signaling and by upregulating the microRNA miR (show MLXIP Proteins)-200 family members (miR200a, miR (show MLXIP Proteins)-200b, miR (show MLXIP Proteins)-200c).
Notch2 may confer stemness properties in HCC (show FAM126A Proteins).
Macrophage notch1 (show NOTCH1 Proteins) may play a more important role than notch2 and notch 3 (show NOTCH3 Proteins) in the regulation of NF-kappaB (show NFKB1 Proteins) signaling pathway in atherosclerosis.
AGS (show JAG1 Proteins) is caused by mutations in one of two genes, namely, JAG1 (show JAG1 Proteins) or NOTCH2. These genes are part of the Notch (show NOTCH1 Proteins) signaling pathway, which is involved in cell fate determination. JAG1 (show JAG1 Proteins) mutations have been identified in 70-94% of individuals with clinically diagnosed AGS (show JAG1 Proteins)
This is supported by the depletion of CTCF (show CTCF Proteins) in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR (show MLXIP Proteins)-181c. CONCLUSION: Together, our results point to the epigenetic role of CTCF (show CTCF Proteins) in the regulation of microRNAs implicated in tumorigenesis
suggest that Notch2 has an essential role in the cell growth, invasion, and migration of SACC. Notch2 may therefore be a potential target gene for the treatment of SACC by interfering with cell growth and metastasis
Notch2 and Notch3 (show NOTCH3 Proteins) inhibited both cell proliferation and cell apoptosis in BeWo and JAR (show MYO6 Proteins) trophoblast cell lines.
A functional polymorphism in the premiR146a gene influences the prognosis of glioblastoma multiforme by interfering with the balance between Notch1 (show NOTCH1 Proteins) and Notch2
Results suggest that Notch2 pathway and miR (show MLXIP Proteins)-23b interplay in a reciprocal regulation loop in gastric cancer cells and this axis plays an important role in gastric carcinogenesis.
These findings suggested that the NOTCH2 signaling may confer aggressive behavior and immature morphology in human hepatocellular carcinoma cells.
In this study, authors use a smooth muscle-specific (show EIF3K Proteins) deletion of Notch2 together with a global Notch3 (show NOTCH3 Proteins) deletion to produce mice with combinations of mutant and wild-type Notch2/3 alleles in vascular smooth muscle cells
6955C-->T mutation in the Notch2 locus leading to cancellous and cortical bone osteopenia.
Data (including data from studies in transgenic/knockout mice) suggest deletion of Notch1 (show NOTCH1 Proteins) in podocytes prevents diabetic nephropathy development and up-regulates Notch2 expression; overexpression of Notch2 does not promote diabetic nephropathy.
Expression of Notch1 and Notch2 was decreased in regenerated epidermis of wounds, where features of keratinocytes were altered. Notch1 and Notch2 down-regulation contributed to the induction of interleukin-36alpha expression.
data indicate distinct effects of Notch (show NOTCH1 Proteins) signaling on invariant natural killer T cells in the thymus and liver, which are at least partly independent of RBP-j (show RBPJ Proteins) in the thymus.
Notch1 (show NOTCH1 Proteins) and Notch2 intracellular domains are functionally equivalent during development and carcinogenesis
NOTCH2 inhibits PDGF-B (show PDGFB Proteins)-dependent proliferation and its expression is decreased by PDGF-B (show PDGFB Proteins).
BTK (show BTK Proteins) synergizes with Notch2 to govern marginal zone B cells in non-obese diabetic mice.
Surface expression of NOTCH2 was seen in specified E11 (show PDPN Proteins) AGM (show IGFBP7 Proteins) (CD45 (show PTPRC Proteins)+VE-cadherin (show CDH5 Proteins)+) hematopoietic progenitors. NOTCH (show NOTCH1 Proteins) activation by Delta1 can increase long-term engrafting HSC (show FUT1 Proteins) numbers from these cells.
Notch1 (show NOTCH1 Proteins) is the primary receptor regulating intestinal stem cell function and Notch1 (show NOTCH1 Proteins) and Notch2 together regulate epithelial cell proliferation, cell fate determination, and post-injury regeneration
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 (show NOTCH1 Proteins) and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch (show NOTCH1 Proteins).
DeltaC/Notch1a and Notch2 signaling is responsible for a survival signal provided by xanthophores to melanophores.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
, neurogenic locus notch homolog protein 2-like
, Notch homolog 2
, neurogenic locus notch homolog protein 2
, Motch B
, Notch gene homolog 2
, notch gene homolog 2
, notch receptor protein 6