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Mouse (Murine) NOTCH2 Protein expressed in CHO Cells - ABIN1344244
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
miR (show MLXIP Proteins)-34a expression is silenced epigenetically by EZH2 (show EZH2 Proteins) and DNA methylation (show HELLS Proteins), which promotes cholangiocarcinoma cell growth through activation of the Notch (show NOTCH1 Proteins) pathway.
Human biliary atresia and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC (show DDC Proteins))-induced experimental cholestasis in mice are associated with increased expression of Notch2.
In conclusion, Notch (show NOTCH1 Proteins) siganling appears to be an important mediator of the liver inflammation by modulating hepatic IL-22 (show IL22 Proteins)-secreting NKp46 (show NCR1 Proteins)(+) innate lymphoid cells.
The data showed that the overexpression of miR (show MLXIP Proteins)-18a-5p could downregulate Notch2 expression and subsequently suppress endothelial-mesenchymal transition and cardiac fibrosis.
Major genomic mutation profiles in lacrimal gland adenoid cystic carcinoma (LGACC) were uncovered by exome-seq. Although preliminary in nature, the Notch (show NOTCH1 Proteins) pathway could be a potential therapeutic target for LGACC.
Data indicate that mRNA high expression level of Notch1 (show NOTCH1 Proteins) was associated with better overall survival (OS) for all NSCLC, hazard ratio (HR), better OS in adenocarcinoma (Ade), HR, as well as in squamous cell carcinoma (SCC (show CYP11A1 Proteins)), HR, and mRNA high expression levels of Notch2 and Notch3 (show NOTCH3 Proteins) were associated with worsen OS for all NSCLC, and mRNA high expression level of Notch4 (show NOTCH4 Proteins) was not found to be associated with to OS for all NSCLC.
Mutation in NOTCH2 gene is associated with nodal marginal zone lymphoma.
Transgenic mice harboring Notch2 mutation analogous to that in patients with Hajdu-Cheney syndrome (HCS (show HLCS Proteins)) are severely osteopenic because of enhanced bone resorption; this model has now been validated. Data from further studies in transgenic mice suggest that the HCS (show HLCS Proteins) mutation in osteoblasts, but not in osteoclasts, causes osteopenia in this model.
Intermittent compressive stress regulates Notch (show NOTCH1 Proteins) receptor and target gene expression via the TGF-beta (show TGFB1 Proteins) signaling pathway. Notch (show NOTCH1 Proteins) signaling participates in TGF-beta (show TGFB1 Proteins)-induced sclerostin (show SOST Proteins) expression in periodontal ligament cells.
The authors present novel structures of human ligands Jagged2 (show JAG2 Proteins) and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (show NOTCH1 Proteins) binding is likely to be critical in establishing the optimal context for Notch (show NOTCH1 Proteins) signalling.
this study shows that Notch (show NOTCH1 Proteins) signaling regulates basophils biological function, at least partially via the modulation of MAPK (show MAPK1 Proteins)
Postnatal development analysis revealed that in cilia-deficient corneal epithelial cells downregulation of the Notch (show NOTCH1 Proteins) pathway precedes cell proliferation defects.
these results show that ADAM10 (show ADAM10 Proteins)-Notch (show NOTCH1 Proteins) signaling in ovarian somatic cells governs the primordial follicle formation by controlling the development of ovarian pregranulosa cells.
Notch1 (show NOTCH1 Proteins) and Notch2 are the primary Notch (show NOTCH1 Proteins) receptors regulating epithelial cell homoeostasis in mouse and human stomach.
These results suggested that Notch2 signaling is linked to c-Myc (show MYC Proteins) expression and plays a key role in the regulation of MSC (show MSC Proteins) proliferation.
this study shows that Notch2 activity is required for the maintenance of lung tissue-resident memory CD103 (show ITGAE Proteins)+ T cells
In this study, authors use a smooth muscle-specific (show EIF3K Proteins) deletion of Notch2 together with a global Notch3 (show NOTCH3 Proteins) deletion to produce mice with combinations of mutant and wild-type Notch2/3 alleles in vascular smooth muscle cells
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 (show NOTCH1 Proteins) and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch (show NOTCH1 Proteins).
DeltaC/Notch1a and Notch2 signaling is responsible for a survival signal provided by xanthophores to melanophores.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
, neurogenic locus notch homolog protein 2-like
, Notch homolog 2
, neurogenic locus notch homolog protein 2
, Motch B
, Notch gene homolog 2
, notch gene homolog 2
, notch receptor protein 6