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Notch 2 Proteins (NOTCH2)
On www.antibodies-online.com are 12 Notch 2 (NOTCH2) Proteins from 5 different suppliers available. Additionally we are shipping NOTCH2 Antibodies (198) and NOTCH2 Kits (15) and many more products for this protein. A total of 234 NOTCH2 products are currently listed.
Synonyms:
AGS2, AI853703, HJCYS, hN2, N2, notch6, sb:cb884
list all proteins Gene Name GeneID UniProt
NOTCH2 4853 Q04721
NOTCH2 18129 O35516
Rat NOTCH2 NOTCH2 29492 Q9QW30

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NOTCH2 Proteins (NOTCH2) by Origin

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Top referenced NOTCH2 Proteins

  1. Mouse (Murine) NOTCH2 Protein expressed in CHO Cells - ABIN1344244 : Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Proteins for NOTCH2 Interaction Partners

Human Notch 2 (NOTCH2) interaction partners

  1. The data showed that the overexpression of miR (show MLXIP Proteins)-18a-5p could downregulate Notch2 expression and subsequently suppress endothelial-mesenchymal transition and cardiac fibrosis.

  2. Major genomic mutation profiles in lacrimal gland adenoid cystic carcinoma (LGACC) were uncovered by exome-seq. Although preliminary in nature, the Notch (show NOTCH1 Proteins) pathway could be a potential therapeutic target for LGACC.

  3. Data indicate that mRNA high expression level of Notch1 (show NOTCH1 Proteins) was associated with better overall survival (OS) for all NSCLC, hazard ratio (HR), better OS in adenocarcinoma (Ade), HR, as well as in squamous cell carcinoma (SCC (show CYP11A1 Proteins)), HR, and mRNA high expression levels of Notch2 and Notch3 (show NOTCH3 Proteins) were associated with worsen OS for all NSCLC, and mRNA high expression level of Notch4 (show NOTCH4 Proteins) was not found to be associated with to OS for all NSCLC.

  4. Mutation in NOTCH2 gene is associated with nodal marginal zone lymphoma.

  5. Transgenic mice harboring Notch2 mutation analogous to that in patients with Hajdu-Cheney syndrome (HCS (show HLCS Proteins)) are severely osteopenic because of enhanced bone resorption; this model has now been validated. Data from further studies in transgenic mice suggest that the HCS (show HLCS Proteins) mutation in osteoblasts, but not in osteoclasts, causes osteopenia in this model.

  6. Intermittent compressive stress regulates Notch (show NOTCH1 Proteins) receptor and target gene expression via the TGF-beta (show TGFB1 Proteins) signaling pathway. Notch (show NOTCH1 Proteins) signaling participates in TGF-beta (show TGFB1 Proteins)-induced sclerostin (show SOST Proteins) expression in periodontal ligament cells.

  7. The authors present novel structures of human ligands Jagged2 (show JAG2 Proteins) and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (show NOTCH1 Proteins) binding is likely to be critical in establishing the optimal context for Notch (show NOTCH1 Proteins) signalling.

  8. Notch1 (show NOTCH1 Proteins) and Notch2 are the primary Notch (show NOTCH1 Proteins) receptors regulating epithelial cell homoeostasis in mouse and human stomach.

  9. our results indicated epidermal growth factor (show EGF Proteins)-like domain multiple 7 protein participates in growth hormone (show GH1 Proteins)-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 (show DLL3 Proteins) signaling pathway. These findings raised the possibility that epidermal growth factor (show EGF Proteins)-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone (show GH1 Proteins)-secreting pituitary adenoma invasion and prognosis

  10. Mutations in NOTCH2 gene is associated with T-cell acute lymphoblastic leukemia.

Mouse (Murine) Notch 2 (NOTCH2) interaction partners

  1. The data showed that the overexpression of miR (show MLXIP Proteins)-18a-5p could downregulate Notch2 expression and subsequently suppress endothelial-mesenchymal transition and cardiac fibrosis.

  2. these results show that ADAM10 (show ADAM10 Proteins)-Notch (show NOTCH1 Proteins) signaling in ovarian somatic cells governs the primordial follicle formation by controlling the development of ovarian pregranulosa cells.

  3. Transgenic mice harboring Notch2 mutation analogous to that in patients with Hajdu-Cheney syndrome (HCS (show HLCS Proteins)) are severely osteopenic because of enhanced bone resorption; this model has now been validated. Data from further studies in transgenic mice suggest that the HCS (show HLCS Proteins) mutation in osteoblasts, but not in osteoclasts, causes osteopenia in this model.

  4. Notch1 (show NOTCH1 Proteins) and Notch2 are the primary Notch (show NOTCH1 Proteins) receptors regulating epithelial cell homoeostasis in mouse and human stomach.

  5. These results suggested that Notch2 signaling is linked to c-Myc (show MYC Proteins) expression and plays a key role in the regulation of MSC (show MSC Proteins) proliferation.

  6. this study shows that Notch2 activity is required for the maintenance of lung tissue-resident memory CD103 (show ITGAE Proteins)+ T cells

  7. In this study, authors use a smooth muscle-specific (show EIF3K Proteins) deletion of Notch2 together with a global Notch3 (show NOTCH3 Proteins) deletion to produce mice with combinations of mutant and wild-type Notch2/3 alleles in vascular smooth muscle cells

  8. 6955C-->T mutation in the Notch2 locus leading to cancellous and cortical bone osteopenia.

  9. Data (including data from studies in transgenic/knockout mice) suggest deletion of Notch1 (show NOTCH1 Proteins) in podocytes prevents diabetic nephropathy development and up-regulates Notch2 expression; overexpression of Notch2 does not promote diabetic nephropathy.

  10. Expression of Notch1 and Notch2 was decreased in regenerated epidermis of wounds, where features of keratinocytes were altered. Notch1 and Notch2 down-regulation contributed to the induction of interleukin-36alpha expression.

Cow (Bovine) Notch 2 (NOTCH2) interaction partners

  1. bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 (show NOTCH1 Proteins) and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch (show NOTCH1 Proteins).

Zebrafish Notch 2 (NOTCH2) interaction partners

  1. DeltaC/Notch1a and Notch2 signaling is responsible for a survival signal provided by xanthophores to melanophores.

NOTCH2 Protein Profile

Protein Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NOTCH2

  • notch 2 (NOTCH2)
  • notch 2 (notch2)
  • notch 2 (Notch2)
  • notch homolog 2 (notch2)
  • AGS2 protein
  • AI853703 protein
  • HJCYS protein
  • hN2 protein
  • N2 protein
  • notch6 protein
  • sb:cb884 protein

Protein level used designations for Notch 2 Proteins (NOTCH2)

notch 2 , neurogenic locus notch homolog protein 2-like , Notch homolog 2 , neurogenic locus notch homolog protein 2 , Motch B , Notch gene homolog 2 , notch gene homolog 2 , notch receptor protein 6

GENE ID SPECIES
581186 Strongylocentrotus purpuratus
100081510 Ornithorhynchus anatinus
100464781 Ailuropoda melanoleuca
100567900 Anolis carolinensis
100584613 Nomascus leucogenys
100224680 Taeniopygia guttata
4853 Homo sapiens
457173 Pan troglodytes
483148 Canis lupus familiaris
18129 Mus musculus
29492 Rattus norvegicus
100153369 Sus scrofa
513730 Bos taurus
58065 Danio rerio
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