NOTCH2 Protein (AA 26-530) (Fc Tag)
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- Target See all NOTCH2 Proteins
- NOTCH2 (Notch 2 (NOTCH2))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 26-530
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NOTCH2 protein is labelled with Fc Tag.
- Characteristics
- Human NOTCH2 Protein, Fc Tag (MALS verified)
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NOTCH2 Protein
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Notch 2 (NOTCH2) protein (His-Avi Tag,Biotin)
NOTCH2 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Notch 2 (NOTCH2) (AA 27-136) protein (GST tag)NOTCH2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Notch 2 (NOTCH2) protein (His tag)NOTCH2 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Notch 2 (NOTCH2) (AA 1699-2471) protein (His tag)Crystallography grade NOTCH2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Notch 2 (NOTCH2) (AA 1699-2470) protein (His tag)Crystallography grade NOTCH2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Notch 2 (NOTCH2) (AA 1666-2471) protein (rho-1D4 tag)Crystallography grade NOTCH2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Notch 2 (NOTCH2) (AA 1697-2471) protein (rho-1D4 tag)Crystallography grade NOTCH2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Notch 2 (NOTCH2) (AA 1666-2470) protein (rho-1D4 tag)Crystallography grade NOTCH2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Notch 2 (NOTCH2) (AA 1697-2470) protein (rho-1D4 tag)Crystallography grade NOTCH2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Application Notes
- MALS verified
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- NOTCH2 (Notch 2 (NOTCH2))
- Alternative Name
- NOTCH2 (NOTCH2 Products)
- Synonyms
- AGS2 Protein, HJCYS Protein, hN2 Protein, AI853703 Protein, N2 Protein, notch6 Protein, sb:cb884 Protein, neurogenic locus notch homolog protein 2 Protein, notch 2 Protein, notch 3 Protein, LOC581186 Protein, NOTCH2 Protein, notch3 Protein, Notch2 Protein, notch2 Protein
- Background
- Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .
- Molecular Weight
- 80.5 kDa
- Pathways
- Notch Signaling, Stem Cell Maintenance
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