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Notch 3 Proteins (NOTCH3)
On www.antibodies-online.com are 10 Notch 3 (NOTCH3) Proteins from 3 different suppliers available. Additionally we are shipping NOTCH3 Antibodies (206) and NOTCH3 Kits (9) and many more products for this protein. A total of 229 NOTCH3 products are currently listed.
Synonyms:
AW229011, CADASIL, CASIL, fa14b08, hpbk, IMF2, N3, notch5, wu:fa14b08
list all proteins Gene Name GeneID UniProt
NOTCH3 4854 Q9UM47
NOTCH3 18131 Q61982
Rat NOTCH3 NOTCH3 56761 Q9R172

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NOTCH3 Proteins (NOTCH3) by Origin

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More Proteins for NOTCH3 Interaction Partners

Human Notch 3 (NOTCH3) interaction partners

  1. Low Notch3 expression is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.

  2. High NOTCH3 expression is associated with basal breast cancer.

  3. in in silico gene expression analysis of human T-ALL samples we observed a significant correlation between Pin1 (show PIN1 Proteins) and Notch3 expression levels, which may further suggest a key role of the newly identified Notch3-Pin1 (show PIN1 Proteins) axis in T-cell Acute Lymphoblastic Leukemia (T-ALL) aggressiveness and progression. Thus, combined suppression of Pin1 (show PIN1 Proteins) and Notch3 proteins may be exploited as an additional target therapy for T-ALL

  4. Data indicate that mRNA high expression level of Notch1 (show NOTCH1 Proteins) was associated with better overall survival (OS) for all NSCLC, hazard ratio (HR), better OS in adenocarcinoma (Ade), HR, as well as in squamous cell carcinoma (SCC (show CYP11A1 Proteins)), HR, and mRNA high expression levels of Notch2 (show NOTCH2 Proteins) and Notch3 were associated with worsen OS for all NSCLC, and mRNA high expression level of Notch4 (show NOTCH4 Proteins) was not found to be associated with to OS for all NSCLC.

  5. MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3 pathway.

  6. Intermittent compressive stress regulates Notch (show NOTCH1 Proteins) receptor and target gene expression via the TGF-beta (show TGFB1 Proteins) signaling pathway. Notch (show NOTCH1 Proteins) signaling participates in TGF-beta (show TGFB1 Proteins)-induced sclerostin (show SOST Proteins) expression in periodontal ligament cells.

  7. Specific Notch3 and Jag1 (show JAG1 Proteins) subcellular localization patterns may provide clues for the behavior of the corresponding tumors and could potentially be applied in the clinic for Jag1 (show JAG1 Proteins) targeting in triple-negative breast cancer patients

  8. there is a cross-talk between Jagged1 (show JAG1 Proteins)/Notch3 and VEGF (show VEGFA Proteins) in TNBC angiogenesis. Jagged1 (show JAG1 Proteins)/Notch3 is expected to be an important signaling pathway for TNBC progression and a potential target for TNBC neovascularization therapy.

  9. Mutations in NOTCH3 gene is associated with T-cell acute lymphoblastic leukemia.

  10. Loss of Notch3 expression may be fundamental to the process of dedifferentiation that accompanies thyroid oncogenesis. Conversely, activation of Notch3 in thyroid cancer exerts an antiproliferative effect and restores elements of a differentiated phenotype

Mouse (Murine) Notch 3 (NOTCH3) interaction partners

  1. this study shows that Notch (show NOTCH1 Proteins) signaling regulates basophils biological function, at least partially via the modulation of MAPK (show MAPK1 Proteins)

  2. Knock-in mice with the R169C mutation (Notch3(R170C/R170C)) exhibited similar reductions in arterial lumen, and both TgNotch3(R169C) and Notch3(R170C/R170C) mice showed increased cerebral artery expression of Notch3 target genes.

  3. Notch3 is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 is attributable to its action on TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) signaling.

  4. Data indicate that Notch (show NOTCH1 Proteins) receptors Notch1 (show NOTCH1 Proteins) and Notch3 deficiency compromises pericyte function and contributes to vascular pathologies.

  5. In this study, authors use a smooth muscle-specific (show EIF3K Proteins) deletion of Notch2 (show NOTCH2 Proteins) together with a global Notch3 deletion to produce mice with combinations of mutant and wild-type Notch2 (show NOTCH2 Proteins)/3 alleles in vascular smooth muscle cells

  6. Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions.

  7. Mutant Notch3 accumulates in pericytes and causes progressive pericyte loss and BBB leakage in the cerebral cortex in CADASIL mouse model.

  8. Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4 (show NOTCH4 Proteins)-/- compared with wild-type and Notch3-/- mice.

  9. The mechanism of Oncostatin M (show OSM Proteins) on cardiac ischemia/reperfusion injury is partly mediated by the Notch3/Akt (show AKT1 Proteins) pathway.

  10. miR (show MLXIP Proteins)-7a regulates the differentiation of Muller glia through the suppression of Notch3 expression.

Zebrafish Notch 3 (NOTCH3) interaction partners

  1. The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC (show FUT1 Proteins)) emergence in a non-cell-autonomous manner.

  2. 90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b.

  3. Notch3 regulates oligodendrocyte precursor cells development and mbp (show MBP Proteins) gene expression in larvae, and maintains vascular integrity in adults.

  4. new role for Notch (show NOTCH1 Proteins) signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population

  5. Notch3 activity gates neural stem cell activation in the adult pallium.

  6. Cellular correlates of Notch (show NOTCH1 Proteins)-delta gene expression in the regenerating zebrafish retina.

  7. knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia

NOTCH3 Protein Profile

Protein Summary

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Alternative names and synonyms associated with NOTCH3

  • notch 3 (NOTCH3)
  • notch 3 (Notch3)
  • notch homolog 3 (notch3)
  • AW229011 protein
  • CADASIL protein
  • CASIL protein
  • fa14b08 protein
  • hpbk protein
  • IMF2 protein
  • N3 protein
  • notch5 protein
  • wu:fa14b08 protein

Protein level used designations for Notch 3 Proteins (NOTCH3)

Notch homolog 3 , neurogenic locus notch homolog protein 3 , Notch gene homolog 3

GENE ID SPECIES
4854 Homo sapiens
18131 Mus musculus
56761 Rattus norvegicus
58066 Danio rerio
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