NOTCH3 Protein (AA 40-467) (Fc Tag)

Catalog No. ABIN6992329

This Recombinant NOTCH3 protein is expressed in HEK-293 Cells.

Quick Overview for NOTCH3 Protein (AA 40-467) (Fc Tag) (ABIN6992329)

Target: NOTCH3 (Notch 3 (NOTCH3))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 40-467

Purification tag / Conjugate: This NOTCH3 protein is labelled with Fc Tag.

Purpose: Human NOTCH3 Protein, Fc Tag

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Storage: -20 °C

Target Details

Target: NOTCH3 (Notch 3 (NOTCH3))

Alternative Name: NOTCH3

Background: Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Molecular Weight: 71.4 kDa

NCBI Accession: NP_000426

Pathways: Notch Signaling