NOTCH3 Protein (AA 40-467) (Fc Tag)
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- Target See all NOTCH3 Proteins
- NOTCH3 (Notch 3 (NOTCH3))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 40-467
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NOTCH3 protein is labelled with Fc Tag.
- Purpose
- Human NOTCH3 Protein, Fc Tag
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NOTCH3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
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- Target
- NOTCH3 (Notch 3 (NOTCH3))
- Alternative Name
- NOTCH3 (NOTCH3 Products)
- Synonyms
- CADASIL Protein, CASIL Protein, IMF2 Protein, AW229011 Protein, N3 Protein, hpbk Protein, fa14b08 Protein, notch5 Protein, wu:fa14b08 Protein, notch 3 Protein, NOTCH3 Protein, Notch3 Protein, notch3 Protein
- Background
- Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs
- Molecular Weight
- 71.4 kDa
- NCBI Accession
- NP_000426
- Pathways
- Notch Signaling
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