Browse our Presenilin 1 Proteins (PSEN1)

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Presenilin 1 Proteins (PSEN1)
On are 12 Presenilin 1 (PSEN1) Proteins from 4 different suppliers available. Additionally we are shipping Presenilin 1 Antibodies (267) and Presenilin 1 Kits (33) and many more products for this protein. A total of 329 Presenilin 1 products are currently listed.
AD3, Ad3h, FAD, pre1, PS-1, PS1, psen, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1
list all proteins Gene Name GeneID UniProt
PSEN1 5663 P49768
PSEN1 19164 P49769
Rat PSEN1 PSEN1 29192 P97887

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Presenilin 1 Proteins (PSEN1) by Origin

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More Proteins for Presenilin 1 Interaction Partners

Zebrafish Presenilin 1 (PSEN1) interaction partners

  1. Using an antisense morpholino oligonucleotide, study blocked induction of PS1IV isoform that normally occurs under hypoxia,identified gene regulatory networks that are modulated by PS1IV: observed changes in expression of genes controlling inflammation, vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation

  2. We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish

  3. These results suggest that Psen2 (show PSEN2 Proteins) plays a more prominent role in Notch (show NOTCH1 Proteins) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 (show PSEN2 Proteins) can be ameliorated by Psen1 loss.

Human Presenilin 1 (PSEN1) interaction partners

  1. APP (show APP Proteins) + PS1 double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP (show APP Proteins) rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP (show APP Proteins) + PS1 rats showed brain pathology as well as reduced memory retention compared to the APP (show APP Proteins) and the ...

  2. gamma-Secretase is a multimeric membrane protease involved in processing of the amyloid precursor protein (show APP Proteins) with high clinical relevance as mutations in its catalytic subunit (Presenilin) cause early-onset Alzheimer's disease

  3. Using purified PSEN1/Aph1A gamma-secretase and the APPC99-3XFLAG substrate, authors show that substrate shortening progressively destabilizes the consecutive enzyme-substrate complexes that characterize the sequential gamma-secretase processing of APP (show APP Proteins); present a unifying model for how PSEN or APP (show APP Proteins) mutations enhance amyloidogenic Abeta (show APP Proteins) production, suggests that environmental factors may increase Alzheimer's Disease risk.

  4. Findings do not provide significant support for presenilin 1 (PSEN1) E318G as a risk factor for Alzheimer's disease (AD) in apolipoprotein E4 (APOEepsilon4) carriers.

  5. Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b), presenilin 2 (PS2 (show PSEN2 Proteins))/Aph1aL, PS2 (show PSEN2 Proteins)/Aph1aS and PS2 (show PSEN2 Proteins)/anterior pharynx defective 1 homolog B (Aph1b) gamma-secretase produced amyloid beta peptide (Abeta (show APP Proteins)) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  6. PSEN1 mutations are associated with specific AD phenotype.

  7. association of PS1 carboxyl peptide (residues 445-467, HL9 (show LILRB3 Proteins)) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 and F252 from DREAM.

  8. This review reveled that Mutations in APP (show APP Proteins) and PS-1 and PS-2 (show PSEN2 Proteins) genes that are associated with early-onset, autosomal, dominantly inherited AD

  9. Mice overexpressing the Swedish (K594M/N595L) mutation of human APP (show APP Proteins) together with PS1 deleted in exon 9 were used in this study which traces age- and brain region-specific changes of glucose metabolic disorder, learning, and memory dysfunction in early Alzheimer's Disease using 18)F-labed fluorodeoxyglucose ((18)F-FDG (show SMUG1 Proteins)) microPET.

  10. Three early-onset Alzheimer's disease (EOAD) causative genes (APP (show APP Proteins), PSEN1, and PSEN2 (show PSEN2 Proteins)) were discovered in Asian countries. Most of the EOAD-associated mutations have been detected in PSEN1, and several novel PSEN1 mutations were recently identified in patients from various parts of the world, including Asia.[review]

Mouse (Murine) Presenilin 1 (PSEN1) interaction partners

  1. Study shows that the binding of HSF-1 (show HSF1 Proteins), Cdx1 (show CDX1 Proteins), Ets-1 (show ETS1 Proteins) and Sp1 (show SP1 Proteins) to Presenilin 1 promoter and that of Nkx2.2 (show Nkx2-2 Proteins), HFH-2 (show FOXD3 Proteins), Cdx1 (show CDX1 Proteins) and NF-kappaB (show NFKB1 Proteins) to Presenilin 2 (show PSEN2 Proteins) promoter regulate their differential expression during brain development.

  2. conclusion that the PSEN1 mutations are extreme examples of the previously proposed ''dysfunction'' of gamma-secretase that characterizes familial Alzheimer's disease

  3. PS1 expression is triggered by glutamate (show GRIN1 Proteins) through p38alpha (show MAPK14 Proteins), contributing to the excitotoxic stimulus of EW

  4. amino acid sensing of mechanistic target of rapamycin (show FRAP1 Proteins) complex 1 (mTORC1) is dysregulated in cells deficient in presenilin.

  5. the G206D mutation reduced presenilin-1-presenilin enhancer 2 (show PSENEN Proteins) interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis

  6. This study deals with the effect of attenuated endoproteolysis of PS1 on store-operated calcium (SOC (show UBXN11 Proteins)) entry in neuronal cells and mouse fibroblasts with double knockouts of PS1 and PS2 (show PDCD6 Proteins)

  7. Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 and PS2 (show PDCD6 Proteins) during cerebral cortical development

  8. lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP (show APP Proteins)/PS1 mice

  9. PS1 deficiency depletes vATPase (show ATP6V1H Proteins), impairing lysosomal acidification and calcium homeostasis.

  10. Abeta (show APP Proteins) oligomers in the cerebrospinal fluid (CSF (show CSF2 Proteins)) further promoted the expression of APH-1alpha/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP (show APP Proteins) and Abeta (show APP Proteins) deposition during AD progression

Pig (Porcine) Presenilin 1 (PSEN1) interaction partners

  1. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Proteins) and PSEN1 genes via a STAT3 (show STAT3 Proteins)-dependent pathway

Cow (Bovine) Presenilin 1 (PSEN1) interaction partners

  1. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1 (show FLT1 Proteins)

Presenilin 1 (PSEN1) Protein Profile

Protein Summary

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Alternative names and synonyms associated with Presenilin 1 (PSEN1)

  • presenilin 1 (psen1)
  • presenilin 1 (PSEN1)
  • presenilin 1 (Psen1)
  • AD3 protein
  • Ad3h protein
  • FAD protein
  • pre1 protein
  • PS-1 protein
  • PS1 protein
  • psen protein
  • S182 protein
  • X-PS-alpha protein
  • X-PS-beta protein
  • zf-PS1 protein
  • zfPS1 protein

Protein level used designations for Presenilin 1 Proteins (PSEN1)

PS-1 , presenilin-1 , presenilin 1 (Alzheimer disease 3) , presenilin-1 isoform I-463 , presenilin-1 isoform I-467 , presenilin 1 , presenilin-1-like , PS-alpha , presenilin alpha , presenilin-alpha

30221 Danio rerio
394924 Xenopus (Silurana) tropicalis
739740 Pan troglodytes
100173083 Pongo abelii
696274 Macaca mulatta
100401034 Callithrix jacchus
100586383 Nomascus leucogenys
5663 Homo sapiens
19164 Mus musculus
29192 Rattus norvegicus
373977 Gallus gallus
403408 Canis lupus familiaris
780411 Sus scrofa
282705 Bos taurus
100008886 Oryctolagus cuniculus
399258 Xenopus laevis
100728153 Cavia porcellus
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