Browse our Presenilin 2 Proteins (PSEN2)

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Presenilin 2 (Alzheimer Disease 4) Proteins (PSEN2)
On are 6 Presenilin 2 (Alzheimer Disease 4) (PSEN2) Proteins from 3 different suppliers available. Additionally we are shipping Presenilin 2 Antibodies (142) and Presenilin 2 Kits (31) and many more products for this protein. A total of 184 Presenilin 2 products are currently listed.
AD3L, AD4, Ad4h, ALG-3, Alg3, CMD1V, pre2, PS-2, PS2, PSEN2, PSNL2, STM2, zf-PS2
list all proteins Gene Name GeneID UniProt
PSEN2 81751 O88777
PSEN2 19165 Q61144
PSEN2 5664 P49810

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Presenilin 2 Proteins (PSEN2) by Origin

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More Proteins for Presenilin 2 Interaction Partners

Mouse (Murine) Presenilin 2 (Alzheimer Disease 4) (PSEN2) interaction partners

  1. Study shows that the binding of HSF-1 (show HSF1 Proteins), Cdx1 (show CDX1 Proteins), Ets-1 (show ETS1 Proteins) and Sp1 (show SP1 Proteins) to Presenilin 1 (show PSEN1 Proteins) promoter and that of Nkx2.2 (show Nkx2-2 Proteins), HFH-2 (show FOXD3 Proteins), Cdx1 (show CDX1 Proteins) and NF-kappaB (show NFKB1 Proteins) to Presenilin 2 promoter regulate their differential expression during brain development.

  2. ARF4 (show ARF4 Proteins) is required for Presenilin basal body localization, Notch (show NOTCH1 Proteins) signaling, and subsequent epidermal differentiation.

  3. Results suggest that mutation of PS2 (show PDCD6 Proteins) can lead to NF-kappaB (show NFKB1 Proteins) mediate amyloidogensis, and this effect can be amplified by the absence of estrogen.

  4. Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 (show PSEN1 Proteins) and PS2 (show PDCD6 Proteins) during cerebral cortical development

  5. This study presents novel evidence for the differential expression of PS proteins in a nongenetic model for aging, resulting in an overall increase of the PS2 (show PDCD6 Proteins) to PS1 (show PSEN1 Proteins) ratio.

  6. The loss of PS2 (show PDCD6 Proteins) could have a critical role in lung tumor development through the upregulation of iPLA2 (show PLA2G6 Proteins) activity by reducing gamma-secretase.

  7. One mechanism by which PS2 (show PDCD6 Proteins) works to reign in proinflammatory microglial behavior and PS2 (show PDCD6 Proteins) dysfunction or deficiency could result in unchecked proinflammatory activation. contributing to neurodegeneration.

  8. At the transcriptional level, Psen1/2 removal induced cyclic AMP response element-binding protein (CREB)/CREB-binding protein binding.

  9. Upregulation of PS1 (show PSEN1 Proteins)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.

  10. mechanism by which PS regulates synaptic function and calcium homeostasis using acute hippocampal slices from PS1 (show PSEN1 Proteins) and PS2 (show PDCD6 Proteins) conditional knockouts and primary cultured postnatal hippocampal neurons

Zebrafish Presenilin 2 (Alzheimer Disease 4) (PSEN2) interaction partners

  1. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation.

  2. These results suggest that Psen2 plays a more prominent role in Notch (show NOTCH1 Proteins) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 can be ameliorated by Psen1 (show PSEN1 Proteins) loss.

Human Presenilin 2 (Alzheimer Disease 4) (PSEN2) interaction partners

  1. Data show that presenilin 1 (PS1 (show PSEN1 Proteins))/anterior-pharynx-defective protein 1 (Aph1b), presenilin 2 (PS2)/Aph1aL, PS2/Aph1aS and PS2/anterior pharynx defective 1 homolog B (Aph1b) gamma-secretase produced amyloid beta peptide (Abeta (show APP Proteins)) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  2. This review reveled that Mutations in APP (show APP Proteins) and PS-1 (show PSEN1 Proteins) and PS-2 genes that are associated with early-onset, autosomal, dominantly inherited AD.

  3. Most of the early-onset Alzheimer's disease -associated mutations have been detected in PSEN1 (show PSEN1 Proteins), and several novel PSEN1 (show PSEN1 Proteins) mutations were recently identified in patients from various parts of the world, including Asia. Until 2014, no PSEN2 mutations were found in Asian patients; however, emerging studies from Korea and the People's Republic of China discovered probably pathogenic PSEN2 mutations. [review]

  4. Familial Alzheimer's disease Patients with PSEN2 mutations have a delayed AOO with longest disease duration and presented more frequently with disorientation. [review]

  5. Study identified a unique motif in PSEN2 that directs gamma-secretase to late endosomes/lysosomes via a phosphorylation-dependent interaction with the AP-1 (show FOSB Proteins) adaptor complex. PSEN2 selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular Abeta (show APP Proteins) that contains longer Abeta (show APP Proteins); familial Alzheimer's disease-associated mutations in PSEN2 increased the levels of longer Ab...

  6. Data show that presenilin 1 (PS1 (show PSEN1 Proteins))-containing gamma-secretase complexes were targeted to the plasma membrane, whereas presenilin 2 (PS2)-containing ones were addressed to the trans-Golgi network, to recycling endosomes.

  7. German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants.

  8. This study identified variants in PSEN2 across a range of phenotypes (Alzheimer's Disease , Alzheimer's Disease and cerebrovascular disease,frontotemporal dementia and progressive supranuclear palsy.

  9. Its mutations of PSEN2 account for pathogenicity of early-onset familial Alzheimer's disease.

  10. PSEN2 mutations appeared not only in Alzheimer's Disease patients but also in patients with other disorders, including frontotemporal dementia, dementia with Lewy bodies, breast cancer, dilated cardiomyopathy, and Parkinson's disease with dementia

Presenilin 2 (PSEN2) Protein Profile

Protein Summary

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Alternative names and synonyms associated with Presenilin 2 (PSEN2)

  • presenilin 2 (Alzheimer disease 4) (PSEN2)
  • presenilin 2 (Alzheimer disease 4) (psen2)
  • presenilin 2 (Psen2)
  • presenilin 2 (psen2)
  • presenilin-2-like (LOC100717114)
  • AD3L protein
  • AD4 protein
  • Ad4h protein
  • ALG-3 protein
  • Alg3 protein
  • CMD1V protein
  • pre2 protein
  • PS-2 protein
  • PS2 protein
  • PSEN2 protein
  • PSNL2 protein
  • STM2 protein
  • zf-PS2 protein

Protein level used designations for PSEN2

presenilin 2 (Alzheimer disease 4) , presenilin-2 , PS-2 , AD3LP , AD5 , E5-1 , STM-2 , PS-beta , presenilin beta , presenilin-beta

457790 Pan troglodytes
549935 Xenopus (Silurana) tropicalis
698770 Macaca mulatta
100596029 Nomascus leucogenys
81751 Rattus norvegicus
19165 Mus musculus
58026 Danio rerio
5664 Homo sapiens
397713 Xenopus laevis
374188 Gallus gallus
490382 Canis lupus familiaris
780410 Sus scrofa
282010 Bos taurus
100172138 Pongo abelii
100717114 Cavia porcellus
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