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anti-Mouse (Murine) PDX1 Antibodies:
anti-Rat (Rattus) PDX1 Antibodies:
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Human Monoclonal PDX1 Primary Antibody for BI, IF - ABIN967683
Babu, Deering, Mirmira: A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. in Molecular genetics and metabolism 2007
Show all 5 Pubmed References
Human Polyclonal PDX1 Primary Antibody for IF (cc), IHC (p) - ABIN729883
Hefei, Yu, Haiqing, Xiao, Jingyuan, Dongjun: Morphological Characteristics and Identification of Islet-like Cells Derived From Rat Adipose-derived Stem Cells Cocultured with Pancreas Adult Stem Cells. in Cell biology international 2014
Show all 3 Pubmed References
Mouse (Murine) Polyclonal PDX1 Primary Antibody for ChIP, IHC (p) - ABIN258270
Ahlgren, Jonsson, Jonsson, Simu, Edlund: beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. in Genes & development 1998
Show all 4 Pubmed References
Human Monoclonal PDX1 Primary Antibody for FACS - ABIN4897819
Vishwakarma, Rahamathulla, Bardia, Tiwari, Srinivas, Raj, Tripura, Sandhya, Habeeb, Khan, Pande, Reddy, Reddy: In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx-1, Ngn-3, Isl-1, Pax-4, Pax-6 and Nkx-6.1 in trans-differentiated human hepatic progenitors. in Journal of diabetes investigation 2014
Show all 2 Pubmed References
Human Monoclonal PDX1 Primary Antibody for FACS, ELISA - ABIN969554
Mitnala, Pondugala, Guduru, Rabella, Thiyyari, Chivukula, Boddupalli, Hardikar, Reddy: Reduced expression of PDX-1 is associated with decreased beta cell function in chronic pancreatitis. in Pancreas 2010
Show all 2 Pubmed References
Human Monoclonal PDX1 Primary Antibody for IF, IHC - ABIN2452675
Pondugala, Sasikala, Guduru, Rebala, Nageshwar Reddy: Interferon-? Decreases Nuclear Localization of Pdx-1 and Triggers ?-Cell Dysfunction in Chronic Pancreatitis. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015
Human Monoclonal PDX1 Primary Antibody for FACS, ELISA - ABIN969553
Fernandez-Zapico, van Velkinburgh, Gutiérrez-Aguilar, Neve, Froguel, Urrutia, Stein: MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. in The Journal of biological chemistry 2009
Human Polyclonal PDX1 Primary Antibody for WB - ABIN1881463
Ma, Chen, Wang, Xia, Zhu, Liang, Gu, Qiao, Dai, Zou, Li, Zhang, Lan, Wong: Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer. in Carcinogenesis 2008
These results suggest that Oc1 (show ONECUT1 Antibodies) and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells.
Data suggest that Ad4BP (show NR5A1 Antibodies) plays role in regulation of intracellular NADPH (show FDXR Antibodies) concentration via transcription of Me1 (show ME1 Antibodies) and Mthfd2 (show MTHFD2 Antibodies) genes in adrenocortical cells. (Ad4BP (show NR5A1 Antibodies) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Antibodies); Me1 (show ME1 Antibodies) = malic enzyme 1 (show ME1 Antibodies); Mthfd2 (show MTHFD2 Antibodies) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
Data suggest that hepatocytes can be reprogrammed into insulin (show INS Antibodies)-producing cells in vivo by transfection of neurogenin-3 (show NEUROG3 Antibodies), Pdx1, and MafA (show MAFA Antibodies) genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA (show MAFA Antibodies) = v-maf (show MAF Antibodies) musculoaponeurotic fibrosarcoma oncogene (show RAB1A Antibodies) family, protein A (show GPR153 Antibodies))
PDX1 and ISL1 (show ISL1 Antibodies) regulation of insulin (show INS Antibodies) gene expression in pancreatic beta cells, was investigated.
WT1 (show WT1 Antibodies) is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (show SF1 Antibodies) expression. Without Wt1 (show WT1 Antibodies), the expression of Sf1 (show SF1 Antibodies) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
Creating the Pdx1(DeltaAREAII) state after cells entered an insulin (show INS Antibodies)-expressing stage led to immature and dysfunctional islet beta cells carrying abnormal chromatin marking in vital beta-cell-associated genes. Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and beta-cell-specific Pdx1 functions.
The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed us to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP(+) population for downstream applications.
Our data suggested that lipid accumulation in the Leydig cells of the 46,XY disorders of sex development phenotype with a steroidogenic factor 1 (show NR5A1 Antibodies) mutation is due, at least in part, to the suppression of steroidogenic acute regulatory protein (show STAR Antibodies) and CYP11A1 (show CYP11A1 Antibodies), and a resulting increase in unmetabolized cholesterol.
Upon neoplastic transformation, the role of PDX1 changes from tumor-suppressive to oncogenic
PDX1 role in beta-cell function and diabetes
Efficiency of differentiation of Induced pluripotent stem cells to insulin (show INS Antibodies) producing cells can be increased by concurrent expression of PDX1 and NKX6.1 (show NKX6-1 Antibodies) during progenitor cells maturation.
Mutation in PDX1 gene is associated with Maturity Onset Diabetes of the Young.
Results found that Pdx-1 overexpression exerts its effects on islet cell replication via a noncell-autonomous mechanism involving induction of a secreted soluble factor or factors. Also, Inhbb (show INHBB Antibodies) is identified as one factor mediating the proliferative effect of Pdx-1.
Our findings indicate that MET induces the differentiation of Pdx1-expressing cells within the definitive endoderm in a time-dependent manner, and suggest useful application for regenerative medicine.
Pdx1 and MafA (show KLRG1 Antibodies) play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 and MafA (show KLRG1 Antibodies) were significantly upregulated after a sleeve gastrectomy for morbid obesity.
Data show that the expression patterns of sex determining region Y-box 2 (SOX2 (show SOX2 Antibodies)) and pancreatic and duodenal homeobox 1 (Pdx1)) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).
The ERK (show EPHB2 Antibodies)-PDX-1 interaction in PANC-1 cells.
Foxo1 (show FOXO1 Antibodies) and PDX1 are colocalized in fetal pancreatic islets, suggesting they function in parallel in beta cells.
This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet beta cells.
the human Pdx1 is highly effective in triggering human biliary tree stem cells differentiation toward functional beta-pancreatic cells.
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment
A pdx1-dependent progenitor population essential for the formation of duct-associated, second wave endocrine cells, is demonstrated.
Pdx-1 plays multiple roles in maintaining the phenotype of the islet during embryogenesis.
Report pancreatic expression of Pdx-1 in pancreas.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
pancreatic and duodenal homeobox 1
, pancreas/duodenum homeobox protein 1
, adrenal 4-binding protein
, embryonal LTR-binding protein
, embryonal long terminal repeat-binding protein
, fushi tarazu 1 factor homolog
, fushi tarazu factor homolog 1
, steroid hormone receptor Ad4BP
, steroid hydroxylase positive regulator
, steroidogenic factor 1
, glucose-sensitive factor
, insulin promoter factor 1, homeodomain transcription factor
, insulin upstream factor 1
, islet/duodenum homeobox-1
, pancreatic-duodenal homeobox factor 1
, somatostatin transcription factor 1
, somatostatin-transactivating factor 1
, pancreatic and duodenum homeobox 1
, pancreatic duodenal homeobox gene 1
, islet/duodenum homeobox 1
, pancreatic and duodenal homeobox gene 1
, Insulin promoter factor 1
, insulin promotor factor 1
, somatostatin transactivating factor 1
, homeodomain protein PDX1
, homeodomain protein PDX-1
, Homeobox protein 8
, XlHbox 8 protein