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Browse our anti-BBC3 (BBC3) Antibodies

Full name:
anti-BCL2 Binding Component 3 Antibodies (BBC3)
On www.antibodies-online.com are 284 BCL2 Binding Component 3 (BBC3) Antibodies from 29 different suppliers available. Additionally we are shipping BBC3 Kits (16) and BBC3 Proteins (9) and many more products for this protein. A total of 328 BBC3 products are currently listed.
Synonyms:
BBC3, JFY-1, JFY1, PUMA, PUMA/JFY1

Most Popular Reactivities for anti-BBC3 (BBC3) Antibodies

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anti-Rat (Rattus) BBC3 Antibodies:

anti-Human BBC3 Antibodies:

anti-Mouse (Murine) BBC3 Antibodies:

All available anti-BBC3 Antibodies

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Top referenced anti-BBC3 Antibodies

  1. Human Polyclonal BBC3 Primary Antibody for EIA, IF - ABIN401380 : Yu, Zhang, Hwang, Kinzler, Vogelstein: PUMA induces the rapid apoptosis of colorectal cancer cells. in Molecular cell 2001 (PubMed)
    Show all 3 references for ABIN401380

  2. Human Polyclonal BBC3 Primary Antibody for EIA, IF - ABIN500559 : Nakano, Vousden: PUMA, a novel proapoptotic gene, is induced by p53. in Molecular cell 2001 (PubMed)
    Show all 3 references for ABIN500559

  3. Human Polyclonal BBC3 Primary Antibody for ICC, IF - ABIN361748 : Han, Flemington, Houghton, Gu, Zambetti, Lutz, Zhu, Chittenden: Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 3 references for ABIN361748

  4. Human Polyclonal BBC3 Primary Antibody for EIA, FACS - ABIN356830 : Hoque, Begum, Sommer, Lee, Trink, Ratovitski, Sidransky: PUMA in head and neck cancer. in Cancer letters 2003 (PubMed)
    Show all 3 references for ABIN356830

  5. Human Polyclonal BBC3 Primary Antibody for EIA, WB - ABIN569626 : Qiu, Leibowitz, Zhang, Yu: Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. in Oncogene 2010 (PubMed)

  6. Human Polyclonal BBC3 Primary Antibody for IF (p), IHC (p) - ABIN731528 : Zhang, Liu, Xia, Zhang, Zhang, Zhao, Chao, Jiang, Jiang: Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. in International journal of molecular medicine 2013 (PubMed)

  7. Human Polyclonal BBC3 Primary Antibody for IHC (p), WB - ABIN658021 : Liu, Newland, Jia: Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. in Biochemical and biophysical research communications 2003 (PubMed)

  8. Human Polyclonal BBC3 Primary Antibody for FACS, IF - ABIN388112 : Vesela, Matalova: Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2015 (PubMed)

More Antibodies against BBC3 Interaction Partners

Human BCL2 Binding Component 3 (BBC3) interaction partners

  1. p53 (show TP53 Antibodies)/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis

  2. Suggest that the accumulation of PUMA in the cytosol may be important for the participation of this protein in apoptosis without the need for prior transcription in Burkitt's lymphoma b cells.

  3. in vitro OGT (show OGT Antibodies) knockdown induced more cell apoptosis through increasing PUMA and caspase-3 (show CASP3 Antibodies) expression

  4. our data purport that p53 (show TP53 Antibodies) not only increased Puma expression directly, but that it may also do so through miR (show MLXIP Antibodies)-203. Additionally, functional studies revealed that miR (show MLXIP Antibodies)-203 overexpression induced apoptosis and inhibited cell invasiveness.

  5. the selective degradation of BBC3 underlies the prosurvival role of chaperone-mediated autophagy.

  6. puma-mediated apoptosis is not induced in mucosal melanomas by cisplatin

  7. There-fore, stable transfection of PUMA can significantly enhance epirubicin-induced apoptosis sensitivity of MCF-7 breast cancer cells.

  8. inhibition of AKT (show AKT1 Antibodies)/FoxO3a (show FOXO3 Antibodies) signaling may contribute to H1-mediated PUMA induction, suggesting that inhibition of AKT (show AKT1 Antibodies)/FoxO3a (show FOXO3 Antibodies) signaling result in PUMA expression in response to p53 (show TP53 Antibodies)-independent cytotoxic effects of H1.

  9. Beta-arrestin 2 (show ARRB2 Antibodies) promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis.

  10. Puma is the major mediator of virus-induced Bax (show BAX Antibodies)/Bak (show BAK1 Antibodies) activation and mitochondrial membrane permeabilization induction.

Mouse (Murine) BCL2 Binding Component 3 (BBC3) interaction partners

  1. Bim (show BCL2L11 Antibodies) and Puma overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.

  2. Beta-arrestin 2 (show ARRB2 Antibodies) promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis.

  3. Puma is the major mediator of virus-induced Bax (show BAX Antibodies)/Bak (show BAK1 Antibodies) activation and mitochondrial membrane permeabilization induction.

  4. Oxidative stress increases PUMA expression regulated by FoxO1 (show FOXO1 Antibodies) in follicular granulosa cells.

  5. Results indicate that PUMA is involved in the apoptosis of cerebral astrocytes upon ischemia/reperfusion injury

  6. by preventing the consumption of IL-15 (show IL15 Antibodies), Bim (show BCL2L11 Antibodies) limits the role of Noxa (show PMAIP1 Antibodies) and Puma in causing the death of effector cells with less memory potential.

  7. These results demonstrate that antagonism between PUMA and MCL-1 constitutes the major axis of control of hematopoietic stem cell survival.

  8. caspase-9 (show CASP9 Antibodies) mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells.

  9. Stable knockdown of Bim (show BCL2L11 Antibodies) or PUMA expression prevented cell toxicity induced by loss of Keap1 (show KEAP1 Antibodies).

  10. Loss of Bbc3 results in prolonged fertility.

Zebrafish BCL2 Binding Component 3 (BBC3) interaction partners

  1. Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.

  2. Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin (show TUBA4A Antibodies) mutation

BBC3 Antigen Profile

Antigen Summary

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with BBC3

  • BCL2 binding component 3 (BBC3) antibody
  • Bcl-2 binding component 3 (Bbc3) antibody
  • BCL2 binding component 3 (Bbc3) antibody
  • BCL2 binding component 3 (bbc3) antibody
  • BBC3 antibody
  • JFY-1 antibody
  • JFY1 antibody
  • PUMA antibody
  • PUMA/JFY1 antibody

Protein level used designations for BBC3

BCL2 binding component 3 , bcl-2-binding component 3 , p53 up-regulated modulator of apoptosis , BH3-only , Bcl-2 binding component 3 , Puma

GENE ID SPECIES
612153 Canis lupus familiaris
746617 Pan troglodytes
317673 Rattus norvegicus
27113 Homo sapiens
170770 Mus musculus
751763 Danio rerio
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