Browse our anti-BBC3 (BBC3) Antibodies

Full name:
anti-BCL2 Binding Component 3 Antibodies (BBC3)
On www.antibodies-online.com are 288 BCL2 Binding Component 3 (BBC3) Antibodies from 27 different suppliers available. Additionally we are shipping BBC3 Kits (13) and BBC3 Proteins (9) and many more products for this protein. A total of 328 BBC3 products are currently listed.
Synonyms:
BBC3, JFY-1, JFY1, PUMA, PUMA/JFY1

Most Popular Reactivities for anti-BBC3 (BBC3) Antibodies

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anti-Rat (Rattus) BBC3 Antibodies:

anti-Human BBC3 Antibodies:

anti-Mouse (Murine) BBC3 Antibodies:

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Top referenced anti-BBC3 Antibodies

  1. Human Polyclonal BBC3 Primary Antibody for IHC, WB - ABIN361754 : Nakano, Vousden: PUMA, a novel proapoptotic gene, is induced by p53. in Molecular cell 2001 (PubMed)
    Show all 4 references for 361754

  2. Human Polyclonal BBC3 Primary Antibody for ICC, IF - ABIN361748 : Han, Flemington, Houghton, Gu, Zambetti, Lutz, Zhu, Chittenden: Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 3 references for 361748

  3. Human Polyclonal BBC3 Primary Antibody for EIA, FACS - ABIN356830 : Hoque, Begum, Sommer, Lee, Trink, Ratovitski, Sidransky: PUMA in head and neck cancer. in Cancer letters 2003 (PubMed)
    Show all 3 references for 356830

  4. Human Polyclonal BBC3 Primary Antibody for EIA, IF - ABIN401380 : Yu, Zhang, Hwang, Kinzler, Vogelstein: PUMA induces the rapid apoptosis of colorectal cancer cells. in Molecular cell 2001 (PubMed)
    Show all 3 references for 401380

  5. Human Polyclonal BBC3 Primary Antibody for FACS, IF (p) - ABIN731528 : Zhang, Liu, Xia, Zhang, Zhang, Zhao, Chao, Jiang, Jiang: Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. in International journal of molecular medicine 2013 (PubMed)
    Show all 2 references for 731528

  6. Human Polyclonal BBC3 Primary Antibody for ICC, IF - ABIN153058 : Stylianou, Clarke, Brennan: Aberrant activation of notch signaling in human breast cancer. in Cancer research 2006 (PubMed)
    Show all 2 references for 153058

  7. Human Polyclonal BBC3 Primary Antibody for IHC (p), WB - ABIN658021 : Liu, Newland, Jia: Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. in Biochemical and biophysical research communications 2003 (PubMed)

  8. Human Polyclonal BBC3 Primary Antibody for FACS, IF - ABIN388112 : Vesela, Matalova: Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2015 (PubMed)

  9. Human Polyclonal BBC3 Primary Antibody for ELISA, WB - ABIN4348682 : Qiu, Leibowitz, Zhang, Yu: Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. in Oncogene 2010 (PubMed)

More Antibodies against BBC3 Interaction Partners

Human BCL2 Binding Component 3 (BBC3) interaction partners

  1. Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 Antibodies) phosphorylation leads to decreased expression of c-MYC (show MYC Antibodies) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Antibodies) family member PUMA, whereas inhibition of mTORC2 (show CRTC2 Antibodies) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 Antibodies)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 Antibodies) locus encoding BIM (show BCL2L11 Antibodies).

  2. These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1 (show HMGB1 Antibodies)- and oxidative stress-mediated injury to islets.

  3. miR (show MLXIP Antibodies)-23a-3p, miR (show MLXIP Antibodies)-23b-3p, and miR (show MLXIP Antibodies)-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 (show BCL2 Antibodies) proteins DP5 (show HRK Antibodies) and PUMA and consequent human beta-cell apoptosis.

  4. Our results revealed that Slug (show SNAI2 Antibodies) siRNA transfection in combination with radiation increased the expression of PUMA, which contributed to radiosensitivity of oral squamous cell carcinoma cells

  5. p53 (show TP53 Antibodies) and Bax (show BAX Antibodies) might play an important role in microcystin-LR (MC-LR)-induced apoptosis in HepG2 cells in which PUMA and survivin (show BIRC5 Antibodies) were involved.

  6. Therapeutic response to non-genotoxic activation of p53 (show TP53 Antibodies) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.

  7. p53 (show TP53 Antibodies)/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis

  8. Suggest that the accumulation of PUMA in the cytosol may be important for the participation of this protein in apoptosis without the need for prior transcription in Burkitt's lymphoma b cells.

  9. in vitro OGT (show OGT Antibodies) knockdown induced more cell apoptosis through increasing PUMA and caspase-3 (show CASP3 Antibodies) expression

  10. our data purport that p53 (show TP53 Antibodies) not only increased Puma expression directly, but that it may also do so through miR (show MLXIP Antibodies)-203. Additionally, functional studies revealed that miR (show MLXIP Antibodies)-203 overexpression induced apoptosis and inhibited cell invasiveness.

Mouse (Murine) BCL2 Binding Component 3 (BBC3) interaction partners

  1. Our data show a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic host cell death during Listeria infection.

  2. Overexpression of miR (show MLXIP Antibodies)-29 or miR (show MLXIP Antibodies)-24 is sufficient to inhibit the induction of Bim (show BCL2L11 Antibodies) and Puma in young sympathetic neurons.

  3. loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL (show BCL2L1 Antibodies). It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL (show BCL2L1 Antibodies) with BAK (show BAK1 Antibodies) and BAX (show BAX Antibodies).

  4. PUMA is dispensable for glucose homeostasis in lean and obese mice, but it can affect leptin (show LEP Antibodies) levels and food intake during obesity.

  5. MYSM1 (show MYSM1 Antibodies) is a critical negative regulator of p53 (show TP53 Antibodies) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cel function.

  6. Therapeutic response to non-genotoxic activation of p53 (show TP53 Antibodies) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.

  7. Bim (show BCL2L11 Antibodies) and Puma overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.

  8. Beta-arrestin 2 (show ARRB2 Antibodies) promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis.

  9. Puma is the major mediator of virus-induced Bax (show BAX Antibodies)/Bak (show BAK1 Antibodies) activation and mitochondrial membrane permeabilization induction.

  10. Oxidative stress increases PUMA expression regulated by FoxO1 (show FOXO1 Antibodies) in follicular granulosa cells.

Zebrafish BCL2 Binding Component 3 (BBC3) interaction partners

  1. Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.

  2. Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin (show TUBA4A Antibodies) mutation

BBC3 Antigen Profile

Antigen Summary

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with BBC3

  • BCL2 binding component 3 (BBC3) antibody
  • Bcl-2 binding component 3 (Bbc3) antibody
  • BCL2 binding component 3 (Bbc3) antibody
  • BCL2 binding component 3 (bbc3) antibody
  • BBC3 antibody
  • JFY-1 antibody
  • JFY1 antibody
  • PUMA antibody
  • PUMA/JFY1 antibody

Protein level used designations for BBC3

BCL2 binding component 3 , bcl-2-binding component 3 , p53 up-regulated modulator of apoptosis , BH3-only , Bcl-2 binding component 3 , Puma

GENE ID SPECIES
612153 Canis lupus familiaris
746617 Pan troglodytes
317673 Rattus norvegicus
27113 Homo sapiens
170770 Mus musculus
751763 Danio rerio
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