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Browse our CDKN1A Proteins (CDKN1A)

Full name:
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) Proteins (CDKN1A)
On are 14 Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Proteins from 8 different suppliers available. Additionally we are shipping CDKN1A Antibodies (565) and CDKN1A Kits (12) and many more products for this protein. A total of 628 CDKN1A products are currently listed.
CAP20, CCND1, CDKI, Cdkn1, CDKN1A, CIP1, MDA-6, mda6, p16Xic2, P21, p21Cip1, p21WAF, SDI1, si:ch1073-48m5.2, UV96, WAF1
list all proteins Gene Name GeneID UniProt
Rat CDKN1A CDKN1A 114851  
CDKN1A 1026 P38936
CDKN1A 12575 P39689

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CDKN1A Proteins (CDKN1A) by Origin

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Top referenced CDKN1A Proteins

  1. Human CDKN1A Protein expressed in Escherichia coli (E. coli) - ABIN1098681 : el-Deiry, Harper, OConnor, Velculescu, Canman, Jackman, Pietenpol, Burrell, Hill, Wang: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. in Cancer research 1994 (PubMed)
    Show all 2 references for ABIN1098681

More Proteins for CDKN1A Interaction Partners

Zebrafish Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21, PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.

Human Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. These findings demonstrated that p21 plays a critical role in furazolidone-induced apoptosis in HepG2 cells by influencing the caspase-3 (show CASP3 Proteins) activation and ROS (show ROS1 Proteins) generation.

  2. results suggested that high CDKN1A/p21 and low TGFBR2 (show TGFBR2 Proteins) expression was closely correlated with adverse pathological parameters and poor prognosis in breast cancer.

  3. Study provides evidence that miR (show MLXIP Proteins)-208a can affect the proliferation and radio-sensitivity of human lung cancer cells by targeting p21.

  4. Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2 (show CCNG2 Proteins) in human brain microvascular endothelial cells.

  5. Estrogen-related receptor gamma (show ESRRG Proteins) is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27 (show PAK2 Proteins).

  6. accumulation of HDAC4 (show HDAC4 Proteins) induced by fibrillar collagen matrices in the nucleus via co-localization of PP1alpha (show PPP1CA Proteins), leads to repression of the mRNA/protein of p21 and in turn promotes the proliferation and migration of epithelial ovarian cancer cells

  7. Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21, p27 (show PAK2 Proteins)-cyclin E (show CCNE1 Proteins),A/Cdk2 (show CDK2 Proteins) pathway.

  8. Suggest that the p53-p21-DREAM-CDE/CHR pathway regulates p53-dependent repression of Survivin, CDC25C, and PLK1 in HCT116 cells.

  9. Overexpression of miR (show MLXIP Proteins)-512-5p led to the decrease of p21 protein (show NRAS Proteins).

  10. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Proteins) pathways and p21 Cip1 expression.

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. The lack of functional Waf1 is indispensable for maintaining self-renewal and pluripotency of embryonic stem cells.

  2. p27(Kip1 (show CDKN1B Proteins)) and p21(Cip1) are insufficient for the proliferative inhibition of smooth muscle cells cultured in type 1 collagen.

  3. Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (show CDK2 Proteins).

  4. TFAP2C (show TFAP2C Proteins) in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK (show MAPK1 Proteins) pathway, further supporting differentiation of glycogen (show GYS1 Proteins) cells by activating the AKT (show AKT1 Proteins) pathway

  5. Interaction between ASPM and the Cdk2 (show CDK2 Proteins)/Cyclin E (show CCNE1 Proteins) complex regulated the Cyclin (show PCNA Proteins) activity by modulating its ubiquitination and localization into the nucleus.

  6. we present evidence that VPA administration to mice increases hippocampal p21 expression, accompanied by DNA demethylation at the distal CpG island.

  7. LKB1 (show STK11 Proteins) mediates CDKN1A degradation in response to ultraviolet DNA damage.

  8. At high glucose concentrations in vitro, AdipoR1 (show ADIPOR1 Proteins) regulated the survival of neural stem cells through the p53 (show TP53 Proteins)/p21 pathway and the proliferation- and differentiation-related factors of neural stem cells via TLX (show NR2E1 Proteins).

  9. Phosphorylation of p53 (show TP53 Proteins) by LRRK2 (show LRRK2 Proteins) induces p21(WAF1/CIP1) expression and apoptosis.

  10. AMP-18 (show GKN1 Proteins) appears to act through PI3K/AKT (show AKT1 Proteins) pathways to increase p21 phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha (show TNF Proteins).

CDKN1A Protein Profile

Protein Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Alternative names and synonyms associated with CDKN1A

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (cdkn1a)
  • cyclin-dependent kinase inhibitor 1 (cki1)
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A)
  • cyclin-dependent kinase inhibitor 1A (cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (LOC100348489)
  • cyclin-dependent kinase inhibitor 1A (Cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (Cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a)
  • CAP20 protein
  • CCND1 protein
  • CDKI protein
  • Cdkn1 protein
  • CDKN1A protein
  • CIP1 protein
  • MDA-6 protein
  • mda6 protein
  • p16Xic2 protein
  • P21 protein
  • p21Cip1 protein
  • p21WAF protein
  • SDI1 protein
  • si:ch1073-48m5.2 protein
  • UV96 protein
  • WAF1 protein

Protein level used designations for CDKN1A

cyclin dependent kinase inhibitor p16Xic2 , cyclin-dependent kinase inhibitor 1 , cyclin D1 , cyclin-dependent kinase inhibitor 1A (p21, Cip1) , cip1 , p21 , waf1 , cyclin-dependent kinase inhibitor 1A , cyclin-dependent kinase inhibitor 1A (P21) , CDK-interacting protein 1 , CDK-interaction protein 1 , DNA synthesis inhibitor , melanoma differentiation associated protein 6 , wild-type p53-activated fragment 1 , p21/WAF1 , melanoma differentiation-associated protein , p21

492305 Xenopus laevis
606440 Zea mays
747442 Pan troglodytes
100038054 Xenopus (Silurana) tropicalis
100302083 Ovis aries
100151416 Danio rerio
100348489 Oryctolagus cuniculus
114851 Rattus norvegicus
1026 Homo sapiens
474890 Canis lupus familiaris
513497 Bos taurus
100152215 Sus scrofa
100720449 Cavia porcellus
493943 Felis catus
12575 Mus musculus
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