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Browse our CDKN1A Proteins (CDKN1A)

Full name:
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) Proteins (CDKN1A)
On www.antibodies-online.com are 14 Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Proteins from 9 different suppliers available. Additionally we are shipping CDKN1A Antibodies (572) and CDKN1A Kits (12) and many more products for this protein. A total of 635 CDKN1A products are currently listed.
Synonyms:
CAP20, CCND1, CDKI, Cdkn1, CDKN1A, CIP1, MDA-6, mda6, p16Xic2, P21, p21Cip1, p21WAF, SDI1, si:ch1073-48m5.2, UV96, WAF1
list all proteins Gene Name GeneID UniProt
Rat CDKN1A CDKN1A 114851  
CDKN1A 1026 P38936
CDKN1A 12575 P39689

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CDKN1A Proteins (CDKN1A) by Origin

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Top referenced CDKN1A Proteins

  1. Human CDKN1A Protein expressed in Escherichia coli (E. coli) - ABIN1098681 : el-Deiry, Harper, OConnor, Velculescu, Canman, Jackman, Pietenpol, Burrell, Hill, Wang: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. in Cancer research 1994 (PubMed)
    Show all 2 references for ABIN1098681

  2. Human CDKN1A Protein expressed in Human - ABIN2713874 : Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)

More Proteins for CDKN1A Interaction Partners

Zebrafish Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21, PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.

Human Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. these findings indicated that HMGB1 (show HMGB1 Proteins) promoted hepatocellular carcinoma progression partly by enhancing the ERK1/2 and NF-kappaB (show NFKB1 Proteins) pathways, upregulating MMP-2 (show MMP2 Proteins), and downregulating p21 via an ERK (show EPHB2 Proteins)/c-Myc (show MYC Proteins) pathway

  2. High CIP1 expression is associated with metastasis occurrence in Prostate Cancer.

  3. Results indicated that p21 was responsible for the downregulation of G2/M transition regulatory proteins and the bypass of mitosis induced by irradiation.

  4. JMJD5 (show JMJD5 Proteins) is a tumor suppressor gene in HCC (show FAM126A Proteins) pathogenesis, and the epigenetic silencing of JMJD5 (show JMJD5 Proteins) promotes HCC (show FAM126A Proteins) cell proliferation by directly down-regulating CDKN1A transcription.

  5. Nested multiplex polymerase chain reactions to detect the presence of the HPV types, as well as immunohistochemical reactions were performed for the detection of cell cycle-related proteins p16, p27 (show PAK2 Proteins), p53 (show TP53 Proteins) and Ki-67 (show MKI67 Proteins). The expression of all analyzed cell cycle-related proteins was increased in HPV-infected papillomas

  6. High expression of CIP1 is associated with recurrence in oral squamous cell carcinoma.

  7. Urolithin A incubation caused the up-regulation of CDKN1A and down-regulation of FN-1 (show FN1 Proteins) in prostate cancer cells.

  8. Results show that while HOXB13 (show HOXB13 Proteins) suppressed p21 expression via regulation of JNK (show MAPK8 Proteins) signals, alteration of p21 expression also affected c-Jun (show JUN Proteins) and AP-1 (show FOSB Proteins) activity in prostate cancer cells.

  9. HIF-alpha promotes chronic CML (show BCR Proteins) cell proliferation by up-regulating p21 expression

  10. Alterations in p53 (show TP53 Proteins) and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 (show TP53 Proteins) and hMSH2 (show MSH2 Proteins) seem to be interrelated in early events of this process.

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. lincRNA-p21 overexpression dramatically inhibited acetylation of H3 and H4 at the Thy-1 (show THY1 Proteins) promoter and Thy-1 (show THY1 Proteins) expression levels in HLF1 (show HLF Proteins) cells. Finally, lincRNA-p21 interference rescued LPS (show TLR4 Proteins)-induced increase of lung and BAL collagen contents. LincRNA-p21 could lead to pulmonary fibrosis in ARDS by inhibition of the expression of Thy-1 (show THY1 Proteins).

  2. p21 upregulation in hair follicle stem cells is associated with telogen retention in aged mice

  3. MiR-17-92 functions as a hepatocyte proliferation stimulator and acts in an estrogen-dependent manner. The loss of this miRNA results in increases in p21 and Pten expression and therefore impairs liver regeneration in female mice.

  4. we observed that miR (show MLXIP Proteins)-378 modulates the oscillation amplitudes of Cdkn1a in the control of cell cycle and Por (show POR Proteins) in the regulation of oxidation reduction by forming partnership with different circadian transcription factors

  5. The findings define PRMT7 (show PRMT7 Proteins) as a regulator of the DNMT3b (show DNMT3B Proteins)/p21 axis required to maintain muscle stem cell regenerative capacity.

  6. Dynamics of CDKN1A in single cells has been defined defined by an endogenous fluorescent tagging.

  7. Ablation of p21Cip1 in the Cdk4 (show CDK4 Proteins) R24C background accelerates mesenchymal tumor development in mice.

  8. The lack of functional Waf1 is indispensable for maintaining self-renewal and pluripotency of embryonic stem cells.

  9. p27(Kip1 (show CDKN1B Proteins)) and p21(Cip1) are insufficient for the proliferative inhibition of smooth muscle cells cultured in type 1 collagen.

  10. Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (show CDK2 Proteins).

CDKN1A Protein Profile

Protein Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Alternative names and synonyms associated with CDKN1A

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (cdkn1a)
  • cyclin-dependent kinase inhibitor 1 (cki1)
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A)
  • cyclin-dependent kinase inhibitor 1A (cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (LOC100348489)
  • cyclin-dependent kinase inhibitor 1A (Cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (Cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a)
  • CAP20 protein
  • CCND1 protein
  • CDKI protein
  • Cdkn1 protein
  • CDKN1A protein
  • CIP1 protein
  • MDA-6 protein
  • mda6 protein
  • p16Xic2 protein
  • P21 protein
  • p21Cip1 protein
  • p21WAF protein
  • SDI1 protein
  • si:ch1073-48m5.2 protein
  • UV96 protein
  • WAF1 protein

Protein level used designations for CDKN1A

cyclin dependent kinase inhibitor p16Xic2 , cyclin-dependent kinase inhibitor 1 , cyclin D1 , cyclin-dependent kinase inhibitor 1A (p21, Cip1) , cip1 , p21 , waf1 , cyclin-dependent kinase inhibitor 1A , cyclin-dependent kinase inhibitor 1A (P21) , CDK-interacting protein 1 , CDK-interaction protein 1 , DNA synthesis inhibitor , melanoma differentiation associated protein 6 , wild-type p53-activated fragment 1 , p21/WAF1 , melanoma differentiation-associated protein , p21

GENE ID SPECIES
492305 Xenopus laevis
606440 Zea mays
747442 Pan troglodytes
100038054 Xenopus (Silurana) tropicalis
100302083 Ovis aries
100151416 Danio rerio
100348489 Oryctolagus cuniculus
114851 Rattus norvegicus
1026 Homo sapiens
474890 Canis lupus familiaris
513497 Bos taurus
100152215 Sus scrofa
100720449 Cavia porcellus
493943 Felis catus
12575 Mus musculus
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