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Browse our CHEK1 Proteins (CHEK1)

Full name:
Checkpoint Kinase 1 Proteins (CHEK1)
On are 16 Checkpoint Kinase 1 (CHEK1) Proteins from 9 different suppliers available. Additionally we are shipping CHEK1 Antibodies (486) and CHEK1 Kits (25) and many more products for this protein. A total of 567 CHEK1 products are currently listed.
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093
list all proteins Gene Name GeneID UniProt
CHEK1 1111 O14757
CHEK1 12649 O35280
CHEK1 140583 Q91ZN7

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CHEK1 Proteins (CHEK1) by Origin

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Top referenced CHEK1 Proteins

  1. Human CHEK1 Protein expressed in Baculovirus infected Insect Cells - ABIN457519 : Larsen, Rampalli, Burns, Brunette, Dilworth, Megeney: Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Proteins for CHEK1 Interaction Partners

Human Checkpoint Kinase 1 (CHEK1) interaction partners

  1. High CHK1 expression is associated with increased radioresistance of non-small cell lung cancer.

  2. CHEK1 loss-of-function mutations have not been found in human tumors, and transgenic expression of Chek1 in mice promotes oncogene (show RAB1A Proteins)-induced transformation. [review]

  3. persistence of CHK1 levels in response to DNA damage in p53 (show TP53 Proteins)-deficient cancer cells, leads to CHK1-mediated activation of NF-kappaB (show NFKB1 Proteins) and induction of NF-kappaB (show NFKB1 Proteins)-regulated genes in cells and in associated tumor-derived microvesicles, both of which are abrogated by loss or inhibition of CHK1.

  4. Chk1's expression is controlled by p53 (show TP53 Proteins) and RB/E2F1 (show E2F1 Proteins) at the transcriptional level.

  5. High CHK1 expression correlates with urinary bladder cancer.

  6. Inappropriate activation of CDK2 (show CDK2 Proteins) in S phase underlies the sensitivity of a subset of cell lines to Chk1 inhibitors.

  7. In conclusion, this study exemplifies cancer-specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining ATR (show ANTXR1 Proteins) and CHK1 inhibitors as promising cancer therapy.

  8. This study shows that Chk1 indeed maintains a closed conformation in the absence of DNA damage through an intramolecular interaction between a region (residues 31-87) at the N-terminal kinase domain and the distal C terminus. A highly conserved Leu-449 at the C terminus is important for this intramolecular interaction.

  9. Avoiding damage formation through invalidation of Mus81 (show MUS81 Proteins)-Eme2 (show EME2 Proteins) and Mre11 (show MRE11A Proteins), or preventing damage signaling by turning off the ATM (show ATM Proteins) pathway, suppresses the replication phenotypes of Chk1-deficient cells.

  10. Chk1 is a predictive biomarker of radiotherapy resistance and early local recurrence.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (show CDC45 Proteins) onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (show DCLRE1C Proteins) activity of Mre11 (show MRE11A Proteins), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (show POLK Proteins)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (show APEX2 Proteins) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (show APEX2 Proteins) is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 (show APEX2 Proteins) in ATR-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (show MAPK1 Proteins) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Proteins) and JNK (show MAPK8 Proteins).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH Proteins)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (show CDC25A Proteins) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. RAD9 (show RAD9A Proteins) has a prominent role in the ATR-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  2. Acute inactivation of E4F1 (show E4F1 Proteins) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (show ROS1 Proteins) production, energy stress, and inhibition of de novo pyrimidine synthesis

  3. Altogether, our results classify E4F1 (show E4F1 Proteins) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  4. Heterozygous loss of Chk1 in a Wnt (show WNT2 Proteins)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  5. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  6. ATM (show ATM Proteins) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  7. High level of phospho-Chk1 is associated with skin tumors.

  8. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

  9. activated Akt1 (show AKT1 Proteins) in Brca1 (show BRCA1 Proteins)-deficient cells impairs Chk1 nuclear localization and subsequently disrupts interaction of Chk1 and Rad51 (show RAD51 Proteins) leading to homologous recombination defects.

  10. Our results uncover a novel p53 (show TP53 Proteins)-independent function for p21 in protecting cells from the lethal effects of DNA damage followed by Chk1 inhibition

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The Chk1 directly phosphorylates eNOS (show NOS3 Proteins) Ser (show SIGLEC1 Proteins)(1179) in response to UV irradiation, which is dependent on Hsp90 (show HSP90 Proteins) interaction.

CHEK1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1)
  • serine/threonine-protein kinase chk1 (ANI_1_2436074)
  • serine/threonine-protein kinase chk1 (AOR_1_768154)
  • serine/threonine-protein kinase Chk1 (PTRG_04183)
  • serine/threonine-protein kinase chk1 (SJAG_01680)
  • serine/threonine-protein kinase chk1 (PAAG_04978)
  • serine/threonine-protein kinase chk1 (MCYG_03290)
  • serine/threonine-protein kinase chk1 (VDBG_03742)
  • checkpoint kinase 1 (chek1)
  • checkpoint kinase 1 (Chek1)
  • CHK1 checkpoint homolog (S. pombe) (chek1)
  • CHK1 checkpoint homolog (S. pombe) (CHEK1)
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A)
  • An08g10320 protein
  • AO090003000441 protein
  • C85740 protein
  • CHEK1 protein
  • Chk1 protein
  • id:ibd2720 protein
  • rad27 protein
  • zgc:56093 protein

Protein level used designations for Checkpoint Kinase 1 Proteins (CHEK1)

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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