Browse our FAS Proteins (FAS)

Full name:
Fas (TNF Receptor Superfamily, Member 6) Proteins (FAS)
On are 65 Fas (TNF Receptor Superfamily, Member 6) (FAS) Proteins from 15 different suppliers available. Additionally we are shipping FAS Antibodies (756) and FAS Kits (87) and many more products for this protein. A total of 946 FAS products are currently listed.
A630082H08Rik, AI196731, ALPS1A, APO-1, APO1, APT1, CD95, FAS, FAS1, FASTM, lpr, TNFR6, TNFRSF6
list all proteins Gene Name GeneID UniProt
FAS 14102 P25446
FAS 355 P25445
FAS 246097 Q63199

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FAS Proteins (FAS) by Origin

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Top referenced FAS Proteins

  1. Human FAS Protein expressed in HEK-293 - ABIN2666539 : Cheng, Zhou, Liu, Shapiro, Brauer, Kiefer, Barr, Mountz: Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 6 references for 2666539

  2. Human FAS Protein expressed in Human Cells - ABIN2002374 : Brunner, Mogil, LaFace, Yoo, Mahboubi, Echeverri, Martin, Force, Lynch, Ware: Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. in Nature 1995 (PubMed)
    Show all 5 references for 2002374

  3. Rat (Rattus) FAS Protein expressed in Human Cells - ABIN2009085 : Suda, Takahashi, Golstein, Nagata: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. in Cell 1994 (PubMed)
    Show all 5 references for 2009085

  4. Cynomolgus FAS Protein expressed in Human Cells - ABIN2010073 : Cascino, Fiucci, Papoff, Ruberti: Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 5 references for 2010073

  5. Mouse (Murine) FAS Protein expressed in Human Cells - ABIN2007176 : Hirata, Takahashi, Kobayashi, Yonehara, Sawai, Okazaki, Yamamoto, Sasada: Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. in The Journal of experimental medicine 1998 (PubMed)
    Show all 5 references for 2007176

  6. Human FAS Protein expressed in HEK-293 Cells - ABIN2181070 : Wajant: The Fas signaling pathway: more than a paradigm. in Science (New York, N.Y.) 2002 (PubMed)

More Proteins for FAS Interaction Partners

Mouse (Murine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. this study shows that CD95-mediated calcium signaling promotes Th17 cell trafficking to inflamed organs in lupus-prone mice

  2. accelerating effects of Tlr9 (show TLR9 Proteins) deficiency

  3. K8/K18 (show KRT18 Proteins)-dependent PKCdelta (show PKCd Proteins)- and ASMase (show SMPD1 Proteins)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Proteins) loss.

  4. The present results suggest that Fas/S1P1 (show S1PR1 Proteins) signaling via activation of NF-kappaB (show NFKB1 Proteins) in osteoclast precursor cells is a key factor in the pathogenesis of rheumatoid arthritis in the temporomandibular joint.

  5. Data show that TCF1 (show HNF1A Proteins) proteindeficiency relieved most manifestations of autoimmune lymphoproliferative syndrome (ALPS)-like phenotype, which were caused by Fas protein mutation in TCF1 (show HNF1A Proteins)(-/-) lpr/lpr mice.

  6. Results indicate that the close interaction between Thy-1 (show THY1 Proteins) and Fas in lipid rafts regulates fibroblast apoptosis, and decreased fibroblast apoptosis associated with myofibroblast accumulation in mice lacking Thy-1 (show THY1 Proteins).

  7. genetic deletion of FASN totally suppresses hepatocarcinogenesis driven by AKT and AKT/c-Met protooncogenes in mice.

  8. Statistically significant increases in the expression of Fas and caspase-8 (show CASP8 Proteins) were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (show DAPK1 Proteins), Traf3 (show TRAF3 Proteins), Tnsf12, Tnfrsf1A (show TNFRSF1A Proteins) and Ripk1 (show RIPK1 Proteins).

  9. Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn (show FASN Proteins)) promoter specifically in refeeding states.

  10. Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha (show CEBPA Proteins), PPAR-gamma (show PPARG Proteins), FAS, perilipin A (show PLIN1 Proteins), and STAT-3 (show STAT3 Proteins).

Rabbit Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Ligustrazine has notable protective effects on pulmonary ischemia/reperfusion injury inhibiting Fas/FasL (show FASL Proteins) mRNA express in lung tissue and decreasing apoptosis.

Pig (Porcine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Fas was expressed on fetal pig pancreatic cells, both beta and non-beta cells, and the level of expression could be upregulated by exposure to interleukin 1beta

  2. The expression of FAS and FAS ligand (show FASL Proteins) in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported

Cow (Bovine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (show PTGES Proteins)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF Proteins)) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  2. Results did not support that K8/K18 (show KRT18 Proteins) filaments influence the expression of Fas on the surface of luteal cells.

  3. activation of the Fas pathway and presence of FSH (show BRD2 Proteins) during in vitro maturation increased the incidence of apoptosis in cumulus cells

  4. demonstrated for the first time that normal ejaculated spermatozoa express Fas antigen (show FASL Proteins); data showed that a large percentage of normal ejaculated spermatozoa of fertile bulls are immunocytochemically positive for Fas

Rhesus Monkey Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. The present results may provide some insights to understand the role of Fas/FasL (show FASL Proteins) in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.

Human Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. These findings suggest that rs1800682, rs2234767, and rs763110 genotypes are not associated with the presence of HTLV-1-associated myelopathy/tropical spastic paraparesis, but that the FAS-670 AA genotype can promote higher proviral load values in HTLV-1-associated myelopathy/tropical spastic paraparesis patients.

  2. findings showed the variant allele and genotype of the FAS c.-671A>G polymorphism were significantly associated with increased risk of cervical cancer in Malaysian population, particularly those of Malay ethnicity; however, results of meta-analysis showed a lack of association between the polymorphism and cervical cancer risk

  3. Fas cell surface death receptor (FAS) was identified as an independent prognostic marker for recurrence free survival in breast cancer, with large variation in expression by receptor subtypes.

  4. data also demonstrated that the CD154 (show CD40LG Proteins)-triggered inhibition of the Fas-mediated cell death response was dependent on a suppression of caspase-8 (show CASP8 Proteins) cleavage, but independent of de novo protein synthesis or alterations in Fas expression on cell surface.

  5. We have identified two single nucleotide polymorphisms in two immune-related genes ( MBL (show MBL2 Proteins)" and CD95) that have an association with severe and potentially life-threatening infection following doxorubicin and cyclophosphamide therapy for breast cancer

  6. With rs7901656 on the FAS gene as a paradigm, we show how allele specific transcription factor complex assembly and disruption by a causal variant contributes to disease and phenotypic diversity

  7. Increased TIM3 (show HAVCR2 Proteins)+CD8 (show CD8A Proteins)+T cells with lower perforin (show PRF1 Proteins) and granzyme B expression and higher CD95 expression in MDS (show PAFAH1B1 Proteins) patients were observed.

  8. FAS c.-671AG genotype is not to be a risk factor in familial mediterranean fever (show MEFV Proteins).

  9. functional inhibition of miR (show MLXIP Proteins)-29c caused resistance to Fas-mediated apoptosis in lung fibroblasts.

  10. Most of the plasma cells of a paient with a heterozygous germline FAS mutation were Fas-deficient suggesting that Fas signaling plays a role also in the selection of germinal center B cells into the pool of long-lived plasma cells, similar to switched memory B cells.

FAS Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Alternative names and synonyms associated with FAS

  • Fas (TNF receptor superfamily member 6) (Fas)
  • Fas (TNF receptor superfamily, member 6) (FAS)
  • Fas cell surface death receptor (FAS)
  • Fas cell surface death receptor (Fas)
  • fatty acid synthase (Fasn)
  • A630082H08Rik protein
  • AI196731 protein
  • ALPS1A protein
  • APO-1 protein
  • APO1 protein
  • APT1 protein
  • CD95 protein
  • FAS protein
  • FAS1 protein
  • FASTM protein
  • lpr protein
  • TNFR6 protein
  • TNFRSF6 protein

Protein level used designations for FAS

FASLG receptor , Fas (TNF receptor superfamily member) , Fas antigen , apo-1 antigen , apoptosis-mediating surface antigen FAS , lymphoproliferation , tumor necrosis factor receptor superfamily member 6 , Fas receptor , apoptosis (APO-1) antigen 1 ( FAS ), member 6 , tumor necrosis factor receptor superfamily, member 6 , Fas receptor CD95 , APO-1 cell surface antigen , CD95 antigen , Delta Fas/APO-1/CD95 , FAS 827dupA , Fas (TNF receptor superfamily, member 6) , Fas AMA , TNF receptor superfamily member 6 , apoptosis antigen 1 , Fas antigen (ATP1) , Tumor necrosis factor receptor superfamily, member 6

14102 Mus musculus
100008609 Oryctolagus cuniculus
396826 Sus scrofa
282488 Bos taurus
574332 Macaca mulatta
355 Homo sapiens
246097 Rattus norvegicus
100726403 Cavia porcellus
14104 Mus musculus
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