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Browse our FAS Proteins (FAS)

Full name:
Fas (TNF Receptor Superfamily, Member 6) Proteins (FAS)
On are 61 Fas (TNF Receptor Superfamily, Member 6) (FAS) Proteins from 15 different suppliers available. Additionally we are shipping FAS Antibodies (750) and FAS Kits (85) and many more products for this protein. A total of 935 FAS products are currently listed.
A630082H08Rik, AI196731, ALPS1A, APO-1, APO1, APT1, CD95, FAS, FAS1, FASTM, lpr, TNFR6, TNFRSF6
list all proteins Gene Name GeneID UniProt
FAS 14102 P25446
FAS 355 P25445
FAS 246097 Q63199

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FAS Proteins (FAS) by Origin

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Top referenced FAS Proteins

  1. Human FAS Protein expressed in HEK-293 - ABIN2666539 : Cheng, Zhou, Liu, Shapiro, Brauer, Kiefer, Barr, Mountz: Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 6 references for ABIN2666539

  2. Rat (Rattus) FAS Protein expressed in Human Cells - ABIN2009083 : Suda, Takahashi, Golstein, Nagata: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. in Cell 1994 (PubMed)
    Show all 5 references for ABIN2009083

  3. Cynomolgus FAS Protein expressed in Human Cells - ABIN2010073 : Brunner, Mogil, LaFace, Yoo, Mahboubi, Echeverri, Martin, Force, Lynch, Ware: Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. in Nature 1995 (PubMed)
    Show all 5 references for ABIN2010073

  4. Mouse (Murine) FAS Protein expressed in Human Cells - ABIN2007176 : Hirata, Takahashi, Kobayashi, Yonehara, Sawai, Okazaki, Yamamoto, Sasada: Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. in The Journal of experimental medicine 1998 (PubMed)
    Show all 5 references for ABIN2007176

  5. Human FAS Protein expressed in Human Cells - ABIN2002374 : Milhas, Cuvillier, Therville, Clavé, Thomsen, Levade, Benoist, Ségui: Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for ABIN2002374

  6. Human FAS Protein expressed in HEK-293 Cells - ABIN2181070 : Wajant: The Fas signaling pathway: more than a paradigm. in Science (New York, N.Y.) 2002 (PubMed)

More Proteins for FAS Interaction Partners

Mouse (Murine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. The MWM showed that compared with FAS- and FASL (show FASL Proteins)-knockout mice treated with sevoflurane, sevoflurane treatment of wild-type mice significantly prolonged the escape latency and reduced platform crossing times.

  2. CD44 (show CD44 Proteins), NOD2, and Fas have distinct functions in regulating changes in trabecular and cortical bone indices during unloading.

  3. the individual functions of the NF-kappaB (show NFKB1 Proteins) family members NF-kappaB1 (show NFKB1 Proteins), NF-kappaB2 and c-REL (show NFkBP65 Proteins) in the various autoimmune pathologies of Fas(lpr/lpr) mutant mice, were investigated.

  4. When Bax (show BAX Proteins)(-/-)Bak (show BAK1 Proteins)(-/-) murine embryonic stem cells (ESCs (show NR2E3 Proteins)) are stimulated to differentiate, a subpopulation fails to do so and instead upregulates FAS in a p53 (show TP53 Proteins)-dependent manner to trigger Bax (show BAX Proteins)/Bak (show BAK1 Proteins)-dependent apoptosis.

  5. This study for the first time revealed that increased CRT (show SLC6A8 Proteins) inhibited Fas/FasL (show FASL Proteins)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  6. These results demonstrate that during ectromelia virus infection, Fas/FasL (show FASL Proteins) can regulate development of tolerogenic DCs and Tregs, leading to an ineffective immune response.

  7. Data determined the transmembrane domain structure of Fas and showed that the trimer assembly, which is mediated by a proline-containing motif, is essential for Fas signaling providing structural explanation for many known cancer mutations in this domain.

  8. CASP8 (show CASP8 Proteins) is present exclusively as its cleaved p43 (show AIMP1 Proteins) product, bound to cFLIPL.

  9. Inhibition of G-protein-coupled Receptor Kinase 2 (show ADRBK1 Proteins) Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase (show FASN Proteins) Transgenic Mice.

  10. Impaired Fas-Fas Ligand (show FASL Proteins) Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice

Rabbit Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Ligustrazine has notable protective effects on pulmonary ischemia/reperfusion injury inhibiting Fas/FasL (show FASL Proteins) mRNA express in lung tissue and decreasing apoptosis.

Pig (Porcine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Fas was expressed on fetal pig pancreatic cells, both beta and non-beta cells, and the level of expression could be upregulated by exposure to interleukin 1beta

  2. The expression of FAS and FAS ligand (show FASL Proteins) in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported

Cow (Bovine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (show PTGES Proteins)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF Proteins)) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  2. Results did not support that K8/K18 (show KRT18 Proteins) filaments influence the expression of Fas on the surface of luteal cells.

  3. activation of the Fas pathway and presence of FSH (show BRD2 Proteins) during in vitro maturation increased the incidence of apoptosis in cumulus cells

  4. demonstrated for the first time that normal ejaculated spermatozoa express Fas antigen (show FASL Proteins); data showed that a large percentage of normal ejaculated spermatozoa of fertile bulls are immunocytochemically positive for Fas

Rhesus Monkey Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. The present results may provide some insights to understand the role of Fas/FasL (show FASL Proteins) in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.

Human Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Advanced glycation end-product induces apoptosis in human retinal cells via promoting mitochondrial dysfunction and activating the Fas-FasL (show FASL Proteins) signaling.

  2. K8/18 filaments provide resistance to apoptosis in granulosa cell tumor cells by impairing FAS expression.

  3. Fas/FasL (show FASL Proteins) system and downstream activation of caspases are important mediators of apoptosis and may be involved in the pathogenesis of pulmonary edema in severe P. falciparum malaria patients.

  4. Data show that Ras protein regulates inhibitor of growth protein 4 (ING4 (show ING4 Proteins))-thymine-DNA glycosylase (TDG (show TDG Proteins))-Fas protein axis to promote apoptosis resistance in pancreatic cancer.

  5. These results suggested that FAS/FASL (show FASL Proteins) polymorphisms might significantly modify SPM (show NPC1 Proteins) risk among patients with SCCHN in a tumor site-specific manner.

  6. Abnormal Fas/FasL (show FASL Proteins) expression in gastric cardia carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer.

  7. Meta-analysis: FAS -670 A/G, and FAS -1377 G/A polymorphisms are associated with susceptibility to systemic lupus erythematosus.

  8. Frequencies of SNPs rs2234978 and rs1045487 of FAS and CASP8 (show CASP8 Proteins) genes were significantly higher in Autoimmune Lymphoproliferative Syndrome patients.

  9. Three cases of autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline CASP10 (show CASP10 Proteins) variation have been described.

  10. stichoposide D inhibits growth of experimental leukemia by activating Fas/ceramide synthase 6 (show CERS6 Proteins)/p38 (show CRK Proteins) kinase in lipid rafts

FAS Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Alternative names and synonyms associated with FAS

  • Fas (TNF receptor superfamily member 6) (Fas)
  • Fas (TNF receptor superfamily, member 6) (FAS)
  • Fas cell surface death receptor (FAS)
  • Fas cell surface death receptor (Fas)
  • fatty acid synthase (Fasn)
  • A630082H08Rik protein
  • AI196731 protein
  • ALPS1A protein
  • APO-1 protein
  • APO1 protein
  • APT1 protein
  • CD95 protein
  • FAS protein
  • FAS1 protein
  • FASTM protein
  • lpr protein
  • TNFR6 protein
  • TNFRSF6 protein

Protein level used designations for FAS

FASLG receptor , Fas (TNF receptor superfamily member) , Fas antigen , apo-1 antigen , apoptosis-mediating surface antigen FAS , lymphoproliferation , tumor necrosis factor receptor superfamily member 6 , Fas receptor , apoptosis (APO-1) antigen 1 ( FAS ), member 6 , tumor necrosis factor receptor superfamily, member 6 , Fas receptor CD95 , APO-1 cell surface antigen , CD95 antigen , Delta Fas/APO-1/CD95 , FAS 827dupA , Fas (TNF receptor superfamily, member 6) , Fas AMA , TNF receptor superfamily member 6 , apoptosis antigen 1 , Fas antigen (ATP1) , Tumor necrosis factor receptor superfamily, member 6

14102 Mus musculus
100008609 Oryctolagus cuniculus
396826 Sus scrofa
282488 Bos taurus
574332 Macaca mulatta
355 Homo sapiens
246097 Rattus norvegicus
100726403 Cavia porcellus
14104 Mus musculus
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