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Browse our FAS Proteins (FAS)

Full name:
Fas (TNF Receptor Superfamily, Member 6) Proteins (FAS)
On are 64 Fas (TNF Receptor Superfamily, Member 6) (FAS) Proteins from 15 different suppliers available. Additionally we are shipping FAS Antibodies (744) and FAS Kits (88) and many more products for this protein. A total of 934 FAS products are currently listed.
A630082H08Rik, AI196731, ALPS1A, APO-1, APO1, APT1, CD95, FAS, FAS1, FASTM, lpr, TNFR6, TNFRSF6
list all proteins Gene Name GeneID UniProt
FAS 14102 P25446
FAS 355 P25445
FAS 246097 Q63199

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FAS Proteins (FAS) by Origin

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Top referenced FAS Proteins

  1. Human FAS Protein expressed in HEK-293 - ABIN2666539 : Cheng, Zhou, Liu, Shapiro, Brauer, Kiefer, Barr, Mountz: Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 6 references for ABIN2666539

  2. Mouse (Murine) FAS Protein expressed in Human Cells - ABIN2007176 : Brunner, Mogil, LaFace, Yoo, Mahboubi, Echeverri, Martin, Force, Lynch, Ware: Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. in Nature 1995 (PubMed)
    Show all 5 references for ABIN2007176

  3. Rat (Rattus) FAS Protein expressed in Human Cells - ABIN2009083 : Suda, Takahashi, Golstein, Nagata: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. in Cell 1994 (PubMed)
    Show all 5 references for ABIN2009083

  4. Cynomolgus FAS Protein expressed in Human Cells - ABIN2010073 : Cascino, Fiucci, Papoff, Ruberti: Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 5 references for ABIN2010073

  5. Human FAS Protein expressed in Human Cells - ABIN2002374 : Hirata, Takahashi, Kobayashi, Yonehara, Sawai, Okazaki, Yamamoto, Sasada: Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. in The Journal of experimental medicine 1998 (PubMed)
    Show all 5 references for ABIN2002374

  6. Human FAS Protein expressed in HEK-293 Cells - ABIN2181070 : Wajant: The Fas signaling pathway: more than a paradigm. in Science (New York, N.Y.) 2002 (PubMed)

More Proteins for FAS Interaction Partners

Mouse (Murine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Results indicate that the close interaction between Thy-1 (show THY1 Proteins) and Fas in lipid rafts regulates fibroblast apoptosis, and decreased fibroblast apoptosis associated with myofibroblast accumulation in mice lacking Thy-1 (show THY1 Proteins).

  2. genetic deletion of FASN totally suppresses hepatocarcinogenesis driven by AKT and AKT/c-Met protooncogenes in mice.

  3. Statistically significant increases in the expression of Fas and caspase-8 (show CASP8 Proteins) were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (show DAPK1 Proteins), Traf3 (show TRAF3 Proteins), Tnsf12, Tnfrsf1A (show TNFRSF1A Proteins) and Ripk1 (show RIPK1 Proteins).

  4. Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn (show FASN Proteins)) promoter specifically in refeeding states.

  5. Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha (show CEBPA Proteins), PPAR-gamma (show PPARG Proteins), FAS, perilipin A (show PLIN1 Proteins), and STAT-3 (show STAT3 Proteins).

  6. ING4 (show ING4 Proteins) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas-induced apoptosis in a caspase-8 (show CASP8 Proteins)-dependent pathway.

  7. study demonstrates that co-activation of AKT (show AKT1 Proteins) and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN (show FASN Proteins) pathway.

  8. Fas/FasL (show FASL Proteins) Complex Promotes Proliferation and Migration of Brain Endothelial Cells Via FADD (show FADD Proteins)-FLIP-TRAF (show TRAF1 Proteins)-NF-kappaB (show NFKB1 Proteins) Pathway

  9. Cardiac Fas-dependent and mitochondria-dependent apoptotic pathways were activated in transgenic mice with Huntington's disease.

  10. The MWM showed that compared with FAS- and FASL (show FASL Proteins)-knockout mice treated with sevoflurane, sevoflurane treatment of wild-type mice significantly prolonged the escape latency and reduced platform crossing times.

Rabbit Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Ligustrazine has notable protective effects on pulmonary ischemia/reperfusion injury inhibiting Fas/FasL (show FASL Proteins) mRNA express in lung tissue and decreasing apoptosis.

Pig (Porcine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Fas was expressed on fetal pig pancreatic cells, both beta and non-beta cells, and the level of expression could be upregulated by exposure to interleukin 1beta

  2. The expression of FAS and FAS ligand (show FASL Proteins) in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported

Cow (Bovine) Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (show PTGES Proteins)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF Proteins)) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  2. Results did not support that K8/K18 (show KRT18 Proteins) filaments influence the expression of Fas on the surface of luteal cells.

  3. activation of the Fas pathway and presence of FSH (show BRD2 Proteins) during in vitro maturation increased the incidence of apoptosis in cumulus cells

  4. demonstrated for the first time that normal ejaculated spermatozoa express Fas antigen (show FASL Proteins); data showed that a large percentage of normal ejaculated spermatozoa of fertile bulls are immunocytochemically positive for Fas

Rhesus Monkey Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. The present results may provide some insights to understand the role of Fas/FasL (show FASL Proteins) in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.

Human Fas (TNF Receptor Superfamily, Member 6) (FAS) interaction partners

  1. With rs7901656 on the FAS gene as a paradigm, we show how allele specific transcription factor complex assembly and disruption by a causal variant contributes to disease and phenotypic diversity

  2. Increased TIM3 (show HAVCR2 Proteins)+CD8 (show CD8A Proteins)+T cells with lower perforin (show PRF1 Proteins) and granzyme B expression and higher CD95 expression in MDS (show PAFAH1B1 Proteins) patients were observed.

  3. FAS c.-671AG genotype is not to be a risk factor in familial mediterranean fever (show MEFV Proteins).

  4. functional inhibition of miR (show MLXIP Proteins)-29c caused resistance to Fas-mediated apoptosis in lung fibroblasts.

  5. Most of the plasma cells of a paient with a heterozygous germline FAS mutation were Fas-deficient suggesting that Fas signaling plays a role also in the selection of germinal center B cells into the pool of long-lived plasma cells, similar to switched memory B cells.

  6. a substantial subgroup of the ITP (show ITPA Proteins) patients displayed a defective Fas function; most of them displayed decreased Fas expression in T cells activated in vitro.

  7. Fas gene polymorphism is associated with Hashimoto's thyroiditis.

  8. There is a positive correlation of the serum level of sFasL (show FASL Proteins)( Fas/FasL (show FASL Proteins) axis ) with uptake index of parotid gland in our expectation. In addition, liver injury involvement in SS patients showed decreased level of sFasL (show FASL Proteins). Furthermore, we here also observed that the protective cytokine IL-10 (show IL10 Proteins) expression was positively correlated with sFasL (show FASL Proteins) expression

  9. The Fas-1377G > A polymorphism is associated with a higher risk of pre-eclampsia.

  10. Fas rs2234767 G/A SNPs might be associated with an increased risk of rheumatoid arthritis.

FAS Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Alternative names and synonyms associated with FAS

  • Fas (TNF receptor superfamily member 6) (Fas)
  • Fas (TNF receptor superfamily, member 6) (FAS)
  • Fas cell surface death receptor (FAS)
  • Fas cell surface death receptor (Fas)
  • fatty acid synthase (Fasn)
  • A630082H08Rik protein
  • AI196731 protein
  • ALPS1A protein
  • APO-1 protein
  • APO1 protein
  • APT1 protein
  • CD95 protein
  • FAS protein
  • FAS1 protein
  • FASTM protein
  • lpr protein
  • TNFR6 protein
  • TNFRSF6 protein

Protein level used designations for FAS

FASLG receptor , Fas (TNF receptor superfamily member) , Fas antigen , apo-1 antigen , apoptosis-mediating surface antigen FAS , lymphoproliferation , tumor necrosis factor receptor superfamily member 6 , Fas receptor , apoptosis (APO-1) antigen 1 ( FAS ), member 6 , tumor necrosis factor receptor superfamily, member 6 , Fas receptor CD95 , APO-1 cell surface antigen , CD95 antigen , Delta Fas/APO-1/CD95 , FAS 827dupA , Fas (TNF receptor superfamily, member 6) , Fas AMA , TNF receptor superfamily member 6 , apoptosis antigen 1 , Fas antigen (ATP1) , Tumor necrosis factor receptor superfamily, member 6

14102 Mus musculus
100008609 Oryctolagus cuniculus
396826 Sus scrofa
282488 Bos taurus
574332 Macaca mulatta
355 Homo sapiens
246097 Rattus norvegicus
100726403 Cavia porcellus
14104 Mus musculus
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