Browse our MDM2 Proteins (MDM2)

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Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) Proteins (MDM2)
On are 21 Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Proteins from 5 different suppliers available. Additionally we are shipping MDM2 Antibodies (382) and MDM2 Kits (10) and many more products for this protein. A total of 449 MDM2 products are currently listed.
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834
list all proteins Gene Name GeneID UniProt
MDM2 4193 Q00987
Rat MDM2 MDM2 314856  
MDM2 17246 P23804

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Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53 (show TP53 Proteins) status in tumor cells.

  2. Disruption of CK1alpha (show CSNK1A1 Proteins) function in myeloma cells resulted in decreased Mdm2, increased p53 (show TP53 Proteins) and p21 (show CDKN1A Proteins) and reduced expression of beta-catenin (show CTNNB1 Proteins) and AKT (show AKT1 Proteins).

  3. In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 (show NEDD8 Proteins) NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.

  4. Results show that monoubiquitination of mutant p53 (show TP53 Proteins) following DNA damage is MDM2 dependent and its RING domain is required for this modulation.

  5. Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159.

  6. conclude that p16 is highly sensitive for retroperitoneal DDL. However, the lack of specificity limits the diagnostic utility compared with the more established markers MDM2 and CDK4 (show CDK4 Proteins)

  7. HIV-1 Tat (show TAT Proteins) appears to stabilise Mdm2, which in turn enhances Tat (show TAT Proteins)-mediated viral replication.

  8. Overexpression of long non-coding RNA LOC572558 was associated with dephosphorylation of AKT (show AKT1 Proteins), MDM2 and phosphorylation of p53 (show TP53 Proteins) protein in bladder cancer cells.

  9. In conclusion, genetic variants of the p14ARF/MDM2/TP53 (show TP53 Proteins) pathway are significantly related to overall survival and disease-free survival, and may be predictors of the prognosis of esophageal squamous cell carcinoma after surgery.

  10. 2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol shows excellent anti-breast cancer activity in vivo and in vitro and induces p53 (show TP53 Proteins)-independent apoptosis, which is associated with MDM2 inhibition.

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (show TP53 Proteins)-dependent apoptosis of Theileria parva (show PARVA Proteins)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (show PARVA Proteins), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (show PARVA Proteins)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (show MDM4 Proteins) caused dramatic accumulation of mutant p53 protein (show TP53 Proteins).

  2. Together with p53 (show TP53 Proteins), provides an experimental model for characterizing drugs and genes that affect p53 (show TP53 Proteins) signaling.

  3. Data show that liver-specific expression of p53 (show TP53 Proteins)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.

  2. MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (show TP53 Proteins)-independent pathway dependant on Notch1 (show NOTCH1 Proteins) ubiquitination and proteasome degradation.

  3. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Proteins)/Mdm2-Mdm4 (show MDM4 Proteins) via a RING domain-mediated biochemical mechanism.

  4. both MDM2 and MDMX (show MDM4 Proteins) deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 Proteins), verifying the crucial role of the MDM2 and/or MDMX (show MDM4 Proteins) in regulating p53 (show TP53 Proteins) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  5. Vif (show BTG1 Proteins) stabilization by CBFbeta (show CBFB Proteins) is mainly caused by impairing MDM2-mediated degradation.

  6. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  7. we failed to detect any increase in p53 (show TP53 Proteins) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 Proteins)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (show MDM4 Proteins), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  8. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 Proteins).

  9. Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 Proteins) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.

  10. These findings elucidate a critical role of Mdm2-p53 (show TP53 Proteins)-Nedd4-2 (show NEDD4L Proteins) signaling underlying the regulation of neural network synchrony and seizure susceptibility.

MDM2 Protein Profile

Protein Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2)
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2)
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2)
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2)
  • p53 E3 ubiquitin protein ligase (Mdm2)
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2)
  • transformed mouse 3T3 cell double minute 2 (Mdm2)
  • 1700007J15Rik protein
  • AA415488 protein
  • ACTFS protein
  • hdm2 protein
  • HDMX protein
  • Mdm-2 protein
  • zgc:109834 protein

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
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