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Browse our MDM2 Proteins (MDM2)

Full name:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) Proteins (MDM2)
On are 21 Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Proteins from 5 different suppliers available. Additionally we are shipping MDM2 Antibodies (393) and MDM2 Kits (12) and many more products for this protein. A total of 461 MDM2 products are currently listed.
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834
list all proteins Gene Name GeneID UniProt
MDM2 4193 Q00987
Rat MDM2 MDM2 314856  
MDM2 17246 P23804

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Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. MDM2 T309G polymorphism is associated with endometrial cancer, especially in Caucasians.

  2. WDR79 (show WRAP53 Proteins) colocalized and interacted with USP7 (show USP7 Proteins) in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 and p53 (show TP53 Proteins), thereby increasing the stability and extending the half-life of the two proteins.

  3. p53 (show TP53 Proteins) expression is low in luminal breast carcinomas than HER-2 (show ERBB2 Proteins) and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total.

  4. Our findings support no major role for the MDM2 SNP309 in KS development although it might influence the clinical outcome of KS in younger patients.

  5. the present study is the first to provide evidence suggesting that miR610 directly targets MDM2 proto-oncogene (show RAB1A Proteins) E3 ubiquitin protein ligase (show UBE2K Proteins) to function as a tumor suppressor in glioma.

  6. P53 (show TP53 Proteins) and MDM2 mRNA and protein were elevated in endometrial polyps and endometrial adenocarcinoma and their expressions were correlated with clinical staging of endometrial adenocarcinoma.

  7. Results suggest that microRNA miRNA-509-5p negatively regulates c-mdm2 proto-oncogene protein (MDM2) expression via targeting the 3' untranslated region (3'-UTR) of genes.

  8. our study suggests that FOXQ1 (show FOXQ1 Proteins) regulates prostate cancer cell proliferation and apoptosis by regulating BCL11A (show BCL11A Proteins)/MDM2 expression and indicates that FOXQ1 (show FOXQ1 Proteins) may serve as a potential therapeutic target for prostate cancer.

  9. The cells with siRNA-MDM2 transfection had a greater decrease in cell viability.

  10. expression of MDM2, somatostatin (show SST Proteins) receptor 2A, and PD-L1 (show CD274 Proteins) in follicular dendritic cell sarcoma

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (show TP53 Proteins)-dependent apoptosis of Theileria parva (show PARVA Proteins)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (show PARVA Proteins), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (show PARVA Proteins)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (show MDM4 Proteins) caused dramatic accumulation of mutant p53 protein (show TP53 Proteins).

  2. Together with p53 (show TP53 Proteins), provides an experimental model for characterizing drugs and genes that affect p53 (show TP53 Proteins) signaling.

  3. Data show that liver-specific expression of p53 (show TP53 Proteins)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 Proteins).

  2. Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 Proteins) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.

  3. These findings elucidate a critical role of Mdm2-p53 (show TP53 Proteins)-Nedd4-2 (show NEDD4L Proteins) signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  4. These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for Triple-negative breast cancers .

  5. there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 (show TP53 Proteins) axis which is important in normal hematopoiesis.

  6. Study showed that demonstrate that Mdm2 intertwines the mammalian target of RAPA (show TRERF1 Proteins), mTOR (show FRAP1 Proteins), and the receptor kinase GRK2 (show ADRBK1 Proteins) in regulating the desensitization/inactivation of the GPR17 (show GPR17 Proteins) receptor

  7. MDM2 mediates p73 (show ARHGAP24 Proteins) ubiquitination

  8. MDM2 supports the PRC2 mediated repression of lineage-specific genes in stem cells, independent of p53 (show TP53 Proteins).

  9. physiological activation of the 5S RNP (show RNPC3 Proteins)-Mdm2-p53 (show TP53 Proteins) pathway may contribute to functional decline of the hematopoietic system in a cell-autonomous manner over time.

  10. Ribosomal proteins L11 (show RPL11 Proteins) and L5 activate TAp73 (show TP73 Proteins) by overcoming MDM2 inhibition.

MDM2 Protein Profile

Protein Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2)
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2)
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2)
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2)
  • p53 E3 ubiquitin protein ligase (Mdm2)
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2)
  • transformed mouse 3T3 cell double minute 2 (Mdm2)
  • 1700007J15Rik protein
  • AA415488 protein
  • ACTFS protein
  • hdm2 protein
  • HDMX protein
  • Mdm-2 protein
  • zgc:109834 protein

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
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