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Human MDM2 Protein expressed in Wheat germ - ABIN1310600
Zhang, Zhong, Chen: LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer. in Journal of proteomics 2016
High MDM2 expression is associated with acute myeloid leukemia (show BCL11A Proteins).
mutant Mdm2 was unable to rescue a p53 (show TP53 Proteins)-induced apoptotic phenotype.
High MDM2 expression is associated with Sjogren's syndrome.
MDM2 expression was an independent and unfavorable prognostic factor of overall survival. Additionally, MDM2 expression was significantly associated with progressive disease and death
These results suggested that variants MDM2 SNP309 and p53 (show TP53 Proteins) Arg72Pro are susceptibility factors for hepatocellular carcinoma
MDM2 SNP285-SNP309 polymorphisms association with genetic predisposition to cancer in Li-Fraumeni syndrome (show TP53 Proteins) Italian patients.
a novel molecular mechanism which, in silico, is capable of triggering p53 (show TP53 Proteins) oscillations. The mechanism that is based on Mdm2's dual regulation of p53 (show TP53 Proteins) can provide mechanistic insights into an excitability of the p53 (show TP53 Proteins) network, thus it contributes to understanding of variability of p53 (show TP53 Proteins) dynamics in response to single and double strand breaks.
Histologically low-grade and relatively low-grade cases of extraskeletal osteosarcoma are not always associated with MDM2 amplification. ESOS cases with MDM2 amplification could be high grade.
Disturbed p53 (show TP53 Proteins)-MDM2 feedback loop contributing to the pathogenesis of thoracic aortic dissection may be linked to TRIM25 (show TRIM25 Proteins) overexpression.
These results identify a novel function for FKBP12 in downregulating MDM2, which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment.
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (show TP53 Proteins)-dependent apoptosis of Theileria parva (show PARVA Proteins)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (show PARVA Proteins), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (show PARVA Proteins)-infected lymphocytes
Data indicate that knockdown of the Mdm2 and Mdm4 (show MDM4 Proteins) caused dramatic accumulation of mutant p53 protein (show TP53 Proteins).
Together with p53 (show TP53 Proteins), provides an experimental model for characterizing drugs and genes that affect p53 (show TP53 Proteins) signaling.
Data show that liver-specific expression of p53 (show TP53 Proteins)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
the existence of an unusual functional interplay between STATs and CREB (show CREB1 Proteins) at the onset of adipogenesis through shared CRTC cofactors, is reported.
Mdm2 expression is required for cell survival even in the absence of p53 (show TP53 Proteins). Moreover, results suggest that p73 (show ARHGAP24 Proteins) compensates for loss of p53 (show TP53 Proteins).
In Fmr1 (show FMR1 Proteins) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (show MEF2C Proteins) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (show TSFM Proteins) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (show FMR1 Proteins) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (show DLG4 Proteins) ubiquitination, degradation and synapse elimination in Fmr1 (show FMR1 Proteins) KO neurons.
MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (show TP53 Proteins) overexpression-related cell death.
The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.
MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (show TP53 Proteins)-independent pathway dependant on Notch1 (show NOTCH1 Proteins) ubiquitination and proteasome degradation.
These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Proteins)/Mdm2-Mdm4 (show MDM4 Proteins) via a RING domain-mediated biochemical mechanism.
both MDM2 and MDMX (show MDM4 Proteins) deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 Proteins), verifying the crucial role of the MDM2 and/or MDMX (show MDM4 Proteins) in regulating p53 (show TP53 Proteins) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.
Vif (show BTG1 Proteins) stabilization by CBFbeta (show CBFB Proteins) is mainly caused by impairing MDM2-mediated degradation.
These results demonstrated a critical prosurvival role for MDM2 in the oocytes
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog