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Browse our MDM2 Proteins (MDM2)

Full name:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) Proteins (MDM2)
On www.antibodies-online.com are 21 Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Proteins from 5 different suppliers available. Additionally we are shipping MDM2 Antibodies (376) and MDM2 Kits (10) and many more products for this protein. A total of 443 MDM2 products are currently listed.
Synonyms:
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834
list all proteins Gene Name GeneID UniProt
MDM2 4193 Q00987
Rat MDM2 MDM2 314856  
MDM2 17246 P23804

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MDM2 Proteins (MDM2) by Origin

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More Proteins for MDM2 Interaction Partners

Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Proteins)/Mdm2-Mdm4 (show MDM4 Proteins) via a RING domain-mediated biochemical mechanism.

  2. Tat (show TAT Proteins) exploited the cellular HDM2 (human double minute 2 protein) ubiquitin ligase to accelerate IRF-1 (show IRF1 Proteins) proteasome-mediated degradation, resulting in a quenching of IRF-1 (show IRF1 Proteins) transcriptional activity during HIV-1 infection.

  3. Data show that long noncoding RNAs lnc00462717 direct target MDM2 protein and regulate MAPK (show MAPK1 Proteins) relevant pathway expression.

  4. TLP (show TBPL1 Proteins) Prevents p53 (show TP53 Proteins) Degradation through Disrupting the p53 (show TP53 Proteins)-MDM2 Interaction.

  5. MDM2 T309G polymorphism is associated with risk and prognosis of lung cancer. TT or T genotype may be associated with the reduced risk of lung cancer, especially in Asians (Meta-Analysis)

  6. NF2 (show NF2 Proteins) regulates the interaction of FAK (show PTK2 Proteins)-p53 (show TP53 Proteins) and MDM2-p53 (show TP53 Proteins).

  7. Report up-regulation of TP53 (show TP53 Proteins)/MDM2 signaling pathway in breast carcinomas.

  8. Expressions of COX-2, p53 (show TP53 Proteins), and MDM2 increased with oral submucous fibrosis progression.

  9. LRRC8A (show LRRC8A Proteins) is an essential regulator of cisplatin induced p53 (show TP53 Proteins) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2, as well as activation of caspase-9 (show CASP9 Proteins) and -3 in tumor cell lines.

  10. These results indicate that p53 (show TP53 Proteins)-independent upregulation of MDM2 by increasing selected clones may lead to oncogenesis.

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (show TP53 Proteins)-dependent apoptosis of Theileria parva (show PARVA Proteins)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (show PARVA Proteins), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (show PARVA Proteins)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (show MDM4 Proteins) caused dramatic accumulation of mutant p53 protein (show TP53 Proteins).

  2. Together with p53 (show TP53 Proteins), provides an experimental model for characterizing drugs and genes that affect p53 (show TP53 Proteins) signaling.

  3. Data show that liver-specific expression of p53 (show TP53 Proteins)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Proteins)/Mdm2-Mdm4 (show MDM4 Proteins) via a RING domain-mediated biochemical mechanism.

  2. both MDM2 and MDMX (show MDM4 Proteins) deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 Proteins), verifying the crucial role of the MDM2 and/or MDMX (show MDM4 Proteins) in regulating p53 (show TP53 Proteins) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  3. Vif (show BTG1 Proteins) stabilization by CBFbeta (show CBFB Proteins) is mainly caused by impairing MDM2-mediated degradation.

  4. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  5. we failed to detect any increase in p53 (show TP53 Proteins) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 Proteins)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (show MDM4 Proteins), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  6. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 Proteins).

  7. Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 Proteins) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.

  8. These findings elucidate a critical role of Mdm2-p53 (show TP53 Proteins)-Nedd4-2 (show NEDD4L Proteins) signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  9. These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for Triple-negative breast cancers .

  10. there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 (show TP53 Proteins) axis which is important in normal hematopoiesis.

MDM2 Protein Profile

Protein Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2)
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2)
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2)
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2)
  • p53 E3 ubiquitin protein ligase (Mdm2)
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2)
  • transformed mouse 3T3 cell double minute 2 (Mdm2)
  • 1700007J15Rik protein
  • AA415488 protein
  • ACTFS protein
  • hdm2 protein
  • HDMX protein
  • Mdm-2 protein
  • zgc:109834 protein

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

GENE ID SPECIES
4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
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