MDM2 Products
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
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This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008].
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Featured MDM2 Categories
MDM2 Antibodies
High quality antibodies with extensive validation data.
MDM2 ELISA Kits
Reliable ELISA kits for a wide range of species.
MDM2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MDM2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p), IP, ICC, ChIP
Validations
- (7)
Cat. No.
ABIN2854782
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), RNAi, PLA
Validations
- (6)
Cat. No.
ABIN517806
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse
Application
WB, ELISA, IHC, IF, ICC
Validations
- (5)
Cat. No.
ABIN6256167
Quantity
100 μL
Datasheet
Datasheet
Recommended MDM2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6957727
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957728
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380227
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended MDM2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1310600
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123867
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123866
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our MDM2 products
: "Sensitive and simultaneous surface plasmon resonance detection of free and p53-bound MDM2 proteins from human sarcomas." in: The Analyst, Vol. 143, Issue 9, pp. 2029-2034, (2019) (PubMed).: "The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and ..." in: The Journal of biological chemistry, Vol. 291, Issue 31, pp. 16339-47, (2017) (PubMed).
: "Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression." in: Molecular medicine reports, Vol. 15, Issue 4, pp. 1455-1460, (2017) (PubMed).
: "Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy." in: Investigative ophthalmology & visual science, Vol. 58, Issue 12, pp. 5361-5367, (2017) (PubMed).
: "Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 22, Issue 3, pp. 746-56, (2016) (PubMed).
: "LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer." in: Journal of proteomics, Vol. 152, pp. 172-180, (2016) (PubMed).
: "P53-Derived peptides conjugation to PEI: an approach to producing versatile and highly efficient targeted gene delivery carriers into cancer cells." in: Expert opinion on drug delivery, Vol. 13, Issue 4, pp. 477-91, (2016) (PubMed).
: "RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel." in: Oncotarget, Vol. 6, Issue 6, pp. 4202-13, (2015) (PubMed).
: "Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro." in: International journal of oncology, Vol. 46, Issue 4, pp. 1677-84, (2015) (PubMed).
: "The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22649-61, (2015) (PubMed).
Synonyms and alternative names related to MDM2
MDM2 proto-oncogene (MDM2), MDM2 proto-oncogene S homeolog (mdm2.S), MDM2 proto-oncogene (Mdm2), Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2), MDM2 oncogene, E3 ubiquitin protein ligase (mdm2), transformed mouse 3T3 cell double minute 2 (Mdm2), 1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834Protein level used designations for MDM2
- E3 ubiquitin-protein ligase Mdm2
- Mdm2, p53 E3 ubiquitin protein ligase homolog
- Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
- double minute 2, human homolog of; p53-binding protein
- oncoprotein Mdm2
- Mdm2 p53 binding protein homolog
- double minute 2 protein
- p53-binding protein Mdm2
- xdm2
- MDM2 alpha
- cdm2
- double minute 2 homolog
- double minute 2
- MDM2-like protein
- edm2
- transformed mouse 3T3 cell double minute 2
- etID309863.4
- murine double minute 2 homolog
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