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Browse our Carboxypeptidase E Proteins (CPE)

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Carboxypeptidase E Proteins (CPE)
On are 28 Carboxypeptidase E (CPE) Proteins from 11 different suppliers available. Additionally we are shipping Carboxypeptidase E Antibodies (82) and Carboxypeptidase E Kits (16) and many more products for this protein. A total of 134 Carboxypeptidase E products are currently listed.
CARBE, CPE, Cph, Cph-1, Cph1, fat, R74677, si:ch211-198g9.2, zgc:85981
list all proteins Gene Name GeneID UniProt
CPE 1363 P16870
CPE 12876 Q00493
CPE 25669 P15087

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Carboxypeptidase E Proteins (CPE) by Origin

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Top referenced Carboxypeptidase E Proteins

  1. Human CPE Protein expressed in Human Cells - ABIN2002009 : Cool, Normant, Shen, Chen, Pannell, Zhang, Loh: Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. in Cell 1997 (PubMed)
    Show all 5 references for ABIN2002009

  2. Mouse (Murine) CPE Protein expressed in HEK-293 Cells - ABIN2180680 : Manser, Fernandez, Loo, Goh, Monfries, Hall, Lim: Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. in The Biochemical journal 1990 (PubMed)
    Show all 4 references for ABIN2180680

  3. Human CPE Protein expressed in HEK-293 Cells - ABIN2180678 : Jeffrey, Alejandro, Luciani, Kalynyak, Hu, Li, Lin, Townsend, Polonsky, Johnson: Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 4 references for ABIN2180678

  4. Human CPE Protein expressed in Escherichia coli (E. coli) - ABIN1098768 : Chu, Briggs, Albrecht, Drain, Johnson: Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells. in Islets 2011 (PubMed)
    Show all 2 references for ABIN1098768

  5. Human CPE Protein expressed in Human Cells - ABIN2215367 : Skalka, Caspi, Caspi, Loh, Rosin-Arbesfeld: Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. in Oncogene 2013 (PubMed)

More Proteins for Carboxypeptidase E Interaction Partners

Human Carboxypeptidase E (CPE) interaction partners

  1. Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.

  2. Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin (show CCK Proteins) and contribute to the formation of cholesterol gallstone.

  3. Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.

  4. Disruption of insulin receptor (IR (show INSR Proteins)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (show EIF2A Proteins) Eif4g1 (show EIF4G1 Proteins).

  5. Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.

  6. Data suggest that splice variant of carboxypeptidase E (CPE-DeltaN) that CPE-DeltaN expression might be a potential prognostic marker for colorectal cancer patients.

  7. CPE is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested

  8. CPE forms a complex, probably through sequences located at its N-terminal domain, with Wnt3a (show WNT3A Proteins) and the extracellular cysteine rich domain of Fz1 (show FZD4 Proteins).

  9. Neither high glucose nor insulin (show INS Proteins) (with low glucose) regulates beta-cell CPE (but either up-regulates CPD (show CPD Proteins)).

  10. an N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers

Mouse (Murine) Carboxypeptidase E (CPE) interaction partners

  1. we show by RNA silencing that CPE and SgIII (show SCG3 Proteins) play a synergistic role in the trafficking of POMC (show POMC Proteins) to granules of the regulated secretory pathway in AtT20 cells

  2. An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.

  3. This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 (show FGF2 Proteins) and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior

  4. The neuroprotective effect of CPE-DeltaN against neuronal glutamate (show GRIN1 Proteins) neurotoxicity was mediated by secreted FGF2 (show FGF2 Proteins).

  5. Carboxypeptidase E is an important modulator of RANKL (show TNFSF11 Proteins)-induced osteoclast differentiation.

  6. Report the effects of ovalbumin (show OVA Proteins) sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.

  7. Disruption of insulin receptor (IR (show INSR Proteins)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (show EIF2A Proteins) Eif4g1 (show EIF4G1 Proteins).

  8. This study has identified CPE as a new neurotrophic factor (show NTF3 Proteins) that can protect neurons against degeneration.

  9. Data suggests that CPE plays critical role in neuroprotection/allostasis in hippocampal neurons during mild chronic stress; up-regulation of CPE and BCL2 (B cell leukemia/lymphoma 2) expression is possibly mediated by glucocorticoids.

  10. There are multiple mechanisms for sorting proglucagon (show GCG Proteins) to the regulated secretory pathway, including a role for carboxypeptidase E in pancreatic alpha cells, initial cleavage at K70R71 and multiple sorting signals.

Carboxypeptidase E (CPE) Protein Profile

Protein Summary

This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.

Alternative names and synonyms associated with Carboxypeptidase E (CPE)

  • carboxypeptidase E (CPE)
  • carboxypeptidase E (cpe)
  • carboxypeptidase E (Cpe)
  • CARBE protein
  • CPE protein
  • Cph protein
  • Cph-1 protein
  • Cph1 protein
  • fat protein
  • R74677 protein
  • si:ch211-198g9.2 protein
  • zgc:85981 protein

Protein level used designations for Carboxypeptidase E Proteins (CPE)

carboxypeptidase E , carboxypeptidase E preproprotein , carboxypeptidase E-like , CPH , carboxypeptidase H , cobalt-stimulated chromaffin granule carboxypeptidase , enkephalin convertase , insulin granule-associated carboxypeptidase , prohormone-processing carboxypeptidase

443028 Ovis aries
475492 Canis lupus familiaris
708881 Macaca mulatta
100127580 Xenopus (Silurana) tropicalis
100397838 Callithrix jacchus
100458397 Pongo abelii
1363 Homo sapiens
280753 Bos taurus
12876 Mus musculus
25669 Rattus norvegicus
407979 Danio rerio
100158368 Xenopus laevis
422424 Gallus gallus
100037304 Sus scrofa
461592 Pan troglodytes
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