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Human CPE Protein expressed in Human Cells - ABIN2215367
Skalka, Caspi, Caspi, Loh, Rosin-Arbesfeld: Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. in Oncogene 2013
This study has uncovered a human CPE/NF-alpha1 gene mutation that could lead to comorbidity of dementia and depression, emphasizing the importance of this gene in cognitive function.
CPE through its N'-terminal sequence, forms aggregates with Wnt3a (show WNT3A Proteins) and possible endoplasmic reticulum (ER) stress leading to its loss of function.
we have identified a novel SNP in the CPE gene which results in the loss of its neuroprotective function in cells and may confer neurological disorders in humans
High-level CPE [ carboxypeptidase E] expression was associated with a poor prognosis in early-stage cervical cancer. CPE may serve as a biomarker for predicting PLNM [ pelvic lymph node metastasis ] and survival in these patients.
Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.
Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin (show CCK Proteins) and contribute to the formation of cholesterol gallstone.
Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.
Disruption of insulin receptor (IR (show INSR Proteins)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (show EIF2A Proteins) Eif4g1 (show EIF4G1 Proteins).
Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.
Data suggest that splice variant of carboxypeptidase E (CPE-DeltaN) that CPE-DeltaN expression might be a potential prognostic marker for colorectal cancer patients.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP Proteins)-positive astrocytes for normal neurodevelopment.
we show by RNA silencing that CPE and SgIII (show SCG3 Proteins) play a synergistic role in the trafficking of POMC (show POMC Proteins) to granules of the regulated secretory pathway in AtT20 cells
An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.
This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 (show FGF2 Proteins) and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior
The neuroprotective effect of CPE-DeltaN against neuronal glutamate (show GRIN1 Proteins) neurotoxicity was mediated by secreted FGF2 (show FGF2 Proteins).
Carboxypeptidase E is an important modulator of RANKL (show TNFSF11 Proteins)-induced osteoclast differentiation.
Report the effects of ovalbumin (show OVA Proteins) sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.
This study has identified CPE as a new neurotrophic factor (show NTF3 Proteins) that can protect neurons against degeneration.
Data suggests that CPE plays critical role in neuroprotection/allostasis in hippocampal neurons during mild chronic stress; up-regulation of CPE and BCL2 (B cell leukemia/lymphoma 2) expression is possibly mediated by glucocorticoids.
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
, carboxypeptidase E preproprotein
, carboxypeptidase E-like
, carboxypeptidase H
, cobalt-stimulated chromaffin granule carboxypeptidase
, enkephalin convertase
, insulin granule-associated carboxypeptidase
, prohormone-processing carboxypeptidase