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Human CPE Protein expressed in Human Cells - ABIN2002009
Cool, Normant, Shen, Chen, Pannell, Zhang, Loh: Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. in Cell 1997
Show all 5 references for ABIN2002009
Mouse (Murine) CPE Protein expressed in HEK-293 Cells - ABIN2180680
Manser, Fernandez, Loo, Goh, Monfries, Hall, Lim: Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. in The Biochemical journal 1990
Show all 4 references for ABIN2180680
Human CPE Protein expressed in HEK-293 Cells - ABIN2180678
Jeffrey, Alejandro, Luciani, Kalynyak, Hu, Li, Lin, Townsend, Polonsky, Johnson: Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 4 references for ABIN2180678
Human CPE Protein expressed in Escherichia coli (E. coli) - ABIN1098768
Chu, Briggs, Albrecht, Drain, Johnson: Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells. in Islets 2011
Show all 2 references for ABIN1098768
Human CPE Protein expressed in Human Cells - ABIN2215367
Skalka, Caspi, Caspi, Loh, Rosin-Arbesfeld: Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. in Oncogene 2013
Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.
Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin (show CCK Proteins) and contribute to the formation of cholesterol gallstone.
Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.
Disruption of insulin receptor (IR (show INSR Proteins)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (show EIF2A Proteins) Eif4g1 (show EIF4G1 Proteins).
Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.
Data suggest that splice variant of carboxypeptidase E (CPE-DeltaN) that CPE-DeltaN expression might be a potential prognostic marker for colorectal cancer patients.
CPE is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested
CPE forms a complex, probably through sequences located at its N-terminal domain, with Wnt3a (show WNT3A Proteins) and the extracellular cysteine rich domain of Fz1 (show FZD4 Proteins).
Neither high glucose nor insulin (show INS Proteins) (with low glucose) regulates beta-cell CPE (but either up-regulates CPD (show CPD Proteins)).
an N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers
we show by RNA silencing that CPE and SgIII (show SCG3 Proteins) play a synergistic role in the trafficking of POMC (show POMC Proteins) to granules of the regulated secretory pathway in AtT20 cells
An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.
This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 (show FGF2 Proteins) and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior
The neuroprotective effect of CPE-DeltaN against neuronal glutamate (show GRIN1 Proteins) neurotoxicity was mediated by secreted FGF2 (show FGF2 Proteins).
Carboxypeptidase E is an important modulator of RANKL (show TNFSF11 Proteins)-induced osteoclast differentiation.
Report the effects of ovalbumin (show OVA Proteins) sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.
This study has identified CPE as a new neurotrophic factor (show NTF3 Proteins) that can protect neurons against degeneration.
Data suggests that CPE plays critical role in neuroprotection/allostasis in hippocampal neurons during mild chronic stress; up-regulation of CPE and BCL2 (B cell leukemia/lymphoma 2) expression is possibly mediated by glucocorticoids.
There are multiple mechanisms for sorting proglucagon (show GCG Proteins) to the regulated secretory pathway, including a role for carboxypeptidase E in pancreatic alpha cells, initial cleavage at K70R71 and multiple sorting signals.
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
, carboxypeptidase E preproprotein
, carboxypeptidase E-like
, carboxypeptidase H
, cobalt-stimulated chromaffin granule carboxypeptidase
, enkephalin convertase
, insulin granule-associated carboxypeptidase
, prohormone-processing carboxypeptidase