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anti-Mouse (Murine) PPP2R4 Antibodies:
anti-Human PPP2R4 Antibodies:
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Human Monoclonal PPP2R4 Primary Antibody for ICC, FACS - ABIN969557
Yoon, Jun, Park, Jun Yoo, Moon, Soon Baik, Kim, Kim, Kim, Koh, Taek Lee, You: Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. in Stem cells (Dayton, Ohio) 2010
Show all 2 Pubmed References
Human Polyclonal PPP2R4 Primary Antibody for ChIP, WB - ABIN2668597
Fellner, Lackner, Hombauer, Piribauer, Mudrak, Zaragoza, Juno, Ogris: A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. in Genes & development 2003
Human Polyclonal PPP2R4 Primary Antibody for ELISA, WB - ABIN4347103
Gushiken, Patel, Liu, Pradhan, Bergeron, Peng, Vijayan: Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling. in The Journal of biological chemistry 2008
data indicate that PTPalpha (show PTPRA Antibodies) and FAK (show PTK2 Antibodies), which are enriched in FAs (show FAS Antibodies), interact with IP3R1 (show ITPR1 Antibodies) at adjacent ER sites to spatially sequester IL-1 (show IL1A Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signalling
oocyte-specific deletion of Ppp2r1a (show PPP2R1A Antibodies) led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (show PPP2R2B Antibodies) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (show PLK4 Antibodies) autophosphorylation, thus stabilizing Plk4 (show PLK4 Antibodies) and promoting centriole duplication
PP2A (show PPP2R2B Antibodies)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (show TFAP2A Antibodies), CREB (show CREB1 Antibodies), ETS-1 (show ETS1 Antibodies), and SP-1 (show SP1 Antibodies)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3 (show CASP3 Antibodies)-dependent apoptosis
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 (show RPS3 Antibodies) by both activating PKCdelta (show PKCd Antibodies) and blocking the PP2A (show PPP2R2B Antibodies) interaction with rpS3 (show RPS3 Antibodies)
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A (show PPP2R2B Antibodies) prevents the inhibitory function of CTLA-4 (show CTLA4 Antibodies), before TCR-CTLA-4 (show CTLA4 Antibodies) coligation.
the present study suggested that PP2A has an important role in regulating mast cell beta2-adrenoceptors
The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (show IFNA Antibodies) signaling via increased expression of SOCS3 (show SOCS3 Antibodies) and PP2A.
The current study describes a novel pathogenic mechanism of action for human polyomavirus 6 small tumor (sT) antigen which involves binding to protein phosphatase 2A (PP2A) via its WFG motif and zinc binding sites for activation of PP2A's downstream oncogenic pathways (MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies)/c-Jun (show JUN Antibodies)).
The aim of this review is to shed light on the role of four different phosphatases (PTEN (show PTEN Antibodies), PP2A, CDC25 (show RASGRF1 Antibodies) and DUSP1 (show DUSP1 Antibodies)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Oncoprotein CIP2A (show KIAA1524 Antibodies) is stabilized via interaction with tumor suppressor PP2A/B56
Such effect by miR (show MLXIP Antibodies)-429 was again abolished with AMPKalpha1 (show PRKAA1 Antibodies) silence or mutation. Together, we propose that PP2A-c silence by miR (show MLXIP Antibodies)-429 activates AMPK (show PRKAA1 Antibodies) and protects osteoblastic cells from Dex.
PTPalpha (show PTPRA Antibodies) is identified as a novel substrate of N-Acetylglucosaminyltransferase V (GnT-V (show MGAT5 Antibodies)) and could be a factor regulating promotion of migration in breast cancer cells
This article reviews the involvement of PP2A in the regulation of three cell signaling pathways: wnt (show WNT2 Antibodies), mTOR (show FRAP1 Antibodies) and MAP kinase (show MAPK1 Antibodies), as well as the G1-->S transition, DNA synthesis and mitotic initiation. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases. [review]
PP2A-B55 (show MINK1 Antibodies) substrates were identified and assigned their temporal order in mitotic exit.
Our results provide a novel mechanistic insight into the activation of Myc (show MYC Antibodies) by 27-HC via transcriptional repression of PP2A, SCP1 (show SYCP1 Antibodies) and FBW7 (show FBXW7 Antibodies) to increase Myc (show MYC Antibodies) protein stability in breast cancer cells.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, PP2A phosphatase activator
, PP2A subunit B' isoform PR53
, phosphotyrosyl phosphatase activator
, protein phosphatase 2A, regulatory subunit B' (PR 53)
, serine/threonine-protein phosphatase 2A activator
, serine/threonine-protein phosphatase 2A regulatory subunit B'
, PP2A, subunit B', PR53 isoform
, serine/threonine-protein phosphatase 2A regulatory subunit 4
, protein tyrosine phosphatase, receptor type, A