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Cow (Bovine) Monoclonal CASR Primary Antibody for ELISA, FACS - ABIN266769
Goldsmith, Fan, Ray, Shiloach, McPhie, Rogers, Spiegel: Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. in The Journal of biological chemistry 1999
Show all 14 Pubmed References
Human Monoclonal CASR Primary Antibody for ELISA, FACS - ABIN250524
Handlogten, Shiraishi, Awata, Huang, Miller: Extracellular Ca(2+)-sensing receptor is a promiscuous divalent cation sensor that responds to lead. in American journal of physiology. Renal physiology 2001
Show all 4 Pubmed References
Mouse (Murine) Polyclonal CASR Primary Antibody for WB - ABIN1881139
OSeaghdha, Yang, Glazer, Leak, Dehghan, Smith, Kao, Lohman, Hwang, Johnson, Hofman, Uitterlinden, Chen, Brown, Siscovick, Harris, Psaty, Coresh, Gudnason, Witteman, Liu, Kestenbaum, Fox, Köttgen: Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. in Human molecular genetics 2010
Show all 2 Pubmed References
Human Polyclonal CASR Primary Antibody for IF (p), IHC (p) - ABIN1386858
Huang, Xiao, Tan, Xiao, Wang, Yin, Duan, Huang, Yang, Yin: Chitosan Oligosaccharide Reduces Intestinal Inflammation That Involves Calcium-Sensing Receptor (CaSR) Activation in Lipopolysaccharide (LPS)-Challenged Piglets. in Journal of agricultural and food chemistry 2016
CaSR activation may play a fundamental role in selecting specific differentiation checkpoints of neurogenesis and osteogenesis
The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.
Calcium and the calcimimetic NPS (show NPS Antibodies) R-467 reduce CaSR mRNA expression and stimulate cell growth/proliferation in equine size-sieved umbilical cord matrix mesenchymal stem cell.
The endoplasmic reticulum-associated protein, OS-9 (show OS9 Antibodies), behaves as a lectin in targeting the immature calcium-sensing receptor.
Glucose acts as a positive allosteric modulator of CaSR.
These studies indicate that the CaSR activation impairs glucose tolerance by a combination of alpha- and beta-cell defects and also influences pancreatic islet mass.
Minor alleles rs7652589 and rs1501899 are associated with reduced CaSR expression in neuroblastic tumors and neuroblastoma (show ARHGEF16 Antibodies) cell lines in which the CASR gene promoter P2 is not hypermethylated.
Calcium exerted its effects on cartilaginous endplates matrix protein synthesis through activation of the extracellular calcium-sensing receptor.
Polymorphic variations in VDR (show CYP27B1 Antibodies) and CASR may be associated with survival after a diagnosis of colorectal neoplasms.
CaSR and AP2S1 (show AP2S1 Antibodies) sequencing is worthwhile in patients with familial hyperparathyroidism and phenotype suggesting familial hypocalciuric hypercalcemia as it can diagnose up to 50% of cases.
reduced expression of the CaSR is correlated with activation of the renin-angiotensin system, which induces increased vascular remodeling and vascular smooth muscle cell proliferation, and thereby associated with essential hypertension in the SHR rat model and in the Han Chinese population
CaSR exerts a suppressive function in pancreatic tumorigenesis through a novel NCX1 (show SLC8A1 Antibodies)/Ca(2 (show CA2 Antibodies)+)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
In whites, CaSR gene SNP rs1801725 was associated with serum calcium but not with risk of diabetes.
These findings suggest that trabecular bone formation can occur independently of the CaSR, and that the CaSR plays a collaborative role in the PTH (show PTH Antibodies) anabolic effects on bone.
Vdr (show CYP27B1 Antibodies) and Casr are required for beta-catenin (show CTNNB1 Antibodies)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
we suggest that decreased Ca2 (show CA2 Antibodies)+ levels and increased CaSR expression might be involved in increased insulin (show INS Antibodies) secretion to compensate for insulin (show INS Antibodies) resistance in aged mice.
physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR (show CFTR Antibodies).
CaSR was localized in the basolateral membrane of basolateral membrane of type-B intercalated cell and was more expressed during alkali-loading
Demonstrate a role for CaSR in cardiovascular system and suggest physiologically relevant changes in extracellular Ca(2 (show CA2 Antibodies)+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR.
Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.
fluoride might be able to affect calcium homeostasis by regulating PTH (show PTH Antibodies), PTHrP (show PTHLH Antibodies), and CaSR
the activation of CaSR in the collecting duct prevents the cyclic AMP (show TMPRSS5 Antibodies)-dependent increase in AQP2 (show AQP2 Antibodies)-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin (show AVP Antibodies) response.
Heteromeric TRPV4 (show TRPV4 Antibodies)-TRPC1 (show TRPC1 Antibodies) channels mediate CaSR-induced vasorelaxation through NO production but not IKCa channel activation in rabbit mesenteric arteries.
Long-term activation of CaSR with cinacalcet disrupted the cadherin-catenin complex, induced cytoskeletal remodeling, actin fiber formation, and redistribution of CaSR to the nuclear area. These changes indicate a significant and complex role of CaSR in epithelial remodeling and barrier function of esophageal cells.
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
, vomeronasal receptor F-1
, calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, parathyroid gland calcium-sensing receptor
, extracellular calcium-sensing receptor-like
, extracellular calcium-sensing receptor
, parathyroid Ca(2+)-sensing receptor 1
, parathyroid cell calcium-sensing receptor
, parathyroid Cell calcium-sensing receptor
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism)
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, G protein coupled receptor, family C, group 2, member A
, G protein-coupled receptor, family C, group 2, member A
, cation sensing receptor