CASR Products
(Calcium-Sensing Receptor (CASR))
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The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008].
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Featured CASR Categories
CASR Antibodies
High quality antibodies with extensive validation data.
CASR ELISA Kits
Reliable ELISA kits for a wide range of species.
CASR Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CASR Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (1)
- (4)
Cat. No.
ABIN1678994
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (4)
Cat. No.
ABIN6255749
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Pig
Application
WB, ELISA
Validations
- (2)
- (2)
Cat. No.
ABIN1386858
Quantity
100 μL
Datasheet
Datasheet
Recommended CASR ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954278
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954279
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954280
Quantity
96 tests
Datasheet
Datasheet
Recommended CASR Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348127
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348129
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3090657
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CASR products
: "Activation of the calcium-sensing receptor in human valvular interstitial cells promotes calcification." in: Journal of molecular and cellular cardiology, Vol. 129, pp. 2-12, (2019) (PubMed).: "Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro." in: Cell stem cell, Vol. 25, Issue 2, pp. 225-240.e7, (2019) (PubMed).
: "Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear." in: Cell and tissue research, (2019) (PubMed).
: "Involvement of calcium-sensing receptor activation in the alleviation of intestinal inflammation in a piglet model by dietary aromatic amino acid supplementation." in: The British journal of nutrition, Vol. 120, Issue 12, pp. 1321-1331, (2019) (PubMed).
: "Calcium-sensing receptor (CaSR) promotes development of bone metastasis in renal cell carcinoma." in: Oncotarget, Vol. 9, Issue 21, pp. 15766-15779, (2018) (PubMed).
: "Evaluation of a TPTX model induced by ischemia." in: Experimental animals, Vol. 66, Issue 4, pp. 345-356, (2018) (PubMed).
: "Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin ..." in: Oncotarget, Vol. 8, Issue 34, pp. 56460-56472, (2017) (PubMed).
: "Involvement of the calcium-sensing receptor in mineral trioxide aggregate-induced osteogenic gene expression in murine MC3T3-E1 cells." in: Dental materials journal, Vol. 36, Issue 4, pp. 469-475, (2017) (PubMed).
: "Hypoxia-Induced Mitogenic Factor Acts as a Nonclassical Ligand of Calcium-Sensing Receptor, Therapeutically Exploitable for Intermittent Hypoxia-Induced Pulmonary Hypertension." in: Hypertension (Dallas, Tex. : 1979), Vol. 69, Issue 5, pp. 844-854, (2017) (PubMed).
: "Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor." in: Journal of the American Heart Association, Vol. 6, Issue 4, (2017) (PubMed).
Synonyms and alternative names related to CASR
calcium sensing receptor (CASR), calcium-sensing receptor (Casr), calcium-sensing receptor L homeolog (casr.L), calcium sensing receptor (Casr), CAR, CaR, CASR, EIG8, FHH, FIH, GPRC2A, Gprc2a, gprc2a, HHC, HHC1, HYPOC1, NSHPT, PCAR1, xV2R F-1Protein level used designations for CASR
- extracellular calcium-sensing receptor
- parathyroid Ca(2+)-sensing receptor 1
- parathyroid cell calcium-sensing receptor
- G protein coupled receptor, family C, group 2, member A
- G protein-coupled receptor, family C, group 2, member A
- PCaR1
- cation sensing receptor
- Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism)
- Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
- parathyroid Cell calcium-sensing receptor
- calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
- calcium-sensing receptor
- vomeronasal receptor F-1
- parathyroid gland calcium-sensing receptor
- extracellular calcium-sensing receptor-like
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