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Human GCG ELISA Kit for Competition ELISA - ABIN1979122
Elliott, Ustione, Piston: Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. in American journal of physiology. Endocrinology and metabolism 2015
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Mouse (Murine) GCG ELISA Kit for Sandwich ELISA - ABIN857137
Stockebrand, Hornig, Neu, Atzler, Cordts, Böger, Isbrandt, Schwedhelm, Choe: Homoarginine supplementation improves blood glucose in diet-induced obese mice. in Amino acids 2015
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Human GCG ELISA Kit for Competition ELISA - ABIN414595
He, Wang, Lu, Chen, Jin, Wang, Zhao, Ren, Wang, Li, Cheng: Increasing glucagon secretion could antagonize the action of exogenous insulin for glycemic control in streptozocin-induced diabetic rhesus monkeys. in Experimental biology and medicine (Maywood, N.J.) 2013
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GLP-2 could be considered an hormone causing positive energy balance, which, however has the role to mitigate the metabolic dysfunctions associated with hyper-adiposity. [review]
Studies indicate that nutrient-induced glucagonlike peptide-1 (GLP-1) response was one of the best predictors of type 2 diabetes mellitus (T2DM) remission after Roux-en-Y-gastric-bypass (RYGB).
Insulin (show INS ELISA Kits) resistance in non-diabetic individuals is associated with raised fasting GLP-1 levels but reduced GLP-1 responses to meal stimulation.
we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor (show EGFR ELISA Kits) and activation of Foxo1 (show FOXO1 ELISA Kits), resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase (show AMY ELISA Kits) and lipase (show LIPG ELISA Kits) levels in subjects treated with GLP-1 receptor (show GLP1R ELISA Kits) agonists reflect adaptive growth rather than early-stage pancreatitis.
Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Data suggest early peaks in glucagon-like peptide-1 and glucagon secretion/blood level together trigger exaggerated insulinotropic response (high insulin (show INS ELISA Kits) secretion/level) to eating and consequent hypoglycaemia in patients with postprandial hypoglycaemia as a postoperative complication following Roux-en-Y gastric bypass for obesity complicated by type 2 diabetes; this retrospective cohort study was conducted in London.
A common variant, i.e., single nucleotide polymorphism rs6741949, in the DPP4 (show DPP4 ELISA Kits) gene interacts with body adiposity and negatively affects glucose-stimulated GLP-1 levels, insulin (show INS ELISA Kits) secretion, and glucose tolerance.
Compared with the lean group, the obese group had significantly higher fasting and post-OGTT GIP (show GIP ELISA Kits) levels, but similar fasting GLP-1 and significantly lower post-OGTT GLP-1 levels.
Hemodialysis improves upper GI symptoms and gastric slow waves in CKD patients. An increase in ghrelin (show GHRL ELISA Kits) and a decrease in GLP-1 might be involved in the HD-induced improvement in gastric slow waves.
Data suggest that, in obesity, serum levels of active GLP1 are down-regulated and serum levels of soluble DPP4 (show DPP4 ELISA Kits) are up-regulated; DPP4 (show DPP4 ELISA Kits) levels correlate negatively with active GLP-1 levels but are positively associated with insulin (show INS ELISA Kits) resistance; thus, DPP4 (show DPP4 ELISA Kits) may be biomarker for insulin (show INS ELISA Kits) resistance. This study was conducted in Malaysia. (GLP1 = glucagon-like peptide 1; DPP4 (show DPP4 ELISA Kits) = dipeptidyl peptidase 4 (show DPP4 ELISA Kits))
of glucagon-like peptide-1 in vagotomized mice may prevent VLDL overproduction and insulin (show INS ELISA Kits) resistance induced by high-fat diet.
beta-cell function, plasma active GLP-1 levels, the GLP-1R (show GLP1R ELISA Kits) pathway in beta cells and L cell differentiation, were investigated.
CCK (show CCK ELISA Kits)/GLP-1 play contributory roles in anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol.
The role of syntaxin 1A (show STX1A ELISA Kits) in GLP1 release from intestinal cells as a response to external stimuli is reported.
GCG neurons likely stimulate separate populations of downstream cells to produce a change in food intake and glucose homeostasis and that these effects depend on the metabolic state of the animal.
Together, our data indicate effects of AgoPAMs that go beyond glucose lowering previously observed with GPR40 (show FFAR1 ELISA Kits) partial agonist treatment with additional potential for weight loss.
pancreatic reactivation of Gcg fully restored the effect of exendin-[9-39] to impair both oral and intraperitoneal glucose tolerance.
these findings identify distinct roles for DPP4 (show DPP4 ELISA Kits) in the endothelial cell versus the bone marrow compartment for selective incretin degradation and DPP4 (show DPP4 ELISA Kits) inhibition-mediated glucoregulation.
These findings suggest that TRPV2 (show TRPV2 ELISA Kits) activation via actin reorganization induced by Gq and G12 (show TCF3 ELISA Kits)/13 signaling is involved in LPI (show Slc7a7 ELISA Kits)-stimulated GLP-1 secretion in enteroendocrine L cells.
critical for the regulation of glucagon secretion in response to glucose in obesity
data demonstrate that cattle express proglucagon and glucagon-like peptide 2 receptor (show GLP2R ELISA Kits) mRNA primarily in small intestinal and colon tissues and increased nutrient intake increases ileal proglucagon mRNA and plasma glucagon-like peptide 2
Data suggest that casein, safflower oil, sucrose, and sweetening agent rebaudioside A stimulate GLP1 release/secretion from enteroendocrine cells. (GLP1 = glucagon-like peptide 1, a peptide fragment derived from proglucagon)
The patterns of colocalization of the K cell marker, glucagon-like insulinotropic peptide, and L cell markers, glucagon like peptide-1 and peptide YY, in enteroendocrine cells of the small intestine and colon of mouse and pig, were investigated.
The findings indicate that the brainstem preproglucagon neuronal system is highly conserved between rat and non-human primate
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I
, glucagon-like peptide-1
, preproglucagon B
, glucagon preproprotein
, preproglucagon A
, glucagon I
, proglucagon I