Browse our GCK Proteins (GCK)

On are 64 Glucokinase (Hexokinase 4) (GCK) Proteins from 11 different suppliers available. Additionally we are shipping GCK Antibodies (115) and GCK Kits (38) and many more products for this protein. A total of 231 GCK products are currently listed.
AI385662, BA4487, BL44, FGQTL3, GCK, gck-A, GK, GLK, Gls006, glucokinase, GLUKA, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, Rab8ip, RNGK2
list all proteins Gene Name GeneID UniProt
GCK 103988 P52792
Rat GCK GCK 24385 P17712
GCK 2645 P35557

GCK Proteins (GCK) by Origin

More Proteins for GCK Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. This study using immunoreactive techniques, we have demonstrated in those specific areas of the rainbow trout brain previously described as glucosensor the presence of glucokinase in different cell types.

Xenopus laevis Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GKRP (show GCKR Proteins) binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.

Mouse (Murine) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver.

  2. Absence of Gck expression did not prevent the glucose responsiveness of glucose-excited or glucose-inhibited Sf1 (show SF1 Proteins) neurons in either sex. Thus Gck in the VMN plays a sex-specific role in the glucose-dependent control of autonomic nervous activity; this is, however, unrelated to the control of the firing activity of classical glucose-responsive neurons.

  3. Using a mutant GCK gene (GCK 262) with a knocked out cytosine at position 2643 results in lower protein expression and more ubiquitination-led protein degradation compared with wild-type GCK (GCK 261)

  4. lncLGR facilitates the recruitment of hnRNPL (show HNRNPL Proteins) to the GCK promoter and suppresses GCK transcription.

  5. Given that acetylated GKRP (show GCKR Proteins) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (show GCKR Proteins) acetylation in the liver could reveal novel targets within the GK-GKRP (show GCKR Proteins) pathway, for treating T2DM and other metabolic pathologies.

  6. These results suggest a mechanism for integrative control over GCK activation and, therefore, glucose metabolism and insulin (show INS Proteins) secretion through regulation of cytoplasmic Ca(2 (show CA2 Proteins)+) levels.

  7. GHR (show GHR Proteins) knockdown caused increased glucokinase mRNA and protein levels.

  8. results suggest that chronic suppression of hepatic glucokinase has a small influence on intertissue (liver-to-BAT (show BAAT Proteins) as well as liver-to-beta-cell) metabolic communication

  9. Atf3 (show ATF3 Proteins)-silencing reversed ethanol-mediated Gck down-regulation and beta-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin (show INS Proteins) resistance.

  10. Suggest heterozygous glucokinase knockout mouse as a translatable model of human type 2 diabetes.

Human Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GCK gene mutations (pathogenic or likely pathogenic variants) and a novel intronic variant of uncertain significance (c.208 + 3A>T) were identified in 13/54 probands (24%).

  2. Data suggest that hepatic glucokinase activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP (show GCKR Proteins)) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2 (show PFKFB3 Proteins)/FBP2 (show KHSRP Proteins)); changes in glucokinase expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]

  3. GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver.

  4. GCK mutations are associated with MODY2.

  5. Glucokinase mutations are associated with Maturity-Onset Diabetes of the Young.

  6. The results show that p.Leu77Arg but not p.Val101Met GCK mutation is considered a pathogenic mutation associated with maturity onset diabetes of the young.

  7. GCK mutations are associated with Maturity onset diabetes of youth.

  8. glucokinase mutation is associated with Maturity-Onset Diabetes of the Young, Type 2.

  9. The number of mutations in GCK/MODY2 or even other MODY (show HNF4A Proteins)-related genes is undoubtedly underestimated, as accepted criteria for performing genetic tests include family history of the pathology.

  10. Plasma ghrelin (show GHRL Proteins) is higher in glucokinase-maturity onset diabetes of the young than in the common polygenic forms of diabetes.

GCK Protein Profile

Protein Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Alternative names and synonyms associated with GCK

  • glucokinase (hexokinase 4) (GCK)
  • glucokinase (GCK)
  • glucokinase (glcK)
  • glucokinase (Bphyt_1025)
  • glucokinase (Halhy_6548)
  • glucokinase (gk)
  • glucokinase (hexokinase 4) (gck)
  • glucokinase (Gck)
  • glucokinase (LOC100341946)
  • glucokinase (hexokinase 4) (Gck)
  • mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2)
  • AI385662 protein
  • BA4487 protein
  • BL44 protein
  • FGQTL3 protein
  • GCK protein
  • gck-A protein
  • GK protein
  • GLK protein
  • Gls006 protein
  • glucokinase protein
  • GLUKA protein
  • HHF3 protein
  • HK4 protein
  • HKIV protein
  • HXKP protein
  • LGLK protein
  • MODY2 protein
  • Rab8ip protein
  • RNGK2 protein

Protein level used designations for GCK

glucokinase , hexokinase 4 , HK IV , hexokinase type IV , hexokinase-4 , hexokinase-D , HK4 , ATP:D-hexose 6-phosphotransferase , hexokinase D, pancreatic isozyme , glucokinase (hexokinase 4, maturity onset diabetes of the young 2) , MAPK/ERK kinase kinase kinase 2 , MEK kinase kinase 2 , MEKKK 2 , RAB8 interacting protein , germinal center kinase , mitogen activated protein kinase kinase kinase kinase 2 , rab8-interacting protein

100051836 Equus caballus
374086 Gallus gallus
606490 Canis lupus familiaris
1087979 Bacillus anthracis str. Ames
2797963 Listeria monocytogenes serotype 4b str. F2365
3728664 Carboxydothermus hydrogenoformans Z-2901
6284349 Burkholderia phytofirmans PsJN
10590758 Haliscomenobacter hydrossis DSM 1100
100135866 Oncorhynchus mykiss
378602 Xenopus laevis
100124905 Xenopus (Silurana) tropicalis
103988 Mus musculus
24385 Rattus norvegicus
100341946 Oryctolagus cuniculus
2645 Homo sapiens
100037406 Felis catus
616576 Bos taurus
430370 Gallus gallus
100514142 Sus scrofa
100717630 Cavia porcellus
26412 Mus musculus
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