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GCK Products

(Glucokinase (Hexokinase 4) (GCK))

Categories

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009].

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Featured GCK Categories

GCK Antibodies

High quality antibodies with extensive validation data.

GCK ELISA Kits

Reliable ELISA kits for a wide range of species.

GCK Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GCK Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (6)
Cat. No. ABIN515989
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
  • (3)
Cat. No. ABIN969172
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7429088
Quantity 100 μL
Datasheet Datasheet

Recommended GCK ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956118
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956116
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967028
Quantity 96 tests
Datasheet Datasheet

Recommended GCK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354918
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354920
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123102
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our GCK products

Tu, Liu, Cao, Zhu, Li, Ji, Han, Xiao: "Hypoglycemic effects of wheat bran alkyresorcinols in high-fat/high-sucrose diet and low-dose streptozotocin-induced type 2 diabetic male mice and protection of pancreatic β cells." in: Food & function, Vol. 10, Issue 6, pp. 3282-3290, (2019) (PubMed).

Xu, Xiao, Liu, Yang, Zhang, Chen, Chen, Liu, Huang: "Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt." in: Frontiers in pharmacology, Vol. 10, pp. 261, (2019) (PubMed).

Zang, Fan, Chen, Huang, Qin: "Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway." in: Journal of agricultural and food chemistry, Vol. 66, Issue 26, pp. 6772-6781, (2018) (PubMed).

Ali, Eid, Hanafi: "Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats." in: Life sciences, Vol. 194, pp. 196-204, (2018) (PubMed).

Wang, Liu, Chen, Duan, Chen, Xi: "Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus." in: Journal of diabetes research, Vol. 2017, pp. 5812607, (2017) (PubMed).

Tian, Liu, Wang, Dong, Su, Ma, Zhang: "Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." in: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).

Huang, Chou, Lee, Chen, Chen, Tao, Shih: "MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ." in: RNA (New York, N.Y.), Vol. 21, Issue 3, pp. 385-400, (2015) (PubMed).

Godini, Ghasemi, Zahediasl: "The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats." in: PLoS ONE, Vol. 10, Issue 7, pp. e0131198, (2015) (PubMed).

Jin, Guo, Li, Lei, Li, Mao, Wang, Zhou, Zhang, Hu, Zhang, Niu, Irwin, Tan: "Role of glucokinase in the subcellular localization of glucokinase regulatory protein." in: International journal of molecular sciences, Vol. 16, Issue 4, pp. 7377-93, (2015) (PubMed).

Barbetti, Cobo-Vuilleumier, Dionisi-Vici, Toni, Ciampalini, Massa, Rodriguez-Bada, Colombo, Lenzi, Garcia-Gimeno, Bermudez-Silva, Rodriguez de Fonseca, Banin, Aledo, Baixeras, Sanz, Cuesta-Muñoz: "Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1983-9, (2009) (PubMed).

Synonyms and alternative names related to GCK

glucokinase (GCK), glucokinase (Gck), glucokinase (glcK), glucokinase (Bphyt_1025), glucokinase (Halhy_6548), glucokinase (gk), glucokinase (hexokinase 4) L homeolog (gck.L), glucokinase (hexokinase 4) (gck), BA4487, FGQTL3, GCK, gck-A, GK, Gk, GLK, glk, Gls006, glucokinase, GLUKA, HHF3, hhf3, HK4, hk4, HKIV, hkiv, HXKP, hxkp, LGLK, MODY2, mody2, RNGK2

Protein level used designations for GCK

  • ATP:D-hexose 6-phosphotransferase
  • HK IV
  • glucokinase
  • hexokinase D, pancreatic isozyme
  • hexokinase type IV
  • hexokinase-4
  • hexokinase-D
  • hexokinase 4
  • glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
  • HK4
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