Browse our MCU Proteins (MCU)

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Mitochondrial Calcium Uniporter Proteins (MCU)
On are 6 Mitochondrial Calcium Uniporter (MCU) Proteins from 3 different suppliers available. Additionally we are shipping MCU Kits (12) and MCU Antibodies (4) and many more products for this protein. A total of 22 MCU products are currently listed.
2010012O16Rik, AV064928, C10orf42, Ccdc109a, D130073L02Rik, Gm64
list all proteins Gene Name GeneID UniProt
MCU 90550 Q8NE86
MCU 215999 Q3UMR5

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MCU Proteins (MCU) by Origin

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Human Mitochondrial Calcium Uniporter (MCU) interaction partners

  1. Study indicates that inhibition of mitochondrial calcium uniporter can inhibit excessive mitophagy and protect the neurocytes from ischemia/reperfusion injury.

  2. Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 (show MICU1 Proteins) and an original approach to investigate MCU/EMRE activation in intact cells.

  3. Data suggest that MCU regulator (EMRE) might be a structural factor for opening of the mitochondrial calcium uniporter (MCU)-forming pore.

  4. results suggest that N terminal domain of MCU is essential for the modulation of MCU function, although it does not affect the uniplex formation

  5. MCU-VDAC1 (show VDAC1 Proteins) complex regulates mitochondrial Ca(2 (show CA2 Proteins)+) uptake and oxidative stress-induced (show SQSTM1 Proteins) apoptosis

  6. Loss of heterozygosity of MCU gene on chromosome 10q is associated with pancreatic cancer.

  7. Studies indicate the existence of an inner mitochondrial protein (show COX6B2 Proteins) termed the mitochondrial calcium uniporter for calcium transport.

  8. analyses establish that MCU encodes the pore-forming subunit of the uniporter channel

  9. MCU plays a critical role in breast cancer cell migration by regulating store-operated Ca(2 (show CA2 Proteins)) entry.

  10. SLC25A23 (show SLC25A24 Proteins) augments mitochondrial Ca(2 (show CA2 Proteins)) uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Mouse (Murine) Mitochondrial Calcium Uniporter (MCU) interaction partners

  1. Data show that the serine/threonine kinase (show CDK4 Proteins) LKB1 (show STK11 Proteins) regulates mitochondrial calcium uniporter (MCU)-expression, mitochondria-dependent Ca2 (show CA2 Proteins)+ clearance, and thereby, presynaptic release properties.

  2. the Mcu-regulating Micu gene family profile differs substantially between neurons and astrocytes, while expression of Mcu itself is markedly different between CA3 (show CA3 Proteins) and CA1 (show CA1 Proteins) regions in the adult hippocampus.

  3. Absence of MCU expression does not affect basal cardiac function at either 12 or 20months of age in knockout mice.

  4. MCU is required to match energetics with contractile demand during stress. Deletion of Mcu protects against myocardial IR injury.

  5. Mice lacking MCU in the heart show no pathology. MCU selectively mediates acute mitochondria Ca2 (show CA2 Proteins)+ loading to augment ATP synthesis.

  6. MCU is necessary for complete physiological heart rate acceleration

  7. MCU-VDAC1 (show VDAC1 Proteins) complex regulates mitochondrial Ca(2 (show CA2 Proteins)+) uptake and oxidative stress-induced (show SQSTM1 Proteins) apoptosis

  8. Chromatin immunoprecipitation and promoter reporter analyses revealed that the Ca2 (show CA2 Proteins)+ -regulated transcription factor CREB (show CREB1 Proteins) (cyclic adenosine monophosphate response element-binding protein) directly bound the MCU promoter and stimulated expression.

  9. chronic myocardial MCU inhibition leads to previously unanticipated compensatory changes.

  10. Tetrodotoxin-sensitive mitochondrial Ca(2 (show CA2 Proteins)+) influx was largely blocked by knockdown of MCU expression.

MCU Protein Profile

Protein Summary

This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with MCU

  • mitochondrial calcium uniporter (MCU)
  • mitochondrial calcium uniporter (Mcu)
  • 2010012O16Rik protein
  • AV064928 protein
  • C10orf42 protein
  • Ccdc109a protein
  • D130073L02Rik protein
  • Gm64 protein

Protein level used designations for MCU

calcium uniporter protein, mitochondrial , coiled-coil domain-containing protein 109A , coiled-coil domain containing 109A

90550 Homo sapiens
215999 Mus musculus
489042 Canis lupus familiaris
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