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MCU Products

(Mitochondrial Calcium Uniporter (MCU))
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

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Featured MCU Categories

MCU Antibodies

High quality antibodies with extensive validation data.

MCU ELISA Kits

Reliable ELISA kits for a wide range of species.

MCU Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MCU Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN7268549
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7146314
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, WB
Validations
  • (2)
Cat. No. ABIN6260526
Quantity 100 μL
Datasheet Datasheet

Recommended MCU ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
Cat. No. ABIN1744117
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1742896
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1773800
Quantity 96 tests
Datasheet Datasheet

Recommended MCU Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310583
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2713279
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our MCU products

Yan, Li, Yan, Zhao, Liu, Liu: "Effects of luteolin on regulatory proteins and enzymes for myocyte calcium circulation in hypothermic preserved rat heart." in: Experimental and therapeutic medicine, Vol. 15, Issue 2, pp. 1433-1441, (2018) (PubMed).

Lee, Min, Kim, Song, Lim, Kim, Shin, Kang, Kang, Youn, Lee, An, Park, Lim, Kim, Kim, Park, Kim, Wang, Kim, Eom: "Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter." in: EMBO reports, Vol. 16, Issue 10, pp. 1318-33, (2015) (PubMed).

Stauch, Purnell, Fox: "Quantitative proteomics of synaptic and nonsynaptic mitochondria: insights for synaptic mitochondrial vulnerability." in: Journal of proteome research, Vol. 13, Issue 5, pp. 2620-36, (2014) (PubMed).

Kovács-Bogdán, Sancak, Kamer, Plovanich, Jambhekar, Huber, Myre, Blower, Mootha: "Reconstitution of the mitochondrial calcium uniporter in yeast." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 24, pp. 8985-90, (2014) (PubMed).

Arruda, Pers, Parlakgül, Güney, Inouye, Hotamisligil: "Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity." in: Nature medicine, Vol. 20, Issue 12, pp. 1427-35, (2014) (PubMed).

Logan, Szabadkai, Sharpe, Parry, Torelli, Childs, Kriek, Phadke, Johnson, Roberts, Bonthron, Pysden, Whyte, Munteanu, Foley, Wheway, Szymanska, Natarajan, Abdelhamed, Morgan, Roper, Santen, Niks et al.: "Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. ..." in: Nature genetics, Vol. 46, Issue 2, pp. 188-93, (2014) (PubMed).

Samanta, Douglas, Parekh: "Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulation." in: PLoS ONE, Vol. 9, Issue 7, pp. e101188, (2014) (PubMed).

Qiu, Tan, Hagenston, Martel, Kneisel, Skehel, Wyllie, Bading, Hardingham: "Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals." in: Nature communications, Vol. 4, pp. 2034, (2013) (PubMed).

Pan, Liu, Nguyen, Liu, Sun, Teng, Fergusson, Rovira, Allen, Springer, Aponte, Gucek, Balaban, Murphy, Finkel: "The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter." in: Nature cell biology, Vol. 15, Issue 12, pp. 1464-72, (2013) (PubMed).

Baughman, Perocchi, Girgis, Plovanich, Belcher-Timme, Sancak, Bao, Strittmatter, Goldberger, Bogorad, Koteliansky, Mootha: "Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter." in: Nature, Vol. 476, Issue 7360, pp. 341-5, (2011) (PubMed).

Synonyms and alternative names related to MCU

mitochondrial calcium uniporter (MCU), mitochondrial calcium uniporter (Mcu), 2010012O16Rik, AV064928, C10orf42, CCDC109A, Ccdc109a, D130073L02Rik, Gm64

Protein level used designations for MCU

  • calcium uniporter protein, mitochondrial
  • coiled-coil domain-containing protein 109A
  • coiled-coil domain containing 109A
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