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Human PHPT1 Protein expressed in Escherichia coli (E. coli) - ABIN667241
Srivastava, Zhdanova, Di, Li, Albaqumi, Wulff, Skolnik: Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 references for ABIN667241
Human PHPT1 Protein expressed in Escherichia coli (E. coli) - ABIN2005231
Busam, Thorsell, Flores, Hammarström, Persson, Hallberg: First structure of a eukaryotic phosphohistidine phosphatase. in The Journal of biological chemistry 2006
Show all 2 references for ABIN2005231
PHPT1 was expressed in the epithelium of proximal tubuli and nuclei of clear-cell renal cell carcinoma (show MOK Proteins) tissue samples.
PHPT1 can dephosphorylate phospholysine in chemically phosphorylated histone H1 (show H1F0 Proteins) and polylysine
The specific degradation of the PHPT1 splice variant indicates that the quality control and the self-guarding of the cellular system works at two levels, first at the RNA level and proteasome level.
the histidine phosphatase, protein histidine phosphatase 1, inhibits NDPK-B-activated TRPV5 (show TRPV5 Proteins) in inside/out patch experiments.
Overexpression of PHP (show ASAH1 Proteins) by the use of a plasmid vector, pIRES2-AcGFP1-PHP (show ASAH1 Proteins), induced apoptosis in HUVEC
Significantly higher expression levels of PHPT1 protein were found in lung cancer samples than in normal tissues adjacent to lung cancer.
these data implicate regulatory roles for PHPT1 in a G protein-sensitive step involved in nutrient-induced insulin (show INS Proteins) secretion
These results demonstrate for the first time that PHP14 may be functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement.
Overexpression of PHP (show ASAH1 Proteins) results in increased dephosphorylation with concomitant inactivation of ACL (show ACLY Proteins), thus finally leading to cell damage.
PHPT-1 functions to negatively regulate CD4 (show CD4 Proteins) T cells
PHPT1 is an EDTA-insensitive phosphohistidine phosphatase that catalyzes the dephosphorylation of phosphopeptide I (Ek et al., 2002
phosphohistidine phosphatase 1
, 14 kDa phosphohistidine phosphatase
, phosphohistidine phosphatase 14kDa
, protein janus-A homolog
, sex-regulated protein janus-a
, 14kDa phosphohistidine phosphatase