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Browse our anti-TAR DNA Binding Protein (TARDBP) Antibodies

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anti-TAR DNA Binding Protein Antibodies (TARDBP)
On are 236 TAR DNA Binding Protein (TARDBP) Antibodies from 26 different suppliers available. Additionally we are shipping TAR DNA Binding Protein Kits (27) and TAR DNA Binding Protein Proteins (14) and many more products for this protein. A total of 292 TAR DNA Binding Protein products are currently listed.
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
list all antibodies Gene Name GeneID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
TARDBP 298648  

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Top referenced anti-TAR DNA Binding Protein Antibodies

  1. Chicken Polyclonal TARDBP Primary Antibody for ICC, IF - ABIN188986 : Neumann, Sampathu, Kwong, Truax, Micsenyi, Chou, Bruce, Schuck, Grossman, Clark, McCluskey, Miller, Masliah, Mackenzie, Feldman, Feiden, Kretzschmar, Trojanowski, Lee: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 12 references for ABIN188986

  2. Human Polyclonal TARDBP Primary Antibody for EIA, IF - ABIN500883 : Buratti, Dörk, Zuccato, Pagani, Romano, Baralle: Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. in The EMBO journal 2001 (PubMed)
    Show all 3 references for ABIN500883

  3. Chicken Polyclonal TARDBP Primary Antibody for IHC, WB - ABIN2780849 : Buratti, Brindisi, Giombi, Tisminetzky, Ayala, Baralle: TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN2780849

  4. Chicken Polyclonal TARDBP Primary Antibody for IHC, WB - ABIN2780848 : Estes, Boehringer, Zwick, Tang, Grigsby, Zarnescu: Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. in Human molecular genetics 2011 (PubMed)
    Show all 2 references for ABIN2780848

  5. Human Monoclonal TARDBP Primary Antibody for EIA, IHC (p) - ABIN317572 : Kabashi, Valdmanis, Dion, Spiegelman, McConkey, Vande Velde, Bouchard, Lacomblez, Pochigaeva, Salachas, Pradat, Camu, Meininger, Dupre, Rouleau: TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. in Nature genetics 2008 (PubMed)
    Show all 2 references for ABIN317572

  6. Human Polyclonal TARDBP Primary Antibody for IF, WB - ABIN318898 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995 (PubMed)

  7. Human Polyclonal TARDBP Primary Antibody for ELISA, WB - ABIN334503 : Zhang, Xu, Dickey, Buratti, Baralle, Bailey, Pickering-Brown, Dickson, Petrucelli: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  8. Human Polyclonal TARDBP Primary Antibody for IF, IHC (p) - ABIN657685 : Kim, Shanware, Bowler, Tibbetts: Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against TAR DNA Binding Protein Interaction Partners

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. The aim of this review will be to provide a general overview of TDP-43 and FUS/TLS (show FUS Antibodies) proteins and to highlight their physiological functions--{REVIEW}

  2. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in amyotrophic lateral sclerosis is caused by abnormal autoregulation of TDP-43.

  3. Findings suggest a mechanism in which retrotransposable element (RTE) activity contributes to neurodegeneration in TAR DNA-binding protein 43 (TDP-43)-mediated diseases such as Amyotrophic lateral sclerosis (ALS (show IGFALS Antibodies)) and frontotemporal lobar degeneration (FTLD).

  4. Possible role of deregulated DNA binding function of TDP-43 in ALS.

  5. These data suggest that Familial Amyotrophic Lateral Sclerosis-linked PFN1 (show PFN1 Antibodies) mutations exacerbate TDP-43-induced neurodegeneration in a gain-of-function manner, possibly by shifting the localization of TDP-43 from nuclei to cytoplasm.

  6. Data suggest that transitions of TDP-43 among soluble, droplet, and aggregate phases are involved in pathological aggregation; TDP-43 prion (show PRNP Antibodies)-like domain appears to wobble at a cusp of the protein folding energy landscape where any number of factors can tip the balance and trigger the conversion from its native function to its pathological one. [REVIEW]

  7. Secreted PGRN (show GRN Antibodies) is incorporated into cells via sortilin (show SORT1 Antibodies) or cation-independent mannose 6-phosphate receptor (show IGF2R Antibodies), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN (show GRN Antibodies) levels led to a cell-type-specific increase of insoluble TDP-43. In the brain tissue of FTLD-TDP patients with PGRN (show GRN Antibodies) deficiency, CTSD (show CTSD Antibodies) and phosphorylated TDP-43 accumulated in neurons

  8. Various degrees of TDP-43 cytoplasmic accumulation and nuclear TDP-43 depletion were achieved and the resulting cellular viability was evaluated, leading to a quantitative global analysis on the relative effects of LOF and GOF on the overall cytotoxicity.

  9. results from this study suggest that TDP-43 represents a translational repressor not only for specific mRNAs but for overall translation and that its binding to polyribosomes through RACK1 (show GNB2L1 Antibodies) may promote, under conditions inducingAmyotrophic Lateral Sclerosis pathogenesis, the formation of cytoplasmic inclusions.

  10. using an in vitro cellular model, we demonstrated that Drb1 (show RBM45 Antibodies) co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  2. demonstrated that the levels of HSF1 (show HSF1 Antibodies) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  3. The present study identified USP7 (show USP7 Antibodies) and TDP-43 as the regulators of CRY1 (show CRY1 Antibodies) and CRY2 (show CRY2 Antibodies), underscoring the significance of the stability control process of CRY (show CRY2 Antibodies) proteins for period determination in the mammalian circadian clockwork.

  4. TDP-43 functions within a network of hnRNP (show HNRNPH2 Antibodies) proteins to inhibit the production of a truncated human SORT1 (show SORT1 Antibodies) receptor.

  5. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  6. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  7. UBQLN2 (show UBQLN2 Antibodies) dysregulation in neurons can drive NF-kappaB (show NFKB1 Antibodies) activation and cytosolic TDP-43 aggregation.

  8. These findings demonstrate a role for PABPN1 (show PABPN1 Antibodies) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

  9. identifies DDX58 (show DDX58 Antibodies) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1

  10. Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (show CNBP Antibodies) tardbp and RNA binding protein fus (show FUS Antibodies).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (show FUS Antibodies) act in a pathogenic pathway that is independent of SOD1 (show SOD1 Antibodies).

TAR DNA Binding Protein (TARDBP) Antigen Profile

Antigen Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) antibody
  • Tardbp protein (tardbp) antibody
  • TAR DNA binding protein (tardbp) antibody
  • TAR DNA binding protein (Tardbp) antibody
  • TAR DNA-binding protein 43-like (LOC100621383) antibody
  • 1190002A23Rik antibody
  • ALS10 antibody
  • C85084 antibody
  • DKFZp459I2127 antibody
  • tardbp antibody
  • TDP-43 antibody
  • Tdp43 antibody
  • wu:fb77f02 antibody
  • wu:fc52g10 antibody

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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