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Human APOE Protein expressed in HEK-293 Cells - ABIN2714829
Pan, Zhou, Mahsut, Rohm, Berejnaia, Price, Chen, Castro-Perez, Lassman, McLaren, Conway, Jensen, Thomas, Reyes-Soffer, Ginsberg, Gutstein, Cleary, Previs, Roddy: Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS. in Journal of lipid research 2016
Human APOE Protein expressed in Human - ABIN934462
Krul, Cole: Quantitation of apolipoprotein E. in Methods in enzymology 1996
Deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease by inhibiting TGF-beta (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins)/STAT3 (show STAT3 Proteins) signaling.
choroid plexus/CSF (show CSF2 Proteins) provides an additional source of apoE and the glymphatic fluid transporting system delivers it to brain via the periarterial space
Longxuetongluo capsule inhibits atherosclerosis progression in high-fat diet-induced ApoE(-/-) mice by improving endothelial dysfunction via MAPK (show MAPK1 Proteins)/IKK (show CHUK Proteins)/IkappaB/NF-kappaB (show NFKB1 Proteins) signaling pathway.
Major orthopedic surgery in ApoE-/- mice triggers a systemic inflammatory response. Atherosclerotic plaque area is enlarged after surgery mainly due to an increase of the necrotic core.
Saffron (Crocus sativus) protects against myocardial ischemia-reperfusion injury in Wild Type and ApoE((-/-)) mice via Nrf2 (show NFE2L2 Proteins) pathway.
Zinc supplementation has a therapeutic effect on the advanced atherosclerosis of ApoE gene-deleted mice, which can significantly improve the efficacy of irbesartan.
Decreased Hexim-1 (show HEXIM1 Proteins) expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta (show TGFB1 Proteins) pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 (show SOCS3 Proteins) respectively.
DPP-4 (show DPP4 Proteins) inhibitor teneligliptin inhibited atherogenesis in ApoE knockout mice, at least partially, through attenuation of the inflammatory phenotype of perivascular adipose tissue.
Loss of ApoE potentiates a semi-chronic inflammatory arthritis.
apoE4 interacts wiith insulin receptor (show INSR Proteins) and impairs its trafficking by trapping it in the endosomes, leading to impaired insulin (show INS Proteins) signaling and insulin (show INS Proteins)-stimulated mitochondrial respiration and glycolysis.
In this study, we found no significant association between allele and genotype frequencies of APOE; the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 (show LOXL1 Proteins) are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.
APOE epsilon4 allele is neither a risk factor for rapid eye movement sleep behavior disorder(RBD (show CACNA1D Proteins)) nor it is associated with conversion from RBD (show CACNA1D Proteins) to dementia with Lewy bodies or other synucleinopathies.
APOE genotype presents a systematic array of potential associations with cognitive performance
APOE epsilon4 genotype is the major driver of accumulation of white matter hyperintensities volume.
APOE epsilon4 allele increases the risk for sporadic Alzheimer's disease and modifies brain activation patterns of numerous cognitive domains.
indicates that measurable apolipoprotein E-related brain atrophy does not occur in early adulthood and midlife
Self-reported sleep duration, napping, and trouble falling/staying asleep differ by APOE genotype; studies are needed to examine whether APOE promotes AD by degrading sleep and to clarify the role of race in these associations
Study provides support for the argument that Apolipoprotein E (APOE varepsilon4+) and catechol-O-methyl transferase Met/Met genotypes can be used as predictors of faster cognitive decline in Parkinson's disease.
both apolipoprotein E and Abeta1-42 abundance can differ depending upon the type of CJD (show PRNP Proteins).
report association of APOE and TOMM40 (show TOMM40 Proteins) with behavioural variant frontotemporal dementia, and ARHGAP35 (show GRLF1 Proteins) and SERPINA1 (show SERPINA1 Proteins) with progressive non-fluent aphasia.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 Proteins) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE, MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Proteins) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3