Browse our APOE Proteins (APOE)

Full name:
Apolipoprotein E Proteins (APOE)
On are 52 Apolipoprotein E (APOE) Proteins from 11 different suppliers available. Additionally we are shipping APOE Antibodies (354) and APOE Kits (120) and many more products for this protein. A total of 539 APOE products are currently listed.
AD2, AI255918, Apo-E, apoe, APOEA, apoprotein, im:7036787, LDLCQ5, LPG, wu:fb69a05, zgc:110064
list all proteins Gene Name GeneID UniProt
APOE 11816 P08226
APOE 348 P02649
APOE 25728 P02650

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APOE Proteins (APOE) by Origin

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Top referenced APOE Proteins

  1. Human APOE Protein expressed in HEK-293 Cells - ABIN2714829 : Pan, Zhou, Mahsut, Rohm, Berejnaia, Price, Chen, Castro-Perez, Lassman, McLaren, Conway, Jensen, Thomas, Reyes-Soffer, Ginsberg, Gutstein, Cleary, Previs, Roddy: Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS. in Journal of lipid research 2016 (PubMed)

More Proteins for APOE Interaction Partners

Mouse (Murine) Apolipoprotein E (APOE) interaction partners

  1. apoE4 interacts wiith insulin receptor (show INSR Proteins) and impairs its trafficking by trapping it in the endosomes, leading to impaired insulin (show INS Proteins) signaling and insulin (show INS Proteins)-stimulated mitochondrial respiration and glycolysis.

  2. UCP-2 (show UCP2 Proteins) prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice via antioxidant and antiapoptotic activities.

  3. treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4

  4. Adiponectin (show ADIPOQ Proteins), TNF-alpha (show TNF Proteins), and LOX-1 (show OLR1 Proteins) exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE knockout mice.

  5. Apoe-deficient mice and human apoE isoform knockin mice, as well as hypomorphic Apoe mice, have significantly contributed to our understanding of the role of apoE in lipoprotein metabolism. [review]

  6. beta-Sarcoglycan (show SGCB Proteins) deficiency reduces atherosclerotic plaque formation in ApoE-knockout mouse model.

  7. we found that the lack of microbiota caused a significant reduction in atherosclerotic lesion formation compared with Conv ApoE(-/-) mice, which might be associated with the attenuation of lipopolysaccharide-mediated inflammatory responses. Our findings indicated that the gut (show GUSB Proteins) microbiota affected both hypercholesterolemia and atherogenesis in mice

  8. this reduction in lesion formation was associated with reduced numbers of lesional SMCs but not macrophages within the transplanted Cx3cr-/- Apoe-/- aortic segment. No differences in frequencies of proliferating and apoptotic cells could be observed. These results indicate that CX3CR1 (show CX3CR1 Proteins) on resident vessel wall cells plays a key role in atherosclerotic plaque formation in transplanted aortic grafts

  9. Specific inhibition of the NLRP3 (show NLRP3 Proteins) inflammasome using MCC950 can be a promising therapeutic approach to inhibit atherosclerotic lesion development in ApoE deficient mice.

  10. catK (show CTSK Proteins) deficiency almost completely blunted the increased vascular remodeling response of apoE-/- mice to flow cessation, possibly by correcting hyperlipidemia-associated pro-inflammatory effects on the peripheral immune response

Human Apolipoprotein E (APOE) interaction partners

  1. Possession of an Apolipoprotein E (APOE) e4 allele is an established risk factor for Alzheimer's disease.

  2. Association between an Alzheimer's Disease-Related Index and APOE epsilon4 Gene Dose

  3. ApoE levels positively associate with incident CVD risk with apoE-associated risk likely residing in apoB (show APOB Proteins)-containing lipoproteins

  4. APOE protein plays a significant role in Oral squamous cell carcinoma tumor invasion

  5. Results showed that the APOE varepsilon4 genotype impaired neither explicit memory nor memory-based orienting of spatial attention. Interestingly, however, we found that the possession of the varepsilon4 allele broke the relationship between declarative long-term memory and memory-guided orienting of visuo-spatial attention, suggesting an earlier modulation exerted by pure genetic characteristics on cognition.

  6. Report presents the largest population-based study on APOE allele distribution and its association with Alzheimer's disease carried out in China. The results showed the general distribution of ApoE alleles and genotypes similar to those observed in the non-Chinese populations in Western countries. The results suggest that ApoEepsilon4 allele is a risk factor of Alzheimer's disease for Chinese population.

  7. The findings of this study suggested that inheritance of APOE-epsilon4 causes life long changes to the brain that may be related to the late risk of Alzheimer's Disease.

  8. ApoE associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age /=160 mg/dl.

  9. Study found enrichment of epistasis in gonadotropin-releasing hormone signaling with risk single-nucleotide polymorphisms in APOE and MS4A6A (show MS4A6A Proteins). Results suggest that in addition to APOE, MS4A6A (show MS4A6A Proteins) polymorphisms should be considered in hormone trials targeting gonadotropins.

  10. Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40 (show TOMM40 Proteins)], rs4420638 [APOC1 (show APOC1 Proteins)], and rs429358 [APOE]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise

Rabbit Apolipoprotein E (APOE) interaction partners

  1. we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.

  2. The molar ratio ApoE/ApoA-I (show APOA1 Proteins) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.

  3. ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity

  4. The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.

Pig (Porcine) Apolipoprotein E (APOE) interaction partners

  1. These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant

Cow (Bovine) Apolipoprotein E (APOE) interaction partners

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE, MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

  2. Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism

  3. apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Proteins) particles, and lipid-free forms were included in cow plasma

  4. after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E messenger RNA abundance were higher in the liver

Chimpanzee Apolipoprotein E (APOE) interaction partners

  1. The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.

  2. ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.

Rhesus Monkey Apolipoprotein E (APOE) interaction partners

  1. In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals

  2. Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world

  3. There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.

APOE Protein Profile

Protein Summary

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Alternative names and synonyms associated with APOE

  • apolipoprotein E (apoe)
  • apolipoprotein Ea (apoea)
  • apolipoprotein E (Apoe)
  • apolipoprotein E (APOE)
  • AD2 protein
  • AI255918 protein
  • Apo-E protein
  • apoe protein
  • APOEA protein
  • apoprotein protein
  • im:7036787 protein
  • LDLCQ5 protein
  • LPG protein
  • wu:fb69a05 protein
  • zgc:110064 protein

Protein level used designations for Apolipoprotein E Proteins (APOE)

apolipoprotein E , ApoE-1 , apo-E , apolipoprotein E3

394678 Xenopus (Silurana) tropicalis
553587 Danio rerio
100136023 Oncorhynchus mykiss
100380959 Xenopus laevis
11816 Mus musculus
348 Homo sapiens
100009337 Oryctolagus cuniculus
25728 Rattus norvegicus
397576 Sus scrofa
100731633 Cavia porcellus
281004 Bos taurus
476438 Canis lupus familiaris
449586 Pan troglodytes
714623 Macaca mulatta
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